Robert Zhong QI
齐众
PhD in Biochemistry and Molecular Biology
University of Calgary, 1996

Professor
Division of Life Science



(852) 2358 7273
qirz@ust.hk
Room 5458
Personal Web

---

ORCID
0000-0001-5596-8172

Scopus ID
7006273649




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

---

Cell biology
Cytoskeletal dynamics
Cellular and molecular mechanisms
Cancer
Molecular and cellular neuroscience



Publications

---

All Years 113 2022 0 2021 1 2020 1 2019 2 2018 2 2017 10 2016 97

---

Expand All Collapse All


2021 1

Proteolysis of γ-tubulin small complex proteins is mediated by the ubiquitin-proteasome system
FEBS Letters, June 2021
Yin, Can; Lui, Sze Wai; Jiang, Taolue; Qi, Robert Zhong Article

2020 1

Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction
The Journal of cell biology, v. 219, (5), 4 May 2020, article number e201909094
Au, Kin Chung Franco; Hau, K.T.; Qi, Robert Zhong Article

2019 2

Cytolinker Gas2L1 Regulates Axon Morphology Through Microtubule-modulated Actin Stabilization
EMBO Reports, September 2019, article number e47732
van de Willige, Dieudonnée; Hummel, J.J.A.; Alkemade, Celine; Kahn, Olga I.; Au, Kin Chung Franco; Qi, Robert Zhong; Dogterom, Marileen; Koenderink, Gijsje Hendrika; Hoogenraad, Casper C.; Akhmanova, Anna S. Article
The Catalytic Subunit of DNA Polymerase δ is a Nucleocytoplasmic Shuttling Protein
Experimental Cell Research, v. .375, (2), February 2019, p. 36-40
Shen, Yuehong; Wang, Kexin; Qi, Robert Zhong Article

2018 2

A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission
Cell, v. 175, (1), September 2018, p. 254-265.e14
Hoyer, Melissa J.; Chitwood, Patrick J.; Ebmeier, Christopher C.; Striepen, Jonathan F.; Qi, Robert Zhong; Old, William M.; Voeltz, Gia K. Article
Epigenetic Alterations of Wnt Signaling Pathways in Nasopharyngeal Carcinoma
Current Molecular Pharmacology, 30 July 2018, p. 1-9
Liu, Pengfei; Fu, Lu; Qi, Robert Z. Article

2017 10

EB1 and EB3 Regulate Microtubule Minus End Organization and Golgi Morphology
Journal of Cell Biology, v. 216, (10), October 2017, p. 3179-3198
Yang, Chao; Wu, Jingchao; De Heus, Cecilia; Grigoriev, Ilya; Liv, Nalan; Yao, Yao; Smal, Ihor; Meijering, Erik; Klumperman, Judith; Qi, Robert Zhong; Akhmanova, Anna Article
GAS2L1 Is a Centriole-Associated Protein Required for Centrosome Dynamics and Disjunction
Developmental Cell, v. 40, (1), Jan 2017, p. 81-94
Au, Kin Chung Franco; Jia, Yue; Jiang, Kai; Grigoriev, Ilya; Hau, Kwan Tang; Shen, Yuehong; Du, Shengwang; Akhmanova, Anna; Qi, Robert Zhong Article
Microtubule Plus-end Tracking of End-binding Protein 1 (EB1) Is Regulated by CDK5 Regulatory Subunit-associated Protein 2
Journal of Biological Chemistry, v. 292, (18), May 2017, p. 7675-7687
Fong, Ka Wing; Au, Kin Chung Franco; Jia, Yue; Yang, Shaozhong; Zhou, Liying; Qi, Robert Zhong Article
Noncontact Viscoelastic Imaging of Living Cells Using a Long-Needle Atomic Force Microscope with Dual-Frequency Modulation
Physical Review Applied, v. 8, (4), October 2017, article number 044010
Guan, Dongshi; Charlaix, Elisabeth; Qi, Robert Z.; Tong, Penger Article
RNA Editing of SLC22A3 Drives Early Tumor Invasion and Metastasis in Familial Esophageal Cancer
Proceedings of the National Academy of Sciences of the United States of America, v. 114, (23), June 2017, p. 4631-4640
Fu, Li; Qin, Yan-Ru; Ming, Xiao-Yan; Zuo, Xian-Bo; Diao, Yu-Wen; Zhang, Li Yi; Ai, Jiaoyu; Liu, Bei-Lei; Huang, Tu-Xiong; Cao, Ting-Ting; Tan, Bin-Bin; Xiang, Di; Zeng, Chui-Mian; Gong, Jing; Zhang, Qiangfeng; Dong, Sui-Sui; Chen, Juan; Liu, Haibo; Wu, Jian-Lin; Qi, Robert Zhong; Xie, Dan; Wang, Li-Dong; Guan, Xin-Yuan Article
The Catalytic Subunit of DNA Polymerase δ Inhibits γTuRC Activity and Regulates Golgi-derived Microtubules
Nature Communications, v. 8, September 2017, article number 554
Shen, Yuehong; Liu, Pengfei; Jiang, Taolue; Hu, Yu; Au, Kin Chung Franco; Qi, Robert Zhong Article
DNA polymerase δ catalytic subunit is a nucleus and cytoplasm shuttling protein
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Hong Kong, 16 June 2017
Wang, Kexin; Shen, Yuehong; Robert z. qi Conference paper
GAS2L1 is a centriole-associated protein that functions in centrosome disjunction.
EMBO Conference–Centrosomes and Spindle Pole Bodies, EMBL Heidelberg, Germany, 24-27 September 2017
Au, Kin Chung Franco; Jia y; Jiang, k; Grioriey i; Hau, Kwan Tang; Shen, Yuehong; Du, Shengwang; Akhmanova a; Qi, Robert Zhong Conference paper
Identification of γ-Tubulin Ring Complex Regulators in Mammalian Cells
EMBO Conference–Centrosomes and Spindle Pole Bodies, EMBL Heidelberg, Germany, 24-27 September 2017
Shen, Yuehong; Liu, Pengfei; Jiang, Taolue; Hu, Yu; Au, Kin Chung Franco; Qi, Robert Zhong Conference paper
NME7 Functions in ciliogenesis and left-right asymmetry development
EMBO Conference–Centrosomes and Spindle Pole Bodies, EMBL Heidelberg, Germany, 24-27 September 2017
Liu, Pengfei; Yu, Tao; Wen, Zilong; Qi, Robert Zhong Conference paper

2016 3

Identification of Porcine Relaxin in Plasma by Liquid Chromatography-high Resolution Mass Spectrometry
Drug Testing and Analysis, v. 9, (9), December 2016, p. 1412-1420
Wong, April S.Y; Ho, Emmie N.M.; Kwok, Wai Him; Leung, Gary N.W.; Shen, Yuehong; Qi, Robert Zhong; Yue, Samuel Ka Sheng; Wan, Terence See Ming Article
Molecular Pathway of Microtubule Organization at the Golgi Apparatus
Developmental Cell, v. 39, (1), October 2016, p. 44-60
Wu, Jingchao; De Heus, Cecilia; Liu, Qingyang; Bouchet, Benjamin Pierre; Noordstra, Ivar; Jiang, Kai; Hua, Shasha; Martin, Maud; Yang, Chao; Grigoriev, Ilya I.; Katrukha, Eugene A.; Altelaar, A.F. Maarten; Hoogenraad, Casper C.; Qi, Robert Zhong; Klumperman, Judith; Akhmanova, Anna S. Article
GAS2L1 is a Centriolar Protein to Regulate Centrosome Disjunction
2016 ASCB (The American Society for Cell Biology) Annual Meeting, Moscone Center, San Francisco, California, 3-7 December 2016
Au, Kin Chung Franco; Jia, Yue; Jiang, Kai; Grigoriev, Ilya; Hau, Kwan Tang; Du, Shengwang; Akhmanova, Anna; Qi, Robert Zhong Conference paper

2014 8

A newly identified myomegalin isoform functions in Golgi microtubule organization and ER-Golgi transport
Journal of cell science, v. 127, (22), November 2014, p. 4904-4917
Wang, Zhe; Zhang, Chao; Qi, Robert Zhong Article
Assaying microtubule nucleation by the γ-tubulin ring complex
Methods in Enzymology, v. 540, 2014, p. 119-130
Choi, Yu Kwan; Qi, Robert Zhong Article
GATA2 as a potential metastasis-driving gene in prostate cancer
Oncotarget, v. 5, (2), 2014, p. 451-461
Chiang, Yan Ting; Wang, Kendric; Fazli, Ladan; Qi, Robert Zhong; Gleave, Martin E.; Collins, Colin C.; Gout, Peter W.; Wang, Yuzhuo Article
NME7 is a functional component of the gamma-tubulin ring complex
Molecular Biology of the Cell, v. 25, (13), July 2014, p. 2017-2025
Liu, Pengfei; Choi, Yuk-Kwan; Qi, Robert Z. Article
Transmembrane and Coiled-Coil Domain Family 1 Is a Novel Protein of the Endoplasmic Reticulum
PLOS ONE, v. 9, (1), January 2014, article number e85206
Zhang, Chao; Kho, Yik-Shing; Wang, Zhe; Chiang, Yan Ting; Ng, Gary Kar Ho; Shaw, Pang-Chui; Wang, Yuzhuo; Qi, Robert Zhong Article
Analysis of γ-tubulin ring complexes associated with CDK5RAP2 and GCP-WD
EMBO Conference - Centrosomes and Spindle Pole Bodies, Lisbon, Portugal, 30 September - 3 October 2014
Shen, Y.; Hu, Y.; Qi, Robert Zhong Conference paper
Nme7 functions in the growth of primary cilia
EMBO Conference - Centrosomes and Spindle Pole Bodies, Lisbon, Portugal, 30 September - 3 October 2014
Liu, P.; Yu, T.; Wen, Z.; Qi, Robert Zhong Conference paper
Nme7 regulates microtubule nucleation by the γ-tubulin ring complex
EMBO Conference - Centrosomes and Spindle Pole Bodies, Oct. 2014, Lisbon, Portugal. (*Equal contribution)
Liu, Pengfei; Choi, Yukkwan; Qi, Robert Zhong Conference paper

2013 4

Bioinformatic Analysis of Data Generated from MALDI Mass Spectrometry for Biomarker Discovery
Topics in Current Chemistry, v. 331, 2013, p. 193-210
He, Zengyou; Qi, Robert Z.; Yu, Weichuan Article
Dynamic Recruitment of CDK5RAP2 to Centrosomes Requires Its Association with Dynein
PLoS ONE, v. 8, (7), July 2013, article number e68523
Jia, Yue; Fong, Ka-Wing; Choi, Yuk-Kwan; See, Siu-San; Qi, Robert Z. Article
Whole-genome Screening Identifies Proteins Localized to Distinct Nuclear Bodies
The Journal of Cell Biology, v. 203, (1), October 2013, p. 149-164
Fong, Ka-wing; Li, Yujing; Wang, Wenqi; Ma, Wenbin; Li, Kunpeng; Qi, Robert Z.; Liu, Dan; Zhou, Songyang; Chen, Junjie Article
Identification and Characterization of Various Populations of γ-tubulin Ring Complex
Gordon Research Conference - Posttranslational Modification Networks, Hong Kong, 2013
Shen, Yuehong; Choi, Y.K.; Liu, P.F.; Hu, Y.; Qi, Robert Z. Conference paper

2012 2

Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro
Journal of Cellular and Molecular Medicine, v. 16, (4), April 2012, p. 789-811
Ng, Jian Ming Jeremy; Chen, Minghui Jessica; Leung, Jacqueline Y.K.; Peng, Zhao Feng; Manikandan, Jayapal; Qi, Robert Z.; Chuah, Meng Inn; West, Adrian K.; Vickers, James C.; Lu, Jia; Cheung, Nam Sang; Chung, Roger S. Article
NME7 Is a Functional Component of the γ-Tubulin Ring Complex
Biology of Cilia and Flagella (FASEB Science Research Conference), Niagara Falls, New York, U.S.A.
Qi, Robert Zhong; Liu, Pengfei; Choi, Yuk Kwan; Shen, Yuehong Conference paper

2011 2

Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis
British Journal of Cancer, v. 104, (5), March 2011, p. 841-849
Wong, V.C.L.; Ko, J.M.Y.; Qi, R.Z.; Li, P.J.; Wang, L.D.; Li,J-L; Chan, Y.P.; Chan, K.W.; Stanbridge, E.J.; Lung, M.L. Article
The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein
Cellular and molecular life sciences, v. 68, (9), May 2011, p. 1633-1643
He, Lisheng; Zhang, Zhaojun; Yu, Yan; Ahmed, Sohail; Cheung, Nam Sang; Qi, Robert Z. Article

