Jiguang WANG
王吉光
Doctor of Natural Science in Operational Research and Cybernetics
University of the Chinese Academy of Sciences, 2011

Padma Harilela Associate Professor of Life Science

Associate Professor
Division of Life Science
Department of Chemical and Biological Engineering



(852) 3469 2672
jgwang@ust.hk
Room 5577
Personal Web

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Google Scholar
OIWfp-QAAAAJ

ORCID
0000-0002-6923-4097

ResearcherID
B-2717-2012

Scopus ID
53879035100




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Cancer genomics
Cancer
Bioinformatics



Publications

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All Years 79 2022 0 2021 10 2020 8 2019 9 2018 7 2017 5 2016 40

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2021 10

Alternative Splicing of Three Genes Encoding Mechanotransduction-Complex Proteins in Auditory Hair Cells
eNeuro, v. 8, (1), January 2021, article number ENEURO.0381-20.2020, p. 1-11
Zhou, Zijing; Yu, Xiaojie; Jiang, Biaobin; Feng, Wanying; Tian, Ye; Liu, Zhiyong; Wang, Jiguang; Huang, Pingbo Article
Classifying gastric cancer using FLORA reveals clinically relevant molecular subtypes and highlights LINC01614 as a biomarker for patient prognosis
Oncogene, v. 40, (16), April 2021, p. 2898-2909
Chen, Yiyun; Cheng, Wing Yin; Shi, Hongyu; Huang, Shengshuo; Chen, Huarong; Liu, Dabin; Xu, Weiqi; Yu, Jun; Wang, Jiguang Article
Clinical practice guidelines for the management of adult diffuse gliomas
Cancer Letters, v. 499, February 2021, p. 60-72
Jiang, Tao; Nam, Do-Hyun; Ram, Zvi; Poon, Wai-sang; Wang, Jiguang; Boldbaatar, Damdindorj; Mao, Ying; Ma, Wenbin; Mao, Qing; You, Yongping; Jiang, Chuanlu; Yang, Xuejun; Kang, Chunsheng; Qiu, Xiaoguang; Li, Wenbin; Chinese Glioma Cooperative Group (CGCG); Society for Neuro-Oncology of China (SNOChina); Chinese Brain Cancer Association (CBCA); Chinese Glioma Genome Atlas (CGGA); Asian Glioma Genome Atlas (AGGA) network Article
De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation
Circulation Research, v. 129, (9), October 2021, p. 825-839
Li, Hao; Nam, Yoonhee; Huo, Ran; Fu, Weilun; Jiang, Biaobin; Zhou, Qiuxia; Song, Dong; Yang, Yingxi; Jiao, Yuming; Weng, Jiancong; Yan, Zihan; Di, Lin; Li, Jie; Wang, Jie; Xu, Hongyuan; Wang, Shuo; Zhao, Jizong; Wen, Zilong; Wang, Jiguang; Cao, Yong Article
DeepDRK: A Deep Learning Framework for Drug Repurposing through Kernel-Based Multi-Omics Integration
Briefings in Bioinformatics, v. 22, (5), 1 September 2021, article number bbab048
Wang, Yongcui; Yang, Yingxi; Chen, Shilong; Wang, Jiguang Article
EmPC-Seq: Accurate RNA-sequencing And Bioinformatics Platform To Map RNA Polymerases And Remove Background Error
Bio-protocol, v.11, (4), 20 February 2021, article number e3921
Wang, Yuqing; Chong, Tin Hang; Unarta, Ilona Christy; Xu, Xinzhou; Suarez, Gianmarco Domenico; Wang, Jiguang; Lis, John T.; Huang, Xuhui; Cheung, Pak Hang Peter Article
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution
Frontiers of Medicine, 24 April 2021
Bao, Zhaoshi; Wang, Yongzhi; Wang, Qiangwei; Fang, Shengyu; Shan, Xia; Wang, Jiguang; Jiang, Tao Article
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells
Nature Genetics, v. 53, (2), February 2021, p. 230-242
Laffleur, Brice; Lim, Junghyun; Zhang, Wanwei; Chen, Yiyun; Pefanis, Evangelos; Bizarro, Jonathan; Batista, Carolina R.; Wu, Lijing; Economides, Aris N.; Wang, Jiguang; Basu, Uttiya Article
Patient-Derived Nasopharyngeal Cancer Organoids for Disease Modeling and Radiation Dose Optimization
Frontiers in Oncology, v. 11, February 2021, article number 622244
Lucky, Sasidharan Swarnalatha; Law, Martin; Lui, Ming Hong; Mong, Jamie; Shi, Junli; Yu, Sidney; Yoon, Do Kun; Djeng, Shih Kien; Wang, Jiguang; Lim, Chwee Ming; Tan, Min Han Article
Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation
American Journal of Human Genetics, v. 108, (5), May 2021, p. 942-950
Weng, Jiancong; Yang, Yingxi; Song, Dong; Huo, Ran; Li, Hao; Chen, Yiyun; Nam, Yoonhee; Zhou, Qiuxia; Jiao, Yuming; Fu, Weilun; Yan, Zihan; Wang, Jie; Xu, Hongyuan; Di, Lin; Li, Jie; Wang, Shuo; Zhao, Jizong; Wang, Jiguang; Cao, Yong Article

2020 8

A Hepatocyte Differentiation Model Reveals Two Subtypes of Liver Cancer With Different Oncofetal Properties and Therapeutic Targets
Proceedings of the National Academy of Sciences of the United States of America, v. 117, (11), March 2020, p. 6103-6113
Liu, Ming; Yan, Qian; Sun, Yi; Nam, Yoonhee; Hu, Liang; Loong, Jane H. C.; Qi, Ouyang; Zhang, Yu; Li, Hao-Long; Kong, Fan-En; Li, Lei; Li, Yan; Li, Mei-Mei; Cheng, Wei; Jiang, Ling-Xi; Fang, Shuo; Yang, Xiao-Dong; Mo, Jia-Qiang; Gong, Yuan-Feng; Tang, Yun-Qiang; Li, Yan; Yuan, Yun-Fei; Ma, Ning-Fang; Lin, Ge; Ma, Stephanie; Wang, Jiguang; Guan, Xin-Yuan Article
CELLO: a longitudinal data analysis toolbox untangling cancer evolution
Quantitative Biology, v. 8, (3), 27 September 2020, p. 256-266
Jiang, Biaobin; Song, Dong; Mu, Quanhua; Wang, Jiguang Article
Genomic Characterization of HIV-Associated Plasmablastic Lymphoma Identifies Pervasive Mutations in the JAK–STAT Pathway
Blood Cancer Discovery, v. 1, (1), July 2020, p. 112-125
Liu, Zhaoqi; Filip, Ioan; Gomez, Karen; Engelbrecht, Dewaldt; Meer, Shabnum; Lalloo, Pooja N.; Patel, Pareen; Perner, Yvonne; Zhao, Junfei; Wang, Jiguang; Pasqualucci, Laura; Rabadan, Raul; Willem, Pascale Article
Identifying Transcription Error-Enriched Genomic Loci Using Nuclear Run-On Circular-Sequencing Coupled with Background Error Modeling
Journal of Molecular Biology, v. 432, (13), June 2020, p. 3933-3949
Cheung, Pak Hang Peter; Jiang, Biaobin; Booth, Gregory T.; Chong, Tin Hang; Unarta, Ilona Christy; Wang, Yuqing; Suarez, Gianmarco Domenico; Wang, Jiguang; Lis, John T.; Huang, Xuhui Article
MGMT Genomic Rearrangements Contribute to Chemotherapy Resistance in Gliomas
Nature Communications, v. 11, (1), 4 August 2020, article number 3883
Oldrini, Barbara; Vaquero-Siguero, Nuria; Mu, Quanhua; Kroon, Paula; Zhang, Ying; Galán-Ganga, Marcos; Bao, Zhaoshi; Wang, Zhang; Liu, Hanjie; Sa, Jason K.; Zhao, Junfei; Kim, Hoon; Rodriguez-Perales, Sandra; Nam, Do-Hyun; Verhaak, Roel G. W.; Rabadan, Rual; Jiang, Tao; Wang, Jiguang; Squatrito, Massimo Article
Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization
Cancer Discovery, v. 10, (6), June 2020, p. 806-821
Liu, Zhaoqi; Yoshimi, Akihide; Wang, Jiguang; Cho, Hana; Lee, Stanley Chun-Wei; Ki, Michelle; Bitner, Lillian; Chu, Timothy; Shah, Harshal; Liu, Bo; Mato, Anthony R.; Ruvolo, Peter; Fabbri, Giulia; Pasqualucci, Laura; Abdel-Wahab, Omar; Rabadan, Raul Article
Noncoding RNA transcription alters chromosomal topology to promote isotype-specific class switch recombination
Science Immunology, v. 5, (44), February 2020, article number eaay5864
Rothschild, Gerson; Zhang, Wanwei; Lim, Junghyun; Giri, Pankaj Kumar; Laffleur, Brice; Chen, Yiyun; Fang, Mingyan; Chen, Yuling; Nair, Lekha; Liu, Zhi-Ping; Deng, Haiteng; Hammarstrom, Lennart; Wang, Jiguang; Basu, Uttiya Article
Structural Basis for the High-Affinity Interaction between CASK and Mint1
Structure, v. 28, (6), June 2020, p. 664-673.e3
Wu, Xiandeng; Cai, Qixu; Chen, Yiyun; Zhu, Shihan; Mi, Jing; Wang, Jiguang; Zhang, Mingjie Article

2019 9

A Mini-review on Spatiotemporal Evolution of Glioma Under Treatment
Progress in Biochemistry and Biophysics, v. 46, (11), November 2019, p. 1055-1062
Lui, Ming-Hong; Jiang, Biaobin; Bao, Zhao-Shi; Wang, Jiguang Article
CNAPE: A Machine Learning Method for Copy Number Alteration Prediction from Gene Expression
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 18, (1), January 2021, article number 8854155, p. 306-311
Mu, Quanhua; Wang, Jiguang Article
Deciphering Brain Complexity Using Single-cell Sequencing
Genomics, Proteomics & Bioinformatics, v. 17, (4), Augusr 2019, p. 344-366
Mu, Quanhua; Chen, Yiyun; Wang, Jiguang Article
Dynamic MAPK Signaling Activity Underlies a Transition From Growth Arrest to Proliferation in Drosophila Scribble Mutant Tumors
DMM Disease Models and Mechanism, v. 12, (8), August 2019, article number dmm040147
Ji, Tiantian; Zhang, Lina; Deng, Mingxi; Huang, Shengshuo; Wang, Ying; Pham, Tri Thanh; Smith, Andrew Alan; Sridhar, Varun; Cabernard, Clemens; Wang, Jiguang; Yan, Yan Article
Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinoma
Annals of Oncology, v. 30, (6), June 2019, p. 990-997
Xu, L.M.; He, M.H.; Dai, Z.H.; Yu, J.; Wang, Jiguang; Li, X.C.; Jiang, Biaobin; Ke, Z.F.; Su, T.H.; Peng, Z.W.; Guo, Y.; Chen, Z.B.; Chen, S.L.; Peng, S.; Kuang, M. Article
Hierarchical Graphical Model Reveals HFR1 Bridging Circadian Rhythm and Flower Development in Arabidopsis Thaliana
NPJ Systems Biology and Applications, v. 5, (1), August 2019, article number UNSP 28
Duren, Zhana; Wang, Yaling; Wang, Jiguang; Zhao, Xing Ming; Lv, Le; Li, Xiaobo; Liu, Jingdong; Zhu, XinGuang; Chen, Luonan; Wang, Yong Article
Repurposing dasatinib for diffuse large B cell lymphoma
PNAS, v. 116, (34), August 2019, p. 16981-16986
Scuoppo, Claudio; Wang, Jiguang; Persaud, Mirjana; Mittan, Sandeep K.; Basso, Katia; Pasqualucci, Laura; Rabadan, Raul; Inghirami, Giorgio; Grandori, Carla; Bosch, Francesc; Dalla-favera, Riccardo Article
Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs
Development, v. 146, (18), September 2019, article number dev179754, p. 1-10
Deng, Mingxi; Wang, Ying; Zhang, Lina; Yang, Yang; Huang, Shengshuo; Wang, Jiguang; Ge, H.; Ishibashi, Toyotaka; Yan, Yan Article
The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function
Cell Metabolism, v. 30, (6), December 2019, p. 1091-1106.e8
Singer, Ruth A.; Arnes, Luis; Cui, Yi; Wang, Jiguang; Gao, Yuqian; Guney, Michelle A.; Burnum-Johnson, Kristin E.; Rabadan, Raul; Ansong, Charles; Orr, Galya; Sussel, Lori Article

