Hyo Keun PARK
朴孝根
PhD in Chemical Physics
University of Illinois Urbana-Champaign, 2006

Associate Professor
Division of Life Science
Department of Physics



(852) 2358 7322
hkpark@ust.hk
Room 5452
Personal Web

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Google Scholar
fPV6US0AAAAJ

ORCID
0000-0002-2655-4795

Scopus ID
55713623800




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Neuroscience
Biophysics
Imaging techniques



Publications

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All Years 35 2022 0 2021 4 2020 8 2019 6 2018 4 2017 3 2016 10

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2021 4

Analyzing Protein-protein Interactions In Rare Cells Using Microbead-based Single-molecule Pulldown Assay
Lab on a Chip, v. 21, (16), 15 June 2021, p. 3137-3149
Zhao, Qirui; Shen, Yusheng; Li, Xiaofen; Tian, Fang; Yu, Xiaojie; Yobas, Levent; Park, Hyo Keun; Duan, Yuanyuan; Huang, Pingbo Article
Real-time three-dimensional tracking of single vesicles reveals abnormal motion and pools of synaptic vesicles in neurons of Huntington’s disease mice
iScience, v. 24, (10), January 2021, article number 103181
Chen, Sidong; Yoo, Hanna; Li, Chun Hei; Park, Chungwon; Tan, Li Yang; Jung, Sangyong; Park, Hyo Keun Article
Simultaneous Real-Time Three-Dimensional Localization And FRET Measurement Of Two Distinct Particles
Nano Letters, v. 21, (18), 7 September 2021, p. 7479-7485
Chen, Xingxiang; Liu, Teng; Qin, Xianan; Nguyen, Quang Quan; Lee, Chanwoo; Lee, Sang Kwon; Ren, Yaguang; Chu, Jun; Zhu, Guang; Yoon, Tae-Young; Park, Chan Young; Park, Hyo Keun Article
Unique dynamics and exocytosis properties of GABAergic synaptic vesicles revealed by three-dimensional single vesicle tracking
Proceedings of the National Academy of Sciences of the United States of America, v. 118, (9), 2 March 2021, article number e2022133118
Park, Chungwon; Chen, Xingxiang; Tian, Chong-Li; Park, Gyu Nam; Chenouard, Nicolas; Lee, Hunki; Yeo, Xin Yi; Jung, Sangyong; Tsien, Richard W.; Bi, Guoqiang; Park, Hyokeun Article

2020 8

Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store Depletion
Biophysical Journal, v. 118, (1), January 2020, p. 70-84
Qin, Xianan; Liu, Lei; Lee, Sang-kwon; Alsina Lopez, Adolfo; Liu, Teng; Wu, Chao; Park, Hojeong; Yu, Chenglong; Kim, Hajin; Chu, Jun; Triller, Antoine; Tang, Benzhong; Hyeon, Changbong; Park, Chanyoung; Park, Hyo Keun Article
Mechanical Responses of Breast Cancer Cells to Substrates of Varying Stiffness Revealed by Single-Cell Measurements
The Journal of Physical Chemistry Letters, v. 11, (18), 17 September 2020, p. 7643-7649
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Chen, Xingxiang; Yiu, Pak Man; Tsui, Kwan Chui; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun Article
Simultaneous tracking of two motor domains reveals near simultaneous steps and stutter steps of myosin 10 on actin filament bundles
Biochemical and Biophysical Research Communications, v. 525, (1), April 2020, p. 94-99
Qin, Xianan; Yoo, Hanna; Cheng, Harry Chun Man; Nguyen, Quang Quan; Li, Jing; Liu, Xiaoyan; Prunetti, Laurence; Chen, Xingxiang; Liu, Teng; Sweeney, H. Lee; Park, Hyo Keun Article
The inactivation domain of STIM1 acts through intramolecular binding to the coiled-coil domain in the resting state
Journal of Cell Science, v. 133, (1), January 2020
Lee, Sang Kwon; Lee, Min-hsun; Jeong, Su Ji; Qin, Xianan; Lee, Ah Reum; Park, Hyo Keun; Park, Chan Young Article
A novel nanobead-based single-molecule pull-down for cell populations single cells
64th Annual Meeting of the Biophysical Society (bps 2020), San Diego, USA, 15-19 February 2020
Zhao, Qirui; Shen, Yusheng; Tian, Fang; Yobas, Levent; Park, Hyo Keun; Huang, Pingbo Conference paper
Development of simultaneous single-particle tracking and fret measurement
The 64th Annual Meeting of Biophysical Society, San Diego, USA, 15-19 February 2020
Liu, Teng; Qin, Xianan; Lee, Sang Kwon; Chu, Jun; Park, Chan Young; Park, Hyo Keun Conference paper
Different Mechanical Responses to Substrate Stiffness between Cancer Cells and Normal Cells
Biophysical Journal, v. 118, (3), February 2020, article number 1227-Pos, p. 249A
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Yan, Caishan; Yiu, Pak Man; Tsui, Kwan Chui; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun Conference paper
Real-Time Nanometer-Accuracy Tracking of Single Lipid Droplets in Living Cells
The 64th Annual Meeting of Biophysical Society, San Diego, San Diego, USA, 15-19 February 2020
Lau, Hoi Man; Park, Hyo Keun Conference paper