2010 10

A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism
Molecular and Cellular Proteomics, v. 9, (12), 2010, p. 2617-2628
Cai, Z.; Zhao, J.S.; Li, J.J.; Peng, D.N.; Wang, X.Y.; Chen, T.L.; Qiu, Y.P.; Chen, P.P.; Li, W.J.; Xu, L.Y.; Li, E.M.; Tam, J.P.M.; Qi, R.Z.; Jia, W.; Xie, D. Article
CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex
Journal of Cell Biology, v. 191, (6), 2010, p. 1089-1095
Choi, Y.K.; Liu, P.; Sze, S.K.; Dai, C.; Qi, R.Z. Article
Conserved Motif of CDK5RAP2 Mediates Its Localization to Centrosomes and the Golgi Complex
Journal of biological chemistry, v. 285, (29), 2010, JUL 16, p. 22658-22665
Wang, Zhe; Wu, Tao; Shi, Lin; Zhang, Lin; Zheng, Wei; Qu, Jianan Y.; Niu, Ruifang; Qi, Robert Z. Article
Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator
Journal of Cellular Biochemistry, v. 111, (5), 2010, p. 1359-1366
Chew, J.; Chen, M.J.; Lee, A.Y.W.; Peng, Z.F.; Chong, K.W.Y.; He, L.; Bay, B.H.; Ng, J.M.J.; Qi, R.Z.; Cheung, N.S. Article
Optimization-Based Peptide Mass Fingerprinting for Protein Mixture Identification
Journal of Computational Biology, v. 17, (3), March 2010, p. 221-235
He, Zengyou; Yang, Chao; Yang, Can; Qi, Robert Zhong; Tam, P.M.; Yu, Weichuan Article
A conserved protein domain identified by computational alignment is important to cytoskeleton organization
ACM-HK Bioinformatics Symposium, The Hong Kong University of Science and Technology
Choi, Y.K.; Fong, K.W.; Qi, R.Z. Conference paper
CDK5RAP2 in microtubule regulation and autosomal recessive primary microcephaly
Gordon Research Conference – Molecular and Cellular Neurobiology, Jun. 2010, Hong Kong
Fong, Ka Wing; Choi, Yuk Kwan; Qi, Robert Z. Conference paper
Characterization of CDK5RAP2 in the organization and regulation of microtubule ends
EMBO Conference Series Microtubules - Structure, Regulation and Functions, EMBL Heidelberg, Germany
Fong, K.W.; Choi, Y.K.; Qi, R.Z. Conference paper
Characterizing the association of CDK5RAP2 with the γ-tubulin ring complex
EMBO Conference Series Microtubules - Structure, Regulation and Functions, EMBL Heidelberg, Germany
Choi, Y.K.; Fong, K.W.; Qi, R.Z. Conference paper
Involvement of Hsc70 and EBV Latent Membrane Protein-1 in the regulation of cell mitosis
ACM-HK Bioinformatics Symposium, The Hong Kong University of Science and Technology
He, L.; Choi, Y.K.; Qi, R.Z. Conference paper

2009 7

Anxa2 Plays a Critical Role in Enhanced Invasiveness of the Multidrug Resistant Human Breast Cancer Cells
Journal of proteome research, v. 8, (11), 2009, NOV, p. 5041-5047
Zhang, Fei; Zhang, Lin; Zhang, Bin; Wei, Xiyin; Yang, Yi; Qi, Robert Z.; Ying, Guoguang; Zhang, Ning; Niu, Ruifang Article
Interaction of CDK5RAP2 with EB1 to Track Growing Microtubule Tips and to Regulate Microtubule Dynamics
Molecular biology of the cell, v. 20, (16), 2009, AUG 15, p. 3660-3670
Fong, Ka-Wing; Hau, Shiu-Yeung; Kho, Yik-Shing; Jia, Yue; He, Lisheng; Qi, Robert Z. Article
Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway
PLoS ONE, v. 4, (9), 2009
Jiang, L.; Wang, Q.; Yu, Y.; Zhao, F.; Huang, P.; Zeng, R.; Qi, R.Z.; Li, W.; Liu, Y. Article
Proteomics in gastric cancer research: Benefits and challenges
Proteomics Clinical APPLICATIONS, v. 3, (2), 2009, FEB, p. 185-196
Li, Jing-Jing; Qi, Robert Z.; Ng, Gary Kar Ho; Xie, Dong Article
Functional proteomics in the discovery of biomarkers and therapeutic targets
Biomarkers for early detection of cancers: Technological advances & clinical readiness, Croucher Advanced Study Institute, The University of Hong Kong, Mar. 2009, p27
Qi, R.Z. Conference paper
Involvement of CDK5RAP2 in microtubule organization: The ends are the beginning
The Second International Symposium on Cdk5, Tokyo, Japan, Jun. 2009, p10
Qi, R.Z. Conference paper
Optimization-based Peptide Mass Fingerprinting for Protein Mixture Identification
Research in Computational Molecular Biology, 5541, 2009, p. 16-30
He, Zengyou; Yang, Chao; Qi, Robert Zhong; Tam, Jason Po-Ming; Yu, Weichuan Conference paper

2008 8

Calmodulin binding and cdk5 phosphorylation of p35 regulate its effect on microtubules
Journal of biological chemistry, v. 283, (19), 2008, MAY 9, p. 13252-13260
He, Lisheng; Hou, Zhibo; Qi, Robert Z. Article
CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the γ-tubulin ring complex
Molecular Biology of the Cell, v. 19, (1), January 2008, p. 115-125
Fong, Ka Wing; Choi, Yuk Kwan; Rattner, Jerome B.; Qi, Robert Zhong Article
Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma
International journal of cancer, v. 122, (3), 2008, FEB 1, p. 587-594
Leung, Alfred Chi Chung; Wong, Victor Chun Lam; Yang, Li Chun; Chan, Pui Ling; Daigo, Yataro; Nakamura, Yusuke; Qi, Robert Z.; Miller, Lance David; Liu, Edison Tak-Bun; Wang, Li Dong; Li, Ji-Lin; Law, Simon; Tsao, Sai Wah; Lung, Maria Li Article
Protein-protein Interactions Involving the N-terminus of p35
Cyclin Dependent Kinase 5 (Cdk5) / Edited by Li-Huei Tsai, Nancy Y. Ip. New York, NY: Springer Science+Business Media, LLC, c2008, p.159-170
Ng, G.K.H.; He, L.; Qi, R.Z. Book chapter
CDK5RAP2 associates with EB1 and regulates microtubule dynamics
The 1st EMBO Conference on Centrosomes and Spindle Pole Bodies, EMBL, Heidelberg, Germany, Sep. 2008, p93
Fong, K.W.; Hau, S.Y.; Kho, Y.S.; Qi, R.Z. Conference paper
CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the γ-tubulin ring complex
Gordon Research Conference - Molecular and Cellular Neurobiology
Fong, K.W.; Choi, Y.W.; Rattner, J.B.; Qi, R.Z. Conference paper
CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the γ-tubulin ring complex
The 1st EMBO Conference on Centrosomes and Spindle Pole Bodies, EMBL, Heidelberg, Germany, Sep. 2008, p19
Fong, K.W.; Choi, Y.W.; Rattner, J.B.; Qi, R.Z. Conference paper
Functional proteomics to decipher neuronal Cdk5 regulatory pathways
The 9th AEARU Workshop on Molecular Biology and Biotechnology
Qi, R.Z. Conference paper

2007 5

Discovery of stage-related proteins in esophageal squamous cell carcinoma using proteomic analysis
Proteomics Clinical APPLICATIONS, v. 1, (3), 2007, MAR, p. 312-320
Liu, Dong-Ping; Qi, Robert Z.; Wang, Yan; Chen, Ping-Ping; Koeffler, H. Phillip; Xie, Dong Article
Microtubule association of the neuronal p35 activator of Cdk5
Journal of biological chemistry, v. 282, (26), 2007, JUN 29, p. 18666-18670
Hou, Zhibo; Li, Qing; He, Lisheng; Lim, Hui-Ying; Fu, Xinrong; Cheung, Nam Sang; Qi, Donna X.; Qi, Robert Z. Article
Neuronal apoptosis mediated by inhibition of intracellular cholesterol transport: Microarray and proteomics analyses in cultured murine cortical neurons
Journal of cellular physiology, v. 211, (1), 2007, APR, p. 63-87
Koh, Chor Hui Vivien; Peng, Zhao Feng; Ou, Keli; Melendez, Alirio; Manikandan, Jayapal; Qi, Robert Z.; Cheung, Nam Sang Article
Regulation of S6 kinase 1 activation by phosphorylation at Ser-411
Journal of biological chemistry, v. 282, (10), 2007, MAR 9, p. 6922-6928
Hou, Zhibo; He, Lisheng; Qi, Robert Z. Article
Proteomics to dissect Cdk5 signaling pathways in health and disease
Annual Symposium of Hong Kong Proteomics Society and China Human Proteome Organization Satellite Meeting
Qi, R.Z. Conference paper

2006 5

Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes
Journal of neurochemistry, v. 98, (5), 2006, SEP, p. 1597-1609
Yap, Yann Wan; Whiteman, Matthew; Bay, Boon Huat; Li, Yuhong; Sheu, Fwu-Shan; Qi, Robert Z.; Tan, Chee Hong; Cheung, Nam Sang Article
Identification of nuclear import mechanisms for the neuronal Cdk5 activator
Journal of biological chemistry, v. 281, (51), 2006, DEC 22, p. 39014-39021
Fu, Xinrong; Choi, Yuk-Kwan; Qu, Dianbo; Yu, Yan; Cheung, Nam Sang; Qi, Robert Z. Article
U18666A-mediated apoptosis in cultured murine cortical neurons: Role of caspases, calpains and kinases
Cellular signalling, v. 18, (10), 2006, OCT, p. 1572-1583
Koh, Chor Hui Vivien; Qi, Robert Z.; Qu, Dianbo; Melendez, Alirio; Manikandan, Jayapal; Bay, Boon Huat; Duan, Wei; Cheung, Nam Sang Article
不同转移能力乳腺癌细胞株的差异表达蛋白研究
癌症=Chinese Journal of Cancer, v. 2006, (07), 2006, p. 823-827
叶丽虹; 尤嘉琮; 郭威; 徐少峰; 吴莲英; 齐众; 张晓东 Article
Hypochlorous Acid Induces Apoptosis of Cultured Cortical Neurons Through Activation of Calpains and Rupture of Lysosomes
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Yap, Yann Wan; Whiteman, Matthew; Bay, Boon Huat; Sheu, Fwu Shan; Qi, Robert Z.; Cheung, Nam Sang Conference paper

2005 3

Cleavage of the carboxyl-terminus of LEACS2, a tomato 1-aminocyclopropane-1-carboxylic acid synthase isomer, by a 64-kDa tomato metalloprotease produces a truncated but active enzyme
Journal of integrative plant biology, v. 47, (11), 2005, NOV, p. 1352-1363
Li, Jian-Feng; Qi, Robert; Qu, Liang-Hu; Mattoo, Autar K.; Li, Ning Article
Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis
Journal of neurochemistry, v. 94, (4), 2005, AUG, p. 943-956
Yew, EHJ; Cheung, NS; Choy, MS; Qi, RZ; Lee, AYW; Peng, ZF; Melendez, AJ; Manikandan, J.; Koay, ESC; Chiu, LL; Ng, WL; Whiteman, M.; Kandiah, J.; Halliwell, B. Article
Purification and properties of lipases/esterases from a Bacillus strain for enantioselective resolution of (S)-ketoprofen
Artificial Cells Blood Substitutes and Biotechnology, v. 33, (4), 2005, p. 435-445
Zhang, JH; Guan, R.; Tan, ZL; Yu, YT; Hou, ZB; Qi, Z.; Wang, SW Article

2004 9

Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons
Biochemical and biophysical research communications, v. 315, (2), 2004, MAR 5, p. 408-417
Cheung, NS; Koh, CHV; Bay, BH; Qi, RZ; Choy, MS; Li, QT; Wong, KP; Whiteman, M. Article
Direct regulation of microtubule dynamics by protein kinase CK2
Journal of biological chemistry, v. 279, (6), 2004, FEB 6, p. 4433-4439
Lim, ACB; Tiu, SY; Li, Q.; Qi, RZ Article
Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction
Cellular and molecular life sciences, v. 61, (15), 2004, JUL, p. 1926-1934
Cheung, NS; Choy, MS; Halliwell, B.; Teo, TS; Bay, BH; Lee, AYW; Qi, RZ; Koh, VH; Whiteman, M.; Koay, ESC; Chiu, LL; Zhu, HJ; Wong, KP; Beart, PM; Cheng, HC Article
Protein kinase CK2 is an inhibitor of the neuronal Cdk5 kinase
Journal of biological chemistry, v. 279, (45), 2004, NOV 5, p. 46668-46673
Lim, ACB; Hou, ZB; Goh, CP; Qi, RZ Article
Signaling via a novel integral plasma membrane pool of a serine/threonine protein kinase PRK1 in mammalian cells
FASEB JOURNAL, v. 18, (12), 2004, SEP, p. 1722+
Zhu, YM; Stolz, DB; Guo, FL; Ross, MA; Watkins, SC; Tan, BJ; Qi, RZ; Manser, E.; Li, QT; Bay, BH; Teo, TS; Duan, W. Article
Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine
Biochemical and biophysical research communications, v. 317, (1), 2004, APR 23, p. 128-132
Song, YC; Kesuma, D.; Wang, H.; Deng, Y.; Duan, J.; Wang, JH; Qi, RZ Article
α2-Chimaerin, Cyclin-Dependent Kinase 5/p35, and Its Target Collapsin Response Mediator Protein-2 Are Essential Components in Semaphorin 3A-Induced Growth-Cone Collapse
THE JOURNAL OF NEUROSCIENCE, v. 24, (41), 2004, OCT 13, p. 8994-9004
Brown, Matthew; Jacobs, Tom; Eickholt, Britta; Ferrari, Giovanna; Teo, Mabel; Monfries, Clinton; Qi, Robert Z.; Leung, Thomas; Lim, Louis; Hall, Christine Article
α-Chimaerin exists in a functional complex with the Cdk5 kinase in brain
FEBS letters, v. 561, (1-3), 2004, MAR 12, p. 177-180
Qi, Robert Z.; Ching, Yick-Pang; Kung, Hsiang-Fu; Wang, Jerry H. Article
Proteomics to dissect the cell regulatory machinery in brain
HUPO (Human Proteome Organization)3rd World Congress, Beijing P.R. China, Abstract published in Mol. Cell. Proteomics, 3(10), S185, Oct 2004
Qi, R.Z.; Fong, K.W.; Hou, Z.; Fu, X.; Yu, Y.; He, L. Conference paper

