主持项目:
1国家自然科学基金:多功能有机/无机杂化纳米粒眼用给药系统的研究(**),在研。
2国家自然科学基金:基于连接臂和肠转运器PepT1靶向的齐墩果酸口服前药研究(**/H3008),结题。
3教育部新教师基金:新型靶向肠膜PepT1转运器的齐墩果酸口服前药研究(教育部新教师基金(002),结题
参与项目:
1重大专项新型降糖药物G004的临床前研究(2013ZX),进行中。
2“重大新药创制”科技重大专项:新制剂与新释药系统技术平台(Y101018-24),结题。
2 “重大新药创制”科技重大专项:高效原位非病毒基因载体关键技术研究(Y101012-22),结题。
近年代表性论文:
1 Fang L, Wang M, Gou S, Liu X, Zhang H, Cao F(通讯作者).Combination of amino acid/dipeptide with nitric oxide donating oleanolic acid derivatives as PepT1 targeting antitumor prodrugs.J Med Chem. 2014,57(3):1116-20. IF:5.61
2 Fang L, Gou S, Liu X, Cao F(通讯作者), Cheng L.Design, synthesis and anti-Alzheimer properties of dimethylaminomethyl-substituted curcumin derivatives.Bioorg Med Chem Lett. 2014,24(1):40-3. IF:2.34
3 Feng Cao(操锋),Yahan Gao, Meng Wang, Lei Fang, Qineng Ping. Propylene Glycol-Linked Amino Acid/Dipeptide Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability and Pharmacokinetics.Mol Pharmaceutics, 2013, 10(4):1378-1387. IF:4.57
4 Feng Cao(操锋), Yahan Gao, Qineng Ping. Advances in Research of PepT1-Targeted Prodrug.Asian Journal of Pharmaceutical Sciences. 2012, 7(2): 110-122.
5 Feng Cao(操锋), Yahan Gao, Zhi Yin, Qineng Ping. Enhanced Oral Bioavailability of Oleanolic Acid in Rats with Phospholipid Complex. . Letters in Drug Design & Discovery. 2012, 9:505-512. IF:0.85
6 Feng Cao(操锋), Jinghao Jia, Zhi Yin, Yahan Gao, Lei Sha, Yihua Zhang, Yisheng Lai, Qineng Ping. Ethylene Glycol-Linked Amino Acid Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability and Pharmacokinetics. Mol Pharmaceutics, 2012, 9:2127-2135. IF:4.57
7 CaoF(操锋), WangYJ, PingQN, Liao ZG. Zn-Al-NO3-layered double hydroxides with intercalated diclofenac for ocular delivery. Int J Pharm. 2011, 404(1-2): 250-256. IF:3.46
8 Jin X, Huang A, Ping Q, Cao F(操锋), Su Z.Box-Behnken optimization design and enhanced oral bioavailability of thymopentin-loaded poly (butyl cyanoacrylate) nanoparticles. Pharmazie. 2011,66(5):339-47.
9Cao F(操锋), Zhang XL, Ping QN. New method for ophthalmic delivery of azithromycin by poloxamer/carbopol-based in situ gelling system. Drug Deliv, 2010, 17(7): 500-507. IF:2.02
10 Xu Y, Jin X, Ping Q, Cheng J, Sun M,Cao F(操锋), You W, Yuan D.A novel lipoprotein-mimic nanocarrier composed of the modified protein and lipid for tumor cell targeting delivery. J Control Release. 2010, 146(3):299-308.
11 Cao F(操锋), Ren Y, Hua WY. Cyclomaltoheptaose mixed esters of anti-inflammatory drugs and short-chain fatty acids and study of their enzymatic hydrolysis in vitro. Carbohydr Res.2009, 344(4): 526-30. IF:2.04
12 Cao F(操锋), Zhang HY, Guo JX, et al. Mrp2-related efflux of scutellarin in the intestinal absorption in rats. Pharmazie. 2008, 63(1):75-80.
13 Cao F(操锋), Guo JX, Ping QN, et al. Prodrugs of scutellarin: ethyl, benzyl and N, N-diethylglycolamide ester synthesis, physicochemical properties, intestinal metabolism and oral bioavailability in the rats.Eur J Pharm Sci. 2006, 29(5):385-93.
14 Cao F(操锋), Guo J, Ping QN. The physicochemical characteristics of freeze-dried scutellarin-cyclodextrin tetracomponent complexes. Drug
联系方式:njcpucf@gmail.com