2018 7

Comprehensive Characterisation of Compartment-specific Long Non-coding RNAs Associated With Pancreatic Ductal Adenocarcinoma
Gut, v. 68, (3), March 2019, p. 499-511
Arnes, Luis; Liu, Zhaoqi; Wang, Jiguang; Maurer, Hans Carlo; Sagalovskiy, Irina; Sanchen-Martin, Marta; Bommarkanti, Nikhil; Garofalo, Diana C.; Balderes, Dina A.; Sussel, Lori; Olive, Kenneth P.; Rabadan, Raul Article
GeneCT: a generalizable cancerous status and tissue origin classifier for pan-cancer biopsies
Bioinformatics, v. 34, (23), December 2018, p. 4129-4130
Sun, Kun; Wang, Jiguang; Wang, Huating; Sun, Hao Article
Genetic landscape of ultra-stable chronic lymphocytic leukemia patients
Annals of Oncology, v. 29, (4), April 2018, p. 966-972
Raponi, S.; Del Giudice, I.; Marinelli, M.; Wang, Jiguang; Cafforio, L.; Ilari, C.; Piciocchi, A.; Messina, M.; Bonina, S.; Tavolaro, S.; Bordyuh, M.; Mariglia, P.; Peragine, N.; Mauro, F. R.; Chiaretti, S.; Molica, S.; Gentile, M.; Visentin, A.; Trentin, L.; Rigolin, G. M.; Cuneo, A.; Diop, F.; Rossi, D.; Gaidano, G.; Guarini, A.; Rabadan, R.; Foa, R. Article
Increased HOXA5 Expression Provides a Selective Advantage for Gain of Whole Chromosome 7 in IDH Wild-type Glioblastoma
Genes and Development, v. 32, (7-8), April 2018, p. 512-523
Cimino, Patrick J.; Kim, Youngmi; Wu, Hua-Jun; Alexander, Jes; Wirsching, Hans-Georg; Szulzewsky, Frank; Pitter, Ken; Ozawa, Tatsuya; Wang, Jiguang; Vazquez, Julio; Arora, Sonali; Rabadan, Raul; Levine, Ross; Michor, Franziska; Holland, Eric C. Article
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor
Cell, v. 175, (6), November 2018, p. 1665-1678
Hu, Huimin; Mu, Quanhua; Bao, Zhaoshi; Chen, Yiyun; Liu, Yanwei; Chen, Jing; Wang, Kuanyu; Wang, Zheng; Nam, Yoonhee; Jiang, Biaobin; Sa, Jason K; Cho, Hee-Jin; Her, Nam-Gu; Zhang, Chuanbao; Zhao, Zheng; Zhang, Ying; Zeng, Fan; Wu, Fan; Kang, Xun; Liu, Yuqing; Qian, Zenghui; Wang, Zhiliang; Huang, Ruoyu; Wang, Qiangwei; Zhang, Wei; Qiu, Xiaoguang; Li, Wenbin; Nam, Do-Hyun; Fan, Xiaolong; Wang, Jiguang; Jiang, Tao Article
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy
Nature Genetics, v. 50, (10), October 2018, p. 1399-1411
Lee, Jin-Ku; Liu, Zhaoqi; Sa, Jason K.; Shin, Sang; Wang, Jiguang; Bordyuh, Mykola; Cho, Heejin; Elliott, Oliver; Chu, Timothy; Choi, Seung Won; Rosenbloom, Daniel I. S.; Lee, In-Hee; Shin, Yong Jae; Kang, Hyun Ju; Kim, Donggeon; Kim, Sun Young; Sim, Moon-Hee; Kim, Jusun; Lee, Taehyang; Seo, Yun Jee; Shin, Hyemi; Lee, Mijeong; Kim, Sung Heon; Kwon, Yong-Jun; Oh, Jeong-Woo; Song, Minsuk; Kim, Misuk; Kong, Doo-Sik; Choi, Jung Won; Seol, Ho Jun; Lee, Jung-Il; Kim, Seung Tae; Park, Joon Oh; Kim, Kyoung-Mee; Song, Sang-Yong; Lee, Jeong-Won; Kim, Hee-Cheol; Lee, Jeong Eon; Choi, Min Gew; Seo, Sung Wook; Shim, Young Mog; Zo, Jae Ill; Jeong, Byong Chang; Yoon, Yeup; Ryu, Gyu Ha; Kim, Nayoung K. D.; Bae, Joon Seol; Park, Woong-Yang; Lee, Jeongwu; Verhaak, Roel G. W.; Iavarone, Antonio; Lee, Jeeyun; Rabadan, Raul; Nam, Do-Hyun Article
Refined karyotype-based prognostic stratification of chronic lymphocytic leukemia with a low-and very-low-risk genetic profile
Leukemia, v. 32, (2), 1 February 2018, p. 543-546
Giudice, I Del; Rigolin, G. M.; Raponi, S.; Cafforio, L.; Ilari, C.; Wang, Jiguang; Bordyuh, M.; Piciocchi, A.; Marinelli, M.; Nanni, M.; Tavolaro, S.; Filetti, M.; Bardi, A.; Tammiso, E.; Volta, E.; Negrini, M.; Saccenti, E.; Mauro, F. R.; Rossi, D.; Gaidano, G.; Guarini, A.; Rabadan, R.; Cuneo, A.; Foà, R. Article

2017 5

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function
Immunity, v. 47, (3), 19 September 2017, p. 450-465.e5
Hyunju oh; Yenkel grinberg-bleyer; Will liao; Dillon maloney; Pingzhang wang; Zikai wu; Wang, Jiguang; Dev m. bhatt; Nicole heise; Roland m. schmid; Matthew s. hayden; Ulf klein; Raul rabadan; Sankar ghosh Article
Identification of Potentially Oncogenic Alterations from Tumor-only Samples Reveals Fanconi Anemia Pathway Mutations in Bladder Carcinomas
NPJ Genomic Medicine, v. 2, (1), December 2017, article number 32
Madubata, Chioma J.; Roshan-ghias, Alireza; Chu, Timothy; Resnick, Samuel; Zhao, Junfei; Arnes, Luis; Wang, Jiguang; Rabadan, Raul Article
Repurposing Dasatinib for Ibrutinib-Resistant Diffuse Large B-Cell Lymphoma
Blood, v. 130, (Suppl 1), Dec 2017, p. 3843-3843
Claudio scuoppo; Wang, Jiguang; Mirjana persaud; Sandeep mittan; Laura pasqualucci; Raul rabadan; Carla grandori; Riccardo dalla-favera Article
RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells
Stem Cell Reports, v. 9, (4), October 2017, p. 1053-1061
Skamagki, Maria; Zhang, Cheng; Ross, Christian A.; Ananthanarayanan, Aparna; Liu, Zhong; Mu, Quanhua; Basu, Uttiya; Wang, Jiguang; Zhao, Rui; Li, Hu; Kim, Kitai Article
Spatiotemporal Genomic Architecture Informs Precision Oncology in Glioblastoma
Nature Genetics, v. 49, (4), March 2017, p. 594-599
Lee, Jin-Ku; Wang, Jiguang; Sa, Jason K.; Ladewig, Erik; Lee, Hae-Ock; Lee, In-Hee; Kang, Hyun Ju; Rosenbloom, Daniel S.; Camara, Pablo G.; Liu, Zhaoqi; Van nieuwenhuizen, Patrick; Jung, Sang Won; Choi, Seung Won; Kim, Junhyung; Chen, Andrew; Kim, Kyu-Tae; Shin, Sang; Seo, Yun Jee; Oh, Jin-Mi; Shin, Yong Jae; Park, Chul-Kee; Kong, Doo-Sik; Seol, Ho Jun; Blumberg, Andrew; Lee, Jung-Il; Iavarone, Antonio; Park, Woong-Yang; Rabadan, Raul; Nam, Do-Hyun Article

2016 7

Clonal evolution of glioblastoma under therapy
Nature Genetics, v. 48, (7), July 2016, p. 768-776
Wang, Jiguang; Cazzato, Emanuela; Ladewig, Erik; Frattini, Veronique; Rosenbloom, Daniel I.S.; Zairis, Sakellarios; Abate, Francesco; Liu, Zhaoqi; Elliott, Oliver; Shin, Yongjae; Lee, Jinku; Lee, Inhee; Park, Woongyang; Eoli, Marica; Blumberg, Andrew J.; Lasorella, Anna; Nam, Dohyun; Finocchiaro, Gaetano; Iavarone, Antonio; Rabadan, Raul Article
Genetic Landscape and Gene Expression Profile of Chronic Lymphocytic Leukemia Patients with Ultra-Stable Disease
Clinical Lymphoma Myeloma and Leukemia, v. 16, Supplement 2, September 2016, p. S42–S43
Giudice, Ilaria Del; Raponi, Sara; Marinelli, Marilisa; Wang, Jiguang; Cafforio, Luciana; Ilari, Caterina; Messina, Monica; Bonina, Silvia; Tavolaro, Simona; Bordyuh, Mykola; Mauro, Francesca Romana; Chiaretti, Sabina; Rossi, Davide; Gaidano, Gianluca; Guarini, Anna; Rabadan, Raul; Foà, Robin Article
Inter- and intra-patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from circulating and lymph nodal compartments
British Journal of Haematology, v. 172, (3), 2016, February, p. 371-383
Del Giudice, Ilaria; Marinelli, Marilisa; Wang, Jiguang; Bonina, Silvia; Messina, Monica; Chiaretti, Sabina; Ilari, Caterina; Cafforio, Luciana; Raponi, Sara; Mauro, Francesca Romana; Di Maio, Valeria J M; De Propris, Maria Stefania; Nanni, Mauro; Ciardullo, Carmela; Rossi, Davide; Gaidano, Gianluca Luca; Guarini, Anna R.; Rabadan, Raul; Foa, Robin Article
Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
eLife, v. 5, (e14709), June 2016, p. 1-25
Yamamoto, Kenta; Wang, Jiguang; Sprinzen, Lisa; Xu, Jun; Haddock, Christopher J.; Li, Chen; Lee, Brian J.; Loredan, Denis G.; Jiang, Wenxia; Vindigni, Alessandro; Wang, Dong; Rabadan, Raul; Zha, Shan Article
Network Propagation Reveals Novel Features Predicting Drug Response of Cancer Cell Lines
Current Bioinformatics, v. 11, (2), April 2016, p. 203-210
Wang, Jiguang; Kribelbauer, Judith; Rabadan, Raul Article
Network stratification analysis for identifying function-specific network layers
Molecular BioSystems, v. 12, (4), 2016, p. 1232-1240
Zhang, Chuanchao; Wang, Jiguang; Zhang, Chao; Liu, Juan; Xu, Dong; Chen, Luonan Article
Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes
Oncotarget, v. 7, (12), March 2016, p. 13886-13901
Messina, Monica; Chiaretti, Sabina; Wang, Jiguang; Fedullo, Anna Lucia; Peragine, Nadia; Gianfelici, Valentina; Piciocchi, Alfonso; Brugnoletti, Fulvia; Di Giacomo, Filomena; Pauselli, Simona; Holmes, Antony B.; Puzzolo, Maria Cristina; Ceglie, Giulia; Apicella, Valerio; Mancini, Marco; Kronnie, Geertruy Te; Testi, Anna Maria; Vitale, Antonella; Vignetti, Marco; Guarini, Anna; Rabadan, Raul; Foà, Robin Article