2019 6

Real-time Three-dimensional Tracking of Single Synaptic Vesicles Reveals That Synaptic Vesicles Undergoing Kiss-and-run Fusion Remain Close to Their Original Fusion Site Before Reuse
Biochemical and Biophysical Research Communications, v. 514, (3), June 2019, p. 1004-1008
Qin, Xianan; Tsien, Richard; Park, Hyo Keun Article
Altered vesicles dynamics in a Huntington’s disease mouse model studied with 3D tracking of single synaptic vesicle in cortical neurons
The 49th Annual Society for Neuroscience Meeting, Neuroscience 2019, Chicago, USA, 19-23 October 2019
Chen, Sidong; Park, Chungwon; Park, Hyokeun Conference paper
Autophagosome Transport in Huntington's Disease
The European Molecular Biology Organization Workshop: Autophagy: From molecular principles to human diseases, Crieff, Scotland, United Kingdom, 26-30 August 2019
Li, Chun Hei; Park, Hyo Keun Conference paper
Exocytosis of GABAergic synaptic vesicles tracked by real-time three-dimensional microscopy
The 49th Annual Society for Neuroscience Meeting, Neuroscience 2019, Chicago, USA, 19-23 October 2019
Park, Chungwon; Fan, Ching Yeung; Park, Keun Yang; Lee, Cheuk Long Frank; Park, Hyokeun Conference paper
Mechanical Responses of Cancer Cells to Different Matrices Measured by AFM and FRET
Biophysical Journal, v. 116, (3), February 2019, article number 2633-Pos, p. 531a, Supplement 1
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun Conference paper
Tracking of Labeled Motor Domains of Single Full-Length Myosin X on Actin Bundles
Biophysical Journal, v. 116, (3), Supplement 1, 15 February 2019, article number 1281-Pos, p. 259a
Qin, Xianan; Cheung, Chun Man; Li, Jing; Yoo, Hanna; Liu, Xiaoyan; Lin, Tianming; Sweeney, H. LEE; Park, Hyo keun Conference paper

2018 4

Altered synaptic vesicle release and Ca²⁺ influx at single presynaptic terminals of cortical neurons in a knock-in mouse model of huntington's disease
Frontiers in Molecular Neuroscience, v. 11, (478), December 2018
Chen, Sidong; Yu, Chenglong; Li, Chun Hei; Rong, Li; Qin, Xianan; Ryu, Hoon; Park, Hyo Keun Article
Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington’s Disease
Scientific Reports, v. 8, December 2018, article number 16976
Yu, Chenglong; Li, Chun Hei; Chen, Sidong; Yoo, Hanna; Qin, Xianan; Park, Hyo Keun Article
Monitoring the dynamics of cadherin during movement of cancer cells
62nd Annual Meeting of Biophysical Society (BPS18), San Francisco, 17-21 February 2018
Tian, Fang; Chen, Sidong; Chu, jun; Wang, liang; Park, Hyo Keun Conference paper
Subdiffusive Motion of STIM1 at ER Membrane and ER-Plasma Membrane Junction
Biophysical Journal, v. 114, (3), 2 February 2018, p. 94a, Supp. 1
Qin, Xianan; Alsina, adolfo; Lee, sang kwon; Park, chan young; Park, Hyo Keun Conference paper