2003 7

Cyclin-dependent kinases in neural development and degeneration
Journal of Alzheimer's Disease, v. 5, (4), 2003, p. 329-335
Lim, A.C.B.; Qi, R.Z. Article
Phosphoproteomic fingerprinting of epidermal growth factor signaling and anticancer drug action in human tumor cells
Mol. Cancer Ther., v. 2, (12), 2003, p. 1369-1377
Lim, Y.P.; Diong, L.S.; Qi, Robert Zhong; Druker, B.J.; Epstein, R.J. Article
Protein-protein interactions in Cdk5 regulation and function
NeuroSignals, v. 12, (4-5), 2003, p. 230-238
Lim, ACB; Qu, DB; Qi, RZ Article
Role of IGF system of mitogens in the induction of fibroblast proliferation by keloidderived keratinocytes in vitro
Am. J. Physiol.-Cell Physiol., v. 284, (4), 2003, p. 860-869
Phan, T.T.; Lim, I.J.; Bay, B.H.; Qi, Robert Zhong; Longaker, M.T.; Lee, S.T.; Huynh, H. Article
Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor
The Society for Neuroscience 33rd Annual Meeting, New Orleans, Louisiana, USA, Nov
Lim, A.C.; Goh, C.P.; Tiu, S.Y.; Wong, B.S.; Qi, Robert Z. Conference paper
Protein kinase CK2 is an inhibitor of the neuronal Cdk5 kinase
Gordon Research Conference – Molecular and Cellular Neurobiology, Hong Kong, Jun.
Lim, A.C.B.; Hou, Z.; Goh, C.P.; Qi, Robert Z. Conference paper
Proteomic Dissection of Neurosignal Transduction Pathways
Molecular Neuroscience: Technology Applications, organized by the Croucher Advanced Study Institute, Hong Kong.
Qi, Robert Z. Conference paper

2002 8

CD157 undergoes ligand-independent dimerization and colocalizes with caveolin in CHO and MCA102 fibroblasts
Cell Signal, v. 14, (11), 2002, p. 933-939
Liang, F.; Qi, Robert Zhong; Chang, C.F. Article
Differences in collagen production between normal and keloid-derived fibroblasts in serum-media co-culture with keloid-derived keratinocytes
J. Dermatol. Sci., v. 29, (1), 2002, p. 26-34
Phan, T.T.; Lim, I.J.; Bay, B.H.; Qi, Robert Zhong; Huynh, H.T.; Lee, S.T.; Longaker, M.T. Article
Fibroblasts cocultured with keloid keratinocytes: Normal fibroblasts secrete collagen in a keloidlike manner
Am. J. Physiol.-Cell Physiol., v. 283, (1), 2002, p. 212-222
Lim, I.J.; Phan, T.T.; Bay, B.H.; Qi, Robert Zhong; Huynh, H.; Tan, W.T.; Lee, S.T.; Longaker, M.T. Article
Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor
Journal of biological chemistry, v. 277, (18), 2002, MAY 3, p. 15237-15240
Ching, Y.P.; Pang, A.S.H.; Lam, W.H.; Qi, R.Z.; Wang, J.H. Article
The protein SET binds the neuronal Cdk5 activator p35(nck5a) and modulates Cdk5/p35(nck5a) activity
Journal of biological chemistry, v. 277, (9), 2002, MAR 1, p. 7324-7332
Qu, DB; Li, Q.; Lim, HY; Cheung, NS; Li, R.; Wang, JH; Qi, RZ Article
β-Carbolines as specific inhibitors of cyclin-dependent kinases
Bioorganic and Medicinal Chemistry Letters, v. 12, (7), 2002, p. 1129-1132
Song, Y.; Wang, J.; Teng, S.F.; Kesuma, D.; Deng, Y.; Duan, J.; Wang, J.H.; Qi, R.Z.; Sim, M.M. Article
Proteomics of neuronal Cdk5 signaling complexes in brain
Proteomics in the Neurosciences, organized by the National Institute of Neurological Disorders and Stroke of the National Institute of Health, U.S.A.
Qi, Robert Z. Conference paper
Proteomics of Neuronal Cdk5 Signaling Complexes in Health and Disease
Second International Conference on Structural Biology and Functional Genomics, organized by the National University of Singapore, Singapore
Qi, Robert Z. Conference paper

2001 5

A membrane protein enriched in ER exit sites interacts with COPII
J. Biol. Chem., v. 276, (43), 2001, p. 40008-40017
Tang, B.L.; Ong, Y.S.; Huang, B.; Wei, S.; Wong, E.T.; Qi, Robert Zhong; Horstmann, H.; Hong, W. Article
Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members
Biochemical and biophysical research communications, v. 288, (1), 2001, OCT 19, p. 233-239
Rajala, RVS; Datla, RSS; Carlsen, SA; Anderson, DH; Qi, Z.; Wang, JH; Sharma, RK Article
Proteins of mycobacterium bovis BCG induced in the Wayne dormancy model
J. Bacteriol, v. 183, (8), 2001, p. 2672-2676
Boon, C.; Li, R.; Qi, Robert Zhong; Dick, T. Article
Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibrablasts
FEBS Lett., v. 506, (3), 2001, p. 207-210
Liang, F.; Qi, Robert Zhong; Chang, C.F. Article
Structural insights into Cdk5 activation by a neuronal Cdk5 activator
Biochemical and biophysical research communications, v. 285, (1), 2001, JUL 6, p. 77-83
Lim, HY; Seow, KT; Li, Q.; Kesuma, D.; Wang, JH; Qi, RZ Article

2000 2

Cloning of three novel neuronal Cdk5 activator binding proteins
Gene, v. 242, (1-2), 2000, JAN 25, p. 285-294
Ching, YP; Qi, Z.; Wang, JH Article
Identification of a common protein association region in the neuronal Cdk5 activator
Journal of biological chemistry, v. 275, (41), 2000, OCT 13, p. 31763-31769
Wang, Xiujie; Ching, Wilson Yik Pang; Lam, Wing H.; Qi, Zhong; Zhang, Mingjie; Wang, Jerry Hsueh-ching Article

1998 2

Association of neurofilament proteins with neuronal Cdk5 activator
Journal of biological chemistry, v. 273, (4), 1998, JAN 23, p. 2329-2335
Qi, Z.; Tang, DM; Zhu, XD; Fujita, DJ; Wang, JH Article
Effect of heparin on phosphorylation site specificity of neuronal Cdc2-like kinase
FEBS letters, v. 423, (2), 1998, FEB 20, p. 227-230
Qi, Z.; Zhu, XD; Goedert, M.; Fujita, DJ; Wang, JH Article

1997 1

Neuronal Cdc2-like kinases: Neuron-specific forms of Cdk5
International journal of biochemistry & cell biology, v. 29, (7), 1997, JUL, p. 951-958
Lee, KY; Qi, Z.; Yu, YP; Wang, JH Article

1996 1

Neuronal Cdc2-like kinase: From cell cycle to neuronal function
BIOCHEMISTRY and Cell biology-biochimie ET BIOLOGIE cellulaire, v. 74, (4), 1996, p. 419-429
Tang, DM; Lee, KY; Qi, Z.; Matsuura, I.; Wang, JH Article

1995 4

Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase
J. Neurochem., v. 65, (6), 1995, p. 2804-2807
Goedert, M.; Jakes, R.; Qi, Robert Zhong; Wang, J.H.; Cohen, P. Article
Reconstitution of neuronal Cdc2-like kinase from bacteria-expressed Cdk5 and an active fragment of the brain specific activator
J. Biol. Chem., v. 270, (18), 1995, p. 10847-10854
Qi, Robert Zhong; Huang, Q.Q.; Lee, K.Y.; Lew, J.; Wang, J.H. Article
Regulatory properties of neuronal Cdc2-like kinase
Mol. Cell. Biochem., v. 149, 1995, p. 35-39
Qi, Robert Zhong; Yang, D.; Matsuura, I.; Lee, K.Y.; Zhu, X.; Huang, Q.Q.; Wang, J.H. Article
Structure, function, and regulation of neuronal Cdc2-like protein kinase
Neurobiol. Aging, v. 16, 1995, p. 263-270
Lew, J.; Qi, Robert Zhong; Huang, Q.Q.; Paudel, H.K.; Matsuura, I.; Matsushita, M.; Zhu, X.; Wang, J.H. Article

1994 1

A brain-specific activator of cyclin-dependent kinase 5
Nature, v. 371, 1994, p. 423-426
Lew, J.; Huang,Q Q.; Qi, Robert Zhong; Winkfein, R.J.; Aebersold, R.; Hunt, T.; Wang, J.H. Article


Expand All Collapse All


Article 1

Proteolysis of γ-tubulin small complex proteins is mediated by the ubiquitin-proteasome system
FEBS Letters, June 2021
Yin, Can; Lui, Sze Wai; Jiang, Taolue; Qi, Robert Zhong


Expand All Collapse All


Article 1

Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction
The Journal of cell biology, v. 219, (5), 4 May 2020, article number e201909094
Au, Kin Chung Franco; Hau, K.T.; Qi, Robert Zhong


Expand All Collapse All


Article 2

Cytolinker Gas2L1 Regulates Axon Morphology Through Microtubule-modulated Actin Stabilization
EMBO Reports, September 2019, article number e47732
van de Willige, Dieudonnée; Hummel, J.J.A.; Alkemade, Celine; Kahn, Olga I.; Au, Kin Chung Franco; Qi, Robert Zhong; Dogterom, Marileen; Koenderink, Gijsje Hendrika; Hoogenraad, Casper C.; Akhmanova, Anna S.
The Catalytic Subunit of DNA Polymerase δ is a Nucleocytoplasmic Shuttling Protein
Experimental Cell Research, v. .375, (2), February 2019, p. 36-40
Shen, Yuehong; Wang, Kexin; Qi, Robert Zhong


Expand All Collapse All


Article 2

A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission
Cell, v. 175, (1), September 2018, p. 254-265.e14
Hoyer, Melissa J.; Chitwood, Patrick J.; Ebmeier, Christopher C.; Striepen, Jonathan F.; Qi, Robert Zhong; Old, William M.; Voeltz, Gia K.
Epigenetic Alterations of Wnt Signaling Pathways in Nasopharyngeal Carcinoma
Current Molecular Pharmacology, 30 July 2018, p. 1-9
Liu, Pengfei; Fu, Lu; Qi, Robert Z.