2015 3

An information theoretic method to identify combinations of genomic alterations that promote glioblastoma
Journal of Molecular Cell Biology, v. 7, (3), June 2015, p. 203-213
Melamed, Rachel D.; Wang, Jiguang; Iavarone, Antonio; Rabadan, Raul Article
RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity
Cell, v. 161, (4), May 2015, p. 774-789
Pefanis, Evangelos; Wang, Jiguang; Rothschild, Gerson; Lim, Junghyun; Kazadi, David; Sun, Jianbo; Federation, Alexander J.; Chao, Jaime; Elliott, Oliver; Liu, Zhiping; Economides, Aris N.; Bradner., James E.; Rabadan, Raul; Basu, Uttiya Article
Transcriptomics identify CD9 as a marker of murine IL10-competent regulatory B cells
Cell Reports, v. 13, (6), November 2015, p. 1110-1117
Sun, Jianbo; Wang, Jiguang; Pefanis, Evangelos; Chao, Jaime; Rothschild, Gerson; Tachibana, Isao; Chen, Jun Kui; Ivanov, Ivaylo I.; Rabadan, Raul; Takeda, Yoshito; Basu, Uttiya Article

2014 5

Clinical Impact of Small TP53 Mutated Subclones in Chronic Lymphocytic Leukemia
Blood, v. 123, (14), 2014, April, p. 2139-2147
Rossi, Davide; Khiabanian, Hossein; Spina, Valeria; Ciardullo, Carmela; Bruscaggin, Alessio; Fama, Rosella; Rasi, Silvia; Monti, Sara; Deambrogi, Clara; De Paoli, Lorenzo; Wang, Jiguang; Gattei, Valter; Guarini, Anna R.; Foa, Robin; Rabadan, Raul; Gaidano, Gianluca Luca Article
Noncoding RNA Transcription Targets AID to Divergently Transcribed Loci in B Cells
Nature, v. 514, (7522), 2014, Oct, p. 389-393
Pefanis, Evangelos; Wang, Jiguang; Chao, Jaime; Rothschild, Gerson; Lim, Junghyun; Rabadan, Raul; Economides, Aris N.; Basu, Uttiya Article
PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway
Leukemia, v. 28, (7), 2014, July, p. 1436-1448
Wang Jiguang Article
Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia
eLife, v. 3, December 2014, article number e02869
Wang, Jiguang; Khiabanian, Hossein; Rossi, Davide; Fabbri, Giulia; Gattei, Valter; Forconi, Francesco; Laurenti, Luca; Marasca, Roberto; Del Poeta, Giovanni; Foa, Robin; Pasqualucci, Laura; Gaidano, Gianluca Luca; Rabadan, Raul Article
复杂疾病的分子网络模型研究
中国科学: 数学, v. 44, (4), 2014, p. 317-328
Wang, Jiguang Article

2013 5

APG: an active protein-gene network model to quantify regulatory signals in complex biological systems
Scientific Reports, v. 3, 2013, article number 1097
Wang, Jiguang; Sun, Yidan; Zheng, Si; Zhang, Xiang-Sun; Zhou, Huarong; Chen, Luonan Article
E3-ubiquitin Ligase Nedd4 Determines the Fate of AID-associated RNA Polymerase II in B cells
Genes and Development, v. 27, (16), August 2013, p. 1823-1833
Sun, Jianbo; Keim, Celia D.; Wang, Jiguang; Kazadi, David; Oliver, Paula M.; Rabadan, Raul; Basu, Uttiya Article
Genetic Lesions Associated with Chronic Lymphocytic Leukemia Transformation to Richter Syndrome
Journal of Experimental Medicine, v. 210, (11), October 2013, p. 2273-2288
Fabbri, Giulia; Khiabanian, Hossein; Holmes, Antony B.; Wang jiguang; Messina, Monica; Mullighan, Charles G.; Pasqualucci, Laura; Rabadan, Raul; Dalla- favera, Riccardo Dalla Article
NOA: A cytoscape plugin for network ontology analysis
Bioinformatics, v. 29, (16), August 2013, p. 2066-2067
Zhang, Chao; Wang, Jiguang; Hanspers, Kristina; Xu, Dong; Chen, Luonan; Pico, Alexander R. Article
Whole-exome Sequencing Reveals Recurrent Somatic Mutation Networks In Cancer
Cancer Letters, v. 340, (2), November 2013, p. 270-276
Liu, Xiaoping; Wang, Jiguang; Chen, Luonan Article

2012 5

A unified computational model for revealing and predicting subtle subtypes of cancers
BMC Bioinformatics, v. 13, (1), 1 May 2012, Article number 70
Ren, Xianwen; Wang, Yong; Wang, Jiguang; Zhang, Xiangsun Article
Inferring a protein interaction map of Mycobacterium tuberculosis based on sequences and interologs
BMC Bioinformatics, v. 13, (SUPPL.7), May 2012, Article number S6
Liu, Zhiping; Wang, Jiguang; Qiu, Yuqing; Leung, Ross Ka Kit; Zhang, Xiangsun; Tsui, Stephen Kwok-Wing; Chen, Luonan Article
Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis
Journal of Molecular Cell Biology, v. 4, (4), August 2012, p. 197-206
Song, Wei; Wang, Jiguang; Yang, Ying; Jing, Naihe; Zhang, Xiangsun; Chen, Luonan; Wu, Jiarui Article
The coding genome of splenic marginal zone lymphoma: Activation of NOTCH2 and other pathways regulating marginal zone development
Journal of Experimental Medicine, v. 209, (9), Aug 2012, p. 1537-1551
Wang, Jiguang Article
Inferring Protein-Protein Interactions Based on Sequences and Interologs in Mycobacterium Tuberculosis
Bio-Inspired Computing and Applications, Editors: De-Shuang Huang, Yong Gan, Prashan Premaratne, Kyungsook Han. Berlin, Heidelberg : Springer-Verlag, 2011, p. 91-96, Part of the Lecture Notes in Computer Science book series (LNCS, volume 6840)
Liu, Zhi-Ping; Wang, Jiguang; Qiu, Yu-Qing; Leung, Ross K.K.; Zhang, Xiang-Sun; Tsui, Stephen K.W.; Chen, Luonan Conference paper

2011 5

Network screening of Goto-Kakizaki rat liver microarray data during diabetic progression
BMC Systems Biology, v. 5, Issue SUPPL. 1, 20 June 2011, Article number S16
Zhou, Huarong; Saito, Shigeru; Piao, Guanying; Liu, Zhiping; Wang, Jiguang; Horimoto, Katsuhisa; Chen, Luonan Article
NOA: a novel Network Ontology Analysis method
Nucleic Acids Research, v. 39, (13), 2011, Jul, p. e87
Wang, Jiguang; Huang, Qiang; Liu, Zhiping; Wang, Yong; Wu, Lingyun; Chen, Luonan; Zhang, Xiangsun Article
A Regularized Optimization Model for Community Identification in Complex Networks
Operations Research and Its Applications, Edited by: Xiang-Sun Zhang, De-Gang Liu, Ling-Yun Wu, and Yong Wang. ORSC & APORC, 2011, p. 147-156, Lecture Notes in Operations Research 14
Wang, Yong; Wang, Jiguang; Chen, Chen; Zhang, Xiang-Sun Conference paper
A SVC-based Method to Detect Multi-scalar Noisy Communities in Complex Networks
Operations Research and Its Applications, Edited by: Xiang-Sun Zhang, De-Gang Liu, Ling-Yun Wu, and Yong Wang. ORSC & APORC, 2011, p. 133-143, Lecture Notes in Operations Research 14
Zhao, Junfei; Wang, Jiguang; Zhang, Xiang-Sun Conference paper
Multiple Resolution Community Structure Analysis
Operations Research and Its Applications, Edited by: Xiang-Sun Zhang, De-Gang Liu, Ling-Yun Wu, and Yong Wang. ORSC & APORC, 2011, p. 334-349
Xu, Shoujun; Wang, Jiguang; Zhang, Junhua; Zhang, Xiang-Sun Conference paper

2010 2

Sequence-based protein-protein interaction prediction via support vector machine
Journal of Systems Science and Complexity, v. 23, (5), October 2010, p. 1012-1023
Wang, Yongcui; Wang, Jiguang; Yang, Zhixia; Deng, Naiyang Article
Uncover the Transient Transcriptional Regulations by a Novel Sliding Window Correlation Strategy
Lecture Notes in Operations Research, v. 13, 2010, p. 235
Wang, Jiguang; Wang, Yong; Ren, Xianwen; Guo, Wei; Chen, Luonan Conference paper

2009 6

Disease-Aging Network Reveals Significant Roles of Aging Genes in Connecting Genetic Diseases
PLoS Computational Biology, v. 5, (9), 2009, Sep, Article number e1000521
Wang, Jiguang; Zhang, Shihua; Wang, Yong; Chen, Luonan; Zhang, Xiangsun Article
Modularity optimization in community detection of complex networks
Europhysics Letters, v. 87, (3), 1 August 2009, Article number 38002
Zhang, Xiangsun; Wang, Ruisheng; Wang, Yong; Wang, Jiguang; Qiu, Yuqing; Wang, Li; Chen, Luonan Article
A Constrained Optimization Method for Community Detection
Optimization and Systems Biology: Lecture Notes in Operations Research, v. 11, p. 142-150, 2009
Wang, Jiguang; Wang, Lin; Qiu, Yuqing; Wang, Yong; Zhang, Xiangsun Conference paper
Align Protein Surface Structures to Identify Evolutionally and Structurally Conserved Residues
Optimization and Systems Biology: Lecture Notes in Operations Research, v. 11, 2009, p. 296-303
Wang, Lin; Wang, Jiguang; Chen, Luonan Conference paper
Analysis of Transcriptome of Rice Anther
Optimization and Systems Biology: Lecture Notes in Operations Research, v. 11, 2009, p. 371-378
Zhang, Wenjuan; Tang, Wei-Hua; Wang, Jiguang; Liu, Zhiping; Zhao, Xing-Ming; Chen, Luonan Conference paper
Gene Prioritization for Type 2 Diabetes in Tissue-specific Protein Interaction Networks
Optimization and System Biology, v. 11, 2009, p.319-328
Jiang, Biaobin; Wang, Jiguang; Xiao, Jingfa; Wang, Yong Conference paper