2017 3

Real-time Subpixel-Accuracy Tracking of Single Mitochondria in Neurons Reveals Heterogeneous Mitochondrial Motion
Biochemical and Biophysical Research Communications, 5 September 2017
Alsina, Adolfo; Lai, Wu Ming; Wong, Wai Kin; Qin, Xianan; Zhang, Min; Park, Hyo Keun Article
Altered exocytosis of synaptic vesicles and Ca2+ influx in cortical neurons in a Huntington’s disease mouse studied with real-time imaging of single presynaptic terminals
Neuroscience 2017: SfN's 47th Annual Meeting, Washington, DC, USA, 11-15 November 2017
Yu, Chenglong; Chen, Sidong; Rong, Li; Zhang, Min; Qin, Xianan; Park, Hyo Keun Conference paper
Mitochondrial Transport Defect in zQ175 Knock-In Mouse Model of Huntington’s Disease
Federation of American Societies for Experimental Biology, West Palm Beach, FL, 21-16 May 2017
Zhang, Min; Park, Hyo Keun Conference paper

2016 2

Real-time imaging of single synaptic vesicles in live neurons
Frontiers in Biology, v. 11, (2), April 2016, p. 109-118
Yu, Chenglong; Zhang, Min; Qin, Xianan; Yang, Xiaofeng; Park, Hyokeun Article
The Myosin X Motor is Optimized for Movement on Actin Bundles
Nature Communications, v. 7, September 2016, article number 12456
Ropars, Virginie; Yang, Zhaohui; Isabet, Tatiana; Blanc, Florian; Zhou, Kaifeng; Lin, Tianming; Liu, Xiaoyan; Hissier, Pascale; Samazan, Frédéric; Amigues, Béatrice; Yang, Eric D.; Park, Hyo Keun; Pylypenko, Olena; Cecchini, Marco; Sindelar, Charles V.; Sweeney, H. Lee; Houdusse, Anne Article

2012 1

Influence of Synaptic Vesicle Position on Release Probability and Exocytotic Fusion Mode
Science, v. 335, (6074), March 2012, p. 1362-1366
Park, Hyo Keun; Li, Yulong; Tsien, Richard W. Article

2007 3

How myosin VI coordinates its heads during processive movement
EMBO JOURNAL, v. 26, (11), June 2007, p. 2682-2692
Sweeney, H. Lee; Park, Hyokeun; Zong, Alan B.; Yang, Zhaohui; Selvin, Paul R.; Rosenfeld, Steven S. Article
Single-molecule fluorescence to study molecular motors
Q. Rev. Biophys, 40, 1, July 2007, p. 87-111
Park, Hyokeun; Toprak, Erdal; Selvin, Paul R. Article
The unique insert at the end of the myosin VI motor is the sole determinant of directionality
Proc Natl Acad Sci U S A., v. 104, (3), January 2007, p. 778-783
Park, Hyokeun; Li, Anna; Chen, Li-Qiong; Houdusse, Anne; Selvin, Paul R.; Sweeney, H. Lee Article

2004 3

Full length myosin VI dimerizes and moves processively along actin filaments upon monomerculstering
Mol. Cell, v. 21, (3), 2006, Feb, p. 331-336
Park, Hyokeun; Ramamurthy, Bhagavathi; Safer, Dan; Travaglia, Mirko; Chen, Li-Qiong; Franzini-Armstrong, Clara; Selvin, Paul R.; Sweeney, H. Lee Article
Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin
Journal of Biological Chemistry, v.279, (36), 2004, Sep, p. 37223-37226
Yildiz, A.; Park, Hyokeun; Safer, Dan; Yang, Zhaohui; Chen, Li-Qiong; Selvin, Paul R.; Sweeney, H. Lee Article
Nanometer localization of single ReAsH molecules
JOURNAL OF MICROSCOPY-OXFORD, v.216, (3), 2004, Dec, p. 199-205
Park, Hyokeun; Hanson, GT; Duff, SR; Selvin, Paul R. Article

