Jun XIA
夏軍
PhD in Neuroscience
The Johns Hopkins University, 2002

Professor
Division of Life Science
Department of Chemical and Biological Engineering



(852) 2358 7293
jxia@ust.hk
Room 5447
Personal Web

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Google Scholar
GbjGESIAAAAJ

ORCID
0000-0001-9308-2188

ResearcherID
C-7234-2009

Scopus ID
56431873500




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Protein trafficking
Synaptic transmission (Neurotransmission)



Publications

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All Years 63 2022 0 2021 0 2020 0 2019 3 2018 5 2017 2 2016 53

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2019 3

Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity
iScience, v. 13, March 2019, p. 82-97
Lin, Raozhou; Duan, Zhigang; Sun, Haitao; Fung, Man Lung; Chen, Hansen; Wang, Jing; Lau, Chi Fai; Yang, D.; Liu, Yu; Ni, Yanxiang; Wang, Zai; Cui, Ju; Wu, Wutian; Yung, Wingho; Chan, Ying Shing; Lo, Amy Cheuk Yin; Xia, Jun; Shen, Jiangang; Huang, Jiandong Article
Neuroligin 3 Regulates Dendritic Outgrowth by Modulating Akt/mTOR Signaling
Frontiers in Cellular Neuroscience, v. 13, November 2019, article number 518
Xu, Jing; Du, Yong-lan; Xu, Jing-wei; Hu, Xiao-ge; Gu, Lin-fan; Li, Xiu-mao; Hu, Ping-hong; Liao, Tai-lin; Xia, Qiang-qiang; Sun, Qi; Shi, Lei; Luo, Jian-hong; Xia, Jun; Wang, Ziyi; Xu, Junyu Article
Neuroligins Differentially Mediate Subtype-Specific Synapse Formation in Pyramidal Neurons and Interneurons
Neuroscience Bulletin, v. 35, (3), June 2019, p. 497-506
Xia, Qiangqiang; Xu, Jing; Liao, Tailin; Yu, Jie; Shi, Lei; Xia, Jun; Luo, Jianhong; Xu, Junyu Article

2018 5

Changes in synaptic AMPA receptor concentration and composition in chronic temporal lobe epilepsy
Molecular and Cellular Neuroscience, v. 92, October 2018, p. 93-103
Egbenya, Daniel Lawer; Hussain, Suleman S.; Lai, Yichen; Xia, Jun; Anderson, Anne E.; Davanger, Svend Article
Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice
Neuron, v. 97, (6), March 2018, p. 1253-1260.e7
Cao, Wei; Lin, Shen; Xia, Qiang-qiang; Du, Yong-Lan; Yang, Qian; Zhang, Meng-Ying; Lu, Yi-Qing; Xu, Jing; Duan, Shu-Min; Xia, Jun; Feng, Guoping; Xu, Junyu; Luo, Jian-Hong Article
Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4
Cell Reports, v. 23, (6), May 2018, p. 1691-1705
Wu, Min; Tian, Honglei; Liu, Xiaobo; Lai, Ho-chun; Du, Shengwang; Xia, Jun Article
PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect.
Proceedings of the National Academy of Sciences of the United States of America, v. 115, (30), July 2018, p. E7193-E7201
He, Jing; Xia, Mengying; Yeung, Patrick KK; Li, Jiahua; Li, Zhifang; Chung, Ka Kin Kenny; Chung, Sookja K; Xia, Jun Article
PICK1 is Essential for Insulin Production and The Maintenance of Glucose Homeostasis
Molecular Biology of the Cell, v. 29, (5), March 2018, p. 587-596
Li, Jia; Mao, Zhuo; Huang, Jiandong; Xia, Jun Article

2017 2

A nonsense mutation in Ccdc62 gene is responsible for spermiogenesis defects and male infertility in repro29/repro29 mice
Biology of Reproduction, v. 96, (3), March 2017, article number bio141408, p. 587-597
Li, Yuchi; Li, Cailing; Lin, Shouren; Yang, Bo; Huang, Weiren; Wu, Hanwei; Chen, Yuanbin; Yang, Lihua; Luo, Manling; Guo, Huan; Chen, Jianbo; Wang, Tiantian; Ma, Qian; Gu, Yanli; Mou, Lisha; Jiang, Zhimao; Xia, Jun; Gui, Yaoting Article
Presynaptic PICK1 Facilitates Trafficking of AMPA-Receptors between Active Zone and Synaptic Vesicle Pool
Neuroscience, v. 344, March 2017, p. 102-112
Hagler?d, Camilla; Hussain, Suleman S.; Nakamura, Y.; Xia, Jun; Haug, Finn Mogens ?mejda; Ottersen, O.P.; Henley, Jeremy M.; Davanger, Svend Article

2016 1

Syntabulin regulates the trafficking of PICK1-containing vesicles in neurons
Scientific Reports, v. 6, February 2016, article number 20924
Xu, Junyu; Wang, Na; Luo, Jianhong; Xia, Jun Article

2015 1

ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis
Journal of Cell Science, v. 128, (20), October 2015, p. 3822-3836
He, Jing; Xia, Mengying; Tsang, Wai Hung; Chow, King Lau; Xia, Jun Article

2014 3

A Unique Plant ESCRT Component, FREE1, Regulates Multivesicular Body Protein Sorting and Plant Growth
Current Biology, v. 24, (21), November 2014, p. 2556-2563
Gao, Caiji; Luo, Ming; Zhao, Qiong; Yang, Renzhi; Cui, Yong; Zeng, Yonglun; Xia, Jun; Jiang, Liwen Article
Exo70E2 is essential for exocyst subunit recruitment and EXPO formation in both plants and animals
Molecular biology of the cell, v. 25, (3), February 2014, p. 412-426
Ding, Yu; Wang, Juan; Lai, Ho Chun John; Chan, Vivian Hoi Ling; Wang, Xiangfeng; Cai, Yi; Tan, Xiaoyun; Bao, Yiqun; Xia, Jun; Robinson, David G.; Jiang, Liwen Article
PICK1 Mediates Synaptic Recruitment of Ampa Receptors at Neurexin-induced Postsynaptic Sites
The Journal of Neuroscience, v. 34, (46), November 2014, p. 15415-15424
Xu, Junyu; Kam, Chuen; Luo, Jian-Hong; Xia, Jun Article

2013 2

PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance
PLoS Biology, v. 11, (4), April 2013, article number e1001541
Cao, Mian; Mao, Zhuo; Kam, Chuen; Xiao, Nan; Cao, Xiaoxing; Shen, Chong; Cheng, Kenneth K.Y.; Xu, Aimin; Lee, Kwong-Man; Jiang, Liwen; Xia, Jun Article
Rescuing infertility of Pick1 knockout mice by generating testis-specific transgenic mice via testicular infection
Scientific Reports, v. 3, 2013, article number 2842
Li, Xiumao; Mao, Zhuo; Wu, Min; Xia, Jun Article