2008 2

Recognition of Structure Similarities in Proteins
Journal of Systems Science and Complexity, v. 21, (4), 2008, p. 657-667
Wang, Lin; Qiu, Yuqing; Wang, Jiguang; Zhang, Xiangsun Article
Remarks on network community properties
Journal of Systems Science and Complexity, v. 21, (4), December 2008, p. 629-636
Wang, Jiguang; Qiu, Yuqing; Wang, Ruisheng; Zhang, Xiangsun Article


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Article 10

Alternative Splicing of Three Genes Encoding Mechanotransduction-Complex Proteins in Auditory Hair Cells
eNeuro, v. 8, (1), January 2021, article number ENEURO.0381-20.2020, p. 1-11
Zhou, Zijing; Yu, Xiaojie; Jiang, Biaobin; Feng, Wanying; Tian, Ye; Liu, Zhiyong; Wang, Jiguang; Huang, Pingbo
Classifying gastric cancer using FLORA reveals clinically relevant molecular subtypes and highlights LINC01614 as a biomarker for patient prognosis
Oncogene, v. 40, (16), April 2021, p. 2898-2909
Chen, Yiyun; Cheng, Wing Yin; Shi, Hongyu; Huang, Shengshuo; Chen, Huarong; Liu, Dabin; Xu, Weiqi; Yu, Jun; Wang, Jiguang
Clinical practice guidelines for the management of adult diffuse gliomas
Cancer Letters, v. 499, February 2021, p. 60-72
Jiang, Tao; Nam, Do-Hyun; Ram, Zvi; Poon, Wai-sang; Wang, Jiguang; Boldbaatar, Damdindorj; Mao, Ying; Ma, Wenbin; Mao, Qing; You, Yongping; Jiang, Chuanlu; Yang, Xuejun; Kang, Chunsheng; Qiu, Xiaoguang; Li, Wenbin; Chinese Glioma Cooperative Group (CGCG); Society for Neuro-Oncology of China (SNOChina); Chinese Brain Cancer Association (CBCA); Chinese Glioma Genome Atlas (CGGA); Asian Glioma Genome Atlas (AGGA) network
De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation
Circulation Research, v. 129, (9), October 2021, p. 825-839
Li, Hao; Nam, Yoonhee; Huo, Ran; Fu, Weilun; Jiang, Biaobin; Zhou, Qiuxia; Song, Dong; Yang, Yingxi; Jiao, Yuming; Weng, Jiancong; Yan, Zihan; Di, Lin; Li, Jie; Wang, Jie; Xu, Hongyuan; Wang, Shuo; Zhao, Jizong; Wen, Zilong; Wang, Jiguang; Cao, Yong
DeepDRK: A Deep Learning Framework for Drug Repurposing through Kernel-Based Multi-Omics Integration
Briefings in Bioinformatics, v. 22, (5), 1 September 2021, article number bbab048
Wang, Yongcui; Yang, Yingxi; Chen, Shilong; Wang, Jiguang
EmPC-Seq: Accurate RNA-sequencing And Bioinformatics Platform To Map RNA Polymerases And Remove Background Error
Bio-protocol, v.11, (4), 20 February 2021, article number e3921
Wang, Yuqing; Chong, Tin Hang; Unarta, Ilona Christy; Xu, Xinzhou; Suarez, Gianmarco Domenico; Wang, Jiguang; Lis, John T.; Huang, Xuhui; Cheung, Pak Hang Peter
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution
Frontiers of Medicine, 24 April 2021
Bao, Zhaoshi; Wang, Yongzhi; Wang, Qiangwei; Fang, Shengyu; Shan, Xia; Wang, Jiguang; Jiang, Tao
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells
Nature Genetics, v. 53, (2), February 2021, p. 230-242
Laffleur, Brice; Lim, Junghyun; Zhang, Wanwei; Chen, Yiyun; Pefanis, Evangelos; Bizarro, Jonathan; Batista, Carolina R.; Wu, Lijing; Economides, Aris N.; Wang, Jiguang; Basu, Uttiya
Patient-Derived Nasopharyngeal Cancer Organoids for Disease Modeling and Radiation Dose Optimization
Frontiers in Oncology, v. 11, February 2021, article number 622244
Lucky, Sasidharan Swarnalatha; Law, Martin; Lui, Ming Hong; Mong, Jamie; Shi, Junli; Yu, Sidney; Yoon, Do Kun; Djeng, Shih Kien; Wang, Jiguang; Lim, Chwee Ming; Tan, Min Han
Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation
American Journal of Human Genetics, v. 108, (5), May 2021, p. 942-950
Weng, Jiancong; Yang, Yingxi; Song, Dong; Huo, Ran; Li, Hao; Chen, Yiyun; Nam, Yoonhee; Zhou, Qiuxia; Jiao, Yuming; Fu, Weilun; Yan, Zihan; Wang, Jie; Xu, Hongyuan; Di, Lin; Li, Jie; Wang, Shuo; Zhao, Jizong; Wang, Jiguang; Cao, Yong


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Article 8

A Hepatocyte Differentiation Model Reveals Two Subtypes of Liver Cancer With Different Oncofetal Properties and Therapeutic Targets
Proceedings of the National Academy of Sciences of the United States of America, v. 117, (11), March 2020, p. 6103-6113
Liu, Ming; Yan, Qian; Sun, Yi; Nam, Yoonhee; Hu, Liang; Loong, Jane H. C.; Qi, Ouyang; Zhang, Yu; Li, Hao-Long; Kong, Fan-En; Li, Lei; Li, Yan; Li, Mei-Mei; Cheng, Wei; Jiang, Ling-Xi; Fang, Shuo; Yang, Xiao-Dong; Mo, Jia-Qiang; Gong, Yuan-Feng; Tang, Yun-Qiang; Li, Yan; Yuan, Yun-Fei; Ma, Ning-Fang; Lin, Ge; Ma, Stephanie; Wang, Jiguang; Guan, Xin-Yuan
CELLO: a longitudinal data analysis toolbox untangling cancer evolution
Quantitative Biology, v. 8, (3), 27 September 2020, p. 256-266
Jiang, Biaobin; Song, Dong; Mu, Quanhua; Wang, Jiguang
Genomic Characterization of HIV-Associated Plasmablastic Lymphoma Identifies Pervasive Mutations in the JAK–STAT Pathway
Blood Cancer Discovery, v. 1, (1), July 2020, p. 112-125
Liu, Zhaoqi; Filip, Ioan; Gomez, Karen; Engelbrecht, Dewaldt; Meer, Shabnum; Lalloo, Pooja N.; Patel, Pareen; Perner, Yvonne; Zhao, Junfei; Wang, Jiguang; Pasqualucci, Laura; Rabadan, Raul; Willem, Pascale
Identifying Transcription Error-Enriched Genomic Loci Using Nuclear Run-On Circular-Sequencing Coupled with Background Error Modeling
Journal of Molecular Biology, v. 432, (13), June 2020, p. 3933-3949
Cheung, Pak Hang Peter; Jiang, Biaobin; Booth, Gregory T.; Chong, Tin Hang; Unarta, Ilona Christy; Wang, Yuqing; Suarez, Gianmarco Domenico; Wang, Jiguang; Lis, John T.; Huang, Xuhui
MGMT Genomic Rearrangements Contribute to Chemotherapy Resistance in Gliomas
Nature Communications, v. 11, (1), 4 August 2020, article number 3883
Oldrini, Barbara; Vaquero-Siguero, Nuria; Mu, Quanhua; Kroon, Paula; Zhang, Ying; Galán-Ganga, Marcos; Bao, Zhaoshi; Wang, Zhang; Liu, Hanjie; Sa, Jason K.; Zhao, Junfei; Kim, Hoon; Rodriguez-Perales, Sandra; Nam, Do-Hyun; Verhaak, Roel G. W.; Rabadan, Rual; Jiang, Tao; Wang, Jiguang; Squatrito, Massimo
Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization
Cancer Discovery, v. 10, (6), June 2020, p. 806-821
Liu, Zhaoqi; Yoshimi, Akihide; Wang, Jiguang; Cho, Hana; Lee, Stanley Chun-Wei; Ki, Michelle; Bitner, Lillian; Chu, Timothy; Shah, Harshal; Liu, Bo; Mato, Anthony R.; Ruvolo, Peter; Fabbri, Giulia; Pasqualucci, Laura; Abdel-Wahab, Omar; Rabadan, Raul
Noncoding RNA transcription alters chromosomal topology to promote isotype-specific class switch recombination
Science Immunology, v. 5, (44), February 2020, article number eaay5864
Rothschild, Gerson; Zhang, Wanwei; Lim, Junghyun; Giri, Pankaj Kumar; Laffleur, Brice; Chen, Yiyun; Fang, Mingyan; Chen, Yuling; Nair, Lekha; Liu, Zhi-Ping; Deng, Haiteng; Hammarstrom, Lennart; Wang, Jiguang; Basu, Uttiya
Structural Basis for the High-Affinity Interaction between CASK and Mint1
Structure, v. 28, (6), June 2020, p. 664-673.e3
Wu, Xiandeng; Cai, Qixu; Chen, Yiyun; Zhu, Shihan; Mi, Jing; Wang, Jiguang; Zhang, Mingjie


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Article 9

A Mini-review on Spatiotemporal Evolution of Glioma Under Treatment
Progress in Biochemistry and Biophysics, v. 46, (11), November 2019, p. 1055-1062
Lui, Ming-Hong; Jiang, Biaobin; Bao, Zhao-Shi; Wang, Jiguang
CNAPE: A Machine Learning Method for Copy Number Alteration Prediction from Gene Expression
IEEE/ACM Transactions on Computational Biology and Bioinformatics, v. 18, (1), January 2021, article number 8854155, p. 306-311
Mu, Quanhua; Wang, Jiguang
Deciphering Brain Complexity Using Single-cell Sequencing
Genomics, Proteomics & Bioinformatics, v. 17, (4), Augusr 2019, p. 344-366
Mu, Quanhua; Chen, Yiyun; Wang, Jiguang
Dynamic MAPK Signaling Activity Underlies a Transition From Growth Arrest to Proliferation in Drosophila Scribble Mutant Tumors
DMM Disease Models and Mechanism, v. 12, (8), August 2019, article number dmm040147
Ji, Tiantian; Zhang, Lina; Deng, Mingxi; Huang, Shengshuo; Wang, Ying; Pham, Tri Thanh; Smith, Andrew Alan; Sridhar, Varun; Cabernard, Clemens; Wang, Jiguang; Yan, Yan
Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinoma
Annals of Oncology, v. 30, (6), June 2019, p. 990-997
Xu, L.M.; He, M.H.; Dai, Z.H.; Yu, J.; Wang, Jiguang; Li, X.C.; Jiang, Biaobin; Ke, Z.F.; Su, T.H.; Peng, Z.W.; Guo, Y.; Chen, Z.B.; Chen, S.L.; Peng, S.; Kuang, M.
Hierarchical Graphical Model Reveals HFR1 Bridging Circadian Rhythm and Flower Development in Arabidopsis Thaliana
NPJ Systems Biology and Applications, v. 5, (1), August 2019, article number UNSP 28
Duren, Zhana; Wang, Yaling; Wang, Jiguang; Zhao, Xing Ming; Lv, Le; Li, Xiaobo; Liu, Jingdong; Zhu, XinGuang; Chen, Luonan; Wang, Yong
Repurposing dasatinib for diffuse large B cell lymphoma
PNAS, v. 116, (34), August 2019, p. 16981-16986
Scuoppo, Claudio; Wang, Jiguang; Persaud, Mirjana; Mittan, Sandeep K.; Basso, Katia; Pasqualucci, Laura; Rabadan, Raul; Inghirami, Giorgio; Grandori, Carla; Bosch, Francesc; Dalla-favera, Riccardo
Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs
Development, v. 146, (18), September 2019, article number dev179754, p. 1-10
Deng, Mingxi; Wang, Ying; Zhang, Lina; Yang, Yang; Huang, Shengshuo; Wang, Jiguang; Ge, H.; Ishibashi, Toyotaka; Yan, Yan
The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function
Cell Metabolism, v. 30, (6), December 2019, p. 1091-1106.e8
Singer, Ruth A.; Arnes, Luis; Cui, Yi; Wang, Jiguang; Gao, Yuqian; Guney, Michelle A.; Burnum-Johnson, Kristin E.; Rabadan, Raul; Ansong, Charles; Orr, Galya; Sussel, Lori