2003 1

Photoelectron Spectroscopy of s-Triazine Anion Clusters: Polarization-induced Electron Binding in Aza-aromatic Molecule
Journal of Chemical Physics, v.119, (8), 2003, Aug, p.4320-4327
Kim, JH; Song, JK; Park, Hyokeun; Lee, SH; Han, SY; Kim, SK Article


Expand All Collapse All


Article 4

Analyzing Protein-protein Interactions In Rare Cells Using Microbead-based Single-molecule Pulldown Assay
Lab on a Chip, v. 21, (16), 15 June 2021, p. 3137-3149
Zhao, Qirui; Shen, Yusheng; Li, Xiaofen; Tian, Fang; Yu, Xiaojie; Yobas, Levent; Park, Hyo Keun; Duan, Yuanyuan; Huang, Pingbo
Real-time three-dimensional tracking of single vesicles reveals abnormal motion and pools of synaptic vesicles in neurons of Huntington’s disease mice
iScience, v. 24, (10), January 2021, article number 103181
Chen, Sidong; Yoo, Hanna; Li, Chun Hei; Park, Chungwon; Tan, Li Yang; Jung, Sangyong; Park, Hyo Keun
Simultaneous Real-Time Three-Dimensional Localization And FRET Measurement Of Two Distinct Particles
Nano Letters, v. 21, (18), 7 September 2021, p. 7479-7485
Chen, Xingxiang; Liu, Teng; Qin, Xianan; Nguyen, Quang Quan; Lee, Chanwoo; Lee, Sang Kwon; Ren, Yaguang; Chu, Jun; Zhu, Guang; Yoon, Tae-Young; Park, Chan Young; Park, Hyo Keun
Unique dynamics and exocytosis properties of GABAergic synaptic vesicles revealed by three-dimensional single vesicle tracking
Proceedings of the National Academy of Sciences of the United States of America, v. 118, (9), 2 March 2021, article number e2022133118
Park, Chungwon; Chen, Xingxiang; Tian, Chong-Li; Park, Gyu Nam; Chenouard, Nicolas; Lee, Hunki; Yeo, Xin Yi; Jung, Sangyong; Tsien, Richard W.; Bi, Guoqiang; Park, Hyokeun


Expand All Collapse All


Article 4

Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store Depletion
Biophysical Journal, v. 118, (1), January 2020, p. 70-84
Qin, Xianan; Liu, Lei; Lee, Sang-kwon; Alsina Lopez, Adolfo; Liu, Teng; Wu, Chao; Park, Hojeong; Yu, Chenglong; Kim, Hajin; Chu, Jun; Triller, Antoine; Tang, Benzhong; Hyeon, Changbong; Park, Chanyoung; Park, Hyo Keun
Mechanical Responses of Breast Cancer Cells to Substrates of Varying Stiffness Revealed by Single-Cell Measurements
The Journal of Physical Chemistry Letters, v. 11, (18), 17 September 2020, p. 7643-7649
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Chen, Xingxiang; Yiu, Pak Man; Tsui, Kwan Chui; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun
Simultaneous tracking of two motor domains reveals near simultaneous steps and stutter steps of myosin 10 on actin filament bundles
Biochemical and Biophysical Research Communications, v. 525, (1), April 2020, p. 94-99
Qin, Xianan; Yoo, Hanna; Cheng, Harry Chun Man; Nguyen, Quang Quan; Li, Jing; Liu, Xiaoyan; Prunetti, Laurence; Chen, Xingxiang; Liu, Teng; Sweeney, H. Lee; Park, Hyo Keun
The inactivation domain of STIM1 acts through intramolecular binding to the coiled-coil domain in the resting state
Journal of Cell Science, v. 133, (1), January 2020
Lee, Sang Kwon; Lee, Min-hsun; Jeong, Su Ji; Qin, Xianan; Lee, Ah Reum; Park, Hyo Keun; Park, Chan Young

