Randy Yat Choi POON
潘逸才
PhD in Biochemistry
University of Cambridge, 1994

Chair Professor
Division of Life Science



(852) 2358 8703
rycpoon@ust.hk
Room 5526
Personal Web

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Google Scholar
UgRv_agAAAAJ

ORCID
0000-0001-5571-6231

Scopus ID
7103097213




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Cell cycle
Cell death
Cancer
Molecular medicine



Publications

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All Years 153 2022 0 2021 4 2020 3 2019 4 2018 5 2017 7 2016 130

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2021 4

One-step multiplex toolkit for efficient generation of conditional gene silencing human cell lines
Molecular Biology of the Cell, v. 32, (14), July 2021, p. 1267-1330
Yeung, Tsz Kwan; Lau, Ho Wai; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Quantitative Differences Between Cyclin-Dependent Kinases Underlie The Unique Functions Of CDK1 In Human Cells
Cell Reports, v. 37, (2), 12 October 2021, article number 109808
Lau, Ho Wai; Ma, Hoi Tang; Yeung, Tsz Kwan; Tam, Man Yee; Zheng, Danyi; Chu, Siu Ki; Poon, Randy Yat Choi Article
Cell Cycle Control: A System of Interlinking Oscillators
Cell Cycle Oscillators: Methods and Protocols / Edited by Amanda S. Coutts, Louise Weston. New York : Humana Press, 2021, p. 1-18, Ch. 1 Book series: Methods in Molecular Biology, v. 2329
Poon, Randy Yat Choi Book chapter
Re-defining the requirements for mitotic cyclins in mitotic progression in human cells
11th Salk Institute Cell Cycle Meeting, The Salk Institute, USA, 22 - 25 June 2021
Crncec, Adrijana; Ma, Hoi Tang; Poon, Randy Yat Choi Conference paper

2020 3

Aurora kinases and DNA damage response
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, v. 821, May-December 2020, article number 111716
Ma, Hoi Tang; Poon, Randy Y. C. Article
Mitotic slippage is determined by p31^comet and the weakening of the spindle-assembly checkpoint
Oncogene, v. 39, (13), March 2020, p. 2819-2834
Lok, Tsun Ming; Wang, Yang; Xu, Kaichun; Xie, Siwei; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G2 DNA Damage Checkpoint
Molecular Cancer Therapeutics, v. 19, (1), January 2020, p. 123-134
Mak, Joyce P.Y.; Ma, Hoi Tang; Poon, Randy Yat Choi Article

2019 4

Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation
Cell Cycle, v. 18, (2), January 2019, p. 238-248
Ng, Lau Yan; Ma, Hoi Tang; Liu, Julio C. Y.; Huang, Xiner; Lee, Nelson; Poon, Randy Yat Choi Article
Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics
Cell Death and Disease, v. 10, (4), April 2019, article number 314
Zeng, Xiaofang; Xu, Kaichun; Lok, Tsun Ming; Ma, Hoi Tang; Poon, Randy Yat Choi Article
A toolbox for conditional inactivation of essential genes
International Frontier Forum on Chemical Biology and Omics Research, Southern University of Science and Technology, China, 14-15 October 2019
Poon, Randy Yat Choi Conference paper
Characterizing the Role of Cyclin A2 in Cell Cycle Control using a Novel Gene Inactivation Tool
2019 The Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Hong Kong, 8 June 2019
Ng, Lau Yan; Ma, Hoi Tang; Poon, Randy Yat Choi Conference paper

2018 5

TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2
Cell Reports, v. 22, (6), February 2018, p. 1439-1450
Ma, Hoi Tang; Poon, Randy Yat Choi Article
Cyclin A
Encyclopedia of Signalling Molecules (2nd ed.) / edited by Sangdun Choi. New York : Springer, 2018, p. 1254-1259
Poon, Randy Yat Choi Book chapter
Building a novel system to investigate the role of cyclin A2 in G2/M checkpoint
The Hong Kong Inter-University Postgraduate Symposium Science 2018, Hong Kong, 23 Jun 2018
Liu, Julio; Ng, Lau Yan; Ma, Hoi Tang; Poon, Randy Yat Choi Conference paper
Mitotic slippage involves in weakening of the spindle-assembly checkpoint
The Hong Kong Inter-University Postgraduate Symposium Science 2018, Hong Kong, 23 Jun 2018
Lok, Tsun Ming; Xu, Kaichun; Ma, Hoi Tang; Xie, Siwei; Poon, Randy Yat Choi Conference paper
Role of TRIP13 and p31comet in spindle-assembly checkpoint activation and inactivation
ASCB-EMBO 2018 Meeting, San Diego, USA, 8-12 Dec 2018
Ma, Hoi Tang; Poon, Randy Yat Choi Conference paper

2017 7

CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency
Cell Death and Differentiation, v. 24, (1), January 2017, p. 38-48
Wang, Xiao Qi; Lo, Chung Mau; Chen, Lin; Ngan, Elly S-W; Xu, Aimin; Poon, Randy Y. C. Article
DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis
Neuron, v. 96, (5), December 2017, p. 1041-1054
Ye, Fei; Kang, Eunchai; Yu, Chuan; Qian, Xuyu; Jacob, Fadi; Yu, Cong; Mao, Mao; Poon, Randy Y.C.; Kim, Jieun; Song, Hongjun; Ming, Guo-li; Zhang, Mingjie Article
Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells
Oncotarget, v, 8, (24), March 2017, p. 38811-38824
Xia, Wei; Lo, Chung Mau; Poon, Randy Yat Choi; Cheung, Tan To; Chan, Albert Chi Yan; Chen, Lin; Yang, Sitian; Tsao, George Sai Wah; Wang, Xiao Qi Article
Synchronization of HeLa Cells
Cell Cycle Synchronization: Methods and Protocols / Gaspar Banfalvi, editor. New York : Humana Press, 2017, p. 189-201, Book series: Methods in Molecular Biology, v. 1524
Ma, Hoi Tang; Poon, Randy Yat Choi Book chapter
Regulation of mitosis by the AAA+ATPase TRIP13
Workshop on Mitotic Fidelity, Hong Kong, 22 Sep 2017
Poon, Randy Yat Choi Conference paper
Spindle-assembly checkpoint activation: the role of TRIP13 and MAD2 conformation equilibrium
Cell cycle inside out, Conférences Jacques Monod, Roscoff, France, 18-22 Sep 2017
Ma, Hoi Tang; Poon, Randy Yat Choi Conference paper
Synthetic Lethality Induced by Pharmacological Inhibition of ATM and PARP1
Molecular Cancer Research, v. 15, (4) Supplement, April 2017, article number A20
Mak, Joyce P.Y.; Poon, Randy Y C Conference paper

2016 7

BCL-W is a Regulator of Microtubule Inhibitor-induced Mitotic Cell Death
Oncotarget, v. 7, (25), May 2016, p. 38718-38730
Huang, Shan; Tang, Rui; Poon, Randy Y. C. Article
MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation
Scientific Reports, v. 6, 2016, article number 22230
Wong, Po Yee; Ma, Hoi Tang; Lee, Hyun-jung; Poon, Randy Y.C. Article
TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint
Cell Reports, v. 14, (5), February 2016, p. 1086-1099
Ma, Hoitang; Poon, Randy Yat Choi Article
Cell Cycle Control: A System of Interlinking Oscillators
Cell Cycle Oscillators: Methods and Protocols / Edited by Amanda S. Coutts, Louise Weston. New York : Humana Press, 2016, p. 3-19, Ch. 1. Book Series: Methods in Molecular Biology, v. 1342
Poon, Randy Y.C. Book chapter
Mitotic Catastrophe
Encyclopedia of Cell Biology / Ralph A. Bradshaw, Philip D. Stahl, editors. Academic Press, 2016, p. 399-403
Poon, Randy Yat Choi Book chapter
Synergism between the Pharmacological Inhibition of PARP1 and ATM Involves Targeting Major DNA Damage Repair Pathways
2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The Chinese University of Hong Kong, Hong Kong, 11 June 2016
Mak, Joyce P.Y.; Poon, Randy Y.C. Conference paper
TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint
Cold Spring Harbor Laboratory Meeting & Courses Program on The Cell Cycle, NY, USA, 17-21 May 2016
Ma, Hoi Tang; Poon, Randy Y.C. Conference paper

2015 11

Cell Cycle Control
Reference Module in Biomedical Sciences, 2015
Poon, Randy Y.C. Article
Co-inhibition of polo-like kinase 1 and aurora kinases promotes mitotic catastrophe
Oncotarget, v. 6, (11), April 2015, p. 9327-9340
Li, Jingjing; Hong, Myungjin; Chow, Jeremy Pak Hong; Man, Wingyu; Mak, Joyce Pui Ying; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells
Oncotarget, v. 6, (25), 2015, p. 21074-21084
Mak, Joyce Pui Ying; Man, Wingyu; Chow, Jeremy Pak Hong; Ma, Hoitang; Poon, Randy Yat Choi Article
SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A-B56
Cell Cycle, v. 14, (24), January 2015, p. 3965-3977
Wong, Wing Ki; Kelly, Terrenz; Li, Jingjing; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair
Molecular Cell, v. 60, (1), 2015, p. 163-176
Xie, Si; Mortusewicz, Oliver; Ma, Hoi Tang; Herr, Patrick; Poon, Randy Yat Choi; Helleday, Thomas; Qian, Chengmin Article
Drug targets in mitosis
HKUST-Peking University Shenzhen Graduate School Joint Symposium, Shenzhen, 14 March 2015
Poon, Randy Y.C. Conference paper
Exiting mitosis: how the spindle-assembly checkpoint is turned off
Hong Kong-San Diego Workshop on Signaling, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 30 October 2015
Poon, Randy Y.C. Conference paper
Molecular regulation of mitotic slippage
Hong Kong Inter-University Postgraduate Symposium on Life Science, IAS, HKUST, Clear Water Bay, Hong Kong, 23 May 2015
Xu, K.; Poon, Randy Y.C. Conference paper
Multiple anti-apoptotic BCL-2-like proteins determine antimitotic drug-mediated cell fates
EACR-AACR-SIC Special Conference on Anticancer Drug Action and Drug Resistance: From Cancer Biology to the Clinic, Florence, Italy, 20-23 June 2015
Huang, Shan; Poon, Randy Y.C. Conference paper
The role of MASTL in G2 DNA damage checkpoint
Hong Kong Inter-University Postgraduate Symposium, Hong Kong, 23 May 2015
Wong, Po Yee; Ma, Hoi Tang; Lee, H.J.; Poon, Randy Y.C. Conference paper
Turning off the spindle-assembly checkpoint
IAS Focused Program on Genome Damage and Stability, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 16-19 December 2015
Poon, Randy Y.C. Conference paper

2014 12

DNA damage checkpoints in nasopharyngeal carcinoma
Oral Oncology, v. 50, (5), 2014, p. 339-344
Poon, Randy Yat Choi Article
Dovitinib induces mitotic defects and activates the G(2) DNA damage checkpoint
Journal of Cellular and Molecular Medicine, v. 18, (1), January 2014, p. 143-155
Man, Wing Yu; Mak, Joyce Pui Ying; Poon, Randy Yat Choi Article
G1 checkpoint establishment in vivo during embryonic liver development
BMC Developmental Biology, v. 14, (1), May 2014, article number 23
Wang, Xiao Qi; Chan, Kwok Kin; Ming, Xiaoyan; Lui, Vincent C.H.; Poon, Randy Y C; Lo, Chung Mau; Norbury, Chris; Poon, Ronnie T.P. Article
Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes
Biosensors and Bioelectronics, v. 61, November 2014, p. 434-442
Xing, Xiaoxing; Poon, Randy Yat Choi; Wong, Cesar; Yobas, Levent Article
p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases
Oncogene, v. 33, (27), July 2014, p. 3550-3560
Marxer, Miriam; Ma, Hoi Tang; Man, Wingyu; Poon, Randy Yat Choi Article
Pharmacological targeting the ATR-CHK1-WEE1 axis involves balancing cell growth stimulation and apoptosis
Oncotarget, v. 5, (21), November 2014, p. 10546-10557
Mak, Joyce Pui Ying; Man, Wingyu; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death
Cell Death and Disease, v. 5, (4), 2014, article number e1177
Chen, Han; Huang, Shan; Han, Xianxian; Zhang, Junyi; Shan, Changliang; Tsang, Yiu Huen; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance
Molecular Oncology, v. 8, (8), December 2014, p. 1404-1418
Ma, Hoi Tang; Erdal, Sergio; Huang, Shan; Poon, Randy Yat Choi Article
BCL-2 family in mitotic cell death and genome instability
2014 Genomic Instability Gordon Research Conference, The Hong Kong University of Science and Technology, Hong Kong, 6-11 July 2014
Huang, Shan; Ma, Hoi Tang; Poon, Randy Yat Choi Conference paper
DNA damage checkpoints and NPC
The Croucher Foundation? Advanced Study Institute? -? Advances in Nasopharyngeal Carcinoma Studies, Hong Kong, 1-4 November 2014
Poon, Randy Yat Choi Conference paper
Imaging mitosis: understanding cell fates following antimitotic drug challenge
The 7th Asian Pacific Organization for Cell Biology Congress and American Society for Cell Biology Workshops, Biopolis, Singapore, 24-27 February 2014
Poon, Randy Yat Choi Conference paper
Mitotic catastrophe: mechanisms and anticancer potential
Asia GenomeCheck Symposium, Ajou University, Suwon, Korea, 6-7 Mar 2014
Poon, Randy Yat Choi Conference paper

2013 8

Aurora B: Hooking up with Cyclin-dependent Kinases
Cell Cycle, v. 12, (7), April 2013
Poon, Randy Yat Choi Article
Critical Differences between Isoforms of Securin Reveal Mechanisms of Separase Regulation
Molecular and Cellular Biology, v. 33, (17), 2013, p. 3400-3415
Han, Xianxian; Poon, Randy Yat Choi Article
PARP1 Is Overexpressed in Nasopharyngeal Carcinoma and Its Inhibition Enhances Radiotherapy
Molecular Cancer Therapeutics, v. 12, (11), 2013, p. 2517-2528
Chow, Jeremy Pak Hong; Man, Wingyu; Mao, Mao; Chen, Han; Cheung, Florence; Nicholls, John M.; Tsao, Sai Wah; Lung, Maria Li; Poon, Randy Yat Choi Article
The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery
Oncogene, v. 32, (40), October 2013, p. 4778-4788
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi Article
Abrogation of the G2 DNA Damage Checkpoint and Mitotic Catastrophe
Cycling to Death: EMBO International Workshop on Cell Death, DNA-damage and Cell Cycle Control, Obergurgl, Austria, 23-27 January 2013
Poon, Randy Yat Choi Conference paper
Checkpoint Abrogation and Mitotic Catastrophe: Mechanism and Therapeutic Potential
Symposium on Biomedical Research across the Continents—Insight and Innovation, The Hong Kong University of Science and Technology, 7-8 March 2013
Poon, Randy Yat Choi Conference paper
Interplay between Aurora kinase A and the kinesin protein Eg5 in Bipolar Spindle Formation
EMBO Workshop: 'Chromosome Segregation and Aneuploidy', Breukelen, The Netherlands, 22-26 June 2013
Ma, Hoi Tang; Erdal, Sergio; Poon, Randy Yat Choi Conference paper
Mitotic Components as Anticancer Drug Targets
The 2nd HKUST-University of the Philippines Symposium, HKUST, Hong Kong, 6-7 December 2013
Poon, Randy Yat Choi Conference paper