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Article 7

Comprehensive Characterisation of Compartment-specific Long Non-coding RNAs Associated With Pancreatic Ductal Adenocarcinoma
Gut, v. 68, (3), March 2019, p. 499-511
Arnes, Luis; Liu, Zhaoqi; Wang, Jiguang; Maurer, Hans Carlo; Sagalovskiy, Irina; Sanchen-Martin, Marta; Bommarkanti, Nikhil; Garofalo, Diana C.; Balderes, Dina A.; Sussel, Lori; Olive, Kenneth P.; Rabadan, Raul
GeneCT: a generalizable cancerous status and tissue origin classifier for pan-cancer biopsies
Bioinformatics, v. 34, (23), December 2018, p. 4129-4130
Sun, Kun; Wang, Jiguang; Wang, Huating; Sun, Hao
Genetic landscape of ultra-stable chronic lymphocytic leukemia patients
Annals of Oncology, v. 29, (4), April 2018, p. 966-972
Raponi, S.; Del Giudice, I.; Marinelli, M.; Wang, Jiguang; Cafforio, L.; Ilari, C.; Piciocchi, A.; Messina, M.; Bonina, S.; Tavolaro, S.; Bordyuh, M.; Mariglia, P.; Peragine, N.; Mauro, F. R.; Chiaretti, S.; Molica, S.; Gentile, M.; Visentin, A.; Trentin, L.; Rigolin, G. M.; Cuneo, A.; Diop, F.; Rossi, D.; Gaidano, G.; Guarini, A.; Rabadan, R.; Foa, R.
Increased HOXA5 Expression Provides a Selective Advantage for Gain of Whole Chromosome 7 in IDH Wild-type Glioblastoma
Genes and Development, v. 32, (7-8), April 2018, p. 512-523
Cimino, Patrick J.; Kim, Youngmi; Wu, Hua-Jun; Alexander, Jes; Wirsching, Hans-Georg; Szulzewsky, Frank; Pitter, Ken; Ozawa, Tatsuya; Wang, Jiguang; Vazquez, Julio; Arora, Sonali; Rabadan, Raul; Levine, Ross; Michor, Franziska; Holland, Eric C.
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor
Cell, v. 175, (6), November 2018, p. 1665-1678
Hu, Huimin; Mu, Quanhua; Bao, Zhaoshi; Chen, Yiyun; Liu, Yanwei; Chen, Jing; Wang, Kuanyu; Wang, Zheng; Nam, Yoonhee; Jiang, Biaobin; Sa, Jason K; Cho, Hee-Jin; Her, Nam-Gu; Zhang, Chuanbao; Zhao, Zheng; Zhang, Ying; Zeng, Fan; Wu, Fan; Kang, Xun; Liu, Yuqing; Qian, Zenghui; Wang, Zhiliang; Huang, Ruoyu; Wang, Qiangwei; Zhang, Wei; Qiu, Xiaoguang; Li, Wenbin; Nam, Do-Hyun; Fan, Xiaolong; Wang, Jiguang; Jiang, Tao
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy
Nature Genetics, v. 50, (10), October 2018, p. 1399-1411
Lee, Jin-Ku; Liu, Zhaoqi; Sa, Jason K.; Shin, Sang; Wang, Jiguang; Bordyuh, Mykola; Cho, Heejin; Elliott, Oliver; Chu, Timothy; Choi, Seung Won; Rosenbloom, Daniel I. S.; Lee, In-Hee; Shin, Yong Jae; Kang, Hyun Ju; Kim, Donggeon; Kim, Sun Young; Sim, Moon-Hee; Kim, Jusun; Lee, Taehyang; Seo, Yun Jee; Shin, Hyemi; Lee, Mijeong; Kim, Sung Heon; Kwon, Yong-Jun; Oh, Jeong-Woo; Song, Minsuk; Kim, Misuk; Kong, Doo-Sik; Choi, Jung Won; Seol, Ho Jun; Lee, Jung-Il; Kim, Seung Tae; Park, Joon Oh; Kim, Kyoung-Mee; Song, Sang-Yong; Lee, Jeong-Won; Kim, Hee-Cheol; Lee, Jeong Eon; Choi, Min Gew; Seo, Sung Wook; Shim, Young Mog; Zo, Jae Ill; Jeong, Byong Chang; Yoon, Yeup; Ryu, Gyu Ha; Kim, Nayoung K. D.; Bae, Joon Seol; Park, Woong-Yang; Lee, Jeongwu; Verhaak, Roel G. W.; Iavarone, Antonio; Lee, Jeeyun; Rabadan, Raul; Nam, Do-Hyun
Refined karyotype-based prognostic stratification of chronic lymphocytic leukemia with a low-and very-low-risk genetic profile
Leukemia, v. 32, (2), 1 February 2018, p. 543-546
Giudice, I Del; Rigolin, G. M.; Raponi, S.; Cafforio, L.; Ilari, C.; Wang, Jiguang; Bordyuh, M.; Piciocchi, A.; Marinelli, M.; Nanni, M.; Tavolaro, S.; Filetti, M.; Bardi, A.; Tammiso, E.; Volta, E.; Negrini, M.; Saccenti, E.; Mauro, F. R.; Rossi, D.; Gaidano, G.; Guarini, A.; Rabadan, R.; Cuneo, A.; Foà, R.


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Article 5

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function
Immunity, v. 47, (3), 19 September 2017, p. 450-465.e5
Hyunju oh; Yenkel grinberg-bleyer; Will liao; Dillon maloney; Pingzhang wang; Zikai wu; Wang, Jiguang; Dev m. bhatt; Nicole heise; Roland m. schmid; Matthew s. hayden; Ulf klein; Raul rabadan; Sankar ghosh
Identification of Potentially Oncogenic Alterations from Tumor-only Samples Reveals Fanconi Anemia Pathway Mutations in Bladder Carcinomas
NPJ Genomic Medicine, v. 2, (1), December 2017, article number 32
Madubata, Chioma J.; Roshan-ghias, Alireza; Chu, Timothy; Resnick, Samuel; Zhao, Junfei; Arnes, Luis; Wang, Jiguang; Rabadan, Raul
Repurposing Dasatinib for Ibrutinib-Resistant Diffuse Large B-Cell Lymphoma
Blood, v. 130, (Suppl 1), Dec 2017, p. 3843-3843
Claudio scuoppo; Wang, Jiguang; Mirjana persaud; Sandeep mittan; Laura pasqualucci; Raul rabadan; Carla grandori; Riccardo dalla-favera
RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells
Stem Cell Reports, v. 9, (4), October 2017, p. 1053-1061
Skamagki, Maria; Zhang, Cheng; Ross, Christian A.; Ananthanarayanan, Aparna; Liu, Zhong; Mu, Quanhua; Basu, Uttiya; Wang, Jiguang; Zhao, Rui; Li, Hu; Kim, Kitai
Spatiotemporal Genomic Architecture Informs Precision Oncology in Glioblastoma
Nature Genetics, v. 49, (4), March 2017, p. 594-599
Lee, Jin-Ku; Wang, Jiguang; Sa, Jason K.; Ladewig, Erik; Lee, Hae-Ock; Lee, In-Hee; Kang, Hyun Ju; Rosenbloom, Daniel S.; Camara, Pablo G.; Liu, Zhaoqi; Van nieuwenhuizen, Patrick; Jung, Sang Won; Choi, Seung Won; Kim, Junhyung; Chen, Andrew; Kim, Kyu-Tae; Shin, Sang; Seo, Yun Jee; Oh, Jin-Mi; Shin, Yong Jae; Park, Chul-Kee; Kong, Doo-Sik; Seol, Ho Jun; Blumberg, Andrew; Lee, Jung-Il; Iavarone, Antonio; Park, Woong-Yang; Rabadan, Raul; Nam, Do-Hyun


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Article 7

Clonal evolution of glioblastoma under therapy
Nature Genetics, v. 48, (7), July 2016, p. 768-776
Wang, Jiguang; Cazzato, Emanuela; Ladewig, Erik; Frattini, Veronique; Rosenbloom, Daniel I.S.; Zairis, Sakellarios; Abate, Francesco; Liu, Zhaoqi; Elliott, Oliver; Shin, Yongjae; Lee, Jinku; Lee, Inhee; Park, Woongyang; Eoli, Marica; Blumberg, Andrew J.; Lasorella, Anna; Nam, Dohyun; Finocchiaro, Gaetano; Iavarone, Antonio; Rabadan, Raul
Genetic Landscape and Gene Expression Profile of Chronic Lymphocytic Leukemia Patients with Ultra-Stable Disease
Clinical Lymphoma Myeloma and Leukemia, v. 16, Supplement 2, September 2016, p. S42–S43
Giudice, Ilaria Del; Raponi, Sara; Marinelli, Marilisa; Wang, Jiguang; Cafforio, Luciana; Ilari, Caterina; Messina, Monica; Bonina, Silvia; Tavolaro, Simona; Bordyuh, Mykola; Mauro, Francesca Romana; Chiaretti, Sabina; Rossi, Davide; Gaidano, Gianluca; Guarini, Anna; Rabadan, Raul; Foà, Robin
Inter- and intra-patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from circulating and lymph nodal compartments
British Journal of Haematology, v. 172, (3), 2016, February, p. 371-383
Del Giudice, Ilaria; Marinelli, Marilisa; Wang, Jiguang; Bonina, Silvia; Messina, Monica; Chiaretti, Sabina; Ilari, Caterina; Cafforio, Luciana; Raponi, Sara; Mauro, Francesca Romana; Di Maio, Valeria J M; De Propris, Maria Stefania; Nanni, Mauro; Ciardullo, Carmela; Rossi, Davide; Gaidano, Gianluca Luca; Guarini, Anna R.; Rabadan, Raul; Foa, Robin
Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
eLife, v. 5, (e14709), June 2016, p. 1-25
Yamamoto, Kenta; Wang, Jiguang; Sprinzen, Lisa; Xu, Jun; Haddock, Christopher J.; Li, Chen; Lee, Brian J.; Loredan, Denis G.; Jiang, Wenxia; Vindigni, Alessandro; Wang, Dong; Rabadan, Raul; Zha, Shan
Network Propagation Reveals Novel Features Predicting Drug Response of Cancer Cell Lines
Current Bioinformatics, v. 11, (2), April 2016, p. 203-210
Wang, Jiguang; Kribelbauer, Judith; Rabadan, Raul
Network stratification analysis for identifying function-specific network layers
Molecular BioSystems, v. 12, (4), 2016, p. 1232-1240
Zhang, Chuanchao; Wang, Jiguang; Zhang, Chao; Liu, Juan; Xu, Dong; Chen, Luonan
Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes
Oncotarget, v. 7, (12), March 2016, p. 13886-13901
Messina, Monica; Chiaretti, Sabina; Wang, Jiguang; Fedullo, Anna Lucia; Peragine, Nadia; Gianfelici, Valentina; Piciocchi, Alfonso; Brugnoletti, Fulvia; Di Giacomo, Filomena; Pauselli, Simona; Holmes, Antony B.; Puzzolo, Maria Cristina; Ceglie, Giulia; Apicella, Valerio; Mancini, Marco; Kronnie, Geertruy Te; Testi, Anna Maria; Vitale, Antonella; Vignetti, Marco; Guarini, Anna; Rabadan, Raul; Foà, Robin