Conference paper 4

A novel nanobead-based single-molecule pull-down for cell populations single cells
64th Annual Meeting of the Biophysical Society (bps 2020), San Diego, USA, 15-19 February 2020
Zhao, Qirui; Shen, Yusheng; Tian, Fang; Yobas, Levent; Park, Hyo Keun; Huang, Pingbo
Development of simultaneous single-particle tracking and fret measurement
The 64th Annual Meeting of Biophysical Society, San Diego, USA, 15-19 February 2020
Liu, Teng; Qin, Xianan; Lee, Sang Kwon; Chu, Jun; Park, Chan Young; Park, Hyo Keun
Different Mechanical Responses to Substrate Stiffness between Cancer Cells and Normal Cells
Biophysical Journal, v. 118, (3), February 2020, article number 1227-Pos, p. 249A
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Yan, Caishan; Yiu, Pak Man; Tsui, Kwan Chui; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun
Real-Time Nanometer-Accuracy Tracking of Single Lipid Droplets in Living Cells
The 64th Annual Meeting of Biophysical Society, San Diego, San Diego, USA, 15-19 February 2020
Lau, Hoi Man; Park, Hyo Keun


Expand All Collapse All


Article 1

Real-time Three-dimensional Tracking of Single Synaptic Vesicles Reveals That Synaptic Vesicles Undergoing Kiss-and-run Fusion Remain Close to Their Original Fusion Site Before Reuse
Biochemical and Biophysical Research Communications, v. 514, (3), June 2019, p. 1004-1008
Qin, Xianan; Tsien, Richard; Park, Hyo Keun

Conference paper 5

Altered vesicles dynamics in a Huntington’s disease mouse model studied with 3D tracking of single synaptic vesicle in cortical neurons
The 49th Annual Society for Neuroscience Meeting, Neuroscience 2019, Chicago, USA, 19-23 October 2019
Chen, Sidong; Park, Chungwon; Park, Hyokeun
Autophagosome Transport in Huntington's Disease
The European Molecular Biology Organization Workshop: Autophagy: From molecular principles to human diseases, Crieff, Scotland, United Kingdom, 26-30 August 2019
Li, Chun Hei; Park, Hyo Keun
Exocytosis of GABAergic synaptic vesicles tracked by real-time three-dimensional microscopy
The 49th Annual Society for Neuroscience Meeting, Neuroscience 2019, Chicago, USA, 19-23 October 2019
Park, Chungwon; Fan, Ching Yeung; Park, Keun Yang; Lee, Cheuk Long Frank; Park, Hyokeun
Mechanical Responses of Cancer Cells to Different Matrices Measured by AFM and FRET
Biophysical Journal, v. 116, (3), February 2019, article number 2633-Pos, p. 531a, Supplement 1
Tian, Fang; Lin, Tsung-Cheng; Wang, Liang; Chen, Sidong; Chu, Jun; Kiang, Ching-Hwa; Park, Hyo Keun
Tracking of Labeled Motor Domains of Single Full-Length Myosin X on Actin Bundles
Biophysical Journal, v. 116, (3), Supplement 1, 15 February 2019, article number 1281-Pos, p. 259a
Qin, Xianan; Cheung, Chun Man; Li, Jing; Yoo, Hanna; Liu, Xiaoyan; Lin, Tianming; Sweeney, H. LEE; Park, Hyo keun


Expand All Collapse All


Article 2

Altered synaptic vesicle release and Ca²⁺ influx at single presynaptic terminals of cortical neurons in a knock-in mouse model of huntington's disease
Frontiers in Molecular Neuroscience, v. 11, (478), December 2018
Chen, Sidong; Yu, Chenglong; Li, Chun Hei; Rong, Li; Qin, Xianan; Ryu, Hoon; Park, Hyo Keun
Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington’s Disease
Scientific Reports, v. 8, December 2018, article number 16976
Yu, Chenglong; Li, Chun Hei; Chen, Sidong; Yoo, Hanna; Qin, Xianan; Park, Hyo Keun

Conference paper 2

Monitoring the dynamics of cadherin during movement of cancer cells
62nd Annual Meeting of Biophysical Society (BPS18), San Francisco, 17-21 February 2018
Tian, Fang; Chen, Sidong; Chu, jun; Wang, liang; Park, Hyo Keun
Subdiffusive Motion of STIM1 at ER Membrane and ER-Plasma Membrane Junction
Biophysical Journal, v. 114, (3), 2 February 2018, p. 94a, Supp. 1
Qin, Xianan; Alsina, adolfo; Lee, sang kwon; Park, chan young; Park, Hyo Keun