2012 5

A review on the current neuroligin mouse models
Acta Physiologica Sinica=生理学报, v. 64, (5), 2012, p. 550-562
XU, Jun-Yu; Xia, Qiang-Qiang; Xia, Jun Article
AMPA Receptors Regulate Exocytosis and Insulin Release in Pancreatic beta Cells
Traffic, v. 13, (8), August 2012, p. 1124-1139
Wu, Zhen-Yong; Zhu, Li-Jun; Zou, Na; Bombek, Lidija K.; Shao, Chong-Yu; Wang, Na; Wang, Xin-Xin; Liang, Li; Xia, Jun; Rupnik, Marjan; Shen, Ying Article
Chronic Zinc Exposure Decreases the Surface Expression of NR2A-Containing NMDA Receptors in Cultured Hippocampal Neurons
PLoS ONE, v. 7, (9), September 2012
Zhu, Jia; Shao, Chong-Yu; Yang, Wei; Zhang, Xiao-Min; Wu, Zhen-Yong; Zhou, Liang; Wang, Xin-Xin; Li, Yun-Hong; Xia, Jun; Luo, Jian-Hong; Shen, Ying Article
PICK1 promotes caveolin-dependent degradation of TGF-beta type I receptor
Cell Research, v. 22, (10), October 2012, p. 1467-1478
Zhao, Bing; Wang, Qiang; Du, Jun; Luo, Shiwen; Xia, Jun; Chen, Ye-Guang Article
PICK1-ICA69 BAR domain protein complex regulates insulin trafficking in pancreatic beta-cells
Gordon Conference: Proprotein Processing, Trafficking & Secretion, USA, New Hampshire, July 15-20 2012
Xia, Jun Conference paper

2011 4

Apccdh1 Mediates Epha4-dependent Downregulation of Ampa Receptors in Homeostatic Plasticity
Nature Neuroscience, v. 14, (2), February 2011, p. 181-191
Fu, Kit Yu; Hung, Kwok Wang; Fu, Wing Yu; Shen, Chong; Chen, Yu; Xia, Jun; Lai, Kwok On; Ip, Nancy Yuk-yu Article
Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration
EMBO journal, v. 30, (4), 2011, p. 665-678
Huo, Lin; Wen, Wenyu; Wang, Rui; Kam, Chuen; Xia, Jun; Feng, Wei; Zhang, Mingjie Article
Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1
Molecular pain, v. 7, (11), February 2011
Wang, Wei; Petralia, Ronald S.; Takamiya, Kogo; Xia, Jun; Li, Yun-Qing; Huganir, Richard L.; Tao, Yuan-Xiang; Yaster, Myron Article
Regulation of AMPA Receptor Function by the Human Memory-Associated Gene KIBRA
Neuron, v. 71, (6), September 2011, p. 1022-1029
Makuch, Lauren; Volk, Lenora; Anggono, Victor; Johnson, Richard C.; Yu, Yilin; Duning, Kerstin; Kremerskothen, Joachim; Xia, Jun; Takamiya, Kogo; Huganir, Richard L. Article

2010 10

Pathologically Activated Neuroprotection via Uncompetitive Blockade of N-Methyl-D-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin
Journal of biological chemistry, v. 285, (26), 2010, JUN 25, p. 19947-19958
Luo, Jialie; Li, Wenming; Zhao, Yuming; Fu, Hongjun; Ma, Dik-Lung; Tang, Jing; Li, Chaoying; Peoples, Robert W.; Li, Fushun; Wang, Qinwen; Huang, Pingbo; Xia, Jun; Pang, Yuanping; Han, Yifan Article
PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner
Molecular Brain, v. 3, (39), 2010
Jin, Wenying; Shen, Chong; Jing, Lan; Zha, Xiang-ming; Xia, Jun Article
Redox-Regulated Lipid Membrane Binding of the PICK1 PDZ Domain
Biochemistry, v. 49, (21), 2010, JUN 1, p. 4432-4439
Shi, Yawei; Yu, Jiang; Jia, Yuan; Pan, Lifeng; Shen, Chong; Xia, Jun; Zhang, Mingjie Article
Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain
Pain, v. 151, (1), 2010, p. 226-234
Atianjoh, F.E.; Yaster, M.; Zhao, X.; Takamiya, K.; Xia, J.; Gauda, E.B.; Huganir, R.L.; Tao, Y.X. Article
Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization
Neurochemistry international, v. 56, (8), 2010, JUL, p. 962-970
Shao, Xin; Zhu, Lijun; Wang, Yubin; Lu, Yuting; Wang, Wenhai; Zhu, Jia; Shen, Ying; Xia, Jun; Luo, Jianhong Article
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1
Nature Neuroscience, v. 13, (1), 2010, JAN, p. 22-24
Xu, Junyu; Xiao, Nan; Xia, Jun Article
EphA4-Dependent Degradation of AMPA Receptor Is Important for the Homeostatic Synaptic Plasticity
The Gordon Research Conference on Molecular and Cellular Neurobiology, Hong Kong, 6 - 11 June 2010
Fu, Kit Yu; Hung, Kwok Wang; Fu, Wing Yu; Shen, Chong; Chen, Yu; Xia, Jun; Lai, Kwok On; Ip, Nancy Yuk-Yu Conference paper
PICK1-ICA69 BAR domain protein complex regulates insulin trafficking in pancreatic beta-cells
Asia Islet Biology & Incretin Symposium (AIBIS) 2010, Kyoto, Japan, July 30-Aug2, 2010
Cao, Mian; Kam, Chuen; Shen, Chong; Cao, Xiaoxing; Lee, Kwong-Man; Xia, Jun Conference paper
Synaptogenesis and AMPA receptor trafficking
Chinese Neuroscientists Worldwide (SCNW 2010), Nan Chang, China, Aug 4-10, 2010
Xu, Junyu; Xia, Jun Conference paper
Targeting of AMPA receptor at neurexin-neuroligin induced synapses
2010 Gordon Research Conference on Molecular and Cellular Neurobiology, Hong Kong University of Science and Technology, Hong Kong, 6-11 Jun 2010
Xia, Jun Conference paper

2009 4

BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells
Plant journal, v. 60, (5), 2009, DEC, p. 865-881
Lam, Sheung Kwan; Cai, Yi; Tse, Yu Chung; Wang, Juan; Law, Angus Ho Yin; Pimpl, Peter; Chan, Ho Yin Edwin; Xia, Jun; Jiang, Liwen Article
PICK1 deficiency causes male infertility in mice by disrupting acrosome formation
JOURNAL OF CLINICAL INVESTIGATION, v. 119, (4), 2009, APR, p. 802-812
Xiao, Nan; Kam, Chuen; Shen, Chong; Jin, Wenying; Wang, Junqi; Lee, Kwong Man; Jiang, Liwen; Xia, Jun Article
EphA4-Mediated Degradation of AMPA Receptor Is Important in Homeostatic Synaptic Plasticity
The 39th Meeting of the Society for Neuroscience, Chicago, USA, 17 - 21
Fu, Kit Yu; Hung, Kwok Wang; Fu, Wing Yu; Shen, Chong; Chen, Yu; Xia, Jun; Lai, Kwok On; Ip, Nancy Yuk-Yu Conference paper
PICK1 and ICA69 Define Three Maturation Stages of Insulin Granules and Their Deficiency Leads to Impaired Glucose Tolerance
American Society for Cell Biology 49th Annual Meeting, San Diego Convention Center, San Diego, California, 5-9 Dec 2009
Cao, M.; Kam, C.; Shen, C.; Cao, X.; Lee, K.; Xia, J. Conference paper

2008 1

PICK1 and ICA69 Define Three Maturation Stages of Insulin Granules and Their Deficiency Leads to Impaired Glucose Tolerance
48th Annual Meeting of the American Society for Cell Biology, The Moscone Center, San Francisco, California (USA), 13-17 Dec 2008
Cao, M.; Kam, C.; Shen, C.; Cao, X.; Lee, K.; Xia, J. Conference paper