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Article 3

An information theoretic method to identify combinations of genomic alterations that promote glioblastoma
Journal of Molecular Cell Biology, v. 7, (3), June 2015, p. 203-213
Melamed, Rachel D.; Wang, Jiguang; Iavarone, Antonio; Rabadan, Raul
RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity
Cell, v. 161, (4), May 2015, p. 774-789
Pefanis, Evangelos; Wang, Jiguang; Rothschild, Gerson; Lim, Junghyun; Kazadi, David; Sun, Jianbo; Federation, Alexander J.; Chao, Jaime; Elliott, Oliver; Liu, Zhiping; Economides, Aris N.; Bradner., James E.; Rabadan, Raul; Basu, Uttiya
Transcriptomics identify CD9 as a marker of murine IL10-competent regulatory B cells
Cell Reports, v. 13, (6), November 2015, p. 1110-1117
Sun, Jianbo; Wang, Jiguang; Pefanis, Evangelos; Chao, Jaime; Rothschild, Gerson; Tachibana, Isao; Chen, Jun Kui; Ivanov, Ivaylo I.; Rabadan, Raul; Takeda, Yoshito; Basu, Uttiya


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Article 5

Clinical Impact of Small TP53 Mutated Subclones in Chronic Lymphocytic Leukemia
Blood, v. 123, (14), 2014, April, p. 2139-2147
Rossi, Davide; Khiabanian, Hossein; Spina, Valeria; Ciardullo, Carmela; Bruscaggin, Alessio; Fama, Rosella; Rasi, Silvia; Monti, Sara; Deambrogi, Clara; De Paoli, Lorenzo; Wang, Jiguang; Gattei, Valter; Guarini, Anna R.; Foa, Robin; Rabadan, Raul; Gaidano, Gianluca Luca
Noncoding RNA Transcription Targets AID to Divergently Transcribed Loci in B Cells
Nature, v. 514, (7522), 2014, Oct, p. 389-393
Pefanis, Evangelos; Wang, Jiguang; Chao, Jaime; Rothschild, Gerson; Lim, Junghyun; Rabadan, Raul; Economides, Aris N.; Basu, Uttiya
PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway
Leukemia, v. 28, (7), 2014, July, p. 1436-1448
Wang Jiguang
Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia
eLife, v. 3, December 2014, article number e02869
Wang, Jiguang; Khiabanian, Hossein; Rossi, Davide; Fabbri, Giulia; Gattei, Valter; Forconi, Francesco; Laurenti, Luca; Marasca, Roberto; Del Poeta, Giovanni; Foa, Robin; Pasqualucci, Laura; Gaidano, Gianluca Luca; Rabadan, Raul
复杂疾病的分子网络模型研究
中国科学: 数学, v. 44, (4), 2014, p. 317-328
Wang, Jiguang


Expand All Collapse All


Article 5

APG: an active protein-gene network model to quantify regulatory signals in complex biological systems
Scientific Reports, v. 3, 2013, article number 1097
Wang, Jiguang; Sun, Yidan; Zheng, Si; Zhang, Xiang-Sun; Zhou, Huarong; Chen, Luonan
E3-ubiquitin Ligase Nedd4 Determines the Fate of AID-associated RNA Polymerase II in B cells
Genes and Development, v. 27, (16), August 2013, p. 1823-1833
Sun, Jianbo; Keim, Celia D.; Wang, Jiguang; Kazadi, David; Oliver, Paula M.; Rabadan, Raul; Basu, Uttiya
Genetic Lesions Associated with Chronic Lymphocytic Leukemia Transformation to Richter Syndrome
Journal of Experimental Medicine, v. 210, (11), October 2013, p. 2273-2288
Fabbri, Giulia; Khiabanian, Hossein; Holmes, Antony B.; Wang jiguang; Messina, Monica; Mullighan, Charles G.; Pasqualucci, Laura; Rabadan, Raul; Dalla- favera, Riccardo Dalla
NOA: A cytoscape plugin for network ontology analysis
Bioinformatics, v. 29, (16), August 2013, p. 2066-2067
Zhang, Chao; Wang, Jiguang; Hanspers, Kristina; Xu, Dong; Chen, Luonan; Pico, Alexander R.
Whole-exome Sequencing Reveals Recurrent Somatic Mutation Networks In Cancer
Cancer Letters, v. 340, (2), November 2013, p. 270-276
Liu, Xiaoping; Wang, Jiguang; Chen, Luonan


Expand All Collapse All


Article 4

A unified computational model for revealing and predicting subtle subtypes of cancers
BMC Bioinformatics, v. 13, (1), 1 May 2012, Article number 70
Ren, Xianwen; Wang, Yong; Wang, Jiguang; Zhang, Xiangsun
Inferring a protein interaction map of Mycobacterium tuberculosis based on sequences and interologs
BMC Bioinformatics, v. 13, (SUPPL.7), May 2012, Article number S6
Liu, Zhiping; Wang, Jiguang; Qiu, Yuqing; Leung, Ross Ka Kit; Zhang, Xiangsun; Tsui, Stephen Kwok-Wing; Chen, Luonan
Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis
Journal of Molecular Cell Biology, v. 4, (4), August 2012, p. 197-206
Song, Wei; Wang, Jiguang; Yang, Ying; Jing, Naihe; Zhang, Xiangsun; Chen, Luonan; Wu, Jiarui
The coding genome of splenic marginal zone lymphoma: Activation of NOTCH2 and other pathways regulating marginal zone development
Journal of Experimental Medicine, v. 209, (9), Aug 2012, p. 1537-1551
Wang, Jiguang

Conference paper 1

Inferring Protein-Protein Interactions Based on Sequences and Interologs in Mycobacterium Tuberculosis
Bio-Inspired Computing and Applications, Editors: De-Shuang Huang, Yong Gan, Prashan Premaratne, Kyungsook Han. Berlin, Heidelberg : Springer-Verlag, 2011, p. 91-96, Part of the Lecture Notes in Computer Science book series (LNCS, volume 6840)
Liu, Zhi-Ping; Wang, Jiguang; Qiu, Yu-Qing; Leung, Ross K.K.; Zhang, Xiang-Sun; Tsui, Stephen K.W.; Chen, Luonan


Expand All Collapse All


Article 2

Network screening of Goto-Kakizaki rat liver microarray data during diabetic progression
BMC Systems Biology, v. 5, Issue SUPPL. 1, 20 June 2011, Article number S16
Zhou, Huarong; Saito, Shigeru; Piao, Guanying; Liu, Zhiping; Wang, Jiguang; Horimoto, Katsuhisa; Chen, Luonan
NOA: a novel Network Ontology Analysis method
Nucleic Acids Research, v. 39, (13), 2011, Jul, p. e87
Wang, Jiguang; Huang, Qiang; Liu, Zhiping; Wang, Yong; Wu, Lingyun; Chen, Luonan; Zhang, Xiangsun

Conference paper 3

A Regularized Optimization Model for Community Identification in Complex Networks
Operations Research and Its Applications, Edited by: Xiang-Sun Zhang, De-Gang Liu, Ling-Yun Wu, and Yong Wang. ORSC & APORC, 2011, p. 147-156, Lecture Notes in Operations Research 14
Wang, Yong; Wang, Jiguang; Chen, Chen; Zhang, Xiang-Sun
A SVC-based Method to Detect Multi-scalar Noisy Communities in Complex Networks
Operations Research and Its Applications, Edited by: Xiang-Sun Zhang, De-Gang Liu, Ling-Yun Wu, and Yong Wang. ORSC & APORC, 2011, p. 133-143, Lecture Notes in Operations Research 14
Zhao, Junfei; Wang, Jiguang; Zhang, Xiang-Sun
Multiple Resolution Community Structure Analysis
Operations Research and Its Applications, Edited by: Xiang-Sun Zhang, De-Gang Liu, Ling-Yun Wu, and Yong Wang. ORSC & APORC, 2011, p. 334-349
Xu, Shoujun; Wang, Jiguang; Zhang, Junhua; Zhang, Xiang-Sun


Expand All Collapse All


Article 1

Sequence-based protein-protein interaction prediction via support vector machine
Journal of Systems Science and Complexity, v. 23, (5), October 2010, p. 1012-1023
Wang, Yongcui; Wang, Jiguang; Yang, Zhixia; Deng, Naiyang

Conference paper 1

Uncover the Transient Transcriptional Regulations by a Novel Sliding Window Correlation Strategy
Lecture Notes in Operations Research, v. 13, 2010, p. 235
Wang, Jiguang; Wang, Yong; Ren, Xianwen; Guo, Wei; Chen, Luonan


Expand All Collapse All


Article 2

Disease-Aging Network Reveals Significant Roles of Aging Genes in Connecting Genetic Diseases
PLoS Computational Biology, v. 5, (9), 2009, Sep, Article number e1000521
Wang, Jiguang; Zhang, Shihua; Wang, Yong; Chen, Luonan; Zhang, Xiangsun
Modularity optimization in community detection of complex networks
Europhysics Letters, v. 87, (3), 1 August 2009, Article number 38002
Zhang, Xiangsun; Wang, Ruisheng; Wang, Yong; Wang, Jiguang; Qiu, Yuqing; Wang, Li; Chen, Luonan

