理学博士，教授、博士生导师，国家****科学基金获得者、新世纪百千****才工程国家级人选。1983年7月毕业于南京药学院(现中国药科大学)中药学专业，获学士学位；1983年8月-1988年10月在安徽中医药高等专科学校任教；1988年11月-1997年7月在中国药科大学天然药物化学教研室任教，先后任讲师、副教授；1997年8月-2001年10月在香港科技大学化学系学习，获博士学位；2001年11月起任中国药科大学教授、博士生导师；2002年8月-2016年7月先后担任暨南大学中药及天然药物研究所常务副所长，中药系主任，药学院副院长、院长。2014年10月起任暨南大学副校长。
一直围绕着揭示中药及天然药物的药效物质基础、发现新药候选化合物以及在此基础上的创新药物开展系统的研究工作。已对150余种中药和天然药物进行了系统的化学成分研究，共分离鉴定了3000余个天然化合物，其中新化合物400余种、新骨架结构30余类。通过进一步的结构修饰和生物活性评价，发现具显著生物活性的化合物40余个，并比较深入地评价了10余个化合物的药效作用和作用机制。先后主持了国家****科学基金、国家自然科学基金重点和面上项目、国家重大科技专项、广东省自然科学基金团队项目、广东省和广州市重大科技专项等科研项目40余项。已发表研究论文650余篇(其中SCI收录论文350余篇)，论文被他引3400余次，2014、2015年连续被列入Elsevier中国高被引****榜单。获授权国内外发明专利40余项，获一类和五类中药新药临床研究批件各1项，获广东省科学技术奖一等奖、中国专利优秀奖各1项，并获中国药学发展奖(地奥)中药奖、广东丁颖科技奖、全国模范教师、全国优秀科技工作者等称号。讲授了多门本科生和研究生课程，培养硕士和博士研究生100余名。
兼任国家药典委员会委员、广东省药学会副理事长、中国植物学会植物化学与资源学专业委员会副主任委员、广东省学位委员会委员、广东省高校设置评议委员会委员。此外，还兼任多个国际和国内专业学术期刊编委、国家和省部级重点实验室学术委员会委员。
主要研究方向:
1. 中药及天然药物活性成分
2. 活性天然产物的化学生物学研究
3. 中药及天然药物来源的创新药物研究
近年发表的代表性论文：
1.Wu ZL, Zhao BX, Huang XJ, Tang GY, Shi L, Jiang RW, Liu X, Wang Y*, Ye WC*. Suffrutines A and B: A pair of Z/E isomeric indolizidine alkaloids from the roots of Flueggea suffruticosa. Angew Chem Int Ed, 2014, 53: 5796-5799. (IF: 11.709)
2.Zhang DM, Xu HG, Wang L, Li YJ, Sun PH, Wu XM, Wang GJ, Chen WM*, Ye WC*. Betulinic acid and its derivatives as potential antitumor agents. Medicinal Research Reviews, 2015, 35: 1127-1155. (IF: 9.135)
3.Cao JQ, Huang XJ, Li YT, Wang Y, Wang L*, Jiang RW*, Ye WC*. Callistrilones A and B, Triketone-Phloroglucinol-Monoterpene Hybrids with a New Skeleton from Callistemon rigidus, Organic Letters, 2016, 18: 120-123. (IF: 6.732)
4.Li XL, Zhao BX, Huang XJ, Zhang DM, Jiang RW, Li YJ, Jian YQ, Wang Y*, Li YL*, Ye WC*. (+)- and (-)-Cajanusine, a pair of new enantiomeric stilbene dimers with a new skeleton from the leaves of Cajanus cajan. Organic Letters, 2014, 16: 224-227. (IF: 6.732)
5.Shao M, Wang Y*, Jian YQ, Huang XJ, Zhang DM, Tang QF, Jiang RW, Sun XG, Lv ZP, Zhang XQ*, Ye WC*. Guadial A and Psiguadials C and D, Three Unusual Meroterpenoids from Psidium guajava. Organic Letters, 2012, 14: 5262-5265. (IF: 6.732)
6.Zhao BX, Wang Y*, Zhang DM, Huang XQ, Bai LL, Yan Y, Chen JM, Lu TB, Wang YT, Zhang QW*, Ye WC*. Virosaines A and B, Two New Birdcage-Shaped Securinega Alkaloids with an Unprecedented Skeleton from Flueggea virosa. Organic Letters, 2012, 14: 3096-3099. (IF: 6.732)
7.Wang CQ, Wang L, Fan CL, Zhang DM, Huang XJ, Jiang RW, Bai LL, Shi JM, Wang Y, Ye WC*. Ilelic Acids A and B, two unusual triterpenes with a seven-membered ring from Ilex latifolia. Organic Letters, 2012, 14: 4102-4105. (IF: 6.732)
8.Zhao BX, Wang Y, Zhang DM, Jiang RW, Wang GC, Shi JM, Huang XJ, Chen WM, Che CT, Ye WC*. Flueggines A and B, two new dimericindolizidine alkaloids from Flueggea virosa. Organic Letters, 2011, 13: 3888-3891. (IF: 6.732)