2012 6

Depletion of p31(comet) Protein Promotes Sensitivity to Antimitotic Drugs
Journal of biological chemistry, v. 287, (25), June 2012, p. 21561-21569
Ma, Hoi Tang; Chan, Yan Yan; Chen, Xiao; On, Kin Fan; Poon, Randy Yat Choi Article
Inhibition of Eg5 Acts Synergistically with Checkpoint Abrogation in Promoting Mitotic Catastrophe
Molecular cancer research, v. 10, (5), May 2012, p. 626-635
Chen, Yue; Chow, Jeremy Pak Hong; Poon, Randy Yat Choi Article
Novel Functions of the Phosphatase SHP2 in the DNA Replication and Damage Checkpoints
PLoS ONE, v. 7, (11), November 2012, Article number e49943
Tsang, Yiu Huen; Han, Xianxian; Man, Wingyu; Lee, Nelson Tsz Kin; Poon, Randy Yat Choi Article
Tetraploidization increases sensitivity to Aurora B kinase inhibition
Cell cycle, v. 11, (13), July 2012, p. 2567-2577
Marxer, Miriam; Foucar, Charles Elliott; Man, Wingyu; Chen, Yu; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Cyclin A
Encyclopedia of Signalling Molecules / Edited by Sangdun Choi. Springer, New York, 2012, p. 491-496
Poon, Randy Yat Choi Book chapter
Mitotic catastrophe: mechanisms and therapeutic potential
The 71st Annual Meeting of the Japanese Cancer Association, Sapporo, Japan, 19-21 Sep 2012
Poon, Randy Yat Choi Conference paper

2011 10

Biomedical research in Hong Kong
The biochemist, v. 33, (5), 2011, p. 24-25
Poon, Randy Yat Choi Article
Determinants of Mitotic Catastrophe on Abrogation of the G(2) DNA Damage Checkpoint by UCN-01
Molecular cancer therapeutics, v. 10, (5), May 2011, p. 784-794
On, Kin Fan; Chen, Yue; Ma, Hoi Tang; Chow, Jeremy Pak Hong; Poon, Randy Yat Choi Article
How protein kinases co-ordinate mitosis in animal cells
Biochemical journal, v. 435, (1), April 2011, p. 17-31
Ma, Hoi Tang; Poon, Randy Yat Choi Article
Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit
Molecular and cellular biology, v. 31, (7), 2011, p. 1478-1491
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi; Ma, Hoi Tang Article
Orderly Inactivation of the Key Checkpoint Protein Mitotic Arrest Deficient 2 (MAD2) during Mitotic Progression
Journal of biological chemistry, v. 286, (15), April 2011, p. 13052-13059
Ma, Hoi Tang; Poon, Randy Yat Choi Article
SCF(beta TrCP) mediates stress-activated MAPK-induced Cdc25B degradation
Journal of cell science, v. 124, (16), 2011, Aug, p. 2816-2825
Uchida, Sanae; Watanabe, Nobumoto; Kudo, Yasusei; Yoshioka, Katsuji; Matsunaga, Tsukasa; Ishizaka, Yukihito; Nakagama, Hitoshi; Poon, Randy Y C; Yamashita, Katsumi Article
Synchronization of HeLa Cells
Cell Cycle Synchronization: Methods and Protocols / Edited by: Gaspar Banfalvi. New York : Humana Press, Springer, 2011, p. 151-161, Part of the Methods in Molecular Biology book series (MIMB, volume 761)
Ma, Hoi Tang; Poon, Randy Y.C. Book chapter
Genome-wide identification of novel mitotic kinases
Functional phosphoproteomics in study of plant cell signaling and molecular system biology, Hong Kong, 3-7 Jan 2011
Poon, Randy Yat Choi Conference paper
Identifying novel kinases involved in mitotic progression using kinome-wide screens
Annual Meeting of the American-Society-for-Cell-Biology (ASCB), Denver, CO, USA, 3-7 Dec 2011, v. 22, 2011
Chen, H.; Ma, Hoi Tang; Tsang, Y.; Cheung, C.; Ng, S.S.; Zhang, J.; Poon, Randy Yat Choi Conference paper
The CDK1 inhibitory kinase MYT1 in checkpoint recovery
Cell Cycle Cancer and Development, Saint-Malo, France, 25-28 May 2011
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi Conference paper

2010 7

Gene down-regulation with short hairpin RNAs and validation of specificity by inducible rescue in mammalian cells
Current protocols in cell biology, (SUPPL.49), 2010, Article number 27.2
Ma, Hoi Tang; Poon, Randy Yat Choi Article
Genome reduplication Redeployment of cyclin-CDK complexes and spontaneous oscillation of APC/C
Cell cycle, v. 9, (3), February 2010, p. 431-432
Ma, Hoi Tang; Poon, Randy Yat Choi Article
The requirement of p53 for maintaining chromosomal stability during tetraploidization
Oncotarget, v. 1, (7), 2010, p. 583-595
Ho, Chui Chui; Hau, Pok Man; Marxer, Miriam; Poon, Randy Yat Choi Article
Polyploidization and cancer
Advances in Experimental Medicine and Biology - Polyploidization and cancer /Randy Yat Choi Poon. Springer-Verlag, New York, US, v. 676, 2010
Poon, Randy Yat Choi Book
DNA Damage and Polyploidization
Polyploidization and cancer - Advances in Experimental Medicine and Biology / Edited by Randy Yat Choi Poon. Springer, Berlin, Germany, v. 676, 2010, p. 57-71
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi Book chapter
Dissociation of MAD2 from APC/C and mitotic checkpoint complex are differentially regulated upon checkpoint satisfaction
Jacques Monod Conference: Cell division: time and space, Roscoff, France, 11-15 Sep 2010
Ma, Hoi Tang; Poon, Randy Yat Choi Conference paper
Mitotic-specific checkpoints and genome instability
Biochemistry and Molecular Biology 2010 (BMB2010) Symposium, Kobe, Japan, 7-10 Dec 2010
Poon, Randy Yat Choi Conference paper

2009 9

Cyclin A2-Cyclin-Dependent Kinase 2 Cooperates with the PLK1-SCF beta-TrCP1-EMI1-Anaphase-Promoting Complex/Cyclosome Axis To Promote Genome Reduplication in the Absence of Mitosis
Molecular and cellular biology, v. 29, (24), 2009, Dec, p. 6500-6514
Ma, Hoi Tang; Tsang, Yiu Huen; Marxer, Miriam; Poon, Randy Yat Choi Article
DNA Damage Mediated S and G(2) Checkpoints in Human Embryonal Carcinoma Cells
Stem cells, v. 27, (3), 2009, p. 568-576
Wang, Xiaoqi; Lui, Vincent C.H.; Poon, Ronnie T.P.; Lu, Ping; Poon, Randy Yat Choi Article
Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe
Oncogene, v. 28, (2), 2009, JAN, p. 170-183
Chan, Ying Wai; Chen, Yue; Poon, Randy Yat Choi Article
Stress-Activated Mitogen-Activated Protein Kinases c-Jun NH2-Terminal Kinase and p38 Target Cdc25B for Degradation
Cancer research, v. 69, (16), 2009, AUG, p. 6438-6444
Uchida, Sanae; Yoshioka, Katsuji; Kizu, Ryoichi; Nakagama, Hitoshi; Matsunaga, Tsukasa; Ishizaka, Yukihito; Poon, Randy Yat Choi; Yamashita, Katsumi Article
Genome reduplication: promotion of replication by EMI1-dependent oscillation of APC/C activity in the absence of mitosis
The 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology, Shanghai, China, 2-7 Aug 2009
Ma, Hoi Tang; Tsang, Yiu Huen; Marxer, Miriam; Poon, Randy Yat Choi Conference paper
Genome reduplication: the role of the PLK1-betaTrCP-EMI1-APC/C axis in genome instability
The IMCB and the 12th Australian Cell Cycle Workshop: Cell Cycle Regulation and Tumorigenesis Symposium, Singapore, 7-8 Sep 2009
Poon, Randy Yat Choi Conference paper
The role of CDC20 and CDK1 inhibitory phosphorylation in mitotic exit
The IMCB and the 12th Australian Cell Cycle Workshop: Cell Cycle Regulation and Tumorigenesis Symposium, Singapore, 7-8 Sep 2009
Chow, Jeremy Pak Hong; Ma, Hoi Tang; Poon, Randy Yat Choi Conference paper
The role of cyclin B in cyclin A degradation
The IMCB and the 12th Australian Cell Cycle Workshop: Cell Cycle Regulation and Tumorigenesis Symposium, Singapore 7-8 Sep 2009
Ma, Hoi Tang; Marxer, Miriam; Poon, Randy Y.C. Conference paper
Uncoupling of mitosis and genome instability
Frontiers in Biomedical Research, University of Hong Kong, Hong Kong, 4 Dec 2009
Poon, Randy Yat Choi Conference paper

2008 4

CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis
Cell cycle, v. 7, (10), 2008, May, p. 1449-1461
Chan, Ying Wai; Ma, Hoi Tang; Wong, Winnie; Ho, Chui Chui; On, Kin Fan; Poon, Randy Yat Choi Article
The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint
Journal of biological chemistry, v. 283, (23), 2008, JUN, p. 15716-15723
Chan, Ying Wai; On, Kin Fan; Chan, Wan Mui; Wong, Winnie; Siu, Ho On; Hau, Pok Man; Poon, Randy Yat Choi Article
The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability
Frontiers in bioscience, v. 13, (13), 2008, p. 5016-5029
Chen, Yue; Poon, Randy Yat Choi Article
Precise regulation of A- and B-type cyclins is required to ensure chromosomal stability
Cell Cycle and Cancer 2008, Toulouse, France, 25-28 Mar 2008
Ma, Hoi Tang; Fung, Tsz Kan; Lau, Pui Ngan; Poon, Randy Yat Choi Conference paper

2007 8

An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells
Nucleic acids research, v. 35, (4), 2007, FEB, Article number e22
Ma, Hoi Tang; On, Kin Fan; Tsang, Yiu Huen; Poon, Randy Yat Choi Article
BS69 is involved in cellular senescence through the p53-p21Cip1 pathway
EMBO reports, v. 8, (10), 2007, October, p. 952-958
Zhang, Wei; Chan, Homan; Gao, Yan; Poon, Randy Yat Choi; Wu, Zhenguo Article
Mitotic phosphorylation: breaking the balance of power by a tactical retreat
The biochemical journal, v. 403, (2), April 2007, p. e5-7
Poon, Randy Yat Choi Article
Specialized roles of the two mitotic cyclins in somatic cells: Cyclin a as an activator of m phase-promoting factor
Molecular biology of the cell, v. 18, (5), 2007, MAY, p. 1861-1873
Fung, Tsz Kan; Ma, Hoi Tang; Poon, Randy Yat Choi Article
The p53 isoform Delta p53 lacks intrinsic transcriptional activity and reveals the critical role of nuclear import in dominant-negative activity
Cancer research, v. 67, (5), 2007, MAR, p. 1959-1969
Chan, Wan Mui; Poon, Randy Yat Choi Article
Cell cycle checkpoints in the maintenance of genome stability
12th Medical Research Conference, Faculty of Medicine Building, University of Hong Kong, Pok Fu Lam, Hong Kong, 3 Feb 2007
Poon, Randy Yat Choi Conference paper
Cell cycle control and genome instability
Annual Research Day, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 24 Feb 2007
Poon, Randy Yat Choi Conference paper
Different mitotic cyclin isoforms contribute differentially to mitosis
Cell Regulations in Division and Arrest, Okinawa Institute of Science and Technology, Okinawa, Japan, 25-29 March, 2007
Poon, Randy Yat Choi Conference paper

2006 6

Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells
FEBS letters, v. 580, (19), 2006, AUG, p. 4727-4736
Hau, Pok Man; Siu, Wai Yi; Wong, Nathalie; Lai, Paul B.S.; Poon, Randy Yat Choi Article
Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways
Cancer research, v. 66, (4), 2006, FEB, p. 2233-2241
Ho, Chui Chui; Siu, Wai Yi; Lau, Anita Wan Sze; Chan, Wan Mui; Arooz, Talha; Poon, Randy Yat Choi Article
Ubiquitination of p53 at multiple sites in the DNA-binding domain
Molecular cancer research, v. 4, (1), 2006, JAN, p. 15-25
Chan, Wan Mui; Mak, Man Chi; Fung, Tsz Kan; Lau, Anita Wan Sze; Siu, Wai Yi; Poon, Randy Yat Choi Article
Mitotic catastrophe: life and death during mitosis
Frontiers in Biomedical Research Conference, University of Hong Kong, Hong Kong, 8 Dec 2006
Poon, Randy Yat Choi Conference paper
Regulation of p53 by ribosomal S6 kinase 4
The 13th International p53 conference, Columbia University, New York, USA, 20-24 May 2006
Chan, W.M.; Yeung, W.; Poon, Randy Yat Choi Conference paper
The role of cyclin A-CDK complexes as activators of M phase-promoting factor
Croucher Advanced Study Institute: Signaling in cell growth and differentiation. HKUST, Hong Kong, 16-20 Jan 2006, v. 15, (1), 2006, p. 48
Poon, Randy Yat Choi Conference paper

2005 3

A roller coaster ride with the mitotic cyclins
Seminars in cell & developmental biology, v. 16, (3), 2005, p. 335-342
Fung, Tsz Kan; Poon, Randy Yat Choi Article
The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites
Cell Cycle, v. 4, (10), 2005, p. 1411-1420
Fung, Tsz Kan; Yam, Cain H.; Poon, Randy Yat Choi Article
The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint
Experimental cell research, v. 304, (1), 2005, MAR, p. 1-15
Ho, Chui Chui; Siu, Wai Yi; Chow, Jeremy Pak Hong; Lau, Anita Wan Sze; Arooz, Talha; Tong, Hoi Yee; Ng, Irene O.L.; Poon, Randy Yat Choi Article