Conference paper 4

A Constrained Optimization Method for Community Detection
Optimization and Systems Biology: Lecture Notes in Operations Research, v. 11, p. 142-150, 2009
Wang, Jiguang; Wang, Lin; Qiu, Yuqing; Wang, Yong; Zhang, Xiangsun
Align Protein Surface Structures to Identify Evolutionally and Structurally Conserved Residues
Optimization and Systems Biology: Lecture Notes in Operations Research, v. 11, 2009, p. 296-303
Wang, Lin; Wang, Jiguang; Chen, Luonan
Analysis of Transcriptome of Rice Anther
Optimization and Systems Biology: Lecture Notes in Operations Research, v. 11, 2009, p. 371-378
Zhang, Wenjuan; Tang, Wei-Hua; Wang, Jiguang; Liu, Zhiping; Zhao, Xing-Ming; Chen, Luonan
Gene Prioritization for Type 2 Diabetes in Tissue-specific Protein Interaction Networks
Optimization and System Biology, v. 11, 2009, p.319-328
Jiang, Biaobin; Wang, Jiguang; Xiao, Jingfa; Wang, Yong


Expand All Collapse All


Article 2

Recognition of Structure Similarities in Proteins
Journal of Systems Science and Complexity, v. 21, (4), 2008, p. 657-667
Wang, Lin; Qiu, Yuqing; Wang, Jiguang; Zhang, Xiangsun
Remarks on network community properties
Journal of Systems Science and Complexity, v. 21, (4), December 2008, p. 629-636
Wang, Jiguang; Qiu, Yuqing; Wang, Ruisheng; Zhang, Xiangsun


Expand All Collapse All


2016 7

Clonal evolution of glioblastoma under therapy
Nature Genetics, v. 48, (7), July 2016, p. 768-776
Wang, Jiguang; Cazzato, Emanuela; Ladewig, Erik; Frattini, Veronique; Rosenbloom, Daniel I.S.; Zairis, Sakellarios; Abate, Francesco; Liu, Zhaoqi; Elliott, Oliver; Shin, Yongjae; Lee, Jinku; Lee, Inhee; Park, Woongyang; Eoli, Marica; Blumberg, Andrew J.; Lasorella, Anna; Nam, Dohyun; Finocchiaro, Gaetano; Iavarone, Antonio; Rabadan, Raul Article
Genetic Landscape and Gene Expression Profile of Chronic Lymphocytic Leukemia Patients with Ultra-Stable Disease
Clinical Lymphoma Myeloma and Leukemia, v. 16, Supplement 2, September 2016, p. S42–S43
Giudice, Ilaria Del; Raponi, Sara; Marinelli, Marilisa; Wang, Jiguang; Cafforio, Luciana; Ilari, Caterina; Messina, Monica; Bonina, Silvia; Tavolaro, Simona; Bordyuh, Mykola; Mauro, Francesca Romana; Chiaretti, Sabina; Rossi, Davide; Gaidano, Gianluca; Guarini, Anna; Rabadan, Raul; Foà, Robin Article
Inter- and intra-patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from circulating and lymph nodal compartments
British Journal of Haematology, v. 172, (3), 2016, February, p. 371-383
Del Giudice, Ilaria; Marinelli, Marilisa; Wang, Jiguang; Bonina, Silvia; Messina, Monica; Chiaretti, Sabina; Ilari, Caterina; Cafforio, Luciana; Raponi, Sara; Mauro, Francesca Romana; Di Maio, Valeria J M; De Propris, Maria Stefania; Nanni, Mauro; Ciardullo, Carmela; Rossi, Davide; Gaidano, Gianluca Luca; Guarini, Anna R.; Rabadan, Raul; Foa, Robin Article
Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
eLife, v. 5, (e14709), June 2016, p. 1-25
Yamamoto, Kenta; Wang, Jiguang; Sprinzen, Lisa; Xu, Jun; Haddock, Christopher J.; Li, Chen; Lee, Brian J.; Loredan, Denis G.; Jiang, Wenxia; Vindigni, Alessandro; Wang, Dong; Rabadan, Raul; Zha, Shan Article
Network Propagation Reveals Novel Features Predicting Drug Response of Cancer Cell Lines
Current Bioinformatics, v. 11, (2), April 2016, p. 203-210
Wang, Jiguang; Kribelbauer, Judith; Rabadan, Raul Article
Network stratification analysis for identifying function-specific network layers
Molecular BioSystems, v. 12, (4), 2016, p. 1232-1240
Zhang, Chuanchao; Wang, Jiguang; Zhang, Chao; Liu, Juan; Xu, Dong; Chen, Luonan Article
Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes
Oncotarget, v. 7, (12), March 2016, p. 13886-13901
Messina, Monica; Chiaretti, Sabina; Wang, Jiguang; Fedullo, Anna Lucia; Peragine, Nadia; Gianfelici, Valentina; Piciocchi, Alfonso; Brugnoletti, Fulvia; Di Giacomo, Filomena; Pauselli, Simona; Holmes, Antony B.; Puzzolo, Maria Cristina; Ceglie, Giulia; Apicella, Valerio; Mancini, Marco; Kronnie, Geertruy Te; Testi, Anna Maria; Vitale, Antonella; Vignetti, Marco; Guarini, Anna; Rabadan, Raul; Foà, Robin Article

2015 3

An information theoretic method to identify combinations of genomic alterations that promote glioblastoma
Journal of Molecular Cell Biology, v. 7, (3), June 2015, p. 203-213
Melamed, Rachel D.; Wang, Jiguang; Iavarone, Antonio; Rabadan, Raul Article
RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity
Cell, v. 161, (4), May 2015, p. 774-789
Pefanis, Evangelos; Wang, Jiguang; Rothschild, Gerson; Lim, Junghyun; Kazadi, David; Sun, Jianbo; Federation, Alexander J.; Chao, Jaime; Elliott, Oliver; Liu, Zhiping; Economides, Aris N.; Bradner., James E.; Rabadan, Raul; Basu, Uttiya Article
Transcriptomics identify CD9 as a marker of murine IL10-competent regulatory B cells
Cell Reports, v. 13, (6), November 2015, p. 1110-1117
Sun, Jianbo; Wang, Jiguang; Pefanis, Evangelos; Chao, Jaime; Rothschild, Gerson; Tachibana, Isao; Chen, Jun Kui; Ivanov, Ivaylo I.; Rabadan, Raul; Takeda, Yoshito; Basu, Uttiya Article

2014 5

Clinical Impact of Small TP53 Mutated Subclones in Chronic Lymphocytic Leukemia
Blood, v. 123, (14), 2014, April, p. 2139-2147
Rossi, Davide; Khiabanian, Hossein; Spina, Valeria; Ciardullo, Carmela; Bruscaggin, Alessio; Fama, Rosella; Rasi, Silvia; Monti, Sara; Deambrogi, Clara; De Paoli, Lorenzo; Wang, Jiguang; Gattei, Valter; Guarini, Anna R.; Foa, Robin; Rabadan, Raul; Gaidano, Gianluca Luca Article
Noncoding RNA Transcription Targets AID to Divergently Transcribed Loci in B Cells
Nature, v. 514, (7522), 2014, Oct, p. 389-393
Pefanis, Evangelos; Wang, Jiguang; Chao, Jaime; Rothschild, Gerson; Lim, Junghyun; Rabadan, Raul; Economides, Aris N.; Basu, Uttiya Article
PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway
Leukemia, v. 28, (7), 2014, July, p. 1436-1448
Wang Jiguang Article
Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia
eLife, v. 3, December 2014, article number e02869
Wang, Jiguang; Khiabanian, Hossein; Rossi, Davide; Fabbri, Giulia; Gattei, Valter; Forconi, Francesco; Laurenti, Luca; Marasca, Roberto; Del Poeta, Giovanni; Foa, Robin; Pasqualucci, Laura; Gaidano, Gianluca Luca; Rabadan, Raul Article
复杂疾病的分子网络模型研究
中国科学: 数学, v. 44, (4), 2014, p. 317-328
Wang, Jiguang Article

2013 5

APG: an active protein-gene network model to quantify regulatory signals in complex biological systems
Scientific Reports, v. 3, 2013, article number 1097
Wang, Jiguang; Sun, Yidan; Zheng, Si; Zhang, Xiang-Sun; Zhou, Huarong; Chen, Luonan Article
E3-ubiquitin Ligase Nedd4 Determines the Fate of AID-associated RNA Polymerase II in B cells
Genes and Development, v. 27, (16), August 2013, p. 1823-1833
Sun, Jianbo; Keim, Celia D.; Wang, Jiguang; Kazadi, David; Oliver, Paula M.; Rabadan, Raul; Basu, Uttiya Article
Genetic Lesions Associated with Chronic Lymphocytic Leukemia Transformation to Richter Syndrome
Journal of Experimental Medicine, v. 210, (11), October 2013, p. 2273-2288
Fabbri, Giulia; Khiabanian, Hossein; Holmes, Antony B.; Wang jiguang; Messina, Monica; Mullighan, Charles G.; Pasqualucci, Laura; Rabadan, Raul; Dalla- favera, Riccardo Dalla Article
NOA: A cytoscape plugin for network ontology analysis
Bioinformatics, v. 29, (16), August 2013, p. 2066-2067
Zhang, Chao; Wang, Jiguang; Hanspers, Kristina; Xu, Dong; Chen, Luonan; Pico, Alexander R. Article
Whole-exome Sequencing Reveals Recurrent Somatic Mutation Networks In Cancer
Cancer Letters, v. 340, (2), November 2013, p. 270-276
Liu, Xiaoping; Wang, Jiguang; Chen, Luonan Article

2012 5

A unified computational model for revealing and predicting subtle subtypes of cancers
BMC Bioinformatics, v. 13, (1), 1 May 2012, Article number 70
Ren, Xianwen; Wang, Yong; Wang, Jiguang; Zhang, Xiangsun Article
Inferring a protein interaction map of Mycobacterium tuberculosis based on sequences and interologs
BMC Bioinformatics, v. 13, (SUPPL.7), May 2012, Article number S6
Liu, Zhiping; Wang, Jiguang; Qiu, Yuqing; Leung, Ross Ka Kit; Zhang, Xiangsun; Tsui, Stephen Kwok-Wing; Chen, Luonan Article
Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis
Journal of Molecular Cell Biology, v. 4, (4), August 2012, p. 197-206
Song, Wei; Wang, Jiguang; Yang, Ying; Jing, Naihe; Zhang, Xiangsun; Chen, Luonan; Wu, Jiarui Article
The coding genome of splenic marginal zone lymphoma: Activation of NOTCH2 and other pathways regulating marginal zone development
Journal of Experimental Medicine, v. 209, (9), Aug 2012, p. 1537-1551
Wang, Jiguang Article
Inferring Protein-Protein Interactions Based on Sequences and Interologs in Mycobacterium Tuberculosis
Bio-Inspired Computing and Applications, Editors: De-Shuang Huang, Yong Gan, Prashan Premaratne, Kyungsook Han. Berlin, Heidelberg : Springer-Verlag, 2011, p. 91-96, Part of the Lecture Notes in Computer Science book series (LNCS, volume 6840)
Liu, Zhi-Ping; Wang, Jiguang; Qiu, Yu-Qing; Leung, Ross K.K.; Zhang, Xiang-Sun; Tsui, Stephen K.W.; Chen, Luonan Conference paper