2007 4

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes
EMBO journal, v. 26, (21), 2007, OCT 31, p. 4576-4587
Pan, Lifeng; Wu, Hao; Shen, Chong; Shi, Yawei; Jin, Wenying; Xia, Jun; Zhang, Mingjie Article
Developmental expression of Ca2+-permeable AMPA receptors underlies depolarization-induced long-term depression at mossy fiber-CA3 pyramid Synapses
The Journal of neuroscience, v. 27, (43), October 2007, p. 11651-11662
Ho, Michelle T.W.; Pelkey, Kenneth A.; Topolnik, Lisa; Petralia, Ronald S.; Takamiya, Kogo; Xia, Jun; Huganir, Richard L.; Lacaille, Jean-ClauDe; McBain, Chris J. Article
Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents
Biochemical and biophysical research communications, v. 361, (2), 2007, SEP 21, p. 505-509
Luo, Jialie; Li, Wenming; Liu, Yuwei; Zhang, Wei; Fu, Hongjun; Lee, Nelson T.K.; Yu, Hua; Pang, Yuanping; Huang, Pingbo; Xia, Jun; Li, Zhi-Wang; Li, Chaoying; Han, Yifan Article
PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors
JOURNAL OF NEUROSCIENCE, v. 27, (47), 2007, NOV 21, p. 12945-12956
Cao, Mian; Xu, Junyu; Shen, Chong; Kam, Chuen; Huganir, Richard L.; Xia, Jun Article

2006 8

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity
JOURNAL OF NEUROSCIENCE, v. 26, (9), 2006, MAR 1, p. 2380-2390
Jin, Wenying; Ge, Wooping; Xu, Junyu; Cao, Mian; Peng, Lisheng; Yung, Wing Ho; Liao, Dezhi; Duan, Shumin; Zhang, Mingjie; Xia, Jun Article
Protein interacting with c-kinase 1/protein kinase c alpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction
The Journal of neuroscience, v. 26, (12), March 2006, p. 3192-3205
Bartoe, JL; McKenna, WL; Quan, TK; Stafford, BK; Moore, JA; Xia, J.; Takamiya, K.; Huganir, RL; Hinck, L. Article
Serine racemase binds to PICK1: potential relevance to schizophrenia
Molecular Psychiatry, v. 11, (2), February 2006, p. 150-157
Fujii, K.; Maeda, K.; Hikida, T.; Mustafa, AK; Balkissoon, R.; Xia, J.; Yamada, T.; Ozeki, Y.; Kawahara, R.; Okawa, M.; Huganir, RL; Ujike, H.; Snyder, SH; Sawa, A. Article
Structure and function of PICK1
NeuroSignals, v. 15, (4), 2006, p. 190-201
Xu, Junyu; Xia, Jun Article
Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression
Neuron, v. 49, (6), 2006, MAR 16, p. 845-860
Steinberg, JP; Takamiya, K.; Shen, Y.; Xia, J.; Rubio, ME; Yu, S.; Jin, WY; Thomas, GM; Linden, DJ; Huganir, RL Article
PICK1 Recruits Ampa Receptors and Promotes Maturation of Neurexin-Induced Synapses
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Xu, Junyu; Xia, Jun Conference paper
Role of PICK1 in AMPA Receptor Trafficking and Synaptic Plasticity
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Xia, Jun Conference paper
Specific involvement in chronic inflammatory pain and neuropathic pain of PICK1, an AMPAR subunit GluR2-interacting protein
Abstracts of Society for Neuroscience, 2006
Tao, Y.; Shang, X.; Guan, Y.; Yaster, M.; Takamiya, K.; Xia, Jun; Raja, S.; Johns, RA; Huganir, RL Conference paper

2005 2

Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem
Nature Structural & Molecular Biology, v. 12, (8), August 2005, p. 722-728
Long, Jiafu; Feng, Wei; Wang, Rui; Chan, Ling Nga; Ip, Fanny C.F.; Xia, Jun; Ip, Nancy Yuk-Yu; Zhang, Mingjie Article
Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF
Neuron, v. 45, (6), March 2005, p. 903-915
Gardner, SM; Takamiya, K.; Xia, J.; Suh, JG; Johnson, R.; Yu, S.; Huganir, RL Article

2004 1

PICK1's role in AMPA receptor function and synaptic plasticity
Progress in Neuroscience / Vol 3, page 241-244
Xia, Jun Book chapter

2003 1

Role of PDZ domain protein PICK1 in AMPA receptor function and synaptic plasticity
8th national and 2003 International Symposium on Biomembranes organized by The Biophysical Society of China, Beihai, China, p. 10
Xia, Jun Conference paper

2000 3

Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins
Neuron, v. 28, (2), November 2000, p. 499-510
Xia, J.; Chung, HJ; Wihler, C.; Huganir, RL; Linden, DJ Article
Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins
The Journal of neuroscience, v. 20, (19), October 2000, p. 7258-7267
Chung, HJ; Xia, J.; Scannevin, RH; Zhang, XQ; Huganir, RL Article
Presynaptic clustering of mGluR7a requires the PICK1PDZ domain binding site
Neuron, v. 28, (2), November 2000, p. 485-497
Boudin, H.; Doan, A.; Xia, J.; Shigemoto, R.; Huganir, RL; Worley, P.; Craig, AM Article

1999 1

Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1
Neuron, v. 22, (1), January 1999, p. 179-187
Xia, J.; Zhang, XQ; Staudinger, J.; Huganir, RL Article

1998 1

Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors
Neuron, v. 21, (2), August 1998, p. 393-400
Song, I.; Kamboj, S.; Xia, J.; Dong, HL; Liao, DZ; Huganir, RL Article

1996 1

IPSP-EPSP interactions in lateral geniculate neurons of rat
Chinese Science Bulletin, v. 41, (13), July 1996, p. 1116-1123
Xia, J.; Luo, FS Article


Expand All Collapse All


Article 3

Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity
iScience, v. 13, March 2019, p. 82-97
Lin, Raozhou; Duan, Zhigang; Sun, Haitao; Fung, Man Lung; Chen, Hansen; Wang, Jing; Lau, Chi Fai; Yang, D.; Liu, Yu; Ni, Yanxiang; Wang, Zai; Cui, Ju; Wu, Wutian; Yung, Wingho; Chan, Ying Shing; Lo, Amy Cheuk Yin; Xia, Jun; Shen, Jiangang; Huang, Jiandong
Neuroligin 3 Regulates Dendritic Outgrowth by Modulating Akt/mTOR Signaling
Frontiers in Cellular Neuroscience, v. 13, November 2019, article number 518
Xu, Jing; Du, Yong-lan; Xu, Jing-wei; Hu, Xiao-ge; Gu, Lin-fan; Li, Xiu-mao; Hu, Ping-hong; Liao, Tai-lin; Xia, Qiang-qiang; Sun, Qi; Shi, Lei; Luo, Jian-hong; Xia, Jun; Wang, Ziyi; Xu, Junyu
Neuroligins Differentially Mediate Subtype-Specific Synapse Formation in Pyramidal Neurons and Interneurons
Neuroscience Bulletin, v. 35, (3), June 2019, p. 497-506
Xia, Qiangqiang; Xu, Jing; Liao, Tailin; Yu, Jie; Shi, Lei; Xia, Jun; Luo, Jianhong; Xu, Junyu