2004 8

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation
Genes & development, v. 18, (11), 2004, June, p. 1317-1330
Woo, Richard A.; Poon, Randy Yat Choi Article
Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains
Journal of biological chemistry, v. 279, (10), 2004, MAR, p. 8808-8819
Ng, Chuen Pei; Lee, Hung Chiu; Ho, Chung Wai; Arooz, Talha; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article
Gene mutations and aneuploidy - The instability that causes cancer
Cell cycle, v. 3, (9), 2004, SEP, p. 1101-1103
Woo, Richard A.; Poon, Randy Yat Choi Article
How many mutant p53 molecules are needed to inactivate a tetramer?
Molecular and Cellular Biology, v. 24, (8), April 2004, p. 3536-3551
Chan, Wan Mui; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article
Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia
Biochemical journal, v. 383, (1), 2004, OCT, p. 27-35
Cheung, Ngai; So, Chi Wai; Yam, Judy W.P.; So, Cary K.C.; Poon, Randy Yat Choi; Jin, Dong-Yan; Chan, Li Chong Article
Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms
Molecular cancer therapeutics, v. 3, (5), 2004, MAY, p. 621-632
Siu, Wai Yi; Lau, Anita Wan Sze; Arooz, Talha; Chow, Jeremy Pak Hong; Ho, H.T.B.; Poon, Randy Yat Choi Article
Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation
7th Cancer Research UK Beatson International Cancer Conference: Cell cycle, senescence, apoptosis and cancer, Glasgow, Scotland, v. 18, (11), 2004, June, p. 1317-1330
Woo, Richard A.; Poon, Randy Yat Choi Conference paper
DNA replication checkpoint and p53
DNA Replication and Genome Integrity Meeting, The Salk Institute for Biological Studies, La Jolla, USA, 11-15 August 2004
Ho, Chui Chui; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi Conference paper

2003 4

Cyclin-dependent kinases and S phase control in mammalian cells.
Cell cycle (Georgetown, Tex.), v. 2, (4), 2003, p. 316-324
Woo, Richard A.; Poon, Randy Yat Choi Article
Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints
Journal of biological chemistry, v. 278, (42), 2003, OCT, p. 40815-40828
Chow, Jeremy Pak Hong; Siu, Wai Yi; Ho, H.T.B.; Ma, Hoi Tang; Ho, Chui Chui; Poon, Randy Yat Choi Article
DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase
Molecular biology of the cell, v. 14, (10), 2003, OCT, p. 3989-4002
Chow, Jeremy Pak Hong; Siu, Wai Yi; Fung, Tsz Kan; Chan, Wan Mui; Lau, Anita Wan Sze; Arooz, Talha; Ng, Chuen Pei; Yamashita, Katsumi; Poon, Randy Yat Choi Article
ING1b decreases cell proliferation through p53-dependent and -independent mechanisms
FEBS letters, v. 553, (3), 2003, OCT, p. 277-285
Tsang, Fan Cheung; Po, Laisee; Leung, Kaman; Lau, Anita Wan Sze; Siu, Wai Yi; Poon, Randy Yat Choi Article

2002 6

Activation of cyclin-dependent kinases CDC2 and CDK2 in hepatocellular carcinoma
Liver, v. 22, (3), 2002, June, p. 259-268
Li, Kay K.W.; Ng, Irene O.L.; Fan, Sheung Tat; Albrecht, Jeffrey H.; Yamashita, Katsumi; Poon, Randy Yat Choi Article
Cyclin F is degraded during G(2)-M by mechanisms fundamentally different from other cyclins
Journal of biological chemistry, v. 277, (38), 2002, Sep, p. 35140-35149
Fung, Tsz Kan; Siu, Wai Yi; Yam, Cain H.; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article
Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells
Journal of cell science, v. 115, (17), 2002, SEP, p. 3479-3490
Graeser, Ralph; Gannon, Julian V.; Poon, Randy Yat Choi; Dubois, Thierry; Aitken, Alastair; Hunt, Tim W. Article
The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2
Cancer Research, v. 62, (17), 2002, p. 4890-4893
Leung, Kaman; Po, Laisee; Tsang, Fan Cheung; Siu, Wai Yi; Lau, Anita Wan Sze; Ho, H.T.B.; Poon, Randy Yat Choi Article
Cell Cycle Control
Encyclopedia of Cancer / Edited by Bertino, J.R.. San Diego, US: Academic Press, 2002, p. 393-404
Poon, Randy Yat Choi Book chapter
Proteolysis of cyclins during G2-M by ubiquitination-dependent and independent pathways
28th Federation of European Biochemical Societies Meeting, Istanbul, Turkey, 20-25 October 2002
Poon, Randy Yat Choi Conference paper

2001 5

A possible role of p73 on the modulation of p53 level through MDM2
Cancer research, v. 61, (4), 2001, FEB, p. 1598-1603
Wang, Xiaoqian; Ongkeko, Weg M.; Lau, Anita Wan Sze; Leung, Kaman; Poon, Randy Yat Choi Article
Cleavage of cyclin A at R70/R71 by the bacterial protease OmpT
Proceedings of the National Academy of Sciences of the United States of America, v. 98, (2), 2001, Jan, p. 497-501
Yam, Cain H.; Siu, Wai Yi; Kaganovich, Daniel; Ruderman, Joan V.; Poon, Randy Yat Choi Article
MDM2 and MDMX can interact differently with ARF and members of the p53 family
FEBS letters, v. 490, (3), 2001, FEB, p. 202-208
Wang, Xiaoqi; Arooz, Talha; Siu, Wai Yi; Chiu, Clarissa H.S.; Lau, Anita Wan Sze; Yamashita, Katsumi; Poon, Randy Yat Choi Article
Regulation of the DNA damage checkpoints by cyclin-dependent kinases and p53-dependent pathways
The 4th Conference of Asia-Pacific Molecular Biology Network, Taipei, Taiwan, Nov 2011
Poon, Randy Yat Choi Conference paper
The contribution of human WEE1 to normal cell cycle control and DNA damage checkpoint
EMBO workshop on G2/M progression and associated checkpoints, EMBO, Salamanca, Spain, 6–9 September 2001
Arooz, Talha; Chan, H.Y.; Siu, Wai Yi; Lau, Anita Wan Sze; Yam, Cain H.; Hunter, Tony R.; Watanabe, N.; Poon, Randy Yat Choi Conference paper

2000 4

Degradation of cyclin a does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2
Journal of biological chemistry, v. 275, (5), 2000, Feb, p. 3158-3167
Yam, Cain H.; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article
On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells
Biochemistry, v. 39, (31), 2000, AUG, p. 9494-9501
Arooz, Talha; Yam, Cain H.; Siu, Wai Yi; Lau, Anita Wan Sze; Li, Kay K.W.; Poon, Randy Yat Choi Article
p21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells
Journal of cell biology, v. 149, (2), 2000, APR, p. 281-292
Mal, Asoke K.; Chattopadhyay, Debasish; Ghosh, Mrinal Kanti Anti; Poon, Randy Yat Choi; Hunter, Tony R.; Harter, Marian L. Article
The spindle checkpoint in the dinoflagellate Crypthecodinium cohnii
Experimental cell research, v. 254, (1), 2000, JAN, p. 120-129
Yeung, Patrick Ka Kit; New, David C.; Leveson, Alexis C.; Yam, Cain H.; Poon, Randy Yat Choi; Wong, Joseph Tin Yum Article

1999 5

Differential responses of proliferating versus quiescent cells to adriamycin
Experimental cell research, v. 250, (1), 1999, Jul, p. 131-141
Siu, Wai Yi; Arooz, Talha; Poon, Randy Yat Choi Article
G1 versus G2 cell cycle arrest after adriamycin-induced damage in mouse Swiss3T3 cells
FEBS letters, v. 461, (3), 1999, NOV, p. 299-305
Siu, Wai Yi; Yam, Cain H.; Poon, Randy Yat Choi Article
MDM2 and MDMX bind and stabilize the p53-related protein p73
Current biology, v. 9, (15), 1999, JUL, p. 829-832
Ongkeko, Weg M.; Wang, Xiaoqian; Siu, Wai Yi; Lau, Anita Wan Sze; Yamashita, Katsumi; Harris, Adrian; Cox, Lynne S.; Poon, Randy Yat Choi Article
MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins
Cancer research, v. 59, (20), 1999, OCT, p. 5075-5078
Yam, Cain H.; Siu, Wai Yi; Arooz, Talha; Chiu, Clarissa H.S.; Lau, Anita Wan Sze; Wang, Xiaoqian; Poon, Randy Yat Choi Article
Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2
Molecular and cellular biology, v. 19, (1), 1999, JAN, p. 635-645
Yam, Cain H.; Ng, Raymond Wai Man; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article

1998 3

Characterization of the cullin and F-box protein partner Skp1
FEBS letters, v. 438, (3), 1998, November, p. 183-189
Ng, Raymond Wai Man; Arooz, Talha; Yam, Cain H.; Chan, Iris W.Y.; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article
Expression of a novel form of p21(Cip1/Waf1) in UV-irradiated and transformed cells
Oncogene, v. 16, (10), 1998, MAR, p. 1333-1343
Poon, Randy Yat Choi; Hunter, Tony R. Article
Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver
Oncogene, v. 16, (16), 1998, APR, p. 2141-2150
Albrecht, Jeffrey H.; Poon, Randy Yat Choi; Ahonen, Cory L.; Rieland, Brenda M.; Deng, Chuxia; Crary, Gretchen S. Article

1997 4

Cdc37: A protein kinase chaperone?
Trends in cell biology, v. 7, (4), 1997, April, p. 157-161
Hunter, Tony R.; Poon, Randy Yat Choi Article
Generation of phosphorylated cyclin-dependent kinase 2 and functional characterization of threonine-160-specific phosphatase KAP
Methods in enzymology, v. 283, 1997, p. 283-292
Poon, Randy Yat Choi Article
Identification of functional domains in the neuronal Cdk5 activator protein
Journal of Biological Chemistry, v. 272, (9), 1997, p. 5703-5708
Poon, Randy Yat Choi; Lew, John; Hunter, Tony R. Article
The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells
Cancer research, v. 57, (22), 1997, NOV, p. 5168-5178
Poon, Randy Yat Choi; Chau, Man Sang; Yamashita, Katsumi; Hunter, Tony R. Article


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Article 2

One-step multiplex toolkit for efficient generation of conditional gene silencing human cell lines
Molecular Biology of the Cell, v. 32, (14), July 2021, p. 1267-1330
Yeung, Tsz Kwan; Lau, Ho Wai; Ma, Hoi Tang; Poon, Randy Yat Choi
Quantitative Differences Between Cyclin-Dependent Kinases Underlie The Unique Functions Of CDK1 In Human Cells
Cell Reports, v. 37, (2), 12 October 2021, article number 109808
Lau, Ho Wai; Ma, Hoi Tang; Yeung, Tsz Kwan; Tam, Man Yee; Zheng, Danyi; Chu, Siu Ki; Poon, Randy Yat Choi

Book chapter 1

Cell Cycle Control: A System of Interlinking Oscillators
Cell Cycle Oscillators: Methods and Protocols / Edited by Amanda S. Coutts, Louise Weston. New York : Humana Press, 2021, p. 1-18, Ch. 1 Book series: Methods in Molecular Biology, v. 2329
Poon, Randy Yat Choi

Conference paper 1

Re-defining the requirements for mitotic cyclins in mitotic progression in human cells
11th Salk Institute Cell Cycle Meeting, The Salk Institute, USA, 22 - 25 June 2021
Crncec, Adrijana; Ma, Hoi Tang; Poon, Randy Yat Choi


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Article 3

Aurora kinases and DNA damage response
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, v. 821, May-December 2020, article number 111716
Ma, Hoi Tang; Poon, Randy Y. C.
Mitotic slippage is determined by p31^comet and the weakening of the spindle-assembly checkpoint
Oncogene, v. 39, (13), March 2020, p. 2819-2834
Lok, Tsun Ming; Wang, Yang; Xu, Kaichun; Xie, Siwei; Ma, Hoi Tang; Poon, Randy Yat Choi
Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G2 DNA Damage Checkpoint
Molecular Cancer Therapeutics, v. 19, (1), January 2020, p. 123-134
Mak, Joyce P.Y.; Ma, Hoi Tang; Poon, Randy Yat Choi


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Article 2

Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation
Cell Cycle, v. 18, (2), January 2019, p. 238-248
Ng, Lau Yan; Ma, Hoi Tang; Liu, Julio C. Y.; Huang, Xiner; Lee, Nelson; Poon, Randy Yat Choi
Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics
Cell Death and Disease, v. 10, (4), April 2019, article number 314
Zeng, Xiaofang; Xu, Kaichun; Lok, Tsun Ming; Ma, Hoi Tang; Poon, Randy Yat Choi

Conference paper 2

A toolbox for conditional inactivation of essential genes
International Frontier Forum on Chemical Biology and Omics Research, Southern University of Science and Technology, China, 14-15 October 2019
Poon, Randy Yat Choi
Characterizing the Role of Cyclin A2 in Cell Cycle Control using a Novel Gene Inactivation Tool
2019 The Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Hong Kong, 8 June 2019
Ng, Lau Yan; Ma, Hoi Tang; Poon, Randy Yat Choi


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Article 1

TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2
Cell Reports, v. 22, (6), February 2018, p. 1439-1450
Ma, Hoi Tang; Poon, Randy Yat Choi

Book chapter 1

Cyclin A
Encyclopedia of Signalling Molecules (2nd ed.) / edited by Sangdun Choi. New York : Springer, 2018, p. 1254-1259
Poon, Randy Yat Choi

Conference paper 3

Building a novel system to investigate the role of cyclin A2 in G2/M checkpoint
The Hong Kong Inter-University Postgraduate Symposium Science 2018, Hong Kong, 23 Jun 2018
Liu, Julio; Ng, Lau Yan; Ma, Hoi Tang; Poon, Randy Yat Choi
Mitotic slippage involves in weakening of the spindle-assembly checkpoint
The Hong Kong Inter-University Postgraduate Symposium Science 2018, Hong Kong, 23 Jun 2018
Lok, Tsun Ming; Xu, Kaichun; Ma, Hoi Tang; Xie, Siwei; Poon, Randy Yat Choi
Role of TRIP13 and p31comet in spindle-assembly checkpoint activation and inactivation
ASCB-EMBO 2018 Meeting, San Diego, USA, 8-12 Dec 2018
Ma, Hoi Tang; Poon, Randy Yat Choi