2011 5

Network screening of Goto-Kakizaki rat liver microarray data during diabetic progression
BMC Systems Biology, v. 5, Issue SUPPL. 1, 20 June 2011, Article number S16
Zhou, Huarong; Saito, Shigeru; Piao, Guanying; Liu, Zhiping; Wang, Jiguang; Horimoto, Katsuhisa; Chen, Luonan Article
NOA: a novel Network Ontology Analysis method
Nucleic Acids Research, v. 39, (13), 2011, Jul, p. e87
Wang, Jiguang; Huang, Qiang; Liu, Zhiping; Wang, Yong; Wu, Lingyun; Chen, Luonan; Zhang, Xiangsun Article
A Regularized Optimization Model for Community Identification in Complex Networks
Operations Research and Its Applications, Edited by: Xiang-Sun Zhang, De-Gang Liu, Ling-Yun Wu, and Yong Wang. ORSC & APORC, 2011, p. 147-156, Lecture Notes in Operations Research 14
Wang, Yong; Wang, Jiguang; Chen, Chen; Zhang, Xiang-Sun Conference paper
A SVC-based Method to Detect Multi-scalar Noisy Communities in Complex Networks
Operations Research and Its Applications, Edited by: Xiang-Sun Zhang, De-Gang Liu, Ling-Yun Wu, and Yong Wang. ORSC & APORC, 2011, p. 133-143, Lecture Notes in Operations Research 14
Zhao, Junfei; Wang, Jiguang; Zhang, Xiang-Sun Conference paper
Multiple Resolution Community Structure Analysis
Operations Research and Its Applications, Edited by: Xiang-Sun Zhang, De-Gang Liu, Ling-Yun Wu, and Yong Wang. ORSC & APORC, 2011, p. 334-349
Xu, Shoujun; Wang, Jiguang; Zhang, Junhua; Zhang, Xiang-Sun Conference paper

2010 2

Sequence-based protein-protein interaction prediction via support vector machine
Journal of Systems Science and Complexity, v. 23, (5), October 2010, p. 1012-1023
Wang, Yongcui; Wang, Jiguang; Yang, Zhixia; Deng, Naiyang Article
Uncover the Transient Transcriptional Regulations by a Novel Sliding Window Correlation Strategy
Lecture Notes in Operations Research, v. 13, 2010, p. 235
Wang, Jiguang; Wang, Yong; Ren, Xianwen; Guo, Wei; Chen, Luonan Conference paper

2009 6

Disease-Aging Network Reveals Significant Roles of Aging Genes in Connecting Genetic Diseases
PLoS Computational Biology, v. 5, (9), 2009, Sep, Article number e1000521
Wang, Jiguang; Zhang, Shihua; Wang, Yong; Chen, Luonan; Zhang, Xiangsun Article
Modularity optimization in community detection of complex networks
Europhysics Letters, v. 87, (3), 1 August 2009, Article number 38002
Zhang, Xiangsun; Wang, Ruisheng; Wang, Yong; Wang, Jiguang; Qiu, Yuqing; Wang, Li; Chen, Luonan Article
A Constrained Optimization Method for Community Detection
Optimization and Systems Biology: Lecture Notes in Operations Research, v. 11, p. 142-150, 2009
Wang, Jiguang; Wang, Lin; Qiu, Yuqing; Wang, Yong; Zhang, Xiangsun Conference paper
Align Protein Surface Structures to Identify Evolutionally and Structurally Conserved Residues
Optimization and Systems Biology: Lecture Notes in Operations Research, v. 11, 2009, p. 296-303
Wang, Lin; Wang, Jiguang; Chen, Luonan Conference paper
Analysis of Transcriptome of Rice Anther
Optimization and Systems Biology: Lecture Notes in Operations Research, v. 11, 2009, p. 371-378
Zhang, Wenjuan; Tang, Wei-Hua; Wang, Jiguang; Liu, Zhiping; Zhao, Xing-Ming; Chen, Luonan Conference paper
Gene Prioritization for Type 2 Diabetes in Tissue-specific Protein Interaction Networks
Optimization and System Biology, v. 11, 2009, p.319-328
Jiang, Biaobin; Wang, Jiguang; Xiao, Jingfa; Wang, Yong Conference paper

2008 2

Recognition of Structure Similarities in Proteins
Journal of Systems Science and Complexity, v. 21, (4), 2008, p. 657-667
Wang, Lin; Qiu, Yuqing; Wang, Jiguang; Zhang, Xiangsun Article
Remarks on network community properties
Journal of Systems Science and Complexity, v. 21, (4), December 2008, p. 629-636
Wang, Jiguang; Qiu, Yuqing; Wang, Ruisheng; Zhang, Xiangsun Article


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 4 2020-21 Summer 3 2020-21 Spring 7 2020-21 Winter 0 2020-21 Fall 3

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CBME6000F Data Science in Biological Engineering
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
UROP4100E Undergraduate Research Opportunities Series 4


UROP1000 Undergraduate Research Opportunities
UROP2100D Undergraduate Research Opportunities Series 2
UROP3100D Undergraduate Research Opportunities Series 3


BIEN3320 Data Science for Biology and Medicine
BIEN4930 Bioengineering Thesis Research
LIFS4320 Data Science for Biology and Medicine
LIFS4963 Biotechnology Capstone Project
LIFS4981 Biochemistry and Cell Biology Project Research II
LIFS4983 Biotechnology Project Research II
LIFS6116D Current Topics in Genomics and Bioinformatics


LIFS4960 Biological Science Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS4973 Biotechnology Project Research I


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

---

Doctor of Philosophy DENG, Mingxi (co-supervision)
Life Science( 2021 - )

LIU, Shiyi
Bioscience and Biomedical Engineering( 2021 - )

TANG, Jihong
Life Science( 2021 - )

YUAN, Congmin
Bioengineering( 2021 - )

ZHANG, Xiaomeng (co-supervision)
Data Science and Analytics( 2021 - )

MO, Zongchao
Life Science( 2020 - )

SONG, Dong
Life Science( 2019 - )

YANG, Yingxi (co-supervision)
Bioengineering( 2019 - )

---

Master of Philosophy MA, Ruochen
Life Science( 2021 - )

LI, Jiabao
Life Science( 2020 - )

ZHU, Zhihan
Bioengineering( 2020 - )

---

Graduated RPGs

---

Doctor of Philosophy NAM, Yoonhee
Life Science( Completed in 2022 )

CHEN, Yiyun
Life Science( Completed in 2021 )

MU, Quanhua
Bioengineering( Completed in 2020 )

---

Master of Philosophy HUANG, Hanli
Bioengineering( Completed in 2022 )

HUANG, Shengshuo
Life Science( Completed in 2020 )

LUI, Ming Hong
Bioengineering( Completed in 2020 )









ProjectsFrom January 2020 to December 2022

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All Projects 17 Leading Projects 8 Participating Projects 9

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Development of a Multimodal Cancer Bioinformatics Platform for Drug Target Prioritization in Glioma by Modelling Spatiotemporal Cancer Evolution at a Single-Cell Level


基於單細胞時空演化模型的膠質瘤多模態數據整合與藥物預測平臺構建 Leading


Innovation and Technology Fund


Project Team (HKUST)
WANG Jiguang (Lead)


2022 -




Investigation of pre-treatment genetic and microenvironmental factors that shape the clonal evolution of diffuse glioma under therapy


影響瀰漫性腦膠質瘤克隆演化的治療前遺傳與微環境因素研究 Leading


RGC - General Research Fund


Project Team (HKUST)
WANG Jiguang (Lead)


2021 -




Establishment of a precise immunotherapy decision system for non-small cell lung cancer guided by tumor microenvironment assessment


建立以腫瘤微環境評估為導向的非小細胞肺癌精準免疫治療決策體系 Leading


Department of Science and Technology of Guangdong Province


Project Team (HKUST)
WANG Jiguang (Lead)


2021 -




The Center for Neurodegenerative Diseases


N/A Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LEUNG Danny Chi Yeu
LIU Kai
WANG Jiguang
WONG Yung Hou
WU Zhenguo


2020 -




Exploiting epitranscriptome dysregulation in colorectal carcinogenesis and metastasis: mechanisms and novel therapeutic approaches


RNA修飾在大腸癌發生和轉移的機制和治療研究 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
WANG Jiguang


2020 -




Functional characterization of the splicing isoforms of Tmc1 and Lhfpl5 genes in mouse auditory hair cells


小鼠內耳聽毛細胞TMC1和LHFPL5替代拼接亞型的功能研究 Participating


RGC - General Research Fund


Project Team (HKUST)
HUANG Pingbo (Lead)
WANG Jiguang


2020 -




X-GPU: An Extreme GPU Cluster for Interdisciplinary Research on Molecular Dynamics Simulations and Genomics Studies


X-GPU:一個極高性能的GPU計算集群用於分子動力學模擬和基因組學的跨學科研究 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
YANG Can (Lead)
HAN Yilong
LUO Qiong
PAN Ding
SANDER Pedro
SU Haibin
WANG Jiguang
YAO Yuan
YU Weichuan


2020 -




Bioinformatics


生物信息學 Leading


National Natural Science Foundation of China


Project Team (HKUST)
WANG Jiguang (Lead)


2020 -




Investigation of population-specific tumorigenesis by studying somatic and germline variants in East Asian gliomas


基於東亞人群體細胞變異和種系變異的腦膠質瘤種族特異發生機制研究 Leading


RGC - Early Career Scheme


Project Team (HKUST)
WANG Jiguang (Lead)


2020 -




High-speed, Label-free and Slide-free Histologic Imaging by Photoacoustic Microscopy with Deep Learning for Lung CancerSpecimens


結合深度學習的光聲顯微鏡實現對肺癌樣本進行快速, 無標記和無玻璃切片的組織成像 Participating


Innovation and Technology Fund


Project Team (HKUST)
WONG Terence Tsz Wai (Lead)
WANG Jiguang


2020 - 2021




Patient-Derived Preclinical Models for Translational Cancer Research: a Hong Kong-based Biotechnology Centre for Genomic Medicine


開發轉移性癌癥研究的臨床前模型: 建立香港基因組醫學生物技術中心 Participating


Research Impact Fund


Project Team (HKUST)
WANG Jiguang


2019 -




Computational study of alternative splicing in cancer development and progression by multi-omics integration Leading


Central Reserve Fund - School-based Initiatives


Project Team (HKUST)
WANG Jiguang (Lead)


2019 -




Computational study of precision cancer diagnosis and medicine Leading


Central Reserve Fund - School-based Initiatives


Project Team (HKUST)
WANG Jiguang (Lead)


2019 -




Identification and characterization of genes and microenvironment factors driving the metastasis of upper gastrointestinal tract cancers


發現並研究驅動上消化道腫瘤轉移相關的基因和腫瘤微環境因素 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
WANG Jiguang


2019 -




Using Imaging Data and Genomic Data to Predict Metastasis of Breast Cancer after Treatment


利用圖像數據和基因組數據預測乳腺癌治療後的轉移 Participating


Innovation and Technology Fund


Project Team (HKUST)
YU Weichuan (Lead)
CHENG Tim Kwang-Ting
WANG Jiguang
WU Angela Ruohao


2019 -




Gene fusion study in tumor evolution and precision oncology of glioma


腦膠質瘤進化與精準醫療中的融合基因研究 Leading


National Natural Science Foundation of China / Research Grants Council Joint Research Scheme


Project Team (HKUST)
WANG Jiguang (Lead)


2018 - 2021




Development of infrared-mediated single cell-labeling and study of non-HSC-derived T cells in zebrafish


研發紅外光介導的單細胞標記技術以及研究斑馬魚中非造血幹細胞來源的T淋巴細胞 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
WEN Zilong (Lead)
QU Jianan
WANG Jiguang
WU Angela Ruohao


2018 - 2021