Expand All Collapse All


Article 5

Changes in synaptic AMPA receptor concentration and composition in chronic temporal lobe epilepsy
Molecular and Cellular Neuroscience, v. 92, October 2018, p. 93-103
Egbenya, Daniel Lawer; Hussain, Suleman S.; Lai, Yichen; Xia, Jun; Anderson, Anne E.; Davanger, Svend
Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice
Neuron, v. 97, (6), March 2018, p. 1253-1260.e7
Cao, Wei; Lin, Shen; Xia, Qiang-qiang; Du, Yong-Lan; Yang, Qian; Zhang, Meng-Ying; Lu, Yi-Qing; Xu, Jing; Duan, Shu-Min; Xia, Jun; Feng, Guoping; Xu, Junyu; Luo, Jian-Hong
Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4
Cell Reports, v. 23, (6), May 2018, p. 1691-1705
Wu, Min; Tian, Honglei; Liu, Xiaobo; Lai, Ho-chun; Du, Shengwang; Xia, Jun
PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect.
Proceedings of the National Academy of Sciences of the United States of America, v. 115, (30), July 2018, p. E7193-E7201
He, Jing; Xia, Mengying; Yeung, Patrick KK; Li, Jiahua; Li, Zhifang; Chung, Ka Kin Kenny; Chung, Sookja K; Xia, Jun
PICK1 is Essential for Insulin Production and The Maintenance of Glucose Homeostasis
Molecular Biology of the Cell, v. 29, (5), March 2018, p. 587-596
Li, Jia; Mao, Zhuo; Huang, Jiandong; Xia, Jun


Expand All Collapse All


Article 2

A nonsense mutation in Ccdc62 gene is responsible for spermiogenesis defects and male infertility in repro29/repro29 mice
Biology of Reproduction, v. 96, (3), March 2017, article number bio141408, p. 587-597
Li, Yuchi; Li, Cailing; Lin, Shouren; Yang, Bo; Huang, Weiren; Wu, Hanwei; Chen, Yuanbin; Yang, Lihua; Luo, Manling; Guo, Huan; Chen, Jianbo; Wang, Tiantian; Ma, Qian; Gu, Yanli; Mou, Lisha; Jiang, Zhimao; Xia, Jun; Gui, Yaoting
Presynaptic PICK1 Facilitates Trafficking of AMPA-Receptors between Active Zone and Synaptic Vesicle Pool
Neuroscience, v. 344, March 2017, p. 102-112
Hagler?d, Camilla; Hussain, Suleman S.; Nakamura, Y.; Xia, Jun; Haug, Finn Mogens ?mejda; Ottersen, O.P.; Henley, Jeremy M.; Davanger, Svend


Expand All Collapse All


Article 1

Syntabulin regulates the trafficking of PICK1-containing vesicles in neurons
Scientific Reports, v. 6, February 2016, article number 20924
Xu, Junyu; Wang, Na; Luo, Jianhong; Xia, Jun


Expand All Collapse All


Article 1

ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis
Journal of Cell Science, v. 128, (20), October 2015, p. 3822-3836
He, Jing; Xia, Mengying; Tsang, Wai Hung; Chow, King Lau; Xia, Jun


Expand All Collapse All


Article 3

A Unique Plant ESCRT Component, FREE1, Regulates Multivesicular Body Protein Sorting and Plant Growth
Current Biology, v. 24, (21), November 2014, p. 2556-2563
Gao, Caiji; Luo, Ming; Zhao, Qiong; Yang, Renzhi; Cui, Yong; Zeng, Yonglun; Xia, Jun; Jiang, Liwen
Exo70E2 is essential for exocyst subunit recruitment and EXPO formation in both plants and animals
Molecular biology of the cell, v. 25, (3), February 2014, p. 412-426
Ding, Yu; Wang, Juan; Lai, Ho Chun John; Chan, Vivian Hoi Ling; Wang, Xiangfeng; Cai, Yi; Tan, Xiaoyun; Bao, Yiqun; Xia, Jun; Robinson, David G.; Jiang, Liwen
PICK1 Mediates Synaptic Recruitment of Ampa Receptors at Neurexin-induced Postsynaptic Sites
The Journal of Neuroscience, v. 34, (46), November 2014, p. 15415-15424
Xu, Junyu; Kam, Chuen; Luo, Jian-Hong; Xia, Jun


Expand All Collapse All


Article 2

PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance
PLoS Biology, v. 11, (4), April 2013, article number e1001541
Cao, Mian; Mao, Zhuo; Kam, Chuen; Xiao, Nan; Cao, Xiaoxing; Shen, Chong; Cheng, Kenneth K.Y.; Xu, Aimin; Lee, Kwong-Man; Jiang, Liwen; Xia, Jun
Rescuing infertility of Pick1 knockout mice by generating testis-specific transgenic mice via testicular infection
Scientific Reports, v. 3, 2013, article number 2842
Li, Xiumao; Mao, Zhuo; Wu, Min; Xia, Jun


Expand All Collapse All


Article 4

A review on the current neuroligin mouse models
Acta Physiologica Sinica=生理学报, v. 64, (5), 2012, p. 550-562
XU, Jun-Yu; Xia, Qiang-Qiang; Xia, Jun
AMPA Receptors Regulate Exocytosis and Insulin Release in Pancreatic beta Cells
Traffic, v. 13, (8), August 2012, p. 1124-1139
Wu, Zhen-Yong; Zhu, Li-Jun; Zou, Na; Bombek, Lidija K.; Shao, Chong-Yu; Wang, Na; Wang, Xin-Xin; Liang, Li; Xia, Jun; Rupnik, Marjan; Shen, Ying
Chronic Zinc Exposure Decreases the Surface Expression of NR2A-Containing NMDA Receptors in Cultured Hippocampal Neurons
PLoS ONE, v. 7, (9), September 2012
Zhu, Jia; Shao, Chong-Yu; Yang, Wei; Zhang, Xiao-Min; Wu, Zhen-Yong; Zhou, Liang; Wang, Xin-Xin; Li, Yun-Hong; Xia, Jun; Luo, Jian-Hong; Shen, Ying
PICK1 promotes caveolin-dependent degradation of TGF-beta type I receptor
Cell Research, v. 22, (10), October 2012, p. 1467-1478
Zhao, Bing; Wang, Qiang; Du, Jun; Luo, Shiwen; Xia, Jun; Chen, Ye-Guang

Conference paper 1

PICK1-ICA69 BAR domain protein complex regulates insulin trafficking in pancreatic beta-cells
Gordon Conference: Proprotein Processing, Trafficking & Secretion, USA, New Hampshire, July 15-20 2012
Xia, Jun


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Article 4

Apccdh1 Mediates Epha4-dependent Downregulation of Ampa Receptors in Homeostatic Plasticity
Nature Neuroscience, v. 14, (2), February 2011, p. 181-191
Fu, Kit Yu; Hung, Kwok Wang; Fu, Wing Yu; Shen, Chong; Chen, Yu; Xia, Jun; Lai, Kwok On; Ip, Nancy Yuk-yu
Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration
EMBO journal, v. 30, (4), 2011, p. 665-678
Huo, Lin; Wen, Wenyu; Wang, Rui; Kam, Chuen; Xia, Jun; Feng, Wei; Zhang, Mingjie
Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1
Molecular pain, v. 7, (11), February 2011
Wang, Wei; Petralia, Ronald S.; Takamiya, Kogo; Xia, Jun; Li, Yun-Qing; Huganir, Richard L.; Tao, Yuan-Xiang; Yaster, Myron
Regulation of AMPA Receptor Function by the Human Memory-Associated Gene KIBRA
Neuron, v. 71, (6), September 2011, p. 1022-1029
Makuch, Lauren; Volk, Lenora; Anggono, Victor; Johnson, Richard C.; Yu, Yilin; Duning, Kerstin; Kremerskothen, Joachim; Xia, Jun; Takamiya, Kogo; Huganir, Richard L.


