纪雪梅，女，博士，1985年5月生，副教授，硕士研究生导师。2013年毕业于南京师范大学，获生物化学与分子生物学博士学位。2013年7月至今，任职中国药科大学生命科学与技术学院，主讲《生物化学与分子生物学》、《生物化学与分子生物学实验》、《Being a Biomolecular Scientist 2:Biochemist》课程。主持国家自然科学基金青年基金项目1项、江苏省自然科学基金青年基金项目1项，参与国家科技部“重大新药创制”临床前项目、国家自然科学基金面上项目、藏医药协同创新项目等课题。
研究方向：
1）新型抗体药物的设计及应用研究
2）抗肿瘤抗体药物的作用机制研究

近五年代表性论文：
1. Nannan Kang, Junfei Zhou, Xue Liang, Jiaxin Li, Tianzhen Han, Chen Zhao, Tianwu Yang, Xuemei Ji*, Yu Liu*. Tumor necrosis factor α inhibition overcomes immunosuppressive M2b macrophage-induced bevacizumab resistance in triple-negative breast cancer. Cell Death and Disease (2020) 11:993
2.Xuemei Ji^#,Tianzhen Han#, Nannan Kang, Song Huang, Yu Liu*. Preparation of RGD4C fused anti-TNFa nanobody and inhibitory activity on triple-negative breast cancer in vivo. Life Sciences 260 (2020) 118274
3. Xuemei Ji^#, Hongyan Wang#, Yue Chen, Junfei Zhou and Yu Liu*. Recombinant expressing angiopep-2 fused anti-VEGF single chain Fab (scFab) could crossblood–brain barrier andtarget glioma. AMB Expr (2019) 9:165
4. Zheng Qiao, Xiaoping Li, Nannan Kang, Yue Yang, Chuyuan Chen, Tao Wu, Mingjun Zhao, Yu Liu* and Xuemei Ji*. A Novel Specific Anti-CD73 Antibody Inhibits Triple-Negative Breast Cancer Cell Motility by Regulating Autophagy. International Journal of Molecular Sciences. 2019, 20(5), 1057
5. Chen C, Li X, Gu M, Di R, Kang N, Wang L, Lai Y, Liu Y*, Ji X*. Biological characterisation and application of human MTH1 and monoclonal antibody preparation. Oncol Rep. 2019 Mar;41(3):1851-1862
6. Chenghao Xiong, Yingqing Mao, Tao Wu, Nannan Kang, Mingjun Zhao, Rongrong Di, Xiaoping Li*, Xuemei Ji*, and Yu Liu*, Optimized Expression and Characterization of a Novel Fully Human Bispecific Single-Chain Diabody Targeting Vascular Endothelial Growth Factor165 and Programmed Death-1 in Pichia pastoris and Evaluation of Antitumor Activity In Vivo. International Journal of Molecular Sciences, 2018, 19(10):2900
7. Ji X^#, Peng Z^#, Li X, Yan Z, Yang Y, Qiao Z, Liu Y*. Neutralization of TNFα in tumor with a novel nanobody potentiates paclitaxel-therapy and inhibits metastasis in breast cancer, Cancer Lett. 2017 Feb;386:24-34
专利情况：
1.纪雪梅，刘煜，韩田振，RGD4C融合抗TNFα纳米抗体蛋白、制备方法及其应用，1.8，受理
2.纪雪梅，刘煜，赵明军，一种人源化纳米抗体及其制备方法1.1，公开
3.刘煜, 闫忠辉, 李小平, 别雨薇, 纪雪梅, 叶黄素及其衍生物在制备抗脑胶质瘤药物中的应用, 20**, 授权
联系方式：
江苏省南京市江宁区龙眠大道639号学院实验楼315, 邮编211198
邮箱：jixuemei198530@126.com