Expand All Collapse All


Article 6

EB1 and EB3 Regulate Microtubule Minus End Organization and Golgi Morphology
Journal of Cell Biology, v. 216, (10), October 2017, p. 3179-3198
Yang, Chao; Wu, Jingchao; De Heus, Cecilia; Grigoriev, Ilya; Liv, Nalan; Yao, Yao; Smal, Ihor; Meijering, Erik; Klumperman, Judith; Qi, Robert Zhong; Akhmanova, Anna
GAS2L1 Is a Centriole-Associated Protein Required for Centrosome Dynamics and Disjunction
Developmental Cell, v. 40, (1), Jan 2017, p. 81-94
Au, Kin Chung Franco; Jia, Yue; Jiang, Kai; Grigoriev, Ilya; Hau, Kwan Tang; Shen, Yuehong; Du, Shengwang; Akhmanova, Anna; Qi, Robert Zhong
Microtubule Plus-end Tracking of End-binding Protein 1 (EB1) Is Regulated by CDK5 Regulatory Subunit-associated Protein 2
Journal of Biological Chemistry, v. 292, (18), May 2017, p. 7675-7687
Fong, Ka Wing; Au, Kin Chung Franco; Jia, Yue; Yang, Shaozhong; Zhou, Liying; Qi, Robert Zhong
Noncontact Viscoelastic Imaging of Living Cells Using a Long-Needle Atomic Force Microscope with Dual-Frequency Modulation
Physical Review Applied, v. 8, (4), October 2017, article number 044010
Guan, Dongshi; Charlaix, Elisabeth; Qi, Robert Z.; Tong, Penger
RNA Editing of SLC22A3 Drives Early Tumor Invasion and Metastasis in Familial Esophageal Cancer
Proceedings of the National Academy of Sciences of the United States of America, v. 114, (23), June 2017, p. 4631-4640
Fu, Li; Qin, Yan-Ru; Ming, Xiao-Yan; Zuo, Xian-Bo; Diao, Yu-Wen; Zhang, Li Yi; Ai, Jiaoyu; Liu, Bei-Lei; Huang, Tu-Xiong; Cao, Ting-Ting; Tan, Bin-Bin; Xiang, Di; Zeng, Chui-Mian; Gong, Jing; Zhang, Qiangfeng; Dong, Sui-Sui; Chen, Juan; Liu, Haibo; Wu, Jian-Lin; Qi, Robert Zhong; Xie, Dan; Wang, Li-Dong; Guan, Xin-Yuan
The Catalytic Subunit of DNA Polymerase δ Inhibits γTuRC Activity and Regulates Golgi-derived Microtubules
Nature Communications, v. 8, September 2017, article number 554
Shen, Yuehong; Liu, Pengfei; Jiang, Taolue; Hu, Yu; Au, Kin Chung Franco; Qi, Robert Zhong

Conference paper 4

DNA polymerase δ catalytic subunit is a nucleus and cytoplasm shuttling protein
2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Hong Kong, 16 June 2017
Wang, Kexin; Shen, Yuehong; Robert z. qi
GAS2L1 is a centriole-associated protein that functions in centrosome disjunction.
EMBO Conference–Centrosomes and Spindle Pole Bodies, EMBL Heidelberg, Germany, 24-27 September 2017
Au, Kin Chung Franco; Jia y; Jiang, k; Grioriey i; Hau, Kwan Tang; Shen, Yuehong; Du, Shengwang; Akhmanova a; Qi, Robert Zhong
Identification of γ-Tubulin Ring Complex Regulators in Mammalian Cells
EMBO Conference–Centrosomes and Spindle Pole Bodies, EMBL Heidelberg, Germany, 24-27 September 2017
Shen, Yuehong; Liu, Pengfei; Jiang, Taolue; Hu, Yu; Au, Kin Chung Franco; Qi, Robert Zhong
NME7 Functions in ciliogenesis and left-right asymmetry development
EMBO Conference–Centrosomes and Spindle Pole Bodies, EMBL Heidelberg, Germany, 24-27 September 2017
Liu, Pengfei; Yu, Tao; Wen, Zilong; Qi, Robert Zhong


Expand All Collapse All


Article 2

Identification of Porcine Relaxin in Plasma by Liquid Chromatography-high Resolution Mass Spectrometry
Drug Testing and Analysis, v. 9, (9), December 2016, p. 1412-1420
Wong, April S.Y; Ho, Emmie N.M.; Kwok, Wai Him; Leung, Gary N.W.; Shen, Yuehong; Qi, Robert Zhong; Yue, Samuel Ka Sheng; Wan, Terence See Ming
Molecular Pathway of Microtubule Organization at the Golgi Apparatus
Developmental Cell, v. 39, (1), October 2016, p. 44-60
Wu, Jingchao; De Heus, Cecilia; Liu, Qingyang; Bouchet, Benjamin Pierre; Noordstra, Ivar; Jiang, Kai; Hua, Shasha; Martin, Maud; Yang, Chao; Grigoriev, Ilya I.; Katrukha, Eugene A.; Altelaar, A.F. Maarten; Hoogenraad, Casper C.; Qi, Robert Zhong; Klumperman, Judith; Akhmanova, Anna S.

Conference paper 1

GAS2L1 is a Centriolar Protein to Regulate Centrosome Disjunction
2016 ASCB (The American Society for Cell Biology) Annual Meeting, Moscone Center, San Francisco, California, 3-7 December 2016
Au, Kin Chung Franco; Jia, Yue; Jiang, Kai; Grigoriev, Ilya; Hau, Kwan Tang; Du, Shengwang; Akhmanova, Anna; Qi, Robert Zhong


Expand All Collapse All


Article 5

A newly identified myomegalin isoform functions in Golgi microtubule organization and ER-Golgi transport
Journal of cell science, v. 127, (22), November 2014, p. 4904-4917
Wang, Zhe; Zhang, Chao; Qi, Robert Zhong
Assaying microtubule nucleation by the γ-tubulin ring complex
Methods in Enzymology, v. 540, 2014, p. 119-130
Choi, Yu Kwan; Qi, Robert Zhong
GATA2 as a potential metastasis-driving gene in prostate cancer
Oncotarget, v. 5, (2), 2014, p. 451-461
Chiang, Yan Ting; Wang, Kendric; Fazli, Ladan; Qi, Robert Zhong; Gleave, Martin E.; Collins, Colin C.; Gout, Peter W.; Wang, Yuzhuo
NME7 is a functional component of the gamma-tubulin ring complex
Molecular Biology of the Cell, v. 25, (13), July 2014, p. 2017-2025
Liu, Pengfei; Choi, Yuk-Kwan; Qi, Robert Z.
Transmembrane and Coiled-Coil Domain Family 1 Is a Novel Protein of the Endoplasmic Reticulum
PLOS ONE, v. 9, (1), January 2014, article number e85206
Zhang, Chao; Kho, Yik-Shing; Wang, Zhe; Chiang, Yan Ting; Ng, Gary Kar Ho; Shaw, Pang-Chui; Wang, Yuzhuo; Qi, Robert Zhong

Conference paper 3

Analysis of γ-tubulin ring complexes associated with CDK5RAP2 and GCP-WD
EMBO Conference - Centrosomes and Spindle Pole Bodies, Lisbon, Portugal, 30 September - 3 October 2014
Shen, Y.; Hu, Y.; Qi, Robert Zhong
Nme7 functions in the growth of primary cilia
EMBO Conference - Centrosomes and Spindle Pole Bodies, Lisbon, Portugal, 30 September - 3 October 2014
Liu, P.; Yu, T.; Wen, Z.; Qi, Robert Zhong
Nme7 regulates microtubule nucleation by the γ-tubulin ring complex
EMBO Conference - Centrosomes and Spindle Pole Bodies, Oct. 2014, Lisbon, Portugal. (*Equal contribution)
Liu, Pengfei; Choi, Yukkwan; Qi, Robert Zhong


Expand All Collapse All


Article 3

Bioinformatic Analysis of Data Generated from MALDI Mass Spectrometry for Biomarker Discovery
Topics in Current Chemistry, v. 331, 2013, p. 193-210
He, Zengyou; Qi, Robert Z.; Yu, Weichuan
Dynamic Recruitment of CDK5RAP2 to Centrosomes Requires Its Association with Dynein
PLoS ONE, v. 8, (7), July 2013, article number e68523
Jia, Yue; Fong, Ka-Wing; Choi, Yuk-Kwan; See, Siu-San; Qi, Robert Z.
Whole-genome Screening Identifies Proteins Localized to Distinct Nuclear Bodies
The Journal of Cell Biology, v. 203, (1), October 2013, p. 149-164
Fong, Ka-wing; Li, Yujing; Wang, Wenqi; Ma, Wenbin; Li, Kunpeng; Qi, Robert Z.; Liu, Dan; Zhou, Songyang; Chen, Junjie

Conference paper 1

Identification and Characterization of Various Populations of γ-tubulin Ring Complex
Gordon Research Conference - Posttranslational Modification Networks, Hong Kong, 2013
Shen, Yuehong; Choi, Y.K.; Liu, P.F.; Hu, Y.; Qi, Robert Z.


Expand All Collapse All


Article 1

Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro
Journal of Cellular and Molecular Medicine, v. 16, (4), April 2012, p. 789-811
Ng, Jian Ming Jeremy; Chen, Minghui Jessica; Leung, Jacqueline Y.K.; Peng, Zhao Feng; Manikandan, Jayapal; Qi, Robert Z.; Chuah, Meng Inn; West, Adrian K.; Vickers, James C.; Lu, Jia; Cheung, Nam Sang; Chung, Roger S.

Conference paper 1

NME7 Is a Functional Component of the γ-Tubulin Ring Complex
Biology of Cilia and Flagella (FASEB Science Research Conference), Niagara Falls, New York, U.S.A.
Qi, Robert Zhong; Liu, Pengfei; Choi, Yuk Kwan; Shen, Yuehong


Expand All Collapse All


Article 2

Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis
British Journal of Cancer, v. 104, (5), March 2011, p. 841-849
Wong, V.C.L.; Ko, J.M.Y.; Qi, R.Z.; Li, P.J.; Wang, L.D.; Li,J-L; Chan, Y.P.; Chan, K.W.; Stanbridge, E.J.; Lung, M.L.
The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein
Cellular and molecular life sciences, v. 68, (9), May 2011, p. 1633-1643
He, Lisheng; Zhang, Zhaojun; Yu, Yan; Ahmed, Sohail; Cheung, Nam Sang; Qi, Robert Z.


Expand All Collapse All


Article 5

A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism
Molecular and Cellular Proteomics, v. 9, (12), 2010, p. 2617-2628
Cai, Z.; Zhao, J.S.; Li, J.J.; Peng, D.N.; Wang, X.Y.; Chen, T.L.; Qiu, Y.P.; Chen, P.P.; Li, W.J.; Xu, L.Y.; Li, E.M.; Tam, J.P.M.; Qi, R.Z.; Jia, W.; Xie, D.
CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex
Journal of Cell Biology, v. 191, (6), 2010, p. 1089-1095
Choi, Y.K.; Liu, P.; Sze, S.K.; Dai, C.; Qi, R.Z.
Conserved Motif of CDK5RAP2 Mediates Its Localization to Centrosomes and the Golgi Complex
Journal of biological chemistry, v. 285, (29), 2010, JUL 16, p. 22658-22665
Wang, Zhe; Wu, Tao; Shi, Lin; Zhang, Lin; Zheng, Wei; Qu, Jianan Y.; Niu, Ruifang; Qi, Robert Z.
Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator
Journal of Cellular Biochemistry, v. 111, (5), 2010, p. 1359-1366
Chew, J.; Chen, M.J.; Lee, A.Y.W.; Peng, Z.F.; Chong, K.W.Y.; He, L.; Bay, B.H.; Ng, J.M.J.; Qi, R.Z.; Cheung, N.S.
Optimization-Based Peptide Mass Fingerprinting for Protein Mixture Identification
Journal of Computational Biology, v. 17, (3), March 2010, p. 221-235
He, Zengyou; Yang, Chao; Yang, Can; Qi, Robert Zhong; Tam, P.M.; Yu, Weichuan

Conference paper 5

A conserved protein domain identified by computational alignment is important to cytoskeleton organization
ACM-HK Bioinformatics Symposium, The Hong Kong University of Science and Technology
Choi, Y.K.; Fong, K.W.; Qi, R.Z.
CDK5RAP2 in microtubule regulation and autosomal recessive primary microcephaly
Gordon Research Conference – Molecular and Cellular Neurobiology, Jun. 2010, Hong Kong
Fong, Ka Wing; Choi, Yuk Kwan; Qi, Robert Z.
Characterization of CDK5RAP2 in the organization and regulation of microtubule ends
EMBO Conference Series Microtubules - Structure, Regulation and Functions, EMBL Heidelberg, Germany
Fong, K.W.; Choi, Y.K.; Qi, R.Z.
Characterizing the association of CDK5RAP2 with the γ-tubulin ring complex
EMBO Conference Series Microtubules - Structure, Regulation and Functions, EMBL Heidelberg, Germany
Choi, Y.K.; Fong, K.W.; Qi, R.Z.
Involvement of Hsc70 and EBV Latent Membrane Protein-1 in the regulation of cell mitosis
ACM-HK Bioinformatics Symposium, The Hong Kong University of Science and Technology
He, L.; Choi, Y.K.; Qi, R.Z.


Expand All Collapse All


Article 4

Anxa2 Plays a Critical Role in Enhanced Invasiveness of the Multidrug Resistant Human Breast Cancer Cells
Journal of proteome research, v. 8, (11), 2009, NOV, p. 5041-5047
Zhang, Fei; Zhang, Lin; Zhang, Bin; Wei, Xiyin; Yang, Yi; Qi, Robert Z.; Ying, Guoguang; Zhang, Ning; Niu, Ruifang
Interaction of CDK5RAP2 with EB1 to Track Growing Microtubule Tips and to Regulate Microtubule Dynamics
Molecular biology of the cell, v. 20, (16), 2009, AUG 15, p. 3660-3670
Fong, Ka-Wing; Hau, Shiu-Yeung; Kho, Yik-Shing; Jia, Yue; He, Lisheng; Qi, Robert Z.
Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway
PLoS ONE, v. 4, (9), 2009
Jiang, L.; Wang, Q.; Yu, Y.; Zhao, F.; Huang, P.; Zeng, R.; Qi, R.Z.; Li, W.; Liu, Y.
Proteomics in gastric cancer research: Benefits and challenges
Proteomics Clinical APPLICATIONS, v. 3, (2), 2009, FEB, p. 185-196
Li, Jing-Jing; Qi, Robert Z.; Ng, Gary Kar Ho; Xie, Dong

Conference paper 3

Functional proteomics in the discovery of biomarkers and therapeutic targets
Biomarkers for early detection of cancers: Technological advances & clinical readiness, Croucher Advanced Study Institute, The University of Hong Kong, Mar. 2009, p27
Qi, R.Z.
Involvement of CDK5RAP2 in microtubule organization: The ends are the beginning
The Second International Symposium on Cdk5, Tokyo, Japan, Jun. 2009, p10
Qi, R.Z.
Optimization-based Peptide Mass Fingerprinting for Protein Mixture Identification
Research in Computational Molecular Biology, 5541, 2009, p. 16-30
He, Zengyou; Yang, Chao; Qi, Robert Zhong; Tam, Jason Po-Ming; Yu, Weichuan


Expand All Collapse All


Article 3

Calmodulin binding and cdk5 phosphorylation of p35 regulate its effect on microtubules
Journal of biological chemistry, v. 283, (19), 2008, MAY 9, p. 13252-13260
He, Lisheng; Hou, Zhibo; Qi, Robert Z.
CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the γ-tubulin ring complex
Molecular Biology of the Cell, v. 19, (1), January 2008, p. 115-125
Fong, Ka Wing; Choi, Yuk Kwan; Rattner, Jerome B.; Qi, Robert Zhong
Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma
International journal of cancer, v. 122, (3), 2008, FEB 1, p. 587-594
Leung, Alfred Chi Chung; Wong, Victor Chun Lam; Yang, Li Chun; Chan, Pui Ling; Daigo, Yataro; Nakamura, Yusuke; Qi, Robert Z.; Miller, Lance David; Liu, Edison Tak-Bun; Wang, Li Dong; Li, Ji-Lin; Law, Simon; Tsao, Sai Wah; Lung, Maria Li

Book chapter 1

Protein-protein Interactions Involving the N-terminus of p35
Cyclin Dependent Kinase 5 (Cdk5) / Edited by Li-Huei Tsai, Nancy Y. Ip. New York, NY: Springer Science+Business Media, LLC, c2008, p.159-170
Ng, G.K.H.; He, L.; Qi, R.Z.