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Article 6

Pathologically Activated Neuroprotection via Uncompetitive Blockade of N-Methyl-D-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin
Journal of biological chemistry, v. 285, (26), 2010, JUN 25, p. 19947-19958
Luo, Jialie; Li, Wenming; Zhao, Yuming; Fu, Hongjun; Ma, Dik-Lung; Tang, Jing; Li, Chaoying; Peoples, Robert W.; Li, Fushun; Wang, Qinwen; Huang, Pingbo; Xia, Jun; Pang, Yuanping; Han, Yifan
PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner
Molecular Brain, v. 3, (39), 2010
Jin, Wenying; Shen, Chong; Jing, Lan; Zha, Xiang-ming; Xia, Jun
Redox-Regulated Lipid Membrane Binding of the PICK1 PDZ Domain
Biochemistry, v. 49, (21), 2010, JUN 1, p. 4432-4439
Shi, Yawei; Yu, Jiang; Jia, Yuan; Pan, Lifeng; Shen, Chong; Xia, Jun; Zhang, Mingjie
Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain
Pain, v. 151, (1), 2010, p. 226-234
Atianjoh, F.E.; Yaster, M.; Zhao, X.; Takamiya, K.; Xia, J.; Gauda, E.B.; Huganir, R.L.; Tao, Y.X.
Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization
Neurochemistry international, v. 56, (8), 2010, JUL, p. 962-970
Shao, Xin; Zhu, Lijun; Wang, Yubin; Lu, Yuting; Wang, Wenhai; Zhu, Jia; Shen, Ying; Xia, Jun; Luo, Jianhong
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1
Nature Neuroscience, v. 13, (1), 2010, JAN, p. 22-24
Xu, Junyu; Xiao, Nan; Xia, Jun

Conference paper 4

EphA4-Dependent Degradation of AMPA Receptor Is Important for the Homeostatic Synaptic Plasticity
The Gordon Research Conference on Molecular and Cellular Neurobiology, Hong Kong, 6 - 11 June 2010
Fu, Kit Yu; Hung, Kwok Wang; Fu, Wing Yu; Shen, Chong; Chen, Yu; Xia, Jun; Lai, Kwok On; Ip, Nancy Yuk-Yu
PICK1-ICA69 BAR domain protein complex regulates insulin trafficking in pancreatic beta-cells
Asia Islet Biology & Incretin Symposium (AIBIS) 2010, Kyoto, Japan, July 30-Aug2, 2010
Cao, Mian; Kam, Chuen; Shen, Chong; Cao, Xiaoxing; Lee, Kwong-Man; Xia, Jun
Synaptogenesis and AMPA receptor trafficking
Chinese Neuroscientists Worldwide (SCNW 2010), Nan Chang, China, Aug 4-10, 2010
Xu, Junyu; Xia, Jun
Targeting of AMPA receptor at neurexin-neuroligin induced synapses
2010 Gordon Research Conference on Molecular and Cellular Neurobiology, Hong Kong University of Science and Technology, Hong Kong, 6-11 Jun 2010
Xia, Jun


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Article 2

BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells
Plant journal, v. 60, (5), 2009, DEC, p. 865-881
Lam, Sheung Kwan; Cai, Yi; Tse, Yu Chung; Wang, Juan; Law, Angus Ho Yin; Pimpl, Peter; Chan, Ho Yin Edwin; Xia, Jun; Jiang, Liwen
PICK1 deficiency causes male infertility in mice by disrupting acrosome formation
JOURNAL OF CLINICAL INVESTIGATION, v. 119, (4), 2009, APR, p. 802-812
Xiao, Nan; Kam, Chuen; Shen, Chong; Jin, Wenying; Wang, Junqi; Lee, Kwong Man; Jiang, Liwen; Xia, Jun

Conference paper 2

EphA4-Mediated Degradation of AMPA Receptor Is Important in Homeostatic Synaptic Plasticity
The 39th Meeting of the Society for Neuroscience, Chicago, USA, 17 - 21
Fu, Kit Yu; Hung, Kwok Wang; Fu, Wing Yu; Shen, Chong; Chen, Yu; Xia, Jun; Lai, Kwok On; Ip, Nancy Yuk-Yu
PICK1 and ICA69 Define Three Maturation Stages of Insulin Granules and Their Deficiency Leads to Impaired Glucose Tolerance
American Society for Cell Biology 49th Annual Meeting, San Diego Convention Center, San Diego, California, 5-9 Dec 2009
Cao, M.; Kam, C.; Shen, C.; Cao, X.; Lee, K.; Xia, J.


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Conference paper 1

PICK1 and ICA69 Define Three Maturation Stages of Insulin Granules and Their Deficiency Leads to Impaired Glucose Tolerance
48th Annual Meeting of the American Society for Cell Biology, The Moscone Center, San Francisco, California (USA), 13-17 Dec 2008
Cao, M.; Kam, C.; Shen, C.; Cao, X.; Lee, K.; Xia, J.


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Article 4

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes
EMBO journal, v. 26, (21), 2007, OCT 31, p. 4576-4587
Pan, Lifeng; Wu, Hao; Shen, Chong; Shi, Yawei; Jin, Wenying; Xia, Jun; Zhang, Mingjie
Developmental expression of Ca2+-permeable AMPA receptors underlies depolarization-induced long-term depression at mossy fiber-CA3 pyramid Synapses
The Journal of neuroscience, v. 27, (43), October 2007, p. 11651-11662
Ho, Michelle T.W.; Pelkey, Kenneth A.; Topolnik, Lisa; Petralia, Ronald S.; Takamiya, Kogo; Xia, Jun; Huganir, Richard L.; Lacaille, Jean-ClauDe; McBain, Chris J.
Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents
Biochemical and biophysical research communications, v. 361, (2), 2007, SEP 21, p. 505-509
Luo, Jialie; Li, Wenming; Liu, Yuwei; Zhang, Wei; Fu, Hongjun; Lee, Nelson T.K.; Yu, Hua; Pang, Yuanping; Huang, Pingbo; Xia, Jun; Li, Zhi-Wang; Li, Chaoying; Han, Yifan
PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors
JOURNAL OF NEUROSCIENCE, v. 27, (47), 2007, NOV 21, p. 12945-12956
Cao, Mian; Xu, Junyu; Shen, Chong; Kam, Chuen; Huganir, Richard L.; Xia, Jun


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Article 5

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity
JOURNAL OF NEUROSCIENCE, v. 26, (9), 2006, MAR 1, p. 2380-2390
Jin, Wenying; Ge, Wooping; Xu, Junyu; Cao, Mian; Peng, Lisheng; Yung, Wing Ho; Liao, Dezhi; Duan, Shumin; Zhang, Mingjie; Xia, Jun
Protein interacting with c-kinase 1/protein kinase c alpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction
The Journal of neuroscience, v. 26, (12), March 2006, p. 3192-3205
Bartoe, JL; McKenna, WL; Quan, TK; Stafford, BK; Moore, JA; Xia, J.; Takamiya, K.; Huganir, RL; Hinck, L.
Serine racemase binds to PICK1: potential relevance to schizophrenia
Molecular Psychiatry, v. 11, (2), February 2006, p. 150-157
Fujii, K.; Maeda, K.; Hikida, T.; Mustafa, AK; Balkissoon, R.; Xia, J.; Yamada, T.; Ozeki, Y.; Kawahara, R.; Okawa, M.; Huganir, RL; Ujike, H.; Snyder, SH; Sawa, A.
Structure and function of PICK1
NeuroSignals, v. 15, (4), 2006, p. 190-201
Xu, Junyu; Xia, Jun
Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression
Neuron, v. 49, (6), 2006, MAR 16, p. 845-860
Steinberg, JP; Takamiya, K.; Shen, Y.; Xia, J.; Rubio, ME; Yu, S.; Jin, WY; Thomas, GM; Linden, DJ; Huganir, RL