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Article 3

CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency
Cell Death and Differentiation, v. 24, (1), January 2017, p. 38-48
Wang, Xiao Qi; Lo, Chung Mau; Chen, Lin; Ngan, Elly S-W; Xu, Aimin; Poon, Randy Y. C.
DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis
Neuron, v. 96, (5), December 2017, p. 1041-1054
Ye, Fei; Kang, Eunchai; Yu, Chuan; Qian, Xuyu; Jacob, Fadi; Yu, Cong; Mao, Mao; Poon, Randy Y.C.; Kim, Jieun; Song, Hongjun; Ming, Guo-li; Zhang, Mingjie
Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells
Oncotarget, v, 8, (24), March 2017, p. 38811-38824
Xia, Wei; Lo, Chung Mau; Poon, Randy Yat Choi; Cheung, Tan To; Chan, Albert Chi Yan; Chen, Lin; Yang, Sitian; Tsao, George Sai Wah; Wang, Xiao Qi

Book chapter 1

Synchronization of HeLa Cells
Cell Cycle Synchronization: Methods and Protocols / Gaspar Banfalvi, editor. New York : Humana Press, 2017, p. 189-201, Book series: Methods in Molecular Biology, v. 1524
Ma, Hoi Tang; Poon, Randy Yat Choi

Conference paper 3

Regulation of mitosis by the AAA+ATPase TRIP13
Workshop on Mitotic Fidelity, Hong Kong, 22 Sep 2017
Poon, Randy Yat Choi
Spindle-assembly checkpoint activation: the role of TRIP13 and MAD2 conformation equilibrium
Cell cycle inside out, Conférences Jacques Monod, Roscoff, France, 18-22 Sep 2017
Ma, Hoi Tang; Poon, Randy Yat Choi
Synthetic Lethality Induced by Pharmacological Inhibition of ATM and PARP1
Molecular Cancer Research, v. 15, (4) Supplement, April 2017, article number A20
Mak, Joyce P.Y.; Poon, Randy Y C


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Article 3

BCL-W is a Regulator of Microtubule Inhibitor-induced Mitotic Cell Death
Oncotarget, v. 7, (25), May 2016, p. 38718-38730
Huang, Shan; Tang, Rui; Poon, Randy Y. C.
MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation
Scientific Reports, v. 6, 2016, article number 22230
Wong, Po Yee; Ma, Hoi Tang; Lee, Hyun-jung; Poon, Randy Y.C.
TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint
Cell Reports, v. 14, (5), February 2016, p. 1086-1099
Ma, Hoitang; Poon, Randy Yat Choi

Book chapter 2

Cell Cycle Control: A System of Interlinking Oscillators
Cell Cycle Oscillators: Methods and Protocols / Edited by Amanda S. Coutts, Louise Weston. New York : Humana Press, 2016, p. 3-19, Ch. 1. Book Series: Methods in Molecular Biology, v. 1342
Poon, Randy Y.C.
Mitotic Catastrophe
Encyclopedia of Cell Biology / Ralph A. Bradshaw, Philip D. Stahl, editors. Academic Press, 2016, p. 399-403
Poon, Randy Yat Choi

Conference paper 2

Synergism between the Pharmacological Inhibition of PARP1 and ATM Involves Targeting Major DNA Damage Repair Pathways
2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The Chinese University of Hong Kong, Hong Kong, 11 June 2016
Mak, Joyce P.Y.; Poon, Randy Y.C.
TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint
Cold Spring Harbor Laboratory Meeting & Courses Program on The Cell Cycle, NY, USA, 17-21 May 2016
Ma, Hoi Tang; Poon, Randy Y.C.


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Article 5

Cell Cycle Control
Reference Module in Biomedical Sciences, 2015
Poon, Randy Y.C.
Co-inhibition of polo-like kinase 1 and aurora kinases promotes mitotic catastrophe
Oncotarget, v. 6, (11), April 2015, p. 9327-9340
Li, Jingjing; Hong, Myungjin; Chow, Jeremy Pak Hong; Man, Wingyu; Mak, Joyce Pui Ying; Ma, Hoi Tang; Poon, Randy Yat Choi
Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells
Oncotarget, v. 6, (25), 2015, p. 21074-21084
Mak, Joyce Pui Ying; Man, Wingyu; Chow, Jeremy Pak Hong; Ma, Hoitang; Poon, Randy Yat Choi
SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A-B56
Cell Cycle, v. 14, (24), January 2015, p. 3965-3977
Wong, Wing Ki; Kelly, Terrenz; Li, Jingjing; Ma, Hoi Tang; Poon, Randy Yat Choi
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair
Molecular Cell, v. 60, (1), 2015, p. 163-176
Xie, Si; Mortusewicz, Oliver; Ma, Hoi Tang; Herr, Patrick; Poon, Randy Yat Choi; Helleday, Thomas; Qian, Chengmin

Conference paper 6

Drug targets in mitosis
HKUST-Peking University Shenzhen Graduate School Joint Symposium, Shenzhen, 14 March 2015
Poon, Randy Y.C.
Exiting mitosis: how the spindle-assembly checkpoint is turned off
Hong Kong-San Diego Workshop on Signaling, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 30 October 2015
Poon, Randy Y.C.
Molecular regulation of mitotic slippage
Hong Kong Inter-University Postgraduate Symposium on Life Science, IAS, HKUST, Clear Water Bay, Hong Kong, 23 May 2015
Xu, K.; Poon, Randy Y.C.
Multiple anti-apoptotic BCL-2-like proteins determine antimitotic drug-mediated cell fates
EACR-AACR-SIC Special Conference on Anticancer Drug Action and Drug Resistance: From Cancer Biology to the Clinic, Florence, Italy, 20-23 June 2015
Huang, Shan; Poon, Randy Y.C.
The role of MASTL in G2 DNA damage checkpoint
Hong Kong Inter-University Postgraduate Symposium, Hong Kong, 23 May 2015
Wong, Po Yee; Ma, Hoi Tang; Lee, H.J.; Poon, Randy Y.C.
Turning off the spindle-assembly checkpoint
IAS Focused Program on Genome Damage and Stability, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 16-19 December 2015
Poon, Randy Y.C.


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Article 8

DNA damage checkpoints in nasopharyngeal carcinoma
Oral Oncology, v. 50, (5), 2014, p. 339-344
Poon, Randy Yat Choi
Dovitinib induces mitotic defects and activates the G(2) DNA damage checkpoint
Journal of Cellular and Molecular Medicine, v. 18, (1), January 2014, p. 143-155
Man, Wing Yu; Mak, Joyce Pui Ying; Poon, Randy Yat Choi
G1 checkpoint establishment in vivo during embryonic liver development
BMC Developmental Biology, v. 14, (1), May 2014, article number 23
Wang, Xiao Qi; Chan, Kwok Kin; Ming, Xiaoyan; Lui, Vincent C.H.; Poon, Randy Y C; Lo, Chung Mau; Norbury, Chris; Poon, Ronnie T.P.
Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes
Biosensors and Bioelectronics, v. 61, November 2014, p. 434-442
Xing, Xiaoxing; Poon, Randy Yat Choi; Wong, Cesar; Yobas, Levent
p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases
Oncogene, v. 33, (27), July 2014, p. 3550-3560
Marxer, Miriam; Ma, Hoi Tang; Man, Wingyu; Poon, Randy Yat Choi
Pharmacological targeting the ATR-CHK1-WEE1 axis involves balancing cell growth stimulation and apoptosis
Oncotarget, v. 5, (21), November 2014, p. 10546-10557
Mak, Joyce Pui Ying; Man, Wingyu; Ma, Hoi Tang; Poon, Randy Yat Choi
Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death
Cell Death and Disease, v. 5, (4), 2014, article number e1177
Chen, Han; Huang, Shan; Han, Xianxian; Zhang, Junyi; Shan, Changliang; Tsang, Yiu Huen; Ma, Hoi Tang; Poon, Randy Yat Choi
Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance
Molecular Oncology, v. 8, (8), December 2014, p. 1404-1418
Ma, Hoi Tang; Erdal, Sergio; Huang, Shan; Poon, Randy Yat Choi

Conference paper 4

BCL-2 family in mitotic cell death and genome instability
2014 Genomic Instability Gordon Research Conference, The Hong Kong University of Science and Technology, Hong Kong, 6-11 July 2014
Huang, Shan; Ma, Hoi Tang; Poon, Randy Yat Choi
DNA damage checkpoints and NPC
The Croucher Foundation? Advanced Study Institute? -? Advances in Nasopharyngeal Carcinoma Studies, Hong Kong, 1-4 November 2014
Poon, Randy Yat Choi
Imaging mitosis: understanding cell fates following antimitotic drug challenge
The 7th Asian Pacific Organization for Cell Biology Congress and American Society for Cell Biology Workshops, Biopolis, Singapore, 24-27 February 2014
Poon, Randy Yat Choi
Mitotic catastrophe: mechanisms and anticancer potential
Asia GenomeCheck Symposium, Ajou University, Suwon, Korea, 6-7 Mar 2014
Poon, Randy Yat Choi


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Article 4

Aurora B: Hooking up with Cyclin-dependent Kinases
Cell Cycle, v. 12, (7), April 2013
Poon, Randy Yat Choi
Critical Differences between Isoforms of Securin Reveal Mechanisms of Separase Regulation
Molecular and Cellular Biology, v. 33, (17), 2013, p. 3400-3415
Han, Xianxian; Poon, Randy Yat Choi
PARP1 Is Overexpressed in Nasopharyngeal Carcinoma and Its Inhibition Enhances Radiotherapy
Molecular Cancer Therapeutics, v. 12, (11), 2013, p. 2517-2528
Chow, Jeremy Pak Hong; Man, Wingyu; Mao, Mao; Chen, Han; Cheung, Florence; Nicholls, John M.; Tsao, Sai Wah; Lung, Maria Li; Poon, Randy Yat Choi
The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery
Oncogene, v. 32, (40), October 2013, p. 4778-4788
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi

Conference paper 4

Abrogation of the G2 DNA Damage Checkpoint and Mitotic Catastrophe
Cycling to Death: EMBO International Workshop on Cell Death, DNA-damage and Cell Cycle Control, Obergurgl, Austria, 23-27 January 2013
Poon, Randy Yat Choi
Checkpoint Abrogation and Mitotic Catastrophe: Mechanism and Therapeutic Potential
Symposium on Biomedical Research across the Continents—Insight and Innovation, The Hong Kong University of Science and Technology, 7-8 March 2013
Poon, Randy Yat Choi
Interplay between Aurora kinase A and the kinesin protein Eg5 in Bipolar Spindle Formation
EMBO Workshop: 'Chromosome Segregation and Aneuploidy', Breukelen, The Netherlands, 22-26 June 2013
Ma, Hoi Tang; Erdal, Sergio; Poon, Randy Yat Choi
Mitotic Components as Anticancer Drug Targets
The 2nd HKUST-University of the Philippines Symposium, HKUST, Hong Kong, 6-7 December 2013
Poon, Randy Yat Choi


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Article 4

Depletion of p31(comet) Protein Promotes Sensitivity to Antimitotic Drugs
Journal of biological chemistry, v. 287, (25), June 2012, p. 21561-21569
Ma, Hoi Tang; Chan, Yan Yan; Chen, Xiao; On, Kin Fan; Poon, Randy Yat Choi
Inhibition of Eg5 Acts Synergistically with Checkpoint Abrogation in Promoting Mitotic Catastrophe
Molecular cancer research, v. 10, (5), May 2012, p. 626-635
Chen, Yue; Chow, Jeremy Pak Hong; Poon, Randy Yat Choi
Novel Functions of the Phosphatase SHP2 in the DNA Replication and Damage Checkpoints
PLoS ONE, v. 7, (11), November 2012, Article number e49943
Tsang, Yiu Huen; Han, Xianxian; Man, Wingyu; Lee, Nelson Tsz Kin; Poon, Randy Yat Choi
Tetraploidization increases sensitivity to Aurora B kinase inhibition
Cell cycle, v. 11, (13), July 2012, p. 2567-2577
Marxer, Miriam; Foucar, Charles Elliott; Man, Wingyu; Chen, Yu; Ma, Hoi Tang; Poon, Randy Yat Choi

Book chapter 1

Cyclin A
Encyclopedia of Signalling Molecules / Edited by Sangdun Choi. Springer, New York, 2012, p. 491-496
Poon, Randy Yat Choi

Conference paper 1

Mitotic catastrophe: mechanisms and therapeutic potential
The 71st Annual Meeting of the Japanese Cancer Association, Sapporo, Japan, 19-21 Sep 2012
Poon, Randy Yat Choi


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Article 6

Biomedical research in Hong Kong
The biochemist, v. 33, (5), 2011, p. 24-25
Poon, Randy Yat Choi
Determinants of Mitotic Catastrophe on Abrogation of the G(2) DNA Damage Checkpoint by UCN-01
Molecular cancer therapeutics, v. 10, (5), May 2011, p. 784-794
On, Kin Fan; Chen, Yue; Ma, Hoi Tang; Chow, Jeremy Pak Hong; Poon, Randy Yat Choi
How protein kinases co-ordinate mitosis in animal cells
Biochemical journal, v. 435, (1), April 2011, p. 17-31
Ma, Hoi Tang; Poon, Randy Yat Choi
Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit
Molecular and cellular biology, v. 31, (7), 2011, p. 1478-1491
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi; Ma, Hoi Tang
Orderly Inactivation of the Key Checkpoint Protein Mitotic Arrest Deficient 2 (MAD2) during Mitotic Progression
Journal of biological chemistry, v. 286, (15), April 2011, p. 13052-13059
Ma, Hoi Tang; Poon, Randy Yat Choi
SCF(beta TrCP) mediates stress-activated MAPK-induced Cdc25B degradation
Journal of cell science, v. 124, (16), 2011, Aug, p. 2816-2825
Uchida, Sanae; Watanabe, Nobumoto; Kudo, Yasusei; Yoshioka, Katsuji; Matsunaga, Tsukasa; Ishizaka, Yukihito; Nakagama, Hitoshi; Poon, Randy Y C; Yamashita, Katsumi

Book chapter 1

Synchronization of HeLa Cells
Cell Cycle Synchronization: Methods and Protocols / Edited by: Gaspar Banfalvi. New York : Humana Press, Springer, 2011, p. 151-161, Part of the Methods in Molecular Biology book series (MIMB, volume 761)
Ma, Hoi Tang; Poon, Randy Y.C.