Conference paper 4

CDK5RAP2 associates with EB1 and regulates microtubule dynamics
The 1st EMBO Conference on Centrosomes and Spindle Pole Bodies, EMBL, Heidelberg, Germany, Sep. 2008, p93
Fong, K.W.; Hau, S.Y.; Kho, Y.S.; Qi, R.Z.
CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the γ-tubulin ring complex
Gordon Research Conference - Molecular and Cellular Neurobiology
Fong, K.W.; Choi, Y.W.; Rattner, J.B.; Qi, R.Z.
CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the γ-tubulin ring complex
The 1st EMBO Conference on Centrosomes and Spindle Pole Bodies, EMBL, Heidelberg, Germany, Sep. 2008, p19
Fong, K.W.; Choi, Y.W.; Rattner, J.B.; Qi, R.Z.
Functional proteomics to decipher neuronal Cdk5 regulatory pathways
The 9th AEARU Workshop on Molecular Biology and Biotechnology
Qi, R.Z.


Expand All Collapse All


Article 4

Discovery of stage-related proteins in esophageal squamous cell carcinoma using proteomic analysis
Proteomics Clinical APPLICATIONS, v. 1, (3), 2007, MAR, p. 312-320
Liu, Dong-Ping; Qi, Robert Z.; Wang, Yan; Chen, Ping-Ping; Koeffler, H. Phillip; Xie, Dong
Microtubule association of the neuronal p35 activator of Cdk5
Journal of biological chemistry, v. 282, (26), 2007, JUN 29, p. 18666-18670
Hou, Zhibo; Li, Qing; He, Lisheng; Lim, Hui-Ying; Fu, Xinrong; Cheung, Nam Sang; Qi, Donna X.; Qi, Robert Z.
Neuronal apoptosis mediated by inhibition of intracellular cholesterol transport: Microarray and proteomics analyses in cultured murine cortical neurons
Journal of cellular physiology, v. 211, (1), 2007, APR, p. 63-87
Koh, Chor Hui Vivien; Peng, Zhao Feng; Ou, Keli; Melendez, Alirio; Manikandan, Jayapal; Qi, Robert Z.; Cheung, Nam Sang
Regulation of S6 kinase 1 activation by phosphorylation at Ser-411
Journal of biological chemistry, v. 282, (10), 2007, MAR 9, p. 6922-6928
Hou, Zhibo; He, Lisheng; Qi, Robert Z.

Conference paper 1

Proteomics to dissect Cdk5 signaling pathways in health and disease
Annual Symposium of Hong Kong Proteomics Society and China Human Proteome Organization Satellite Meeting
Qi, R.Z.


Expand All Collapse All


Article 4

Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes
Journal of neurochemistry, v. 98, (5), 2006, SEP, p. 1597-1609
Yap, Yann Wan; Whiteman, Matthew; Bay, Boon Huat; Li, Yuhong; Sheu, Fwu-Shan; Qi, Robert Z.; Tan, Chee Hong; Cheung, Nam Sang
Identification of nuclear import mechanisms for the neuronal Cdk5 activator
Journal of biological chemistry, v. 281, (51), 2006, DEC 22, p. 39014-39021
Fu, Xinrong; Choi, Yuk-Kwan; Qu, Dianbo; Yu, Yan; Cheung, Nam Sang; Qi, Robert Z.
U18666A-mediated apoptosis in cultured murine cortical neurons: Role of caspases, calpains and kinases
Cellular signalling, v. 18, (10), 2006, OCT, p. 1572-1583
Koh, Chor Hui Vivien; Qi, Robert Z.; Qu, Dianbo; Melendez, Alirio; Manikandan, Jayapal; Bay, Boon Huat; Duan, Wei; Cheung, Nam Sang
不同转移能力乳腺癌细胞株的差异表达蛋白研究
癌症=Chinese Journal of Cancer, v. 2006, (07), 2006, p. 823-827
叶丽虹; 尤嘉琮; 郭威; 徐少峰; 吴莲英; 齐众; 张晓东

Conference paper 1

Hypochlorous Acid Induces Apoptosis of Cultured Cortical Neurons Through Activation of Calpains and Rupture of Lysosomes
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Yap, Yann Wan; Whiteman, Matthew; Bay, Boon Huat; Sheu, Fwu Shan; Qi, Robert Z.; Cheung, Nam Sang


Expand All Collapse All


Article 3

Cleavage of the carboxyl-terminus of LEACS2, a tomato 1-aminocyclopropane-1-carboxylic acid synthase isomer, by a 64-kDa tomato metalloprotease produces a truncated but active enzyme
Journal of integrative plant biology, v. 47, (11), 2005, NOV, p. 1352-1363
Li, Jian-Feng; Qi, Robert; Qu, Liang-Hu; Mattoo, Autar K.; Li, Ning
Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis
Journal of neurochemistry, v. 94, (4), 2005, AUG, p. 943-956
Yew, EHJ; Cheung, NS; Choy, MS; Qi, RZ; Lee, AYW; Peng, ZF; Melendez, AJ; Manikandan, J.; Koay, ESC; Chiu, LL; Ng, WL; Whiteman, M.; Kandiah, J.; Halliwell, B.
Purification and properties of lipases/esterases from a Bacillus strain for enantioselective resolution of (S)-ketoprofen
Artificial Cells Blood Substitutes and Biotechnology, v. 33, (4), 2005, p. 435-445
Zhang, JH; Guan, R.; Tan, ZL; Yu, YT; Hou, ZB; Qi, Z.; Wang, SW


Expand All Collapse All


Article 8

Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons
Biochemical and biophysical research communications, v. 315, (2), 2004, MAR 5, p. 408-417
Cheung, NS; Koh, CHV; Bay, BH; Qi, RZ; Choy, MS; Li, QT; Wong, KP; Whiteman, M.
Direct regulation of microtubule dynamics by protein kinase CK2
Journal of biological chemistry, v. 279, (6), 2004, FEB 6, p. 4433-4439
Lim, ACB; Tiu, SY; Li, Q.; Qi, RZ
Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction
Cellular and molecular life sciences, v. 61, (15), 2004, JUL, p. 1926-1934
Cheung, NS; Choy, MS; Halliwell, B.; Teo, TS; Bay, BH; Lee, AYW; Qi, RZ; Koh, VH; Whiteman, M.; Koay, ESC; Chiu, LL; Zhu, HJ; Wong, KP; Beart, PM; Cheng, HC
Protein kinase CK2 is an inhibitor of the neuronal Cdk5 kinase
Journal of biological chemistry, v. 279, (45), 2004, NOV 5, p. 46668-46673
Lim, ACB; Hou, ZB; Goh, CP; Qi, RZ
Signaling via a novel integral plasma membrane pool of a serine/threonine protein kinase PRK1 in mammalian cells
FASEB JOURNAL, v. 18, (12), 2004, SEP, p. 1722+
Zhu, YM; Stolz, DB; Guo, FL; Ross, MA; Watkins, SC; Tan, BJ; Qi, RZ; Manser, E.; Li, QT; Bay, BH; Teo, TS; Duan, W.
Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine
Biochemical and biophysical research communications, v. 317, (1), 2004, APR 23, p. 128-132
Song, YC; Kesuma, D.; Wang, H.; Deng, Y.; Duan, J.; Wang, JH; Qi, RZ
α2-Chimaerin, Cyclin-Dependent Kinase 5/p35, and Its Target Collapsin Response Mediator Protein-2 Are Essential Components in Semaphorin 3A-Induced Growth-Cone Collapse
THE JOURNAL OF NEUROSCIENCE, v. 24, (41), 2004, OCT 13, p. 8994-9004
Brown, Matthew; Jacobs, Tom; Eickholt, Britta; Ferrari, Giovanna; Teo, Mabel; Monfries, Clinton; Qi, Robert Z.; Leung, Thomas; Lim, Louis; Hall, Christine
α-Chimaerin exists in a functional complex with the Cdk5 kinase in brain
FEBS letters, v. 561, (1-3), 2004, MAR 12, p. 177-180
Qi, Robert Z.; Ching, Yick-Pang; Kung, Hsiang-Fu; Wang, Jerry H.

Conference paper 1

Proteomics to dissect the cell regulatory machinery in brain
HUPO (Human Proteome Organization)3rd World Congress, Beijing P.R. China, Abstract published in Mol. Cell. Proteomics, 3(10), S185, Oct 2004
Qi, R.Z.; Fong, K.W.; Hou, Z.; Fu, X.; Yu, Y.; He, L.


Expand All Collapse All


Article 4

Cyclin-dependent kinases in neural development and degeneration
Journal of Alzheimer's Disease, v. 5, (4), 2003, p. 329-335
Lim, A.C.B.; Qi, R.Z.
Phosphoproteomic fingerprinting of epidermal growth factor signaling and anticancer drug action in human tumor cells
Mol. Cancer Ther., v. 2, (12), 2003, p. 1369-1377
Lim, Y.P.; Diong, L.S.; Qi, Robert Zhong; Druker, B.J.; Epstein, R.J.
Protein-protein interactions in Cdk5 regulation and function
NeuroSignals, v. 12, (4-5), 2003, p. 230-238
Lim, ACB; Qu, DB; Qi, RZ
Role of IGF system of mitogens in the induction of fibroblast proliferation by keloidderived keratinocytes in vitro
Am. J. Physiol.-Cell Physiol., v. 284, (4), 2003, p. 860-869
Phan, T.T.; Lim, I.J.; Bay, B.H.; Qi, Robert Zhong; Longaker, M.T.; Lee, S.T.; Huynh, H.

Conference paper 3

Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor
The Society for Neuroscience 33rd Annual Meeting, New Orleans, Louisiana, USA, Nov
Lim, A.C.; Goh, C.P.; Tiu, S.Y.; Wong, B.S.; Qi, Robert Z.
Protein kinase CK2 is an inhibitor of the neuronal Cdk5 kinase
Gordon Research Conference – Molecular and Cellular Neurobiology, Hong Kong, Jun.
Lim, A.C.B.; Hou, Z.; Goh, C.P.; Qi, Robert Z.
Proteomic Dissection of Neurosignal Transduction Pathways
Molecular Neuroscience: Technology Applications, organized by the Croucher Advanced Study Institute, Hong Kong.
Qi, Robert Z.


Expand All Collapse All


Article 6

CD157 undergoes ligand-independent dimerization and colocalizes with caveolin in CHO and MCA102 fibroblasts
Cell Signal, v. 14, (11), 2002, p. 933-939
Liang, F.; Qi, Robert Zhong; Chang, C.F.
Differences in collagen production between normal and keloid-derived fibroblasts in serum-media co-culture with keloid-derived keratinocytes
J. Dermatol. Sci., v. 29, (1), 2002, p. 26-34
Phan, T.T.; Lim, I.J.; Bay, B.H.; Qi, Robert Zhong; Huynh, H.T.; Lee, S.T.; Longaker, M.T.
Fibroblasts cocultured with keloid keratinocytes: Normal fibroblasts secrete collagen in a keloidlike manner
Am. J. Physiol.-Cell Physiol., v. 283, (1), 2002, p. 212-222
Lim, I.J.; Phan, T.T.; Bay, B.H.; Qi, Robert Zhong; Huynh, H.; Tan, W.T.; Lee, S.T.; Longaker, M.T.
Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor
Journal of biological chemistry, v. 277, (18), 2002, MAY 3, p. 15237-15240
Ching, Y.P.; Pang, A.S.H.; Lam, W.H.; Qi, R.Z.; Wang, J.H.
The protein SET binds the neuronal Cdk5 activator p35(nck5a) and modulates Cdk5/p35(nck5a) activity
Journal of biological chemistry, v. 277, (9), 2002, MAR 1, p. 7324-7332
Qu, DB; Li, Q.; Lim, HY; Cheung, NS; Li, R.; Wang, JH; Qi, RZ
β-Carbolines as specific inhibitors of cyclin-dependent kinases
Bioorganic and Medicinal Chemistry Letters, v. 12, (7), 2002, p. 1129-1132
Song, Y.; Wang, J.; Teng, S.F.; Kesuma, D.; Deng, Y.; Duan, J.; Wang, J.H.; Qi, R.Z.; Sim, M.M.