Conference paper 3

PICK1 Recruits Ampa Receptors and Promotes Maturation of Neurexin-Induced Synapses
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Xu, Junyu; Xia, Jun
Role of PICK1 in AMPA Receptor Trafficking and Synaptic Plasticity
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Xia, Jun
Specific involvement in chronic inflammatory pain and neuropathic pain of PICK1, an AMPAR subunit GluR2-interacting protein
Abstracts of Society for Neuroscience, 2006
Tao, Y.; Shang, X.; Guan, Y.; Yaster, M.; Takamiya, K.; Xia, Jun; Raja, S.; Johns, RA; Huganir, RL


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Article 2

Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem
Nature Structural & Molecular Biology, v. 12, (8), August 2005, p. 722-728
Long, Jiafu; Feng, Wei; Wang, Rui; Chan, Ling Nga; Ip, Fanny C.F.; Xia, Jun; Ip, Nancy Yuk-Yu; Zhang, Mingjie
Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF
Neuron, v. 45, (6), March 2005, p. 903-915
Gardner, SM; Takamiya, K.; Xia, J.; Suh, JG; Johnson, R.; Yu, S.; Huganir, RL


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Book chapter 1

PICK1's role in AMPA receptor function and synaptic plasticity
Progress in Neuroscience / Vol 3, page 241-244
Xia, Jun


Expand All Collapse All


Conference paper 1

Role of PDZ domain protein PICK1 in AMPA receptor function and synaptic plasticity
8th national and 2003 International Symposium on Biomembranes organized by The Biophysical Society of China, Beihai, China, p. 10
Xia, Jun


Expand All Collapse All


Article 3

Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins
Neuron, v. 28, (2), November 2000, p. 499-510
Xia, J.; Chung, HJ; Wihler, C.; Huganir, RL; Linden, DJ
Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins
The Journal of neuroscience, v. 20, (19), October 2000, p. 7258-7267
Chung, HJ; Xia, J.; Scannevin, RH; Zhang, XQ; Huganir, RL
Presynaptic clustering of mGluR7a requires the PICK1PDZ domain binding site
Neuron, v. 28, (2), November 2000, p. 485-497
Boudin, H.; Doan, A.; Xia, J.; Shigemoto, R.; Huganir, RL; Worley, P.; Craig, AM


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Article 1

Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1
Neuron, v. 22, (1), January 1999, p. 179-187
Xia, J.; Zhang, XQ; Staudinger, J.; Huganir, RL


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Article 1

Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors
Neuron, v. 21, (2), August 1998, p. 393-400
Song, I.; Kamboj, S.; Xia, J.; Dong, HL; Liao, DZ; Huganir, RL


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Article 1

IPSP-EPSP interactions in lateral geniculate neurons of rat
Chinese Science Bulletin, v. 41, (13), July 1996, p. 1116-1123
Xia, J.; Luo, FS


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2016 1

Syntabulin regulates the trafficking of PICK1-containing vesicles in neurons
Scientific Reports, v. 6, February 2016, article number 20924
Xu, Junyu; Wang, Na; Luo, Jianhong; Xia, Jun Article

2015 1

ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis
Journal of Cell Science, v. 128, (20), October 2015, p. 3822-3836
He, Jing; Xia, Mengying; Tsang, Wai Hung; Chow, King Lau; Xia, Jun Article

2014 3

A Unique Plant ESCRT Component, FREE1, Regulates Multivesicular Body Protein Sorting and Plant Growth
Current Biology, v. 24, (21), November 2014, p. 2556-2563
Gao, Caiji; Luo, Ming; Zhao, Qiong; Yang, Renzhi; Cui, Yong; Zeng, Yonglun; Xia, Jun; Jiang, Liwen Article
Exo70E2 is essential for exocyst subunit recruitment and EXPO formation in both plants and animals
Molecular biology of the cell, v. 25, (3), February 2014, p. 412-426
Ding, Yu; Wang, Juan; Lai, Ho Chun John; Chan, Vivian Hoi Ling; Wang, Xiangfeng; Cai, Yi; Tan, Xiaoyun; Bao, Yiqun; Xia, Jun; Robinson, David G.; Jiang, Liwen Article
PICK1 Mediates Synaptic Recruitment of Ampa Receptors at Neurexin-induced Postsynaptic Sites
The Journal of Neuroscience, v. 34, (46), November 2014, p. 15415-15424
Xu, Junyu; Kam, Chuen; Luo, Jian-Hong; Xia, Jun Article

2013 2

PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance
PLoS Biology, v. 11, (4), April 2013, article number e1001541
Cao, Mian; Mao, Zhuo; Kam, Chuen; Xiao, Nan; Cao, Xiaoxing; Shen, Chong; Cheng, Kenneth K.Y.; Xu, Aimin; Lee, Kwong-Man; Jiang, Liwen; Xia, Jun Article
Rescuing infertility of Pick1 knockout mice by generating testis-specific transgenic mice via testicular infection
Scientific Reports, v. 3, 2013, article number 2842
Li, Xiumao; Mao, Zhuo; Wu, Min; Xia, Jun Article

2012 5

A review on the current neuroligin mouse models
Acta Physiologica Sinica=生理学报, v. 64, (5), 2012, p. 550-562
XU, Jun-Yu; Xia, Qiang-Qiang; Xia, Jun Article
AMPA Receptors Regulate Exocytosis and Insulin Release in Pancreatic beta Cells
Traffic, v. 13, (8), August 2012, p. 1124-1139
Wu, Zhen-Yong; Zhu, Li-Jun; Zou, Na; Bombek, Lidija K.; Shao, Chong-Yu; Wang, Na; Wang, Xin-Xin; Liang, Li; Xia, Jun; Rupnik, Marjan; Shen, Ying Article
Chronic Zinc Exposure Decreases the Surface Expression of NR2A-Containing NMDA Receptors in Cultured Hippocampal Neurons
PLoS ONE, v. 7, (9), September 2012
Zhu, Jia; Shao, Chong-Yu; Yang, Wei; Zhang, Xiao-Min; Wu, Zhen-Yong; Zhou, Liang; Wang, Xin-Xin; Li, Yun-Hong; Xia, Jun; Luo, Jian-Hong; Shen, Ying Article
PICK1 promotes caveolin-dependent degradation of TGF-beta type I receptor
Cell Research, v. 22, (10), October 2012, p. 1467-1478
Zhao, Bing; Wang, Qiang; Du, Jun; Luo, Shiwen; Xia, Jun; Chen, Ye-Guang Article
PICK1-ICA69 BAR domain protein complex regulates insulin trafficking in pancreatic beta-cells
Gordon Conference: Proprotein Processing, Trafficking & Secretion, USA, New Hampshire, July 15-20 2012
Xia, Jun Conference paper

2011 4

Apccdh1 Mediates Epha4-dependent Downregulation of Ampa Receptors in Homeostatic Plasticity
Nature Neuroscience, v. 14, (2), February 2011, p. 181-191
Fu, Kit Yu; Hung, Kwok Wang; Fu, Wing Yu; Shen, Chong; Chen, Yu; Xia, Jun; Lai, Kwok On; Ip, Nancy Yuk-yu Article
Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration
EMBO journal, v. 30, (4), 2011, p. 665-678
Huo, Lin; Wen, Wenyu; Wang, Rui; Kam, Chuen; Xia, Jun; Feng, Wei; Zhang, Mingjie Article
Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1
Molecular pain, v. 7, (11), February 2011
Wang, Wei; Petralia, Ronald S.; Takamiya, Kogo; Xia, Jun; Li, Yun-Qing; Huganir, Richard L.; Tao, Yuan-Xiang; Yaster, Myron Article
Regulation of AMPA Receptor Function by the Human Memory-Associated Gene KIBRA
Neuron, v. 71, (6), September 2011, p. 1022-1029
Makuch, Lauren; Volk, Lenora; Anggono, Victor; Johnson, Richard C.; Yu, Yilin; Duning, Kerstin; Kremerskothen, Joachim; Xia, Jun; Takamiya, Kogo; Huganir, Richard L. Article

