崔浩博士


讲师，硕士生导师
江西师范大学青年英才
● 学习、工作经历：
2015/04–至今，江西师范大学
2013/04 - 2015/01，IMBIM，BMC，Uppsala University，
瑞典，博士后
2009/07 - 2012/12，Menzies Institute for Medical Research/University of Tasmania，
澳大利亚，博士
2008/01 - 2009/06，University of Tasmania，澳大利亚，硕士
2003/09 - 2007/07，南京中医药大学，学士
● 研究兴趣、领域：
主要研究蛋白聚糖在生理（如发育）和病理（如阿尔茨海默症，肿瘤以及炎症等）过程中的功能及分子机制。同时进行天然多糖的结构分析，以及生物活性筛选和机制研究。
● 开设的课程：
本科课程：《分子生物学》、《分子生物学实验》、《专业英语》
研究生课程：《糖生物学》、《专业英语》
● 代表性论文：
1.Jendresen C, Digre A, Cui H, Zhang X, Vlodavsky I, Li JP, Nilsson LNG (2019).Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression. Scientific Reports.doi: 10.1038/s41598-019-40999-4.
2.Tan YX *, Cui H *, Wan LM*, Gong F, Zhang X, Vlodavsky I, Li JP (2018). Overexpression of heparanase in mice promoted megakaryocytopoiesis. Glycobiology. doi: 10.1093/glycob/cwy011. [Epub ahead of print]
3.Cui H, King AE, Jacobson GA, Small DH（2016）. Peripheral treatment with enoxaparin exacerbates amyloid plaque pathology in Tg2576 mice. Journal Neuroscience Research. doi: 10.1002/jnr.23880. [Epub ahead of print]
4.Cui H*, Tan YX*, ?sterholm C, Zhang X, Hedin U, Vlodavsky I, Li JP (2016). Heparanase expression upregulates platelet adhesion activity and thrombogenicity. Oncotarget. doi: 10.18632/oncotarget.8960. [Epub ahead of print]
5.Jendresen CB*, Cui H*, Zhang X, Vlodavsky I, Nilsson LN, Li JP (2015). Overexpression of Heparanase Lowers the Amyloid Burden in Amyloid-beta Precursor Protein Transgenic Mice. The Journal of biological chemistry, 290（8）: 5053-5064.
6.Liu Y, Atkinson RA, Fernandez-Martos CM, Kirkcaldie MT, Cui H, Vickers JC, King AE (2015). Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse. Neurobiology of Aging, 36（2）: 1151-1159.
7.Dawkins E, Gasperini R, Hu Y, Cui H, Vincent AJ, Bolós M, Young KM, Foa L, Small DH (2014). The N-terminal fragment of the beta-amyloid precursor protein of Alzheimer’s disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons. Journal of Neuroscience Research, 92（11）: 1478-1489.
8.Hu Y*, Hung AC*, Cui H, Dawkins E, Bolós M, Foa L, Young KM, Small DH (2013) Role of Cystatin C in Amyloid Precursor Protein-induced Proliferation of Neural Stem/Progenitor Cells, The Journal of biological chemistry, 288（26）: 18853-18862.
9.Cui H, Freeman C, Jacobson GA, Small DH (2013) Proteoglycans in the central nervous system: role in development, neural repair, and Alzheimer's disease, IUBMB life, 65(2): 108-120.
10.Cui H, Hung AC, Freeman C, Narkowicz C, Jacobson GA, Small DH (2012) Size and sulfation are critical for the effect of heparin on APP processing and A? production, Journal of neurochemistry, 123(3): 447-457.
11.Cui H, Hung AC, Klaver DW, Suzuki T, Freeman C, Narkowicz C, Jacobson GA, Small DH (2011) Effects of heparin and enoxaparin on APP processing and Abeta production in primary cortical neurons from Tg2576 mice. PLoS One, 6(7): e23007.
12.Klaver DW1, Wilce MC, Cui H, Hung AC, Gasperini R, Foa L, Small DH (2010) Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions. BiolChem, 391(8): 849-859.
* 共同第一作者
● 科研项目：
1. 江西省自然科学基金(面上): 硫酸乙酰肝素C-5异构化酶（Glce）对非小细胞肺癌中HGF/c-Met信号通路的影响及机制研究，编号：20181BAB204006，2018-2020
2. 江西师范大学青年英才资助培育计划，2017-2019
3. 国家自然科学基金(青年): 硫酸乙酰肝素调控?-分泌酶表达的作用机制研究，批准号：**，2018-2020
4. 江西省自然科学基金(青年): 硫酸乙酰肝素对?-分泌酶表达和?-淀粉样蛋白生成的调控作用及其分子机制，编号：20171BAB214021，2017-2019
5. 江西省教育厅科技项目: 内源性硫酸乙酰肝素在APP代谢产生A?中的作用和机制研究，编号：GJJ160346，2016-2018
● 联系方式：
地址： 江西师范大学（瑶湖校区）方荫楼3区W345
电话：**
E-mail：cuihaoeric@163.com
cuihaoeric@jxnu.edu.cn