Conference paper 3

Genome-wide identification of novel mitotic kinases
Functional phosphoproteomics in study of plant cell signaling and molecular system biology, Hong Kong, 3-7 Jan 2011
Poon, Randy Yat Choi
Identifying novel kinases involved in mitotic progression using kinome-wide screens
Annual Meeting of the American-Society-for-Cell-Biology (ASCB), Denver, CO, USA, 3-7 Dec 2011, v. 22, 2011
Chen, H.; Ma, Hoi Tang; Tsang, Y.; Cheung, C.; Ng, S.S.; Zhang, J.; Poon, Randy Yat Choi
The CDK1 inhibitory kinase MYT1 in checkpoint recovery
Cell Cycle Cancer and Development, Saint-Malo, France, 25-28 May 2011
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi


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Article 3

Gene down-regulation with short hairpin RNAs and validation of specificity by inducible rescue in mammalian cells
Current protocols in cell biology, (SUPPL.49), 2010, Article number 27.2
Ma, Hoi Tang; Poon, Randy Yat Choi
Genome reduplication Redeployment of cyclin-CDK complexes and spontaneous oscillation of APC/C
Cell cycle, v. 9, (3), February 2010, p. 431-432
Ma, Hoi Tang; Poon, Randy Yat Choi
The requirement of p53 for maintaining chromosomal stability during tetraploidization
Oncotarget, v. 1, (7), 2010, p. 583-595
Ho, Chui Chui; Hau, Pok Man; Marxer, Miriam; Poon, Randy Yat Choi

Book 1

Polyploidization and cancer
Advances in Experimental Medicine and Biology - Polyploidization and cancer /Randy Yat Choi Poon. Springer-Verlag, New York, US, v. 676, 2010
Poon, Randy Yat Choi

Book chapter 1

DNA Damage and Polyploidization
Polyploidization and cancer - Advances in Experimental Medicine and Biology / Edited by Randy Yat Choi Poon. Springer, Berlin, Germany, v. 676, 2010, p. 57-71
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi

Conference paper 2

Dissociation of MAD2 from APC/C and mitotic checkpoint complex are differentially regulated upon checkpoint satisfaction
Jacques Monod Conference: Cell division: time and space, Roscoff, France, 11-15 Sep 2010
Ma, Hoi Tang; Poon, Randy Yat Choi
Mitotic-specific checkpoints and genome instability
Biochemistry and Molecular Biology 2010 (BMB2010) Symposium, Kobe, Japan, 7-10 Dec 2010
Poon, Randy Yat Choi


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Article 4

Cyclin A2-Cyclin-Dependent Kinase 2 Cooperates with the PLK1-SCF beta-TrCP1-EMI1-Anaphase-Promoting Complex/Cyclosome Axis To Promote Genome Reduplication in the Absence of Mitosis
Molecular and cellular biology, v. 29, (24), 2009, Dec, p. 6500-6514
Ma, Hoi Tang; Tsang, Yiu Huen; Marxer, Miriam; Poon, Randy Yat Choi
DNA Damage Mediated S and G(2) Checkpoints in Human Embryonal Carcinoma Cells
Stem cells, v. 27, (3), 2009, p. 568-576
Wang, Xiaoqi; Lui, Vincent C.H.; Poon, Ronnie T.P.; Lu, Ping; Poon, Randy Yat Choi
Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe
Oncogene, v. 28, (2), 2009, JAN, p. 170-183
Chan, Ying Wai; Chen, Yue; Poon, Randy Yat Choi
Stress-Activated Mitogen-Activated Protein Kinases c-Jun NH2-Terminal Kinase and p38 Target Cdc25B for Degradation
Cancer research, v. 69, (16), 2009, AUG, p. 6438-6444
Uchida, Sanae; Yoshioka, Katsuji; Kizu, Ryoichi; Nakagama, Hitoshi; Matsunaga, Tsukasa; Ishizaka, Yukihito; Poon, Randy Yat Choi; Yamashita, Katsumi

Conference paper 5

Genome reduplication: promotion of replication by EMI1-dependent oscillation of APC/C activity in the absence of mitosis
The 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology, Shanghai, China, 2-7 Aug 2009
Ma, Hoi Tang; Tsang, Yiu Huen; Marxer, Miriam; Poon, Randy Yat Choi
Genome reduplication: the role of the PLK1-betaTrCP-EMI1-APC/C axis in genome instability
The IMCB and the 12th Australian Cell Cycle Workshop: Cell Cycle Regulation and Tumorigenesis Symposium, Singapore, 7-8 Sep 2009
Poon, Randy Yat Choi
The role of CDC20 and CDK1 inhibitory phosphorylation in mitotic exit
The IMCB and the 12th Australian Cell Cycle Workshop: Cell Cycle Regulation and Tumorigenesis Symposium, Singapore, 7-8 Sep 2009
Chow, Jeremy Pak Hong; Ma, Hoi Tang; Poon, Randy Yat Choi
The role of cyclin B in cyclin A degradation
The IMCB and the 12th Australian Cell Cycle Workshop: Cell Cycle Regulation and Tumorigenesis Symposium, Singapore 7-8 Sep 2009
Ma, Hoi Tang; Marxer, Miriam; Poon, Randy Y.C.
Uncoupling of mitosis and genome instability
Frontiers in Biomedical Research, University of Hong Kong, Hong Kong, 4 Dec 2009
Poon, Randy Yat Choi


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Article 3

CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis
Cell cycle, v. 7, (10), 2008, May, p. 1449-1461
Chan, Ying Wai; Ma, Hoi Tang; Wong, Winnie; Ho, Chui Chui; On, Kin Fan; Poon, Randy Yat Choi
The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint
Journal of biological chemistry, v. 283, (23), 2008, JUN, p. 15716-15723
Chan, Ying Wai; On, Kin Fan; Chan, Wan Mui; Wong, Winnie; Siu, Ho On; Hau, Pok Man; Poon, Randy Yat Choi
The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability
Frontiers in bioscience, v. 13, (13), 2008, p. 5016-5029
Chen, Yue; Poon, Randy Yat Choi

Conference paper 1

Precise regulation of A- and B-type cyclins is required to ensure chromosomal stability
Cell Cycle and Cancer 2008, Toulouse, France, 25-28 Mar 2008
Ma, Hoi Tang; Fung, Tsz Kan; Lau, Pui Ngan; Poon, Randy Yat Choi


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Article 5

An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells
Nucleic acids research, v. 35, (4), 2007, FEB, Article number e22
Ma, Hoi Tang; On, Kin Fan; Tsang, Yiu Huen; Poon, Randy Yat Choi
BS69 is involved in cellular senescence through the p53-p21Cip1 pathway
EMBO reports, v. 8, (10), 2007, October, p. 952-958
Zhang, Wei; Chan, Homan; Gao, Yan; Poon, Randy Yat Choi; Wu, Zhenguo
Mitotic phosphorylation: breaking the balance of power by a tactical retreat
The biochemical journal, v. 403, (2), April 2007, p. e5-7
Poon, Randy Yat Choi
Specialized roles of the two mitotic cyclins in somatic cells: Cyclin a as an activator of m phase-promoting factor
Molecular biology of the cell, v. 18, (5), 2007, MAY, p. 1861-1873
Fung, Tsz Kan; Ma, Hoi Tang; Poon, Randy Yat Choi
The p53 isoform Delta p53 lacks intrinsic transcriptional activity and reveals the critical role of nuclear import in dominant-negative activity
Cancer research, v. 67, (5), 2007, MAR, p. 1959-1969
Chan, Wan Mui; Poon, Randy Yat Choi

Conference paper 3

Cell cycle checkpoints in the maintenance of genome stability
12th Medical Research Conference, Faculty of Medicine Building, University of Hong Kong, Pok Fu Lam, Hong Kong, 3 Feb 2007
Poon, Randy Yat Choi
Cell cycle control and genome instability
Annual Research Day, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 24 Feb 2007
Poon, Randy Yat Choi
Different mitotic cyclin isoforms contribute differentially to mitosis
Cell Regulations in Division and Arrest, Okinawa Institute of Science and Technology, Okinawa, Japan, 25-29 March, 2007
Poon, Randy Yat Choi


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Article 3

Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells
FEBS letters, v. 580, (19), 2006, AUG, p. 4727-4736
Hau, Pok Man; Siu, Wai Yi; Wong, Nathalie; Lai, Paul B.S.; Poon, Randy Yat Choi
Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways
Cancer research, v. 66, (4), 2006, FEB, p. 2233-2241
Ho, Chui Chui; Siu, Wai Yi; Lau, Anita Wan Sze; Chan, Wan Mui; Arooz, Talha; Poon, Randy Yat Choi
Ubiquitination of p53 at multiple sites in the DNA-binding domain
Molecular cancer research, v. 4, (1), 2006, JAN, p. 15-25
Chan, Wan Mui; Mak, Man Chi; Fung, Tsz Kan; Lau, Anita Wan Sze; Siu, Wai Yi; Poon, Randy Yat Choi

Conference paper 3

Mitotic catastrophe: life and death during mitosis
Frontiers in Biomedical Research Conference, University of Hong Kong, Hong Kong, 8 Dec 2006
Poon, Randy Yat Choi
Regulation of p53 by ribosomal S6 kinase 4
The 13th International p53 conference, Columbia University, New York, USA, 20-24 May 2006
Chan, W.M.; Yeung, W.; Poon, Randy Yat Choi
The role of cyclin A-CDK complexes as activators of M phase-promoting factor
Croucher Advanced Study Institute: Signaling in cell growth and differentiation. HKUST, Hong Kong, 16-20 Jan 2006, v. 15, (1), 2006, p. 48
Poon, Randy Yat Choi


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Article 3

A roller coaster ride with the mitotic cyclins
Seminars in cell & developmental biology, v. 16, (3), 2005, p. 335-342
Fung, Tsz Kan; Poon, Randy Yat Choi
The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites
Cell Cycle, v. 4, (10), 2005, p. 1411-1420
Fung, Tsz Kan; Yam, Cain H.; Poon, Randy Yat Choi
The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint
Experimental cell research, v. 304, (1), 2005, MAR, p. 1-15
Ho, Chui Chui; Siu, Wai Yi; Chow, Jeremy Pak Hong; Lau, Anita Wan Sze; Arooz, Talha; Tong, Hoi Yee; Ng, Irene O.L.; Poon, Randy Yat Choi


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Article 6

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation
Genes & development, v. 18, (11), 2004, June, p. 1317-1330
Woo, Richard A.; Poon, Randy Yat Choi
Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains
Journal of biological chemistry, v. 279, (10), 2004, MAR, p. 8808-8819
Ng, Chuen Pei; Lee, Hung Chiu; Ho, Chung Wai; Arooz, Talha; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi
Gene mutations and aneuploidy - The instability that causes cancer
Cell cycle, v. 3, (9), 2004, SEP, p. 1101-1103
Woo, Richard A.; Poon, Randy Yat Choi
How many mutant p53 molecules are needed to inactivate a tetramer?
Molecular and Cellular Biology, v. 24, (8), April 2004, p. 3536-3551
Chan, Wan Mui; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi
Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia
Biochemical journal, v. 383, (1), 2004, OCT, p. 27-35
Cheung, Ngai; So, Chi Wai; Yam, Judy W.P.; So, Cary K.C.; Poon, Randy Yat Choi; Jin, Dong-Yan; Chan, Li Chong
Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms
Molecular cancer therapeutics, v. 3, (5), 2004, MAY, p. 621-632
Siu, Wai Yi; Lau, Anita Wan Sze; Arooz, Talha; Chow, Jeremy Pak Hong; Ho, H.T.B.; Poon, Randy Yat Choi

Conference paper 2

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation
7th Cancer Research UK Beatson International Cancer Conference: Cell cycle, senescence, apoptosis and cancer, Glasgow, Scotland, v. 18, (11), 2004, June, p. 1317-1330
Woo, Richard A.; Poon, Randy Yat Choi
DNA replication checkpoint and p53
DNA Replication and Genome Integrity Meeting, The Salk Institute for Biological Studies, La Jolla, USA, 11-15 August 2004
Ho, Chui Chui; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi


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Article 4

Cyclin-dependent kinases and S phase control in mammalian cells.
Cell cycle (Georgetown, Tex.), v. 2, (4), 2003, p. 316-324
Woo, Richard A.; Poon, Randy Yat Choi
Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints
Journal of biological chemistry, v. 278, (42), 2003, OCT, p. 40815-40828
Chow, Jeremy Pak Hong; Siu, Wai Yi; Ho, H.T.B.; Ma, Hoi Tang; Ho, Chui Chui; Poon, Randy Yat Choi
DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase
Molecular biology of the cell, v. 14, (10), 2003, OCT, p. 3989-4002
Chow, Jeremy Pak Hong; Siu, Wai Yi; Fung, Tsz Kan; Chan, Wan Mui; Lau, Anita Wan Sze; Arooz, Talha; Ng, Chuen Pei; Yamashita, Katsumi; Poon, Randy Yat Choi
ING1b decreases cell proliferation through p53-dependent and -independent mechanisms
FEBS letters, v. 553, (3), 2003, OCT, p. 277-285
Tsang, Fan Cheung; Po, Laisee; Leung, Kaman; Lau, Anita Wan Sze; Siu, Wai Yi; Poon, Randy Yat Choi


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Article 4

Activation of cyclin-dependent kinases CDC2 and CDK2 in hepatocellular carcinoma
Liver, v. 22, (3), 2002, June, p. 259-268
Li, Kay K.W.; Ng, Irene O.L.; Fan, Sheung Tat; Albrecht, Jeffrey H.; Yamashita, Katsumi; Poon, Randy Yat Choi
Cyclin F is degraded during G(2)-M by mechanisms fundamentally different from other cyclins
Journal of biological chemistry, v. 277, (38), 2002, Sep, p. 35140-35149
Fung, Tsz Kan; Siu, Wai Yi; Yam, Cain H.; Lau, Anita Wan Sze; Poon, Randy Yat Choi
Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells
Journal of cell science, v. 115, (17), 2002, SEP, p. 3479-3490
Graeser, Ralph; Gannon, Julian V.; Poon, Randy Yat Choi; Dubois, Thierry; Aitken, Alastair; Hunt, Tim W.
The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2
Cancer Research, v. 62, (17), 2002, p. 4890-4893
Leung, Kaman; Po, Laisee; Tsang, Fan Cheung; Siu, Wai Yi; Lau, Anita Wan Sze; Ho, H.T.B.; Poon, Randy Yat Choi

Book chapter 1

Cell Cycle Control
Encyclopedia of Cancer / Edited by Bertino, J.R.. San Diego, US: Academic Press, 2002, p. 393-404
Poon, Randy Yat Choi