2010 10

Pathologically Activated Neuroprotection via Uncompetitive Blockade of N-Methyl-D-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin
Journal of biological chemistry, v. 285, (26), 2010, JUN 25, p. 19947-19958
Luo, Jialie; Li, Wenming; Zhao, Yuming; Fu, Hongjun; Ma, Dik-Lung; Tang, Jing; Li, Chaoying; Peoples, Robert W.; Li, Fushun; Wang, Qinwen; Huang, Pingbo; Xia, Jun; Pang, Yuanping; Han, Yifan Article
PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner
Molecular Brain, v. 3, (39), 2010
Jin, Wenying; Shen, Chong; Jing, Lan; Zha, Xiang-ming; Xia, Jun Article
Redox-Regulated Lipid Membrane Binding of the PICK1 PDZ Domain
Biochemistry, v. 49, (21), 2010, JUN 1, p. 4432-4439
Shi, Yawei; Yu, Jiang; Jia, Yuan; Pan, Lifeng; Shen, Chong; Xia, Jun; Zhang, Mingjie Article
Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain
Pain, v. 151, (1), 2010, p. 226-234
Atianjoh, F.E.; Yaster, M.; Zhao, X.; Takamiya, K.; Xia, J.; Gauda, E.B.; Huganir, R.L.; Tao, Y.X. Article
Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization
Neurochemistry international, v. 56, (8), 2010, JUL, p. 962-970
Shao, Xin; Zhu, Lijun; Wang, Yubin; Lu, Yuting; Wang, Wenhai; Zhu, Jia; Shen, Ying; Xia, Jun; Luo, Jianhong Article
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1
Nature Neuroscience, v. 13, (1), 2010, JAN, p. 22-24
Xu, Junyu; Xiao, Nan; Xia, Jun Article
EphA4-Dependent Degradation of AMPA Receptor Is Important for the Homeostatic Synaptic Plasticity
The Gordon Research Conference on Molecular and Cellular Neurobiology, Hong Kong, 6 - 11 June 2010
Fu, Kit Yu; Hung, Kwok Wang; Fu, Wing Yu; Shen, Chong; Chen, Yu; Xia, Jun; Lai, Kwok On; Ip, Nancy Yuk-Yu Conference paper
PICK1-ICA69 BAR domain protein complex regulates insulin trafficking in pancreatic beta-cells
Asia Islet Biology & Incretin Symposium (AIBIS) 2010, Kyoto, Japan, July 30-Aug2, 2010
Cao, Mian; Kam, Chuen; Shen, Chong; Cao, Xiaoxing; Lee, Kwong-Man; Xia, Jun Conference paper
Synaptogenesis and AMPA receptor trafficking
Chinese Neuroscientists Worldwide (SCNW 2010), Nan Chang, China, Aug 4-10, 2010
Xu, Junyu; Xia, Jun Conference paper
Targeting of AMPA receptor at neurexin-neuroligin induced synapses
2010 Gordon Research Conference on Molecular and Cellular Neurobiology, Hong Kong University of Science and Technology, Hong Kong, 6-11 Jun 2010
Xia, Jun Conference paper

2009 4

BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells
Plant journal, v. 60, (5), 2009, DEC, p. 865-881
Lam, Sheung Kwan; Cai, Yi; Tse, Yu Chung; Wang, Juan; Law, Angus Ho Yin; Pimpl, Peter; Chan, Ho Yin Edwin; Xia, Jun; Jiang, Liwen Article
PICK1 deficiency causes male infertility in mice by disrupting acrosome formation
JOURNAL OF CLINICAL INVESTIGATION, v. 119, (4), 2009, APR, p. 802-812
Xiao, Nan; Kam, Chuen; Shen, Chong; Jin, Wenying; Wang, Junqi; Lee, Kwong Man; Jiang, Liwen; Xia, Jun Article
EphA4-Mediated Degradation of AMPA Receptor Is Important in Homeostatic Synaptic Plasticity
The 39th Meeting of the Society for Neuroscience, Chicago, USA, 17 - 21
Fu, Kit Yu; Hung, Kwok Wang; Fu, Wing Yu; Shen, Chong; Chen, Yu; Xia, Jun; Lai, Kwok On; Ip, Nancy Yuk-Yu Conference paper
PICK1 and ICA69 Define Three Maturation Stages of Insulin Granules and Their Deficiency Leads to Impaired Glucose Tolerance
American Society for Cell Biology 49th Annual Meeting, San Diego Convention Center, San Diego, California, 5-9 Dec 2009
Cao, M.; Kam, C.; Shen, C.; Cao, X.; Lee, K.; Xia, J. Conference paper

2008 1

PICK1 and ICA69 Define Three Maturation Stages of Insulin Granules and Their Deficiency Leads to Impaired Glucose Tolerance
48th Annual Meeting of the American Society for Cell Biology, The Moscone Center, San Francisco, California (USA), 13-17 Dec 2008
Cao, M.; Kam, C.; Shen, C.; Cao, X.; Lee, K.; Xia, J. Conference paper

2007 4

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes
EMBO journal, v. 26, (21), 2007, OCT 31, p. 4576-4587
Pan, Lifeng; Wu, Hao; Shen, Chong; Shi, Yawei; Jin, Wenying; Xia, Jun; Zhang, Mingjie Article
Developmental expression of Ca2+-permeable AMPA receptors underlies depolarization-induced long-term depression at mossy fiber-CA3 pyramid Synapses
The Journal of neuroscience, v. 27, (43), October 2007, p. 11651-11662
Ho, Michelle T.W.; Pelkey, Kenneth A.; Topolnik, Lisa; Petralia, Ronald S.; Takamiya, Kogo; Xia, Jun; Huganir, Richard L.; Lacaille, Jean-ClauDe; McBain, Chris J. Article
Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents
Biochemical and biophysical research communications, v. 361, (2), 2007, SEP 21, p. 505-509
Luo, Jialie; Li, Wenming; Liu, Yuwei; Zhang, Wei; Fu, Hongjun; Lee, Nelson T.K.; Yu, Hua; Pang, Yuanping; Huang, Pingbo; Xia, Jun; Li, Zhi-Wang; Li, Chaoying; Han, Yifan Article
PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors
JOURNAL OF NEUROSCIENCE, v. 27, (47), 2007, NOV 21, p. 12945-12956
Cao, Mian; Xu, Junyu; Shen, Chong; Kam, Chuen; Huganir, Richard L.; Xia, Jun Article