Conference paper 2

Proteomics of neuronal Cdk5 signaling complexes in brain
Proteomics in the Neurosciences, organized by the National Institute of Neurological Disorders and Stroke of the National Institute of Health, U.S.A.
Qi, Robert Z.
Proteomics of Neuronal Cdk5 Signaling Complexes in Health and Disease
Second International Conference on Structural Biology and Functional Genomics, organized by the National University of Singapore, Singapore
Qi, Robert Z.


Expand All Collapse All


Article 5

A membrane protein enriched in ER exit sites interacts with COPII
J. Biol. Chem., v. 276, (43), 2001, p. 40008-40017
Tang, B.L.; Ong, Y.S.; Huang, B.; Wei, S.; Wong, E.T.; Qi, Robert Zhong; Horstmann, H.; Hong, W.
Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members
Biochemical and biophysical research communications, v. 288, (1), 2001, OCT 19, p. 233-239
Rajala, RVS; Datla, RSS; Carlsen, SA; Anderson, DH; Qi, Z.; Wang, JH; Sharma, RK
Proteins of mycobacterium bovis BCG induced in the Wayne dormancy model
J. Bacteriol, v. 183, (8), 2001, p. 2672-2676
Boon, C.; Li, R.; Qi, Robert Zhong; Dick, T.
Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibrablasts
FEBS Lett., v. 506, (3), 2001, p. 207-210
Liang, F.; Qi, Robert Zhong; Chang, C.F.
Structural insights into Cdk5 activation by a neuronal Cdk5 activator
Biochemical and biophysical research communications, v. 285, (1), 2001, JUL 6, p. 77-83
Lim, HY; Seow, KT; Li, Q.; Kesuma, D.; Wang, JH; Qi, RZ


Expand All Collapse All


Article 2

Cloning of three novel neuronal Cdk5 activator binding proteins
Gene, v. 242, (1-2), 2000, JAN 25, p. 285-294
Ching, YP; Qi, Z.; Wang, JH
Identification of a common protein association region in the neuronal Cdk5 activator
Journal of biological chemistry, v. 275, (41), 2000, OCT 13, p. 31763-31769
Wang, Xiujie; Ching, Wilson Yik Pang; Lam, Wing H.; Qi, Zhong; Zhang, Mingjie; Wang, Jerry Hsueh-ching


Expand All Collapse All


Article 2

Association of neurofilament proteins with neuronal Cdk5 activator
Journal of biological chemistry, v. 273, (4), 1998, JAN 23, p. 2329-2335
Qi, Z.; Tang, DM; Zhu, XD; Fujita, DJ; Wang, JH
Effect of heparin on phosphorylation site specificity of neuronal Cdc2-like kinase
FEBS letters, v. 423, (2), 1998, FEB 20, p. 227-230
Qi, Z.; Zhu, XD; Goedert, M.; Fujita, DJ; Wang, JH


Expand All Collapse All


Article 1

Neuronal Cdc2-like kinases: Neuron-specific forms of Cdk5
International journal of biochemistry & cell biology, v. 29, (7), 1997, JUL, p. 951-958
Lee, KY; Qi, Z.; Yu, YP; Wang, JH


Expand All Collapse All


Article 1

Neuronal Cdc2-like kinase: From cell cycle to neuronal function
BIOCHEMISTRY and Cell biology-biochimie ET BIOLOGIE cellulaire, v. 74, (4), 1996, p. 419-429
Tang, DM; Lee, KY; Qi, Z.; Matsuura, I.; Wang, JH


Expand All Collapse All


Article 4

Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase
J. Neurochem., v. 65, (6), 1995, p. 2804-2807
Goedert, M.; Jakes, R.; Qi, Robert Zhong; Wang, J.H.; Cohen, P.
Reconstitution of neuronal Cdc2-like kinase from bacteria-expressed Cdk5 and an active fragment of the brain specific activator
J. Biol. Chem., v. 270, (18), 1995, p. 10847-10854
Qi, Robert Zhong; Huang, Q.Q.; Lee, K.Y.; Lew, J.; Wang, J.H.
Regulatory properties of neuronal Cdc2-like kinase
Mol. Cell. Biochem., v. 149, 1995, p. 35-39
Qi, Robert Zhong; Yang, D.; Matsuura, I.; Lee, K.Y.; Zhu, X.; Huang, Q.Q.; Wang, J.H.
Structure, function, and regulation of neuronal Cdc2-like protein kinase
Neurobiol. Aging, v. 16, 1995, p. 263-270
Lew, J.; Qi, Robert Zhong; Huang, Q.Q.; Paudel, H.K.; Matsuura, I.; Matsushita, M.; Zhu, X.; Wang, J.H.


Expand All Collapse All


Article 1

A brain-specific activator of cyclin-dependent kinase 5
Nature, v. 371, 1994, p. 423-426
Lew, J.; Huang,Q Q.; Qi, Robert Zhong; Winkfein, R.J.; Aebersold, R.; Hunt, T.; Wang, J.H.


Expand All Collapse All


2016 3

Identification of Porcine Relaxin in Plasma by Liquid Chromatography-high Resolution Mass Spectrometry
Drug Testing and Analysis, v. 9, (9), December 2016, p. 1412-1420
Wong, April S.Y; Ho, Emmie N.M.; Kwok, Wai Him; Leung, Gary N.W.; Shen, Yuehong; Qi, Robert Zhong; Yue, Samuel Ka Sheng; Wan, Terence See Ming Article
Molecular Pathway of Microtubule Organization at the Golgi Apparatus
Developmental Cell, v. 39, (1), October 2016, p. 44-60
Wu, Jingchao; De Heus, Cecilia; Liu, Qingyang; Bouchet, Benjamin Pierre; Noordstra, Ivar; Jiang, Kai; Hua, Shasha; Martin, Maud; Yang, Chao; Grigoriev, Ilya I.; Katrukha, Eugene A.; Altelaar, A.F. Maarten; Hoogenraad, Casper C.; Qi, Robert Zhong; Klumperman, Judith; Akhmanova, Anna S. Article
GAS2L1 is a Centriolar Protein to Regulate Centrosome Disjunction
2016 ASCB (The American Society for Cell Biology) Annual Meeting, Moscone Center, San Francisco, California, 3-7 December 2016
Au, Kin Chung Franco; Jia, Yue; Jiang, Kai; Grigoriev, Ilya; Hau, Kwan Tang; Du, Shengwang; Akhmanova, Anna; Qi, Robert Zhong Conference paper

2014 8

A newly identified myomegalin isoform functions in Golgi microtubule organization and ER-Golgi transport
Journal of cell science, v. 127, (22), November 2014, p. 4904-4917
Wang, Zhe; Zhang, Chao; Qi, Robert Zhong Article
Assaying microtubule nucleation by the γ-tubulin ring complex
Methods in Enzymology, v. 540, 2014, p. 119-130
Choi, Yu Kwan; Qi, Robert Zhong Article
GATA2 as a potential metastasis-driving gene in prostate cancer
Oncotarget, v. 5, (2), 2014, p. 451-461
Chiang, Yan Ting; Wang, Kendric; Fazli, Ladan; Qi, Robert Zhong; Gleave, Martin E.; Collins, Colin C.; Gout, Peter W.; Wang, Yuzhuo Article
NME7 is a functional component of the gamma-tubulin ring complex
Molecular Biology of the Cell, v. 25, (13), July 2014, p. 2017-2025
Liu, Pengfei; Choi, Yuk-Kwan; Qi, Robert Z. Article
Transmembrane and Coiled-Coil Domain Family 1 Is a Novel Protein of the Endoplasmic Reticulum
PLOS ONE, v. 9, (1), January 2014, article number e85206
Zhang, Chao; Kho, Yik-Shing; Wang, Zhe; Chiang, Yan Ting; Ng, Gary Kar Ho; Shaw, Pang-Chui; Wang, Yuzhuo; Qi, Robert Zhong Article
Analysis of γ-tubulin ring complexes associated with CDK5RAP2 and GCP-WD
EMBO Conference - Centrosomes and Spindle Pole Bodies, Lisbon, Portugal, 30 September - 3 October 2014
Shen, Y.; Hu, Y.; Qi, Robert Zhong Conference paper
Nme7 functions in the growth of primary cilia
EMBO Conference - Centrosomes and Spindle Pole Bodies, Lisbon, Portugal, 30 September - 3 October 2014
Liu, P.; Yu, T.; Wen, Z.; Qi, Robert Zhong Conference paper
Nme7 regulates microtubule nucleation by the γ-tubulin ring complex
EMBO Conference - Centrosomes and Spindle Pole Bodies, Oct. 2014, Lisbon, Portugal. (*Equal contribution)
Liu, Pengfei; Choi, Yukkwan; Qi, Robert Zhong Conference paper

2013 4

Bioinformatic Analysis of Data Generated from MALDI Mass Spectrometry for Biomarker Discovery
Topics in Current Chemistry, v. 331, 2013, p. 193-210
He, Zengyou; Qi, Robert Z.; Yu, Weichuan Article
Dynamic Recruitment of CDK5RAP2 to Centrosomes Requires Its Association with Dynein
PLoS ONE, v. 8, (7), July 2013, article number e68523
Jia, Yue; Fong, Ka-Wing; Choi, Yuk-Kwan; See, Siu-San; Qi, Robert Z. Article
Whole-genome Screening Identifies Proteins Localized to Distinct Nuclear Bodies
The Journal of Cell Biology, v. 203, (1), October 2013, p. 149-164
Fong, Ka-wing; Li, Yujing; Wang, Wenqi; Ma, Wenbin; Li, Kunpeng; Qi, Robert Z.; Liu, Dan; Zhou, Songyang; Chen, Junjie Article
Identification and Characterization of Various Populations of γ-tubulin Ring Complex
Gordon Research Conference - Posttranslational Modification Networks, Hong Kong, 2013
Shen, Yuehong; Choi, Y.K.; Liu, P.F.; Hu, Y.; Qi, Robert Z. Conference paper

2012 2

Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro
Journal of Cellular and Molecular Medicine, v. 16, (4), April 2012, p. 789-811
Ng, Jian Ming Jeremy; Chen, Minghui Jessica; Leung, Jacqueline Y.K.; Peng, Zhao Feng; Manikandan, Jayapal; Qi, Robert Z.; Chuah, Meng Inn; West, Adrian K.; Vickers, James C.; Lu, Jia; Cheung, Nam Sang; Chung, Roger S. Article
NME7 Is a Functional Component of the γ-Tubulin Ring Complex
Biology of Cilia and Flagella (FASEB Science Research Conference), Niagara Falls, New York, U.S.A.
Qi, Robert Zhong; Liu, Pengfei; Choi, Yuk Kwan; Shen, Yuehong Conference paper

2011 2

Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis
British Journal of Cancer, v. 104, (5), March 2011, p. 841-849
Wong, V.C.L.; Ko, J.M.Y.; Qi, R.Z.; Li, P.J.; Wang, L.D.; Li,J-L; Chan, Y.P.; Chan, K.W.; Stanbridge, E.J.; Lung, M.L. Article
The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein
Cellular and molecular life sciences, v. 68, (9), May 2011, p. 1633-1643
He, Lisheng; Zhang, Zhaojun; Yu, Yan; Ahmed, Sohail; Cheung, Nam Sang; Qi, Robert Z. Article

2010 10

A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism
Molecular and Cellular Proteomics, v. 9, (12), 2010, p. 2617-2628
Cai, Z.; Zhao, J.S.; Li, J.J.; Peng, D.N.; Wang, X.Y.; Chen, T.L.; Qiu, Y.P.; Chen, P.P.; Li, W.J.; Xu, L.Y.; Li, E.M.; Tam, J.P.M.; Qi, R.Z.; Jia, W.; Xie, D. Article
CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex
Journal of Cell Biology, v. 191, (6), 2010, p. 1089-1095
Choi, Y.K.; Liu, P.; Sze, S.K.; Dai, C.; Qi, R.Z. Article
Conserved Motif of CDK5RAP2 Mediates Its Localization to Centrosomes and the Golgi Complex
Journal of biological chemistry, v. 285, (29), 2010, JUL 16, p. 22658-22665
Wang, Zhe; Wu, Tao; Shi, Lin; Zhang, Lin; Zheng, Wei; Qu, Jianan Y.; Niu, Ruifang; Qi, Robert Z. Article
Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator
Journal of Cellular Biochemistry, v. 111, (5), 2010, p. 1359-1366
Chew, J.; Chen, M.J.; Lee, A.Y.W.; Peng, Z.F.; Chong, K.W.Y.; He, L.; Bay, B.H.; Ng, J.M.J.; Qi, R.Z.; Cheung, N.S. Article
Optimization-Based Peptide Mass Fingerprinting for Protein Mixture Identification
Journal of Computational Biology, v. 17, (3), March 2010, p. 221-235
He, Zengyou; Yang, Chao; Yang, Can; Qi, Robert Zhong; Tam, P.M.; Yu, Weichuan Article
A conserved protein domain identified by computational alignment is important to cytoskeleton organization
ACM-HK Bioinformatics Symposium, The Hong Kong University of Science and Technology
Choi, Y.K.; Fong, K.W.; Qi, R.Z. Conference paper
CDK5RAP2 in microtubule regulation and autosomal recessive primary microcephaly
Gordon Research Conference – Molecular and Cellular Neurobiology, Jun. 2010, Hong Kong
Fong, Ka Wing; Choi, Yuk Kwan; Qi, Robert Z. Conference paper
Characterization of CDK5RAP2 in the organization and regulation of microtubule ends
EMBO Conference Series Microtubules - Structure, Regulation and Functions, EMBL Heidelberg, Germany
Fong, K.W.; Choi, Y.K.; Qi, R.Z. Conference paper
Characterizing the association of CDK5RAP2 with the γ-tubulin ring complex
EMBO Conference Series Microtubules - Structure, Regulation and Functions, EMBL Heidelberg, Germany
Choi, Y.K.; Fong, K.W.; Qi, R.Z. Conference paper
Involvement of Hsc70 and EBV Latent Membrane Protein-1 in the regulation of cell mitosis
ACM-HK Bioinformatics Symposium, The Hong Kong University of Science and Technology
He, L.; Choi, Y.K.; Qi, R.Z. Conference paper