Expand All Collapse All


Article 1

Real-time Subpixel-Accuracy Tracking of Single Mitochondria in Neurons Reveals Heterogeneous Mitochondrial Motion
Biochemical and Biophysical Research Communications, 5 September 2017
Alsina, Adolfo; Lai, Wu Ming; Wong, Wai Kin; Qin, Xianan; Zhang, Min; Park, Hyo Keun

Conference paper 2

Altered exocytosis of synaptic vesicles and Ca2+ influx in cortical neurons in a Huntington’s disease mouse studied with real-time imaging of single presynaptic terminals
Neuroscience 2017: SfN's 47th Annual Meeting, Washington, DC, USA, 11-15 November 2017
Yu, Chenglong; Chen, Sidong; Rong, Li; Zhang, Min; Qin, Xianan; Park, Hyo Keun
Mitochondrial Transport Defect in zQ175 Knock-In Mouse Model of Huntington’s Disease
Federation of American Societies for Experimental Biology, West Palm Beach, FL, 21-16 May 2017
Zhang, Min; Park, Hyo Keun


Expand All Collapse All


Article 2

Real-time imaging of single synaptic vesicles in live neurons
Frontiers in Biology, v. 11, (2), April 2016, p. 109-118
Yu, Chenglong; Zhang, Min; Qin, Xianan; Yang, Xiaofeng; Park, Hyokeun
The Myosin X Motor is Optimized for Movement on Actin Bundles
Nature Communications, v. 7, September 2016, article number 12456
Ropars, Virginie; Yang, Zhaohui; Isabet, Tatiana; Blanc, Florian; Zhou, Kaifeng; Lin, Tianming; Liu, Xiaoyan; Hissier, Pascale; Samazan, Frédéric; Amigues, Béatrice; Yang, Eric D.; Park, Hyo Keun; Pylypenko, Olena; Cecchini, Marco; Sindelar, Charles V.; Sweeney, H. Lee; Houdusse, Anne


Expand All Collapse All


Article 1

Influence of Synaptic Vesicle Position on Release Probability and Exocytotic Fusion Mode
Science, v. 335, (6074), March 2012, p. 1362-1366
Park, Hyo Keun; Li, Yulong; Tsien, Richard W.


Expand All Collapse All


Article 3

How myosin VI coordinates its heads during processive movement
EMBO JOURNAL, v. 26, (11), June 2007, p. 2682-2692
Sweeney, H. Lee; Park, Hyokeun; Zong, Alan B.; Yang, Zhaohui; Selvin, Paul R.; Rosenfeld, Steven S.
Single-molecule fluorescence to study molecular motors
Q. Rev. Biophys, 40, 1, July 2007, p. 87-111
Park, Hyokeun; Toprak, Erdal; Selvin, Paul R.
The unique insert at the end of the myosin VI motor is the sole determinant of directionality
Proc Natl Acad Sci U S A., v. 104, (3), January 2007, p. 778-783
Park, Hyokeun; Li, Anna; Chen, Li-Qiong; Houdusse, Anne; Selvin, Paul R.; Sweeney, H. Lee


Expand All Collapse All


Article 3

Full length myosin VI dimerizes and moves processively along actin filaments upon monomerculstering
Mol. Cell, v. 21, (3), 2006, Feb, p. 331-336
Park, Hyokeun; Ramamurthy, Bhagavathi; Safer, Dan; Travaglia, Mirko; Chen, Li-Qiong; Franzini-Armstrong, Clara; Selvin, Paul R.; Sweeney, H. Lee
Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin
Journal of Biological Chemistry, v.279, (36), 2004, Sep, p. 37223-37226
Yildiz, A.; Park, Hyokeun; Safer, Dan; Yang, Zhaohui; Chen, Li-Qiong; Selvin, Paul R.; Sweeney, H. Lee
Nanometer localization of single ReAsH molecules
JOURNAL OF MICROSCOPY-OXFORD, v.216, (3), 2004, Dec, p. 199-205
Park, Hyokeun; Hanson, GT; Duff, SR; Selvin, Paul R.


