王小兵，博士，教授，博士生导师，江苏省“六大人才高峰”A类高层次人才（2018年），“333工程”第三层次培养对象（2018年），“青蓝工程”优秀青年骨干教师（2017年），主要从事天然活性成分研究与开发工作。
2008年毕业于中国药科大学，获药物化学专业博士学位。2008年7月留校天然药物化学教研室任教，承担本科生《天然药物化学》、《波谱解析》和研究生《高等波谱解析》等课程教学工作。2015-2016年于美国The Scripps Research Institute的Jin-Quan Yu教授课题组从事有机合成中的碳氢活化及其在天然产物中的应用研究工作。在Science, ACS Catalysis, Journal of Medicinal Chemistry, ACS Applied Materials & Interface, European Journal of Medicinal Chemistry，ACS Chemical Neuroscience, Organic & Biomolecular Chemistry, Journal of Enzyme Inhibition and Medicinal Chemistry, RSC Advances, Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters和MedChemComm等SCI源刊发表科研论文100余篇，SCI他引共计2268篇次，获10余项发明专利，主持国家自然科学基金面上项目、江苏省自然科学基金青年项目和面上项目各一项，参与多项国家和省部级基金项目。
研究方向：
基于天然产物的合理药物设计与研究；
天然产物结构修饰与全合成；
天然产物生物转化研究。
主持的基金项目：
国家自然科学基金面上项目，基于天然产物“优势结构”和药物“活性片段”具有均衡活性的多靶点阿尔茨海默病药物分子研究，编号：**, 2016 ~ 2019.
江苏省自然科学基金青年项目，若干常见中草药活性成分的酶促生物转化研究，编号：BK**, 2013 ~ 2016.
奖励：
2015年度国家科学技术进步奖二等奖，排名第三
2013年度江苏省科学技术奖一等奖，排名第四
2012年度教育部科学技术进步奖二等奖，排名第五

科研ID：
ORCID：0000-0001-5044-3721
Researcher ID：H-1541-2011
近三年主要科研论文：
Cheng Wang, Shang Li, Jinhua Zhao, Huali Yang, Fucheng Yin, Ming Ding, Jianguang Luo, Xiaobing Wang*, Lingyi Kong*, Design and SAR of Withangulatin A Analogues that Act as Covalent TrxR Inhibitors through the Michael Addition Reaction Showing Potential in Cancer Treatment, J Med Chem, 2020, 63: 11195-11214.( Supplementary Cover)
Jinhua Zhao, Fucheng Yin, Limei Ji, Cheng Wang, Cunjian Shi, Xingchen Liu, Huali Yang, Xiaobing Wang*, Lingyi Kong*, Development of a Tau-Targeted Drug Delivery System Using a Multifunctional Nanoscale Metal–Organic Framework for Alzheimer’s Disease Therapy, ACS Applied Materials & Interfaces, 2020, 12: 44447-44458.(Supplementary Cover)
Cun-Jian Shi, Wan Peng, Jin-Hua Zhao, Hua-Li Yang, Lai-Liang Qu, Cheng Wang, Ling-Yi Kong*, Xiao-Bing Wang*, Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors, European Journal of Medicinal Chemistry, 2020, 187: 111961.
Siqiang Fang, Xiaobing Wang*, Fucheng Yin, Pei Cai, Huali Yang, Lingyi Kong*, Palladium-Catalyzed meta-C-H Olefination of Arene-Tethered Diols Directed by Well-Designed Pyrimidine-Based Group, Organic Letters, 2019, 21: 1841-1844.
Hua-Li Yang, Si-Qiang Fang, Yan-Wei Tang, Cheng Wang, Heng Luo, Lai-Liang Qu, Jin-Hua Zhao, Cun-Jian Shi, Fu-Cheng Yin, Xiao-Bing Wang *, Ling-Yi Kong*,A hemicyanine derivative for near-infrared imaging of β-amyloid plaques in Alzheimer’s disease.European Journal of Medicinal Chemistry,2019, 179, 736-743.
Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. European Journal of Medicinal Chemistry. 2019, 163: 307-319
Novel 8-hydroxyquinoline derivatives targeting beta-amyloid aggregation, metal chelation and oxidative stress against Alzheimer's disease. Bioorganic & Medicinal Chemistry. 2018, 26: 3191-3201
Qing-Feng Wu, Xiao-Bing Wang, Peng-Xiang Shen, Jin-Quan Yu, Enantioselective C–H Arylation and Vinylation of Cyclobutyl Carboxylic Amides, ACS Catalysis, 2018, 2577-2581. DOI: 10.1021/acscatal.8b00069(Q.-F.W. and X.-B.W. contributed equally to this work.)
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties. European Journal of Medicinal Chemistry. 2018, 157: 161-176
Qing-Feng Wu, Peng-Xiang Shen, Jian He, Xiao-Bing Wang, Forrest Zhang, Qian Shao, Ru-Yi Zhu, Claudio Mapelli, Jennifer X. Qiao, Michael A. Poss, Jin-Quan Yu*, Formation of α-chiral centers by asymmetric β-C(sp3)–H arylation, alkenylation, and alkynylation. Science, 2017, 355, 499-503. DOI: 10.1126/science.aal5175
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. European Journal of Medicinal Chemistry, 2017, 139, 68-83.
Rational Design and Multibiological Profiling of Novel Donepezil–Trolox Hybrids against Alzheimer’s Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties. ACS Chemical Neuroscience, 2017, 8, 2496-2511.
Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 2017, 138, 715-728.
Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease. MedChemComm. 2017, 8, 1459-1467.
Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. Bioorganic & Medicinal Chemistry,2017, 25, 3815-3826.
Polycyclic xanthones viapH-switched biotransformation of α-mangostin catalysed by horseradish peroxidase exhibited cytotoxicity against hepatoblastoma cells in vitro. Journal of Functional Foods2017, 28, 205-214.
Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease. Bioorg Med Chem, 2017, 25, 5917-5928.
Experimental and theoretical calculation studies on the structure elucidation and absolute configuration of calyxins from Alpinia katsumadai. Fitoterapia, 2017, 119, 121-129.

联系方式：
通讯地址：南京市童家巷24号，中国药科大学天然药物化学系
邮政编码：210009
电子信箱：xbwang@cpu.edu.cn**@qq.com
办公电话：(O)