2009 7

Anxa2 Plays a Critical Role in Enhanced Invasiveness of the Multidrug Resistant Human Breast Cancer Cells
Journal of proteome research, v. 8, (11), 2009, NOV, p. 5041-5047
Zhang, Fei; Zhang, Lin; Zhang, Bin; Wei, Xiyin; Yang, Yi; Qi, Robert Z.; Ying, Guoguang; Zhang, Ning; Niu, Ruifang Article
Interaction of CDK5RAP2 with EB1 to Track Growing Microtubule Tips and to Regulate Microtubule Dynamics
Molecular biology of the cell, v. 20, (16), 2009, AUG 15, p. 3660-3670
Fong, Ka-Wing; Hau, Shiu-Yeung; Kho, Yik-Shing; Jia, Yue; He, Lisheng; Qi, Robert Z. Article
Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway
PLoS ONE, v. 4, (9), 2009
Jiang, L.; Wang, Q.; Yu, Y.; Zhao, F.; Huang, P.; Zeng, R.; Qi, R.Z.; Li, W.; Liu, Y. Article
Proteomics in gastric cancer research: Benefits and challenges
Proteomics Clinical APPLICATIONS, v. 3, (2), 2009, FEB, p. 185-196
Li, Jing-Jing; Qi, Robert Z.; Ng, Gary Kar Ho; Xie, Dong Article
Functional proteomics in the discovery of biomarkers and therapeutic targets
Biomarkers for early detection of cancers: Technological advances & clinical readiness, Croucher Advanced Study Institute, The University of Hong Kong, Mar. 2009, p27
Qi, R.Z. Conference paper
Involvement of CDK5RAP2 in microtubule organization: The ends are the beginning
The Second International Symposium on Cdk5, Tokyo, Japan, Jun. 2009, p10
Qi, R.Z. Conference paper
Optimization-based Peptide Mass Fingerprinting for Protein Mixture Identification
Research in Computational Molecular Biology, 5541, 2009, p. 16-30
He, Zengyou; Yang, Chao; Qi, Robert Zhong; Tam, Jason Po-Ming; Yu, Weichuan Conference paper

2008 8

Calmodulin binding and cdk5 phosphorylation of p35 regulate its effect on microtubules
Journal of biological chemistry, v. 283, (19), 2008, MAY 9, p. 13252-13260
He, Lisheng; Hou, Zhibo; Qi, Robert Z. Article
CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the γ-tubulin ring complex
Molecular Biology of the Cell, v. 19, (1), January 2008, p. 115-125
Fong, Ka Wing; Choi, Yuk Kwan; Rattner, Jerome B.; Qi, Robert Zhong Article
Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma
International journal of cancer, v. 122, (3), 2008, FEB 1, p. 587-594
Leung, Alfred Chi Chung; Wong, Victor Chun Lam; Yang, Li Chun; Chan, Pui Ling; Daigo, Yataro; Nakamura, Yusuke; Qi, Robert Z.; Miller, Lance David; Liu, Edison Tak-Bun; Wang, Li Dong; Li, Ji-Lin; Law, Simon; Tsao, Sai Wah; Lung, Maria Li Article
Protein-protein Interactions Involving the N-terminus of p35
Cyclin Dependent Kinase 5 (Cdk5) / Edited by Li-Huei Tsai, Nancy Y. Ip. New York, NY: Springer Science+Business Media, LLC, c2008, p.159-170
Ng, G.K.H.; He, L.; Qi, R.Z. Book chapter
CDK5RAP2 associates with EB1 and regulates microtubule dynamics
The 1st EMBO Conference on Centrosomes and Spindle Pole Bodies, EMBL, Heidelberg, Germany, Sep. 2008, p93
Fong, K.W.; Hau, S.Y.; Kho, Y.S.; Qi, R.Z. Conference paper
CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the γ-tubulin ring complex
Gordon Research Conference - Molecular and Cellular Neurobiology
Fong, K.W.; Choi, Y.W.; Rattner, J.B.; Qi, R.Z. Conference paper
CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the γ-tubulin ring complex
The 1st EMBO Conference on Centrosomes and Spindle Pole Bodies, EMBL, Heidelberg, Germany, Sep. 2008, p19
Fong, K.W.; Choi, Y.W.; Rattner, J.B.; Qi, R.Z. Conference paper
Functional proteomics to decipher neuronal Cdk5 regulatory pathways
The 9th AEARU Workshop on Molecular Biology and Biotechnology
Qi, R.Z. Conference paper

2007 5

Discovery of stage-related proteins in esophageal squamous cell carcinoma using proteomic analysis
Proteomics Clinical APPLICATIONS, v. 1, (3), 2007, MAR, p. 312-320
Liu, Dong-Ping; Qi, Robert Z.; Wang, Yan; Chen, Ping-Ping; Koeffler, H. Phillip; Xie, Dong Article
Microtubule association of the neuronal p35 activator of Cdk5
Journal of biological chemistry, v. 282, (26), 2007, JUN 29, p. 18666-18670
Hou, Zhibo; Li, Qing; He, Lisheng; Lim, Hui-Ying; Fu, Xinrong; Cheung, Nam Sang; Qi, Donna X.; Qi, Robert Z. Article
Neuronal apoptosis mediated by inhibition of intracellular cholesterol transport: Microarray and proteomics analyses in cultured murine cortical neurons
Journal of cellular physiology, v. 211, (1), 2007, APR, p. 63-87
Koh, Chor Hui Vivien; Peng, Zhao Feng; Ou, Keli; Melendez, Alirio; Manikandan, Jayapal; Qi, Robert Z.; Cheung, Nam Sang Article
Regulation of S6 kinase 1 activation by phosphorylation at Ser-411
Journal of biological chemistry, v. 282, (10), 2007, MAR 9, p. 6922-6928
Hou, Zhibo; He, Lisheng; Qi, Robert Z. Article
Proteomics to dissect Cdk5 signaling pathways in health and disease
Annual Symposium of Hong Kong Proteomics Society and China Human Proteome Organization Satellite Meeting
Qi, R.Z. Conference paper

2006 5

Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes
Journal of neurochemistry, v. 98, (5), 2006, SEP, p. 1597-1609
Yap, Yann Wan; Whiteman, Matthew; Bay, Boon Huat; Li, Yuhong; Sheu, Fwu-Shan; Qi, Robert Z.; Tan, Chee Hong; Cheung, Nam Sang Article
Identification of nuclear import mechanisms for the neuronal Cdk5 activator
Journal of biological chemistry, v. 281, (51), 2006, DEC 22, p. 39014-39021
Fu, Xinrong; Choi, Yuk-Kwan; Qu, Dianbo; Yu, Yan; Cheung, Nam Sang; Qi, Robert Z. Article
U18666A-mediated apoptosis in cultured murine cortical neurons: Role of caspases, calpains and kinases
Cellular signalling, v. 18, (10), 2006, OCT, p. 1572-1583
Koh, Chor Hui Vivien; Qi, Robert Z.; Qu, Dianbo; Melendez, Alirio; Manikandan, Jayapal; Bay, Boon Huat; Duan, Wei; Cheung, Nam Sang Article
不同转移能力乳腺癌细胞株的差异表达蛋白研究
癌症=Chinese Journal of Cancer, v. 2006, (07), 2006, p. 823-827
叶丽虹; 尤嘉琮; 郭威; 徐少峰; 吴莲英; 齐众; 张晓东 Article
Hypochlorous Acid Induces Apoptosis of Cultured Cortical Neurons Through Activation of Calpains and Rupture of Lysosomes
4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS 2006), Cheung Kung Hai Conference Centre, Hong Kong City (Hong Kong-S.A.R of China), 30 Nov-2 Dec 2006
Yap, Yann Wan; Whiteman, Matthew; Bay, Boon Huat; Sheu, Fwu Shan; Qi, Robert Z.; Cheung, Nam Sang Conference paper

2005 3

Cleavage of the carboxyl-terminus of LEACS2, a tomato 1-aminocyclopropane-1-carboxylic acid synthase isomer, by a 64-kDa tomato metalloprotease produces a truncated but active enzyme
Journal of integrative plant biology, v. 47, (11), 2005, NOV, p. 1352-1363
Li, Jian-Feng; Qi, Robert; Qu, Liang-Hu; Mattoo, Autar K.; Li, Ning Article
Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis
Journal of neurochemistry, v. 94, (4), 2005, AUG, p. 943-956
Yew, EHJ; Cheung, NS; Choy, MS; Qi, RZ; Lee, AYW; Peng, ZF; Melendez, AJ; Manikandan, J.; Koay, ESC; Chiu, LL; Ng, WL; Whiteman, M.; Kandiah, J.; Halliwell, B. Article
Purification and properties of lipases/esterases from a Bacillus strain for enantioselective resolution of (S)-ketoprofen
Artificial Cells Blood Substitutes and Biotechnology, v. 33, (4), 2005, p. 435-445
Zhang, JH; Guan, R.; Tan, ZL; Yu, YT; Hou, ZB; Qi, Z.; Wang, SW Article

2004 9

Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons
Biochemical and biophysical research communications, v. 315, (2), 2004, MAR 5, p. 408-417
Cheung, NS; Koh, CHV; Bay, BH; Qi, RZ; Choy, MS; Li, QT; Wong, KP; Whiteman, M. Article
Direct regulation of microtubule dynamics by protein kinase CK2
Journal of biological chemistry, v. 279, (6), 2004, FEB 6, p. 4433-4439
Lim, ACB; Tiu, SY; Li, Q.; Qi, RZ Article
Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction
Cellular and molecular life sciences, v. 61, (15), 2004, JUL, p. 1926-1934
Cheung, NS; Choy, MS; Halliwell, B.; Teo, TS; Bay, BH; Lee, AYW; Qi, RZ; Koh, VH; Whiteman, M.; Koay, ESC; Chiu, LL; Zhu, HJ; Wong, KP; Beart, PM; Cheng, HC Article
Protein kinase CK2 is an inhibitor of the neuronal Cdk5 kinase
Journal of biological chemistry, v. 279, (45), 2004, NOV 5, p. 46668-46673
Lim, ACB; Hou, ZB; Goh, CP; Qi, RZ Article
Signaling via a novel integral plasma membrane pool of a serine/threonine protein kinase PRK1 in mammalian cells
FASEB JOURNAL, v. 18, (12), 2004, SEP, p. 1722+
Zhu, YM; Stolz, DB; Guo, FL; Ross, MA; Watkins, SC; Tan, BJ; Qi, RZ; Manser, E.; Li, QT; Bay, BH; Teo, TS; Duan, W. Article
Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine
Biochemical and biophysical research communications, v. 317, (1), 2004, APR 23, p. 128-132
Song, YC; Kesuma, D.; Wang, H.; Deng, Y.; Duan, J.; Wang, JH; Qi, RZ Article
α2-Chimaerin, Cyclin-Dependent Kinase 5/p35, and Its Target Collapsin Response Mediator Protein-2 Are Essential Components in Semaphorin 3A-Induced Growth-Cone Collapse
THE JOURNAL OF NEUROSCIENCE, v. 24, (41), 2004, OCT 13, p. 8994-9004
Brown, Matthew; Jacobs, Tom; Eickholt, Britta; Ferrari, Giovanna; Teo, Mabel; Monfries, Clinton; Qi, Robert Z.; Leung, Thomas; Lim, Louis; Hall, Christine Article
α-Chimaerin exists in a functional complex with the Cdk5 kinase in brain
FEBS letters, v. 561, (1-3), 2004, MAR 12, p. 177-180
Qi, Robert Z.; Ching, Yick-Pang; Kung, Hsiang-Fu; Wang, Jerry H. Article
Proteomics to dissect the cell regulatory machinery in brain
HUPO (Human Proteome Organization)3rd World Congress, Beijing P.R. China, Abstract published in Mol. Cell. Proteomics, 3(10), S185, Oct 2004
Qi, R.Z.; Fong, K.W.; Hou, Z.; Fu, X.; Yu, Y.; He, L. Conference paper