Conference paper 1

Proteolysis of cyclins during G2-M by ubiquitination-dependent and independent pathways
28th Federation of European Biochemical Societies Meeting, Istanbul, Turkey, 20-25 October 2002
Poon, Randy Yat Choi


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Article 3

A possible role of p73 on the modulation of p53 level through MDM2
Cancer research, v. 61, (4), 2001, FEB, p. 1598-1603
Wang, Xiaoqian; Ongkeko, Weg M.; Lau, Anita Wan Sze; Leung, Kaman; Poon, Randy Yat Choi
Cleavage of cyclin A at R70/R71 by the bacterial protease OmpT
Proceedings of the National Academy of Sciences of the United States of America, v. 98, (2), 2001, Jan, p. 497-501
Yam, Cain H.; Siu, Wai Yi; Kaganovich, Daniel; Ruderman, Joan V.; Poon, Randy Yat Choi
MDM2 and MDMX can interact differently with ARF and members of the p53 family
FEBS letters, v. 490, (3), 2001, FEB, p. 202-208
Wang, Xiaoqi; Arooz, Talha; Siu, Wai Yi; Chiu, Clarissa H.S.; Lau, Anita Wan Sze; Yamashita, Katsumi; Poon, Randy Yat Choi

Conference paper 2

Regulation of the DNA damage checkpoints by cyclin-dependent kinases and p53-dependent pathways
The 4th Conference of Asia-Pacific Molecular Biology Network, Taipei, Taiwan, Nov 2011
Poon, Randy Yat Choi
The contribution of human WEE1 to normal cell cycle control and DNA damage checkpoint
EMBO workshop on G2/M progression and associated checkpoints, EMBO, Salamanca, Spain, 6–9 September 2001
Arooz, Talha; Chan, H.Y.; Siu, Wai Yi; Lau, Anita Wan Sze; Yam, Cain H.; Hunter, Tony R.; Watanabe, N.; Poon, Randy Yat Choi


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Article 4

Degradation of cyclin a does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2
Journal of biological chemistry, v. 275, (5), 2000, Feb, p. 3158-3167
Yam, Cain H.; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi
On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells
Biochemistry, v. 39, (31), 2000, AUG, p. 9494-9501
Arooz, Talha; Yam, Cain H.; Siu, Wai Yi; Lau, Anita Wan Sze; Li, Kay K.W.; Poon, Randy Yat Choi
p21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells
Journal of cell biology, v. 149, (2), 2000, APR, p. 281-292
Mal, Asoke K.; Chattopadhyay, Debasish; Ghosh, Mrinal Kanti Anti; Poon, Randy Yat Choi; Hunter, Tony R.; Harter, Marian L.
The spindle checkpoint in the dinoflagellate Crypthecodinium cohnii
Experimental cell research, v. 254, (1), 2000, JAN, p. 120-129
Yeung, Patrick Ka Kit; New, David C.; Leveson, Alexis C.; Yam, Cain H.; Poon, Randy Yat Choi; Wong, Joseph Tin Yum


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Article 5

Differential responses of proliferating versus quiescent cells to adriamycin
Experimental cell research, v. 250, (1), 1999, Jul, p. 131-141
Siu, Wai Yi; Arooz, Talha; Poon, Randy Yat Choi
G1 versus G2 cell cycle arrest after adriamycin-induced damage in mouse Swiss3T3 cells
FEBS letters, v. 461, (3), 1999, NOV, p. 299-305
Siu, Wai Yi; Yam, Cain H.; Poon, Randy Yat Choi
MDM2 and MDMX bind and stabilize the p53-related protein p73
Current biology, v. 9, (15), 1999, JUL, p. 829-832
Ongkeko, Weg M.; Wang, Xiaoqian; Siu, Wai Yi; Lau, Anita Wan Sze; Yamashita, Katsumi; Harris, Adrian; Cox, Lynne S.; Poon, Randy Yat Choi
MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins
Cancer research, v. 59, (20), 1999, OCT, p. 5075-5078
Yam, Cain H.; Siu, Wai Yi; Arooz, Talha; Chiu, Clarissa H.S.; Lau, Anita Wan Sze; Wang, Xiaoqian; Poon, Randy Yat Choi
Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2
Molecular and cellular biology, v. 19, (1), 1999, JAN, p. 635-645
Yam, Cain H.; Ng, Raymond Wai Man; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi


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Article 3

Characterization of the cullin and F-box protein partner Skp1
FEBS letters, v. 438, (3), 1998, November, p. 183-189
Ng, Raymond Wai Man; Arooz, Talha; Yam, Cain H.; Chan, Iris W.Y.; Lau, Anita Wan Sze; Poon, Randy Yat Choi
Expression of a novel form of p21(Cip1/Waf1) in UV-irradiated and transformed cells
Oncogene, v. 16, (10), 1998, MAR, p. 1333-1343
Poon, Randy Yat Choi; Hunter, Tony R.
Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver
Oncogene, v. 16, (16), 1998, APR, p. 2141-2150
Albrecht, Jeffrey H.; Poon, Randy Yat Choi; Ahonen, Cory L.; Rieland, Brenda M.; Deng, Chuxia; Crary, Gretchen S.


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Article 4

Cdc37: A protein kinase chaperone?
Trends in cell biology, v. 7, (4), 1997, April, p. 157-161
Hunter, Tony R.; Poon, Randy Yat Choi
Generation of phosphorylated cyclin-dependent kinase 2 and functional characterization of threonine-160-specific phosphatase KAP
Methods in enzymology, v. 283, 1997, p. 283-292
Poon, Randy Yat Choi
Identification of functional domains in the neuronal Cdk5 activator protein
Journal of Biological Chemistry, v. 272, (9), 1997, p. 5703-5708
Poon, Randy Yat Choi; Lew, John; Hunter, Tony R.
The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells
Cancer research, v. 57, (22), 1997, NOV, p. 5168-5178
Poon, Randy Yat Choi; Chau, Man Sang; Yamashita, Katsumi; Hunter, Tony R.


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2016 7

BCL-W is a Regulator of Microtubule Inhibitor-induced Mitotic Cell Death
Oncotarget, v. 7, (25), May 2016, p. 38718-38730
Huang, Shan; Tang, Rui; Poon, Randy Y. C. Article
MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation
Scientific Reports, v. 6, 2016, article number 22230
Wong, Po Yee; Ma, Hoi Tang; Lee, Hyun-jung; Poon, Randy Y.C. Article
TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint
Cell Reports, v. 14, (5), February 2016, p. 1086-1099
Ma, Hoitang; Poon, Randy Yat Choi Article
Cell Cycle Control: A System of Interlinking Oscillators
Cell Cycle Oscillators: Methods and Protocols / Edited by Amanda S. Coutts, Louise Weston. New York : Humana Press, 2016, p. 3-19, Ch. 1. Book Series: Methods in Molecular Biology, v. 1342
Poon, Randy Y.C. Book chapter
Mitotic Catastrophe
Encyclopedia of Cell Biology / Ralph A. Bradshaw, Philip D. Stahl, editors. Academic Press, 2016, p. 399-403
Poon, Randy Yat Choi Book chapter
Synergism between the Pharmacological Inhibition of PARP1 and ATM Involves Targeting Major DNA Damage Repair Pathways
2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The Chinese University of Hong Kong, Hong Kong, 11 June 2016
Mak, Joyce P.Y.; Poon, Randy Y.C. Conference paper
TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint
Cold Spring Harbor Laboratory Meeting & Courses Program on The Cell Cycle, NY, USA, 17-21 May 2016
Ma, Hoi Tang; Poon, Randy Y.C. Conference paper

2015 11

Cell Cycle Control
Reference Module in Biomedical Sciences, 2015
Poon, Randy Y.C. Article
Co-inhibition of polo-like kinase 1 and aurora kinases promotes mitotic catastrophe
Oncotarget, v. 6, (11), April 2015, p. 9327-9340
Li, Jingjing; Hong, Myungjin; Chow, Jeremy Pak Hong; Man, Wingyu; Mak, Joyce Pui Ying; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells
Oncotarget, v. 6, (25), 2015, p. 21074-21084
Mak, Joyce Pui Ying; Man, Wingyu; Chow, Jeremy Pak Hong; Ma, Hoitang; Poon, Randy Yat Choi Article
SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A-B56
Cell Cycle, v. 14, (24), January 2015, p. 3965-3977
Wong, Wing Ki; Kelly, Terrenz; Li, Jingjing; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair
Molecular Cell, v. 60, (1), 2015, p. 163-176
Xie, Si; Mortusewicz, Oliver; Ma, Hoi Tang; Herr, Patrick; Poon, Randy Yat Choi; Helleday, Thomas; Qian, Chengmin Article
Drug targets in mitosis
HKUST-Peking University Shenzhen Graduate School Joint Symposium, Shenzhen, 14 March 2015
Poon, Randy Y.C. Conference paper
Exiting mitosis: how the spindle-assembly checkpoint is turned off
Hong Kong-San Diego Workshop on Signaling, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 30 October 2015
Poon, Randy Y.C. Conference paper
Molecular regulation of mitotic slippage
Hong Kong Inter-University Postgraduate Symposium on Life Science, IAS, HKUST, Clear Water Bay, Hong Kong, 23 May 2015
Xu, K.; Poon, Randy Y.C. Conference paper
Multiple anti-apoptotic BCL-2-like proteins determine antimitotic drug-mediated cell fates
EACR-AACR-SIC Special Conference on Anticancer Drug Action and Drug Resistance: From Cancer Biology to the Clinic, Florence, Italy, 20-23 June 2015
Huang, Shan; Poon, Randy Y.C. Conference paper
The role of MASTL in G2 DNA damage checkpoint
Hong Kong Inter-University Postgraduate Symposium, Hong Kong, 23 May 2015
Wong, Po Yee; Ma, Hoi Tang; Lee, H.J.; Poon, Randy Y.C. Conference paper
Turning off the spindle-assembly checkpoint
IAS Focused Program on Genome Damage and Stability, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 16-19 December 2015
Poon, Randy Y.C. Conference paper

2014 12

DNA damage checkpoints in nasopharyngeal carcinoma
Oral Oncology, v. 50, (5), 2014, p. 339-344
Poon, Randy Yat Choi Article
Dovitinib induces mitotic defects and activates the G(2) DNA damage checkpoint
Journal of Cellular and Molecular Medicine, v. 18, (1), January 2014, p. 143-155
Man, Wing Yu; Mak, Joyce Pui Ying; Poon, Randy Yat Choi Article
G1 checkpoint establishment in vivo during embryonic liver development
BMC Developmental Biology, v. 14, (1), May 2014, article number 23
Wang, Xiao Qi; Chan, Kwok Kin; Ming, Xiaoyan; Lui, Vincent C.H.; Poon, Randy Y C; Lo, Chung Mau; Norbury, Chris; Poon, Ronnie T.P. Article
Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes
Biosensors and Bioelectronics, v. 61, November 2014, p. 434-442
Xing, Xiaoxing; Poon, Randy Yat Choi; Wong, Cesar; Yobas, Levent Article
p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases
Oncogene, v. 33, (27), July 2014, p. 3550-3560
Marxer, Miriam; Ma, Hoi Tang; Man, Wingyu; Poon, Randy Yat Choi Article
Pharmacological targeting the ATR-CHK1-WEE1 axis involves balancing cell growth stimulation and apoptosis
Oncotarget, v. 5, (21), November 2014, p. 10546-10557
Mak, Joyce Pui Ying; Man, Wingyu; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death
Cell Death and Disease, v. 5, (4), 2014, article number e1177
Chen, Han; Huang, Shan; Han, Xianxian; Zhang, Junyi; Shan, Changliang; Tsang, Yiu Huen; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance
Molecular Oncology, v. 8, (8), December 2014, p. 1404-1418
Ma, Hoi Tang; Erdal, Sergio; Huang, Shan; Poon, Randy Yat Choi Article
BCL-2 family in mitotic cell death and genome instability
2014 Genomic Instability Gordon Research Conference, The Hong Kong University of Science and Technology, Hong Kong, 6-11 July 2014
Huang, Shan; Ma, Hoi Tang; Poon, Randy Yat Choi Conference paper
DNA damage checkpoints and NPC
The Croucher Foundation? Advanced Study Institute? -? Advances in Nasopharyngeal Carcinoma Studies, Hong Kong, 1-4 November 2014
Poon, Randy Yat Choi Conference paper
Imaging mitosis: understanding cell fates following antimitotic drug challenge
The 7th Asian Pacific Organization for Cell Biology Congress and American Society for Cell Biology Workshops, Biopolis, Singapore, 24-27 February 2014
Poon, Randy Yat Choi Conference paper
Mitotic catastrophe: mechanisms and anticancer potential
Asia GenomeCheck Symposium, Ajou University, Suwon, Korea, 6-7 Mar 2014
Poon, Randy Yat Choi Conference paper

2013 8

Aurora B: Hooking up with Cyclin-dependent Kinases
Cell Cycle, v. 12, (7), April 2013
Poon, Randy Yat Choi Article
Critical Differences between Isoforms of Securin Reveal Mechanisms of Separase Regulation
Molecular and Cellular Biology, v. 33, (17), 2013, p. 3400-3415
Han, Xianxian; Poon, Randy Yat Choi Article
PARP1 Is Overexpressed in Nasopharyngeal Carcinoma and Its Inhibition Enhances Radiotherapy
Molecular Cancer Therapeutics, v. 12, (11), 2013, p. 2517-2528
Chow, Jeremy Pak Hong; Man, Wingyu; Mao, Mao; Chen, Han; Cheung, Florence; Nicholls, John M.; Tsao, Sai Wah; Lung, Maria Li; Poon, Randy Yat Choi Article
The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery
Oncogene, v. 32, (40), October 2013, p. 4778-4788
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi Article
Abrogation of the G2 DNA Damage Checkpoint and Mitotic Catastrophe
Cycling to Death: EMBO International Workshop on Cell Death, DNA-damage and Cell Cycle Control, Obergurgl, Austria, 23-27 January 2013
Poon, Randy Yat Choi Conference paper
Checkpoint Abrogation and Mitotic Catastrophe: Mechanism and Therapeutic Potential
Symposium on Biomedical Research across the Continents—Insight and Innovation, The Hong Kong University of Science and Technology, 7-8 March 2013
Poon, Randy Yat Choi Conference paper
Interplay between Aurora kinase A and the kinesin protein Eg5 in Bipolar Spindle Formation
EMBO Workshop: 'Chromosome Segregation and Aneuploidy', Breukelen, The Netherlands, 22-26 June 2013
Ma, Hoi Tang; Erdal, Sergio; Poon, Randy Yat Choi Conference paper
Mitotic Components as Anticancer Drug Targets
The 2nd HKUST-University of the Philippines Symposium, HKUST, Hong Kong, 6-7 December 2013
Poon, Randy Yat Choi Conference paper