9.Shao M, Wang Y, Liu Z, Zhang DM, Cao HH, Jiang RW, Fan CL, Zhang XQ, Chen HR, Yao XS, Ye WC*. Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Organic Letters, 2010, 12: 5040-5043. (IF: 6.732)
10.Ma N, Yao YW, Zhao BX, Wang Y, Ye WC*, Jiang S*. Total synthesis of securinega alkaloids (-)-norsecurinine, (-)-niruroidine and (-)-flueggine A. Chem Commun, 2014, 50: 9284-9287. (IF: 6.567)
11.Ip FCF, Fu WY, Cheng EYL, Tong EPS, Lok KC, Liang Y, Ye WC*, Ip NY*. Anemoside A3 enhances cognition through the regulation of synaptic function and neuroprotection. Neuropsychopharmacology, 2015, 40: 1877-1887. (IF: 6.399)
12.Yu B, Guan M, Peng Y, Shao Y, Zhang C, Yue X, Zhang J, Yang H, Zou H, Ye W*, Wan J*, Zhang W*. Copy number variations of interleukin-17F, interleukin-21, and interleukin-22 are associated with systemic lupus erythematosus. Arthritis & Rheum, 2011, 63: 3487-3492. (IF: 6.009)
13.Jian YQ, Huang XJ, Zhang DM, Jiang RW, Chen MF, Zhao BX, Wang Y*, Ye WC*. Guapsidial A and guadials B and C: Three new meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Chemistry-A European Journal, 2015, 21: 9022-9027. (IF: 5.771)
14.Tian HY, Wang L, Zhang XQ, Wang Y, Zhang DM, Jiang RW, Liu Z, Liu JS, Li YL, Ye WC*. Bufogargarizins A and B: two novel 19-norbufadienolides with unprecedented skeletons from the venom of Bufo bufo gargarizans. Chemistry-A European Journal, 2010, 16: 10989-10993. (IF: 5.771)
15.Liu JS, Zhang DM, Li Y, Chen WM, Ruan ZX, Deng LJ, Wang LW, Tian HY, Yiu A, Fan CL, Luo H, Liu SW, Wang Y, Xiao GK, Chen LX*, Ye WC*. Discovery of Bufadienolides as a Novel Class of ClC-3 Chloride Channel Activators with Antitumor Activities. Journal of Medicinal Chemistry, 2013, 56: 5734-5743. (IF: 5.589)
16.Shi JM, Bai LL, Zhang DM, Yiu A, Yin ZQ, Han WL, Liu JS, Li Y, Fu DY, Ye WC*. Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress. Biochemical Pharmacology, 2013, 85: 913-926. (IF: 5.091)
17.Li MM, Wu SA, Liu Z, Zhang W, Xu J, Wang Y, Liu JS, Zhang DM, Tian HY, Li YL*, Ye WC*. Arenobufagin, abufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGF-2 signaling pathway. Biochemical Pharmacology, 2012, 83, 1251-1260. (IF: 5.091)
18.Zhang DM, Liu JS, Deng LJ, Chen MF, Yiu A, Cao HH, Tian HY, Fung KP, Kurihara H, Pan JX, Ye WC*. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis, 2013, 34: 1331-1342. (IF: 4.874)
19.Zhang YB, Zhang LQ, Li GQ, Wang F, Wang Y, Li YL*, Ye WC*, Wang GC*. Dimeric Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Anti-Hepatitis B Virus Activities. The Journal of Organic Chemistry, 2016, DOI: 10.1021/acs.joc.6b00804. (IF: 4.785)
20.Zhang DM, Shu C, Chen JJ, Sodani K, Wang J, Bhatnagar J, Lan P, Ruan ZX, Xiao ZJ, Ambudkar SV, Chen WM, Chen ZS, Ye WC*. BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo. Molecular Pharmaceutics, 2012, 9: 3147-3159. (IF: 4.342)
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