Expand All Collapse All


Article 1

Photoelectron Spectroscopy of s-Triazine Anion Clusters: Polarization-induced Electron Binding in Aza-aromatic Molecule
Journal of Chemical Physics, v.119, (8), 2003, Aug, p.4320-4327
Kim, JH; Song, JK; Park, Hyokeun; Lee, SH; Han, SY; Kim, SK


Expand All Collapse All


2016 2

Real-time imaging of single synaptic vesicles in live neurons
Frontiers in Biology, v. 11, (2), April 2016, p. 109-118
Yu, Chenglong; Zhang, Min; Qin, Xianan; Yang, Xiaofeng; Park, Hyokeun Article
The Myosin X Motor is Optimized for Movement on Actin Bundles
Nature Communications, v. 7, September 2016, article number 12456
Ropars, Virginie; Yang, Zhaohui; Isabet, Tatiana; Blanc, Florian; Zhou, Kaifeng; Lin, Tianming; Liu, Xiaoyan; Hissier, Pascale; Samazan, Frédéric; Amigues, Béatrice; Yang, Eric D.; Park, Hyo Keun; Pylypenko, Olena; Cecchini, Marco; Sindelar, Charles V.; Sweeney, H. Lee; Houdusse, Anne Article

2012 1

Influence of Synaptic Vesicle Position on Release Probability and Exocytotic Fusion Mode
Science, v. 335, (6074), March 2012, p. 1362-1366
Park, Hyo Keun; Li, Yulong; Tsien, Richard W. Article

2007 3

How myosin VI coordinates its heads during processive movement
EMBO JOURNAL, v. 26, (11), June 2007, p. 2682-2692
Sweeney, H. Lee; Park, Hyokeun; Zong, Alan B.; Yang, Zhaohui; Selvin, Paul R.; Rosenfeld, Steven S. Article
Single-molecule fluorescence to study molecular motors
Q. Rev. Biophys, 40, 1, July 2007, p. 87-111
Park, Hyokeun; Toprak, Erdal; Selvin, Paul R. Article
The unique insert at the end of the myosin VI motor is the sole determinant of directionality
Proc Natl Acad Sci U S A., v. 104, (3), January 2007, p. 778-783
Park, Hyokeun; Li, Anna; Chen, Li-Qiong; Houdusse, Anne; Selvin, Paul R.; Sweeney, H. Lee Article

2004 3

Full length myosin VI dimerizes and moves processively along actin filaments upon monomerculstering
Mol. Cell, v. 21, (3), 2006, Feb, p. 331-336
Park, Hyokeun; Ramamurthy, Bhagavathi; Safer, Dan; Travaglia, Mirko; Chen, Li-Qiong; Franzini-Armstrong, Clara; Selvin, Paul R.; Sweeney, H. Lee Article
Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin
Journal of Biological Chemistry, v.279, (36), 2004, Sep, p. 37223-37226
Yildiz, A.; Park, Hyokeun; Safer, Dan; Yang, Zhaohui; Chen, Li-Qiong; Selvin, Paul R.; Sweeney, H. Lee Article
Nanometer localization of single ReAsH molecules
JOURNAL OF MICROSCOPY-OXFORD, v.216, (3), 2004, Dec, p. 199-205
Park, Hyokeun; Hanson, GT; Duff, SR; Selvin, Paul R. Article

2003 1

Photoelectron Spectroscopy of s-Triazine Anion Clusters: Polarization-induced Electron Binding in Aza-aromatic Molecule
Journal of Chemical Physics, v.119, (8), 2003, Aug, p.4320-4327
Kim, JH; Song, JK; Park, Hyokeun; Lee, SH; Han, SY; Kim, SK Article


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 7 2020-21 Summer 2 2020-21 Spring 5 2020-21 Winter 0 2020-21 Fall 5

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LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS5070 Workshops in Biosciences
LIFS5710 Cellular Regulation
LIFS6112E Current Topics in Neuroscience
PHYS2080 Physics Seminar and Tutorial I
UROP1100E Undergraduate Research Opportunities Series 1
UROP4100E Undergraduate Research Opportunities Series 4