2003 7

Cyclin-dependent kinases in neural development and degeneration
Journal of Alzheimer's Disease, v. 5, (4), 2003, p. 329-335
Lim, A.C.B.; Qi, R.Z. Article
Phosphoproteomic fingerprinting of epidermal growth factor signaling and anticancer drug action in human tumor cells
Mol. Cancer Ther., v. 2, (12), 2003, p. 1369-1377
Lim, Y.P.; Diong, L.S.; Qi, Robert Zhong; Druker, B.J.; Epstein, R.J. Article
Protein-protein interactions in Cdk5 regulation and function
NeuroSignals, v. 12, (4-5), 2003, p. 230-238
Lim, ACB; Qu, DB; Qi, RZ Article
Role of IGF system of mitogens in the induction of fibroblast proliferation by keloidderived keratinocytes in vitro
Am. J. Physiol.-Cell Physiol., v. 284, (4), 2003, p. 860-869
Phan, T.T.; Lim, I.J.; Bay, B.H.; Qi, Robert Zhong; Longaker, M.T.; Lee, S.T.; Huynh, H. Article
Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor
The Society for Neuroscience 33rd Annual Meeting, New Orleans, Louisiana, USA, Nov
Lim, A.C.; Goh, C.P.; Tiu, S.Y.; Wong, B.S.; Qi, Robert Z. Conference paper
Protein kinase CK2 is an inhibitor of the neuronal Cdk5 kinase
Gordon Research Conference – Molecular and Cellular Neurobiology, Hong Kong, Jun.
Lim, A.C.B.; Hou, Z.; Goh, C.P.; Qi, Robert Z. Conference paper
Proteomic Dissection of Neurosignal Transduction Pathways
Molecular Neuroscience: Technology Applications, organized by the Croucher Advanced Study Institute, Hong Kong.
Qi, Robert Z. Conference paper

2002 8

CD157 undergoes ligand-independent dimerization and colocalizes with caveolin in CHO and MCA102 fibroblasts
Cell Signal, v. 14, (11), 2002, p. 933-939
Liang, F.; Qi, Robert Zhong; Chang, C.F. Article
Differences in collagen production between normal and keloid-derived fibroblasts in serum-media co-culture with keloid-derived keratinocytes
J. Dermatol. Sci., v. 29, (1), 2002, p. 26-34
Phan, T.T.; Lim, I.J.; Bay, B.H.; Qi, Robert Zhong; Huynh, H.T.; Lee, S.T.; Longaker, M.T. Article
Fibroblasts cocultured with keloid keratinocytes: Normal fibroblasts secrete collagen in a keloidlike manner
Am. J. Physiol.-Cell Physiol., v. 283, (1), 2002, p. 212-222
Lim, I.J.; Phan, T.T.; Bay, B.H.; Qi, Robert Zhong; Huynh, H.; Tan, W.T.; Lee, S.T.; Longaker, M.T. Article
Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor
Journal of biological chemistry, v. 277, (18), 2002, MAY 3, p. 15237-15240
Ching, Y.P.; Pang, A.S.H.; Lam, W.H.; Qi, R.Z.; Wang, J.H. Article
The protein SET binds the neuronal Cdk5 activator p35(nck5a) and modulates Cdk5/p35(nck5a) activity
Journal of biological chemistry, v. 277, (9), 2002, MAR 1, p. 7324-7332
Qu, DB; Li, Q.; Lim, HY; Cheung, NS; Li, R.; Wang, JH; Qi, RZ Article
β-Carbolines as specific inhibitors of cyclin-dependent kinases
Bioorganic and Medicinal Chemistry Letters, v. 12, (7), 2002, p. 1129-1132
Song, Y.; Wang, J.; Teng, S.F.; Kesuma, D.; Deng, Y.; Duan, J.; Wang, J.H.; Qi, R.Z.; Sim, M.M. Article
Proteomics of neuronal Cdk5 signaling complexes in brain
Proteomics in the Neurosciences, organized by the National Institute of Neurological Disorders and Stroke of the National Institute of Health, U.S.A.
Qi, Robert Z. Conference paper
Proteomics of Neuronal Cdk5 Signaling Complexes in Health and Disease
Second International Conference on Structural Biology and Functional Genomics, organized by the National University of Singapore, Singapore
Qi, Robert Z. Conference paper

2001 5

A membrane protein enriched in ER exit sites interacts with COPII
J. Biol. Chem., v. 276, (43), 2001, p. 40008-40017
Tang, B.L.; Ong, Y.S.; Huang, B.; Wei, S.; Wong, E.T.; Qi, Robert Zhong; Horstmann, H.; Hong, W. Article
Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members
Biochemical and biophysical research communications, v. 288, (1), 2001, OCT 19, p. 233-239
Rajala, RVS; Datla, RSS; Carlsen, SA; Anderson, DH; Qi, Z.; Wang, JH; Sharma, RK Article
Proteins of mycobacterium bovis BCG induced in the Wayne dormancy model
J. Bacteriol, v. 183, (8), 2001, p. 2672-2676
Boon, C.; Li, R.; Qi, Robert Zhong; Dick, T. Article
Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibrablasts
FEBS Lett., v. 506, (3), 2001, p. 207-210
Liang, F.; Qi, Robert Zhong; Chang, C.F. Article
Structural insights into Cdk5 activation by a neuronal Cdk5 activator
Biochemical and biophysical research communications, v. 285, (1), 2001, JUL 6, p. 77-83
Lim, HY; Seow, KT; Li, Q.; Kesuma, D.; Wang, JH; Qi, RZ Article

2000 2

Cloning of three novel neuronal Cdk5 activator binding proteins
Gene, v. 242, (1-2), 2000, JAN 25, p. 285-294
Ching, YP; Qi, Z.; Wang, JH Article
Identification of a common protein association region in the neuronal Cdk5 activator
Journal of biological chemistry, v. 275, (41), 2000, OCT 13, p. 31763-31769
Wang, Xiujie; Ching, Wilson Yik Pang; Lam, Wing H.; Qi, Zhong; Zhang, Mingjie; Wang, Jerry Hsueh-ching Article

1998 2

Association of neurofilament proteins with neuronal Cdk5 activator
Journal of biological chemistry, v. 273, (4), 1998, JAN 23, p. 2329-2335
Qi, Z.; Tang, DM; Zhu, XD; Fujita, DJ; Wang, JH Article
Effect of heparin on phosphorylation site specificity of neuronal Cdc2-like kinase
FEBS letters, v. 423, (2), 1998, FEB 20, p. 227-230
Qi, Z.; Zhu, XD; Goedert, M.; Fujita, DJ; Wang, JH Article

1997 1

Neuronal Cdc2-like kinases: Neuron-specific forms of Cdk5
International journal of biochemistry & cell biology, v. 29, (7), 1997, JUL, p. 951-958
Lee, KY; Qi, Z.; Yu, YP; Wang, JH Article

1996 1

Neuronal Cdc2-like kinase: From cell cycle to neuronal function
BIOCHEMISTRY and Cell biology-biochimie ET BIOLOGIE cellulaire, v. 74, (4), 1996, p. 419-429
Tang, DM; Lee, KY; Qi, Z.; Matsuura, I.; Wang, JH Article

1995 4

Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase
J. Neurochem., v. 65, (6), 1995, p. 2804-2807
Goedert, M.; Jakes, R.; Qi, Robert Zhong; Wang, J.H.; Cohen, P. Article
Reconstitution of neuronal Cdc2-like kinase from bacteria-expressed Cdk5 and an active fragment of the brain specific activator
J. Biol. Chem., v. 270, (18), 1995, p. 10847-10854
Qi, Robert Zhong; Huang, Q.Q.; Lee, K.Y.; Lew, J.; Wang, J.H. Article
Regulatory properties of neuronal Cdc2-like kinase
Mol. Cell. Biochem., v. 149, 1995, p. 35-39
Qi, Robert Zhong; Yang, D.; Matsuura, I.; Lee, K.Y.; Zhu, X.; Huang, Q.Q.; Wang, J.H. Article
Structure, function, and regulation of neuronal Cdc2-like protein kinase
Neurobiol. Aging, v. 16, 1995, p. 263-270
Lew, J.; Qi, Robert Zhong; Huang, Q.Q.; Paudel, H.K.; Matsuura, I.; Matsushita, M.; Zhu, X.; Wang, J.H. Article

1994 1

A brain-specific activator of cyclin-dependent kinase 5
Nature, v. 371, 1994, p. 423-426
Lew, J.; Huang,Q Q.; Qi, Robert Zhong; Winkfein, R.J.; Aebersold, R.; Hunt, T.; Wang, J.H. Article


No Publications






Teaching Assignment

---

2021-22 Winter 0 2021-22 Fall 5 2020-21 Summer 2 2020-21 Spring 6 2020-21 Winter 1 2020-21 Fall 3

---

ENVS5111 Environmental Health
LIFS2210 Biochemistry I
LIFS4910A Independent Study
LIFS5070 Workshops in Biosciences
UROP1100E Undergraduate Research Opportunities Series 1


BTEC5210 Principles and Application in Biotechnology
UROP1000 Undergraduate Research Opportunities


LIFS4960 Biological Science Capstone Project
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS4983 Biotechnology Project Research II
LIFS6117D Current Topics in Cell Biology
LIFS6660 Molecular Medicine


LIFS6660 Molecular Medicine


ENVS5111 Environmental Health
LIFS2210 Biochemistry I
LIFS4973 Biotechnology Project Research I


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

---

All Supervisions Current RPGs Graduated RPGs

---

Current RPGs

---

Doctor of Philosophy LUI, Sze Wai
Life Science( 2020 - )

LI, Gefei
Life Science( 2019 - )

WANG, Kexin
Life Science( 2018 - )

YIN, Can
Life Science( 2018 - )

HAU, Kwan Tang
Life Science( 2017 - )

---

Master of Philosophy LE, Tran Dang Khoi
Life Science( 2021 - )

---

Graduated RPGs

---

Doctor of Philosophy YANG, Shaozhong
Life Science( Completed in 2021 )

JIANG, Taolue
Life Science( Completed in 2020 )

AU, Kin Chung Franco
Life Science( Completed in 2019 )

---

Master of Philosophy CROSSING, Renae Vivienne
Life Science( Completed in 2021 )

LI, Gefei
Life Science( Completed in 2021 )









ProjectsFrom January 2020 to December 2022

---

All Projects 8 Leading Projects 4 Participating Projects 4

---

CDK5RAP2 Autoinhibition as a Control Mechanism of γTuRC-Dependent Microtubule Organization


CDK5RAP2自抑制对依赖於γ-微管蛋白环形复合体的微管组织的调控 Leading


RGC - General Research Fund


Project Team (HKUST)
QI Robert Zhong (Lead)


2020 -




A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases


以干细胞方法解析神经退行性疾病的分子基础 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
CHUNG Kenny K
FU Amy Kit Yu
QI Robert Zhong
QU Jianan
TSIM Karl Wah Keung
WEN Zilong
WONG Yung Hou
WU Zhenguo
XIA Jun


2019 -




Elucidating a Novel Function of GCP6 in Microtubule-Nucleator γ-Tubulin Ring Complexes


阐明GCP6在微管成核体γ-微管蛋白环复合物中的一种新功能 Leading


RGC - General Research Fund


Project Team (HKUST)
QI Robert Zhong (Lead)


2018 -




Experimental study of the volumetric and viscoelastic properties of mitotic cells and their responses to external mechanical cues


细胞的体积和粘弹性在有丝分裂期的特性以及其对外部力学信号反应的实验研究 Participating


RGC - General Research Fund


Project Team (HKUST)
TONG Penger (Lead)
QI Robert Zhong


2018 - 2021




Investigating a Novel Mechanism of Centrosome Disjunction for Bipolar Spindle Assembly


解析中心体分离在双极纺锤体装配中的新机制 Leading


Shenzhen Science and Technology Innovation Committee


Project Team (HKUST)
QI Robert Zhong (Lead)


2018 - 2020




Investigating a Novel Mechanism of Centrosome Disjunction for Bipolar Spindle Assembly


探索形成两极纺锤体过程中中心体分离的新机制 Leading


RGC - General Research Fund


Project Team (HKUST)
QI Robert Zhong (Lead)


2017 - 2021




Open Operation System of Guangdong Provincial Key Laboratory of Brain Science, Disease, and Drug Development (Inspection Qualified in 2017)


广东省脑科学及疾病与药物研究重点实验室开放运行（2017年度考评合格） Participating


Department of Science and Technology of Guangdong Province


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
FU Amy Kit Yu
LIU Kai
QI Robert Zhong
WONG Yung Hou
WU Zhenguo
XIA Jun


2017 - 2020




State Key Laboratory of Molecular Neuroscience (The Hong Kong University of Science and Technology)


分子神经科学国家重点实验室（香港科技大学） Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHOW King Lau
CHUNG Kenny K
DAI Wei Min
GUO Zhihong
HUANG Pingbo
LIANG Chun
MILLER Andrew Leitch
POON Randy Yat Choi
QI Robert Zhong
TSIM Karl Wah Keung
WEN Zilong
WONG Joseph Tin Yum
WONG Yung Hou
WU Zhenguo
ZHU Guang


2011 -