2006 8

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity
JOURNAL OF NEUROSCIENCE, v. 26, (9), 2006, MAR 1, p. 2380-2390
Jin, Wenying; Ge, Wooping; Xu, Junyu; Cao, Mian; Peng, Lisheng; Yung, Wing Ho; Liao, Dezhi; Duan, Shumin; Zhang, Mingjie; Xia, Jun Article
Protein interacting with c-kinase 1/protein kinase c alpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction
The Journal of neuroscience, v. 26, (12), March 2006, p. 3192-3205
Bartoe, JL; McKenna, WL; Quan, TK; Stafford, BK; Moore, JA; Xia, J.; Takamiya, K.; Huganir, RL; Hinck, L. Article
Serine racemase binds to PICK1: potential relevance to schizophrenia
Molecular Psychiatry, v. 11, (2), February 2006, p. 150-157
Fujii, K.; Maeda, K.; Hikida, T.; Mustafa, AK; Balkissoon, R.; Xia, J.; Yamada, T.; Ozeki, Y.; Kawahara, R.; Okawa, M.; Huganir, RL; Ujike, H.; Snyder, SH; Sawa, A. Article
Structure and function of PICK1
NeuroSignals, v. 15, (4), 2006, p. 190-201
Xu, Junyu; Xia, Jun Article
Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression
Neuron, v. 49, (6), 2006, MAR 16, p. 845-860
Steinberg, JP; Takamiya, K.; Shen, Y.; Xia, J.; Rubio, ME; Yu, S.; Jin, WY; Thomas, GM; Linden, DJ; Huganir, RL Article
PICK1 Recruits Ampa Receptors and Promotes Maturation of Neurexin-Induced Synapses
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Xu, Junyu; Xia, Jun Conference paper
Role of PICK1 in AMPA Receptor Trafficking and Synaptic Plasticity
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Xia, Jun Conference paper
Specific involvement in chronic inflammatory pain and neuropathic pain of PICK1, an AMPAR subunit GluR2-interacting protein
Abstracts of Society for Neuroscience, 2006
Tao, Y.; Shang, X.; Guan, Y.; Yaster, M.; Takamiya, K.; Xia, Jun; Raja, S.; Johns, RA; Huganir, RL Conference paper

2005 2

Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem
Nature Structural & Molecular Biology, v. 12, (8), August 2005, p. 722-728
Long, Jiafu; Feng, Wei; Wang, Rui; Chan, Ling Nga; Ip, Fanny C.F.; Xia, Jun; Ip, Nancy Yuk-Yu; Zhang, Mingjie Article
Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF
Neuron, v. 45, (6), March 2005, p. 903-915
Gardner, SM; Takamiya, K.; Xia, J.; Suh, JG; Johnson, R.; Yu, S.; Huganir, RL Article

2004 1

PICK1's role in AMPA receptor function and synaptic plasticity
Progress in Neuroscience / Vol 3, page 241-244
Xia, Jun Book chapter

2003 1

Role of PDZ domain protein PICK1 in AMPA receptor function and synaptic plasticity
8th national and 2003 International Symposium on Biomembranes organized by The Biophysical Society of China, Beihai, China, p. 10
Xia, Jun Conference paper

2000 3

Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins
Neuron, v. 28, (2), November 2000, p. 499-510
Xia, J.; Chung, HJ; Wihler, C.; Huganir, RL; Linden, DJ Article
Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins
The Journal of neuroscience, v. 20, (19), October 2000, p. 7258-7267
Chung, HJ; Xia, J.; Scannevin, RH; Zhang, XQ; Huganir, RL Article
Presynaptic clustering of mGluR7a requires the PICK1PDZ domain binding site
Neuron, v. 28, (2), November 2000, p. 485-497
Boudin, H.; Doan, A.; Xia, J.; Shigemoto, R.; Huganir, RL; Worley, P.; Craig, AM Article

1999 1

Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1
Neuron, v. 22, (1), January 1999, p. 179-187
Xia, J.; Zhang, XQ; Staudinger, J.; Huganir, RL Article

1998 1

Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors
Neuron, v. 21, (2), August 1998, p. 393-400
Song, I.; Kamboj, S.; Xia, J.; Dong, HL; Liao, DZ; Huganir, RL Article

1996 1

IPSP-EPSP interactions in lateral geniculate neurons of rat
Chinese Science Bulletin, v. 41, (13), July 1996, p. 1116-1123
Xia, J.; Luo, FS Article


No Publications


No Publications


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 0 2020-21 Summer 0 2020-21 Spring 4 2020-21 Winter 1 2020-21 Fall 6

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LIFS4960 Biological Science Capstone Project
LIFS5260 Biochemical and Molecular Basis of Diseases
LIFS6660 Molecular Medicine
SCIE1500 Guided Study on Research I


LIFS6660 Molecular Medicine


LIFS4760 Biochemistry of Diseases
LIFS4960 Biological Science Capstone Project
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS4970 Biological Science Project Research I
LIFS6112D Current Topics in Neuroscience


No Teaching Assignments


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy ZHUANG, Mengru
Life Science( 2021 - )

ZHUANG, Mengru
Life Science( 2018 - )

TSOGKA, Marianthi
Life Science( 2017 - )

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Graduated RPGs

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Doctor of Philosophy LAI, Ho-chun
Life Science( Completed in 2019 )

LI, Zhifang
Life Science( Completed in 2019 )

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Master of Philosophy LIU, Xiaobo
Bioengineering( Completed in 2019 )









ProjectsFrom January 2020 to December 2022

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All Projects 9 Leading Projects 2 Participating Projects 7

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Activity regulated neuroligin-2 ubiquitination and inhibitory synapse formation.


神經活動調控neuroligin-2泛素化和抑制性突觸形成 Leading


RGC - General Research Fund


Project Team (HKUST)
XIA Jun (Lead)
GUO Yusong


2020 -




The Role of IL-33 in Synaptic Dysfunctions and Pathogenesis of Alzheimer's Disease


白介素-33在阿茲海默氏癥突觸功能失調及發病過程中的作用 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
WU Zhenguo
XIA Jun


2020 -




A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases


以幹細胞方法解析神經退行性疾病的分子基礎 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
CHUNG Kenny K
FU Amy Kit Yu
QI Robert Zhong
QU Jianan
TSIM Karl Wah Keung
WEN Zilong
WONG Yung Hou
WU Zhenguo
XIA Jun


2019 -




Investigating the Vesicular Dynamics in Inhibitory Synapses using Cryo Correlative Light and Electron Microscopy (CryoCLEM) and Real-Time Three-dimensional Nanometer-accuracy Tracking Microscope


利用冷凍光電關聯顯微和實時三維納米精度跟蹤顯微技術研究抑制性突觸的囊泡動力學 Participating


National Natural Science Foundation of China / Research Grants Council Joint Research Scheme


Project Team (HKUST)
PARK Hyo Keun (Lead)
XIA Jun


2018 -




Aggregation-Induced Emission (AIE): Development of New AIE Systems and Exploration of Their Biomedical Applications


聚集誘導發光: 開發新的發光體系及探索其在生物醫學領域的應用 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
LAM Wing Yip
LEE Yi-Kuen
PARK Hyo Keun
XIA Jun


2018 - 2021




Cellular mechanisms of synaptic functions and plasticity in health and neurodegenerative diseases


健康及神經退行性病變過程中突觸功能和可塑性調控的細胞機制 Participating


RGC - Areas of Excellence Scheme


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LIU Kai
WONG Yung Hou
WU Zhenguo
XIA Jun


2017 -




Identification of a small GTPase as a regulator of PICK1-ICA69 complexes in dense-core vesicle trafficking


鑒定PICK1-ICA69蛋白復合體在致密囊泡轉運中起調控作用的小G蛋白 Leading


RGC - General Research Fund


Project Team (HKUST)
XIA Jun (Lead)


2017 - 2020




Open Operation System of Guangdong Provincial Key Laboratory of Brain Science, Disease, and Drug Development (Inspection Qualified in 2017)


廣東省腦科學及疾病與藥物研究重點實驗室開放運行（2017年度考評合格） Participating


Department of Science and Technology of Guangdong Province


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
FU Amy Kit Yu
LIU Kai
QI Robert Zhong
WONG Yung Hou
WU Zhenguo
XIA Jun


2017 - 2020




Centre for Organelle Biogenesis and Function


細胞器生物合成及功能研究中心 Participating


RGC - Areas of Excellence Scheme


Project Team (HKUST)
XIA Jun


2014 - 2021