UROP1000 Undergraduate Research Opportunities
UROP3100D Undergraduate Research Opportunities Series 3


BIPH2010 Introductory Biological Physics
BIPH4010 Principles of Quantitative Instrumentation
LIFS4981 Biochemistry and Cell Biology Project Research II
LIFS4983 Biotechnology Project Research II
SCIE3500 IRE Research Project I


BIPH3010 Advanced Biological Physics
LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS4973 Biotechnology Project Research I
LIFS5710 Cellular Regulation
LIFS6112D Current Topics in Neuroscience


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy FU, Songdi
Life Science( 2021 - )

MA, Xiangyu
Physics( 2021 - )

NGUYEN, Quang Quan
Physics( 2020 - )

CHEN, Xingxiang
Life Science( 2019 - )

YOO, Hanna
Life Science( 2019 - )

PARK, Chungwon
Life Science( 2017 - )

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Master of Philosophy XU, Chen
Life Science( 2021 - )

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Graduated RPGs

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Doctor of Philosophy CHEN, Sidong
Life Science( Completed in 2021 )

TIAN, Fang
Physics( Completed in 2020 )

QIN, Xianan
Physics( Completed in 2019 )

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Master of Philosophy WU, Chao
Life Science( Completed in 2021 )

LI, Chun Hei
Life Science( Completed in 2020 )









ProjectsFrom January 2020 to December 2022

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All Projects 7 Leading Projects 5 Participating Projects 2

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Investigating the Molecular Mechanisms of the Unique Dynamics and Release of GABAergic Synaptic Vesicles in GABAergic Presynaptic Terminals


研究 GABA 能突触前末梢中 GABA 能突触囊泡的独特动力学和释放的分子机制 Leading


Germany / Hong Kong Joint Research Scheme


Project Team (HKUST)
PARK Hyo Keun (Lead)


2022 -




Ectopic expression and functional study of full-length human TMC1 in the absence or presence of TMIE


人全长TMC1单独或和TMIE一起的外源表达和功能研究 Participating


RGC - General Research Fund


Project Team (HKUST)
HUANG Pingbo (Lead)
PARK Hyo Keun


2021 -




Investigating the Exocytosis and Mobility of Single Synaptic Vesicles in Huntington's Disease using a Real-time Three-dimensional Nanometer-accuracy Tracking Microscope


使用实时三维纳米精度跟踪显微镜研究亨廷顿病中单个突触囊泡的胞吐和迁移 Leading


RGC - General Research Fund


Project Team (HKUST)
PARK Hyo Keun (Lead)


2018 -




Investigating the Vesicular Dynamics in Inhibitory Synapses using Cryo Correlative Light and Electron Microscopy (CryoCLEM) and Real-Time Three-dimensional Nanometer-accuracy Tracking Microscope


利用冷冻光电关联显微和实时三维纳米精度跟踪显微技术研究抑制性突触的囊泡动力学 Leading


National Natural Science Foundation of China / Research Grants Council Joint Research Scheme


Project Team (HKUST)
PARK Hyo Keun (Lead)
XIA Jun


2018 -




Neurotransmitter release and receptor diffusion dynamics during inhibitory synaptic transmission


抑制性突触传递中神经递质释放和受体扩散动力学研究 Leading


ANR / RGC Joint Research Scheme


Project Team (HKUST)
PARK Hyo Keun (Lead)
HUANG Pingbo


2018 - 2021




Aggregation-Induced Emission (AIE): Development of New AIE Systems and Exploration of Their Biomedical Applications


聚集诱导发光: 开发新的发光体系及探索其在生物医学领域的应用 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
LAM Wing Yip
LEE Yi-Kuen
PARK Hyo Keun
XIA Jun


2018 - 2021




Measuring Exocytosis of Single GABAergic Synaptic Vesicles in Live Neurons using the Real-time Three-dimensional Nanometer-accuracy Tracking Microscope


使用实时三维纳米精度跟踪显微镜，测量活体神经元GABA能突触中个体突触小泡的胞吐作用 Leading


RGC - Early Career Scheme


Project Team (HKUST)
PARK Hyo Keun (Lead)


2017 - 2020