自我简介
孔毅，男，博士，中国药科大学副教授，硕士研究生导师。
2001年获中国药科大学博士学位，2003年在南京大学与江苏万邦生化医药股份有限公司从事博士后研究工作。2010年5月-9月，英国帝国理工学院访问****；2012年10月-2013年11月，北卡罗莱纳大学访问****。江苏省青蓝工程中青年学科带头人培养对象。
研究方向
1微生物药物和生化与生物技术药物的开发与应用
2天然生化活性物质及其功能基因的研究
探寻自然界中结构新颖、生理活性强的天然多肽，并研究其结构与功能的关系，为创新药物研发服务。
主要研究技术包括:蛋白质及多肽的分离纯化，多肽的结构分析，酶法及ELISA法活性筛选，体内外抗血栓活性及分子作用机制研究，计算机辅助药物设计等。
发明专利：
申请发明专利10余件，其中授权专利5件。
科研项目：
主持国家自然科学基金1项,省级课题2项,美国强生制药课题1项,企业课题6项.参与国家自然科学基金2项,重大新药创制1项。
近五年发表论文(第一或通讯作者)
2016
Xuan Liu, Caihui Wang, Xue Ding, Xiaodong Liu, Qian Li, Yi Kong.A novel selective inhibitor to thrombin-induced platelet aggregation purified from the leech Whitmania pigra[J]. Biochemical and Biophysical Research Communications, 2016, 473
Wen Su, Yahui Chen, Caihui Wang, Xue Ding, Gamariel Rwibasira, Yi Kong. Human cathelicidin LL-37 inhibits platelet aggregation and thrombosis via Src/PI3K/Akt signaling[J]. Biochemical and Biophysical Research Communications, 2016, 473
Xing-li SU, Wen SU, Ying WANG, Yue-hu WANG, Xin MING, Yi KONG. The pyrrolidinoindoline alkaloid Psm2 inhibits platelet aggregation and thrombus formation by affecting PI3K/Akt signaling[J]. Acta Pharmacologica Sinica 2016: 1–10
2015
Mei-Mei Chen, Xiao-Hui Ye, Xin Ming, Ya-Hui Chen, Ying Wang, Xing-Li Su, Wen Su and Yi Kong. A Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates[J]. Scientific reports, 2015, 5.
Yi Kong, Ying Wang, Wei Yang, Zhou-Ling Xie, Zhi-Yu Li. LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa[J]. Journal of pharmacological sciences, 2015, 127(4): 462-466.
Xing-Li Su, Wen Su, Zhi-Long He, Xin Ming and Yi Kong. Tripeptide SQL Inhibits Platelet Aggregation and Thrombus Formation via Affecting PI3K/Akt Signaling[J]. Journal of cardiovascular pharmacology, 2015.
Xiao-Hui Ye, Mei-Mei Chen, Ya-Hui Chen, Xing-Li Su, Ying Wang, Wen Su, Yi Kong. Isolation and Characterization of a Novel Antithrombotic Peptide from Enzymatic Hydrolysate of Agkistrodon acutus Venom[J]. International Journal of Peptide Research and Therapeutics, 1-9.
Guangyan Cheng, Liying He, Zhibin Sun, Zhongli Cui, Yingxiang Du, Yi Kong. Purification and biochemical characterization of a novel fibrinolytic enzyme from Streptomyces sp. P3[J]. Journal of microbiology and biotechnology, 2015.
2014
Yi Kong, Cheng Xu, Zhi-Long He, Qiu-Mei Zhou, Jin-Bin Wang, Zhi-Yu Li, Xin Ming. A novel peptide inhibitor of platelet aggregation from stiff silkworm, Bombyx batryticatus[J]. Peptides, 2014, 53: 70-78.
Yi Kong, Shuai Li, Yu Shao, Zhi-Long He, Mei-Mei Chen, Xin Ming, Ji-Fu Wei. Antithrombotic Peptides from Scolopendra subspinipes mutilans Hydrolysates[J]. International Journal of Peptide Research and Therapeutics, 2014, 20(2): 245-252.
Yi Kong, Hao Chen, Yong-Qing Wang, Ling Meng and Ji-Fu Wei. Direct thrombin inhibitors: Patents 2002-2012 (Review)[J]. Molecular medicine reports, 2014, 9(5): 1506-1514.
Hao Chen, Min Jin, Yi-Fen Wang, Yong-Qing Wang, Ling Meng, Rong Li, Jia-Ping Wang, Li Gao, Yi Kong and Ji-Fu Wei. Effect of Toona microcarpa Harms Leaf Extract on the Coagulation System[J]. BioMed research international, 2014
2013
Yi Kong, Yu Shao, Hao Chen, Xin Ming, Jin-Bin Wang, Zhi-Yu Li, Ji-Fu Wei. A novel factor Xa-inhibiting peptide from centipedes venom[J]. International journal of peptide research and therapeutics, 2013, 19(4): 303-311.
Yi Kong, Jing Hui, Yu Shao, Shi-Long Huang, Hao Chen and Ji-Fu Wei. Cytotoxic and anticoagulant peptide from Scolopendra subspinipes mutilans venom[J]. African J Pharm Pharmacol, 2013, 7: 2238-2245.
Yi Kong, Shi-Long Huang, Yu Shao, Shuai Li, Ji-Fu Wei. Purification and characterization of a novel antithrombotic peptide from Scolopendra subspinipes mutilans[J]. Journal of ethnopharmacology, 2013, 145(1): 182-186.
2012
Jing Xiong, Li Bai, Wei Fang, Jianyang Fu, Weirong Fang, Juan Cen, Yi Kong, Yunman Li. New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation[J]. European Journal of Pharmaceutical Sciences, 2012, 45(5): 552-558.
联系方式:
电话: e-mail:yikong668@163.com