2012 6

Depletion of p31(comet) Protein Promotes Sensitivity to Antimitotic Drugs
Journal of biological chemistry, v. 287, (25), June 2012, p. 21561-21569
Ma, Hoi Tang; Chan, Yan Yan; Chen, Xiao; On, Kin Fan; Poon, Randy Yat Choi Article
Inhibition of Eg5 Acts Synergistically with Checkpoint Abrogation in Promoting Mitotic Catastrophe
Molecular cancer research, v. 10, (5), May 2012, p. 626-635
Chen, Yue; Chow, Jeremy Pak Hong; Poon, Randy Yat Choi Article
Novel Functions of the Phosphatase SHP2 in the DNA Replication and Damage Checkpoints
PLoS ONE, v. 7, (11), November 2012, Article number e49943
Tsang, Yiu Huen; Han, Xianxian; Man, Wingyu; Lee, Nelson Tsz Kin; Poon, Randy Yat Choi Article
Tetraploidization increases sensitivity to Aurora B kinase inhibition
Cell cycle, v. 11, (13), July 2012, p. 2567-2577
Marxer, Miriam; Foucar, Charles Elliott; Man, Wingyu; Chen, Yu; Ma, Hoi Tang; Poon, Randy Yat Choi Article
Cyclin A
Encyclopedia of Signalling Molecules / Edited by Sangdun Choi. Springer, New York, 2012, p. 491-496
Poon, Randy Yat Choi Book chapter
Mitotic catastrophe: mechanisms and therapeutic potential
The 71st Annual Meeting of the Japanese Cancer Association, Sapporo, Japan, 19-21 Sep 2012
Poon, Randy Yat Choi Conference paper

2011 10

Biomedical research in Hong Kong
The biochemist, v. 33, (5), 2011, p. 24-25
Poon, Randy Yat Choi Article
Determinants of Mitotic Catastrophe on Abrogation of the G(2) DNA Damage Checkpoint by UCN-01
Molecular cancer therapeutics, v. 10, (5), May 2011, p. 784-794
On, Kin Fan; Chen, Yue; Ma, Hoi Tang; Chow, Jeremy Pak Hong; Poon, Randy Yat Choi Article
How protein kinases co-ordinate mitosis in animal cells
Biochemical journal, v. 435, (1), April 2011, p. 17-31
Ma, Hoi Tang; Poon, Randy Yat Choi Article
Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit
Molecular and cellular biology, v. 31, (7), 2011, p. 1478-1491
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi; Ma, Hoi Tang Article
Orderly Inactivation of the Key Checkpoint Protein Mitotic Arrest Deficient 2 (MAD2) during Mitotic Progression
Journal of biological chemistry, v. 286, (15), April 2011, p. 13052-13059
Ma, Hoi Tang; Poon, Randy Yat Choi Article
SCF(beta TrCP) mediates stress-activated MAPK-induced Cdc25B degradation
Journal of cell science, v. 124, (16), 2011, Aug, p. 2816-2825
Uchida, Sanae; Watanabe, Nobumoto; Kudo, Yasusei; Yoshioka, Katsuji; Matsunaga, Tsukasa; Ishizaka, Yukihito; Nakagama, Hitoshi; Poon, Randy Y C; Yamashita, Katsumi Article
Synchronization of HeLa Cells
Cell Cycle Synchronization: Methods and Protocols / Edited by: Gaspar Banfalvi. New York : Humana Press, Springer, 2011, p. 151-161, Part of the Methods in Molecular Biology book series (MIMB, volume 761)
Ma, Hoi Tang; Poon, Randy Y.C. Book chapter
Genome-wide identification of novel mitotic kinases
Functional phosphoproteomics in study of plant cell signaling and molecular system biology, Hong Kong, 3-7 Jan 2011
Poon, Randy Yat Choi Conference paper
Identifying novel kinases involved in mitotic progression using kinome-wide screens
Annual Meeting of the American-Society-for-Cell-Biology (ASCB), Denver, CO, USA, 3-7 Dec 2011, v. 22, 2011
Chen, H.; Ma, Hoi Tang; Tsang, Y.; Cheung, C.; Ng, S.S.; Zhang, J.; Poon, Randy Yat Choi Conference paper
The CDK1 inhibitory kinase MYT1 in checkpoint recovery
Cell Cycle Cancer and Development, Saint-Malo, France, 25-28 May 2011
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi Conference paper

2010 7

Gene down-regulation with short hairpin RNAs and validation of specificity by inducible rescue in mammalian cells
Current protocols in cell biology, (SUPPL.49), 2010, Article number 27.2
Ma, Hoi Tang; Poon, Randy Yat Choi Article
Genome reduplication Redeployment of cyclin-CDK complexes and spontaneous oscillation of APC/C
Cell cycle, v. 9, (3), February 2010, p. 431-432
Ma, Hoi Tang; Poon, Randy Yat Choi Article
The requirement of p53 for maintaining chromosomal stability during tetraploidization
Oncotarget, v. 1, (7), 2010, p. 583-595
Ho, Chui Chui; Hau, Pok Man; Marxer, Miriam; Poon, Randy Yat Choi Article
Polyploidization and cancer
Advances in Experimental Medicine and Biology - Polyploidization and cancer /Randy Yat Choi Poon. Springer-Verlag, New York, US, v. 676, 2010
Poon, Randy Yat Choi Book
DNA Damage and Polyploidization
Polyploidization and cancer - Advances in Experimental Medicine and Biology / Edited by Randy Yat Choi Poon. Springer, Berlin, Germany, v. 676, 2010, p. 57-71
Chow, Jeremy Pak Hong; Poon, Randy Yat Choi Book chapter
Dissociation of MAD2 from APC/C and mitotic checkpoint complex are differentially regulated upon checkpoint satisfaction
Jacques Monod Conference: Cell division: time and space, Roscoff, France, 11-15 Sep 2010
Ma, Hoi Tang; Poon, Randy Yat Choi Conference paper
Mitotic-specific checkpoints and genome instability
Biochemistry and Molecular Biology 2010 (BMB2010) Symposium, Kobe, Japan, 7-10 Dec 2010
Poon, Randy Yat Choi Conference paper

2009 9

Cyclin A2-Cyclin-Dependent Kinase 2 Cooperates with the PLK1-SCF beta-TrCP1-EMI1-Anaphase-Promoting Complex/Cyclosome Axis To Promote Genome Reduplication in the Absence of Mitosis
Molecular and cellular biology, v. 29, (24), 2009, Dec, p. 6500-6514
Ma, Hoi Tang; Tsang, Yiu Huen; Marxer, Miriam; Poon, Randy Yat Choi Article
DNA Damage Mediated S and G(2) Checkpoints in Human Embryonal Carcinoma Cells
Stem cells, v. 27, (3), 2009, p. 568-576
Wang, Xiaoqi; Lui, Vincent C.H.; Poon, Ronnie T.P.; Lu, Ping; Poon, Randy Yat Choi Article
Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe
Oncogene, v. 28, (2), 2009, JAN, p. 170-183
Chan, Ying Wai; Chen, Yue; Poon, Randy Yat Choi Article
Stress-Activated Mitogen-Activated Protein Kinases c-Jun NH2-Terminal Kinase and p38 Target Cdc25B for Degradation
Cancer research, v. 69, (16), 2009, AUG, p. 6438-6444
Uchida, Sanae; Yoshioka, Katsuji; Kizu, Ryoichi; Nakagama, Hitoshi; Matsunaga, Tsukasa; Ishizaka, Yukihito; Poon, Randy Yat Choi; Yamashita, Katsumi Article
Genome reduplication: promotion of replication by EMI1-dependent oscillation of APC/C activity in the absence of mitosis
The 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology, Shanghai, China, 2-7 Aug 2009
Ma, Hoi Tang; Tsang, Yiu Huen; Marxer, Miriam; Poon, Randy Yat Choi Conference paper
Genome reduplication: the role of the PLK1-betaTrCP-EMI1-APC/C axis in genome instability
The IMCB and the 12th Australian Cell Cycle Workshop: Cell Cycle Regulation and Tumorigenesis Symposium, Singapore, 7-8 Sep 2009
Poon, Randy Yat Choi Conference paper
The role of CDC20 and CDK1 inhibitory phosphorylation in mitotic exit
The IMCB and the 12th Australian Cell Cycle Workshop: Cell Cycle Regulation and Tumorigenesis Symposium, Singapore, 7-8 Sep 2009
Chow, Jeremy Pak Hong; Ma, Hoi Tang; Poon, Randy Yat Choi Conference paper
The role of cyclin B in cyclin A degradation
The IMCB and the 12th Australian Cell Cycle Workshop: Cell Cycle Regulation and Tumorigenesis Symposium, Singapore 7-8 Sep 2009
Ma, Hoi Tang; Marxer, Miriam; Poon, Randy Y.C. Conference paper
Uncoupling of mitosis and genome instability
Frontiers in Biomedical Research, University of Hong Kong, Hong Kong, 4 Dec 2009
Poon, Randy Yat Choi Conference paper

2008 4

CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis
Cell cycle, v. 7, (10), 2008, May, p. 1449-1461
Chan, Ying Wai; Ma, Hoi Tang; Wong, Winnie; Ho, Chui Chui; On, Kin Fan; Poon, Randy Yat Choi Article
The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint
Journal of biological chemistry, v. 283, (23), 2008, JUN, p. 15716-15723
Chan, Ying Wai; On, Kin Fan; Chan, Wan Mui; Wong, Winnie; Siu, Ho On; Hau, Pok Man; Poon, Randy Yat Choi Article
The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability
Frontiers in bioscience, v. 13, (13), 2008, p. 5016-5029
Chen, Yue; Poon, Randy Yat Choi Article
Precise regulation of A- and B-type cyclins is required to ensure chromosomal stability
Cell Cycle and Cancer 2008, Toulouse, France, 25-28 Mar 2008
Ma, Hoi Tang; Fung, Tsz Kan; Lau, Pui Ngan; Poon, Randy Yat Choi Conference paper

2007 8

An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells
Nucleic acids research, v. 35, (4), 2007, FEB, Article number e22
Ma, Hoi Tang; On, Kin Fan; Tsang, Yiu Huen; Poon, Randy Yat Choi Article
BS69 is involved in cellular senescence through the p53-p21Cip1 pathway
EMBO reports, v. 8, (10), 2007, October, p. 952-958
Zhang, Wei; Chan, Homan; Gao, Yan; Poon, Randy Yat Choi; Wu, Zhenguo Article
Mitotic phosphorylation: breaking the balance of power by a tactical retreat
The biochemical journal, v. 403, (2), April 2007, p. e5-7
Poon, Randy Yat Choi Article
Specialized roles of the two mitotic cyclins in somatic cells: Cyclin a as an activator of m phase-promoting factor
Molecular biology of the cell, v. 18, (5), 2007, MAY, p. 1861-1873
Fung, Tsz Kan; Ma, Hoi Tang; Poon, Randy Yat Choi Article
The p53 isoform Delta p53 lacks intrinsic transcriptional activity and reveals the critical role of nuclear import in dominant-negative activity
Cancer research, v. 67, (5), 2007, MAR, p. 1959-1969
Chan, Wan Mui; Poon, Randy Yat Choi Article
Cell cycle checkpoints in the maintenance of genome stability
12th Medical Research Conference, Faculty of Medicine Building, University of Hong Kong, Pok Fu Lam, Hong Kong, 3 Feb 2007
Poon, Randy Yat Choi Conference paper
Cell cycle control and genome instability
Annual Research Day, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 24 Feb 2007
Poon, Randy Yat Choi Conference paper
Different mitotic cyclin isoforms contribute differentially to mitosis
Cell Regulations in Division and Arrest, Okinawa Institute of Science and Technology, Okinawa, Japan, 25-29 March, 2007
Poon, Randy Yat Choi Conference paper

2006 6

Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells
FEBS letters, v. 580, (19), 2006, AUG, p. 4727-4736
Hau, Pok Man; Siu, Wai Yi; Wong, Nathalie; Lai, Paul B.S.; Poon, Randy Yat Choi Article
Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways
Cancer research, v. 66, (4), 2006, FEB, p. 2233-2241
Ho, Chui Chui; Siu, Wai Yi; Lau, Anita Wan Sze; Chan, Wan Mui; Arooz, Talha; Poon, Randy Yat Choi Article
Ubiquitination of p53 at multiple sites in the DNA-binding domain
Molecular cancer research, v. 4, (1), 2006, JAN, p. 15-25
Chan, Wan Mui; Mak, Man Chi; Fung, Tsz Kan; Lau, Anita Wan Sze; Siu, Wai Yi; Poon, Randy Yat Choi Article
Mitotic catastrophe: life and death during mitosis
Frontiers in Biomedical Research Conference, University of Hong Kong, Hong Kong, 8 Dec 2006
Poon, Randy Yat Choi Conference paper
Regulation of p53 by ribosomal S6 kinase 4
The 13th International p53 conference, Columbia University, New York, USA, 20-24 May 2006
Chan, W.M.; Yeung, W.; Poon, Randy Yat Choi Conference paper
The role of cyclin A-CDK complexes as activators of M phase-promoting factor
Croucher Advanced Study Institute: Signaling in cell growth and differentiation. HKUST, Hong Kong, 16-20 Jan 2006, v. 15, (1), 2006, p. 48
Poon, Randy Yat Choi Conference paper

2005 3

A roller coaster ride with the mitotic cyclins
Seminars in cell & developmental biology, v. 16, (3), 2005, p. 335-342
Fung, Tsz Kan; Poon, Randy Yat Choi Article
The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites
Cell Cycle, v. 4, (10), 2005, p. 1411-1420
Fung, Tsz Kan; Yam, Cain H.; Poon, Randy Yat Choi Article
The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint
Experimental cell research, v. 304, (1), 2005, MAR, p. 1-15
Ho, Chui Chui; Siu, Wai Yi; Chow, Jeremy Pak Hong; Lau, Anita Wan Sze; Arooz, Talha; Tong, Hoi Yee; Ng, Irene O.L.; Poon, Randy Yat Choi Article

2004 8

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation
Genes & development, v. 18, (11), 2004, June, p. 1317-1330
Woo, Richard A.; Poon, Randy Yat Choi Article
Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains
Journal of biological chemistry, v. 279, (10), 2004, MAR, p. 8808-8819
Ng, Chuen Pei; Lee, Hung Chiu; Ho, Chung Wai; Arooz, Talha; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article
Gene mutations and aneuploidy - The instability that causes cancer
Cell cycle, v. 3, (9), 2004, SEP, p. 1101-1103
Woo, Richard A.; Poon, Randy Yat Choi Article
How many mutant p53 molecules are needed to inactivate a tetramer?
Molecular and Cellular Biology, v. 24, (8), April 2004, p. 3536-3551
Chan, Wan Mui; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article
Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia
Biochemical journal, v. 383, (1), 2004, OCT, p. 27-35
Cheung, Ngai; So, Chi Wai; Yam, Judy W.P.; So, Cary K.C.; Poon, Randy Yat Choi; Jin, Dong-Yan; Chan, Li Chong Article
Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms
Molecular cancer therapeutics, v. 3, (5), 2004, MAY, p. 621-632
Siu, Wai Yi; Lau, Anita Wan Sze; Arooz, Talha; Chow, Jeremy Pak Hong; Ho, H.T.B.; Poon, Randy Yat Choi Article
Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation
7th Cancer Research UK Beatson International Cancer Conference: Cell cycle, senescence, apoptosis and cancer, Glasgow, Scotland, v. 18, (11), 2004, June, p. 1317-1330
Woo, Richard A.; Poon, Randy Yat Choi Conference paper
DNA replication checkpoint and p53
DNA Replication and Genome Integrity Meeting, The Salk Institute for Biological Studies, La Jolla, USA, 11-15 August 2004
Ho, Chui Chui; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi Conference paper

2003 4

Cyclin-dependent kinases and S phase control in mammalian cells.
Cell cycle (Georgetown, Tex.), v. 2, (4), 2003, p. 316-324
Woo, Richard A.; Poon, Randy Yat Choi Article
Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints
Journal of biological chemistry, v. 278, (42), 2003, OCT, p. 40815-40828
Chow, Jeremy Pak Hong; Siu, Wai Yi; Ho, H.T.B.; Ma, Hoi Tang; Ho, Chui Chui; Poon, Randy Yat Choi Article
DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase
Molecular biology of the cell, v. 14, (10), 2003, OCT, p. 3989-4002
Chow, Jeremy Pak Hong; Siu, Wai Yi; Fung, Tsz Kan; Chan, Wan Mui; Lau, Anita Wan Sze; Arooz, Talha; Ng, Chuen Pei; Yamashita, Katsumi; Poon, Randy Yat Choi Article
ING1b decreases cell proliferation through p53-dependent and -independent mechanisms
FEBS letters, v. 553, (3), 2003, OCT, p. 277-285
Tsang, Fan Cheung; Po, Laisee; Leung, Kaman; Lau, Anita Wan Sze; Siu, Wai Yi; Poon, Randy Yat Choi Article

2002 6

Activation of cyclin-dependent kinases CDC2 and CDK2 in hepatocellular carcinoma
Liver, v. 22, (3), 2002, June, p. 259-268
Li, Kay K.W.; Ng, Irene O.L.; Fan, Sheung Tat; Albrecht, Jeffrey H.; Yamashita, Katsumi; Poon, Randy Yat Choi Article
Cyclin F is degraded during G(2)-M by mechanisms fundamentally different from other cyclins
Journal of biological chemistry, v. 277, (38), 2002, Sep, p. 35140-35149
Fung, Tsz Kan; Siu, Wai Yi; Yam, Cain H.; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article
Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells
Journal of cell science, v. 115, (17), 2002, SEP, p. 3479-3490
Graeser, Ralph; Gannon, Julian V.; Poon, Randy Yat Choi; Dubois, Thierry; Aitken, Alastair; Hunt, Tim W. Article
The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2
Cancer Research, v. 62, (17), 2002, p. 4890-4893
Leung, Kaman; Po, Laisee; Tsang, Fan Cheung; Siu, Wai Yi; Lau, Anita Wan Sze; Ho, H.T.B.; Poon, Randy Yat Choi Article
Cell Cycle Control
Encyclopedia of Cancer / Edited by Bertino, J.R.. San Diego, US: Academic Press, 2002, p. 393-404
Poon, Randy Yat Choi Book chapter
Proteolysis of cyclins during G2-M by ubiquitination-dependent and independent pathways
28th Federation of European Biochemical Societies Meeting, Istanbul, Turkey, 20-25 October 2002
Poon, Randy Yat Choi Conference paper

2001 5

A possible role of p73 on the modulation of p53 level through MDM2
Cancer research, v. 61, (4), 2001, FEB, p. 1598-1603
Wang, Xiaoqian; Ongkeko, Weg M.; Lau, Anita Wan Sze; Leung, Kaman; Poon, Randy Yat Choi Article
Cleavage of cyclin A at R70/R71 by the bacterial protease OmpT
Proceedings of the National Academy of Sciences of the United States of America, v. 98, (2), 2001, Jan, p. 497-501
Yam, Cain H.; Siu, Wai Yi; Kaganovich, Daniel; Ruderman, Joan V.; Poon, Randy Yat Choi Article
MDM2 and MDMX can interact differently with ARF and members of the p53 family
FEBS letters, v. 490, (3), 2001, FEB, p. 202-208
Wang, Xiaoqi; Arooz, Talha; Siu, Wai Yi; Chiu, Clarissa H.S.; Lau, Anita Wan Sze; Yamashita, Katsumi; Poon, Randy Yat Choi Article
Regulation of the DNA damage checkpoints by cyclin-dependent kinases and p53-dependent pathways
The 4th Conference of Asia-Pacific Molecular Biology Network, Taipei, Taiwan, Nov 2011
Poon, Randy Yat Choi Conference paper
The contribution of human WEE1 to normal cell cycle control and DNA damage checkpoint
EMBO workshop on G2/M progression and associated checkpoints, EMBO, Salamanca, Spain, 6–9 September 2001
Arooz, Talha; Chan, H.Y.; Siu, Wai Yi; Lau, Anita Wan Sze; Yam, Cain H.; Hunter, Tony R.; Watanabe, N.; Poon, Randy Yat Choi Conference paper

2000 4

Degradation of cyclin a does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2
Journal of biological chemistry, v. 275, (5), 2000, Feb, p. 3158-3167
Yam, Cain H.; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article
On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells
Biochemistry, v. 39, (31), 2000, AUG, p. 9494-9501
Arooz, Talha; Yam, Cain H.; Siu, Wai Yi; Lau, Anita Wan Sze; Li, Kay K.W.; Poon, Randy Yat Choi Article
p21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells
Journal of cell biology, v. 149, (2), 2000, APR, p. 281-292
Mal, Asoke K.; Chattopadhyay, Debasish; Ghosh, Mrinal Kanti Anti; Poon, Randy Yat Choi; Hunter, Tony R.; Harter, Marian L. Article
The spindle checkpoint in the dinoflagellate Crypthecodinium cohnii
Experimental cell research, v. 254, (1), 2000, JAN, p. 120-129
Yeung, Patrick Ka Kit; New, David C.; Leveson, Alexis C.; Yam, Cain H.; Poon, Randy Yat Choi; Wong, Joseph Tin Yum Article

1999 5

Differential responses of proliferating versus quiescent cells to adriamycin
Experimental cell research, v. 250, (1), 1999, Jul, p. 131-141
Siu, Wai Yi; Arooz, Talha; Poon, Randy Yat Choi Article
G1 versus G2 cell cycle arrest after adriamycin-induced damage in mouse Swiss3T3 cells
FEBS letters, v. 461, (3), 1999, NOV, p. 299-305
Siu, Wai Yi; Yam, Cain H.; Poon, Randy Yat Choi Article
MDM2 and MDMX bind and stabilize the p53-related protein p73
Current biology, v. 9, (15), 1999, JUL, p. 829-832
Ongkeko, Weg M.; Wang, Xiaoqian; Siu, Wai Yi; Lau, Anita Wan Sze; Yamashita, Katsumi; Harris, Adrian; Cox, Lynne S.; Poon, Randy Yat Choi Article
MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins
Cancer research, v. 59, (20), 1999, OCT, p. 5075-5078
Yam, Cain H.; Siu, Wai Yi; Arooz, Talha; Chiu, Clarissa H.S.; Lau, Anita Wan Sze; Wang, Xiaoqian; Poon, Randy Yat Choi Article
Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2
Molecular and cellular biology, v. 19, (1), 1999, JAN, p. 635-645
Yam, Cain H.; Ng, Raymond Wai Man; Siu, Wai Yi; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article

1998 3

Characterization of the cullin and F-box protein partner Skp1
FEBS letters, v. 438, (3), 1998, November, p. 183-189
Ng, Raymond Wai Man; Arooz, Talha; Yam, Cain H.; Chan, Iris W.Y.; Lau, Anita Wan Sze; Poon, Randy Yat Choi Article
Expression of a novel form of p21(Cip1/Waf1) in UV-irradiated and transformed cells
Oncogene, v. 16, (10), 1998, MAR, p. 1333-1343
Poon, Randy Yat Choi; Hunter, Tony R. Article
Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver
Oncogene, v. 16, (16), 1998, APR, p. 2141-2150
Albrecht, Jeffrey H.; Poon, Randy Yat Choi; Ahonen, Cory L.; Rieland, Brenda M.; Deng, Chuxia; Crary, Gretchen S. Article

1997 4

Cdc37: A protein kinase chaperone?
Trends in cell biology, v. 7, (4), 1997, April, p. 157-161
Hunter, Tony R.; Poon, Randy Yat Choi Article
Generation of phosphorylated cyclin-dependent kinase 2 and functional characterization of threonine-160-specific phosphatase KAP
Methods in enzymology, v. 283, 1997, p. 283-292
Poon, Randy Yat Choi Article
Identification of functional domains in the neuronal Cdk5 activator protein
Journal of Biological Chemistry, v. 272, (9), 1997, p. 5703-5708
Poon, Randy Yat Choi; Lew, John; Hunter, Tony R. Article
The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells
Cancer research, v. 57, (22), 1997, NOV, p. 5168-5178
Poon, Randy Yat Choi; Chau, Man Sang; Yamashita, Katsumi; Hunter, Tony R. Article


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Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 4 2020-21 Summer 4 2020-21 Spring 6 2020-21 Winter 0 2020-21 Fall 6

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LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
UROP1100E Undergraduate Research Opportunities Series 1
UROP2100E Undergraduate Research Opportunities Series 2


BTEC5210 Principles and Application in Biotechnology
UROP1000 Undergraduate Research Opportunities
UROP1100D Undergraduate Research Opportunities Series 1
UROP2100D Undergraduate Research Opportunities Series 2


BIBU4850 Biotechnology and Business Project Research
LIFS3020 Molecular and Cellular Biology II
LIFS4140 Cancer Biology
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4981 Biochemistry and Cell Biology Project Research II
LIFS6117D Current Topics in Cell Biology


BIBU4850 Biotechnology and Business Project Research
LIFS3520 Junior Research Project II
LIFS4960 Biological Science Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS4973 Biotechnology Project Research I
SCIE4500 IRE Research Project II


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy CHOI, Hon Fung
Life Science( 2021 - )

KIM, Sehong
Life Science( 2021 - )

LAU, Ho Wai
Life Science( 2021 - )

HO, Man Wai
Life Science( 2020 - )

LAU, Tsz Yin
Life Science( 2020 - )

NG, Lau Yan
Life Science( 2019 - )

ZENG, Xiaofang
Life Science( 2014 - )

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Master of Philosophy FU, Wai Kuen
Life Science( 2021 - )

KORANI, Lavisha Ramesh Kumar
Life Science( 2021 - )

TAM, Kwan Ho
Life Science( 2021 - )

YEUNG, Tsz Kwan
Life Science( 2020 - )

YU, Chun Yin
Life Science( 2020 - )

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Graduated RPGs

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Doctor of Philosophy CRNCEC, Adrijana
Life Science( Completed in 2021 )

WANG, Yang
Life Science( Completed in 2021 )

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Master of Philosophy CHOI, Hon Fung
Life Science( Completed in 2021 )

CHU, Siu Ki
Life Science( Completed in 2021 )

LAU, Ho Wai
Life Science( Completed in 2021 )

LAU, Tsz Yin
Life Science( Completed in 2020 )

NG, Lau Yan
Life Science( Completed in 2019 )









ProjectsFrom January 2020 to December 2022

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All Projects 8 Leading Projects 5 Participating Projects 3

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Role and mechanism for Bora phosphorylation by Aurora A kinase in cell cycle regulation


Aurora A 激酶通过磷酸化Bora调控细胞周期的功能及机理研究 Leading


National Natural Science Foundation of China / Research Grants Council Joint Research Scheme


Project Team (HKUST)
POON Randy Yat Choi (Lead)


2021 -




Keeping it in the family - the implication of multiple cyclin-dependent kinases in human cells


保留还是舍弃–人类细胞中多种细胞周期蛋白依赖性激酶的意义 Leading


RGC - General Research Fund


Project Team (HKUST)
POON Randy Yat Choi (Lead)


2021 -




The origins and aftermaths of mitotic slippage


丝分裂滑移的起源和後果 Leading


RGC - General Research Fund


Project Team (HKUST)
POON Randy Yat Choi (Lead)


2020 -




Combination of a Cancer Vaccine with Checkpoint Inhibitors for Melanoma Treatment


治疗黑色素瘤的方法：结合癌症疫苗和免疫检查点抑制剂 Leading


CK Life Sciences Development Ltd., Innovation and Technology Fund


Project Team (HKUST)
POON Randy Yat Choi (Lead)


2018 - 2021




Cyclin A: reassessing its mitotic functions with new arsenal


利用崭新技术重新探视周期蛋白 A(Cyclin A) 在有丝分裂的功能 Leading


RGC - General Research Fund


Project Team (HKUST)
POON Randy Yat Choi (Lead)


2018 - 2021




Understanding the role of TRIP13 and MAD2 conformation equilibrium in spindle assembly checkpoint


TRIP13和MAD2构象平衡在纺锤体组装检查点的角色 Participating


RGC - General Research Fund


Project Team (HKUST)
POON Randy Yat Choi


2018 - 2020




Understanding Cancer Stemness in Liver Cancer - From Regulation to Translational Applications


了解肝癌肿瘤的干细胞特性：从调节机制到转化应用 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
POON Randy Yat Choi


2017 - 2021




State Key Laboratory of Molecular Neuroscience (The Hong Kong University of Science and Technology)


分子神经科学国家重点实验室（香港科技大学） Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHOW King Lau
CHUNG Kenny K
DAI Wei Min
GUO Zhihong
HUANG Pingbo
LIANG Chun
MILLER Andrew Leitch
POON Randy Yat Choi
QI Robert Zhong
TSIM Karl Wah Keung
WEN Zilong
WONG Joseph Tin Yum
WONG Yung Hou
WU Zhenguo
ZHU Guang


2011 -