Yong HUANG
黄涌
PhD in Organic Chemistry
The University of Chicago, 2002

Associate Professor
Department of Chemistry



(852) 3469 2625
yonghuang@ust.hk
Room 4530
Personal Web

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ORCID
0000-0001-8377-8923

Scopus ID
55061665600




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Enantioselective reactions
Synthetic organic chemistry
Organic chemistry
Medicinal chemistry
Organometallic chemistry



Publications

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All Years 85 2022 0 2021 3 2020 5 2019 4 2018 11 2017 9 2016 53

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2021 3

A Bifunctional N-Heterocyclic Carbene as a Noncovalent Organocatalyst for Enantioselective Aza-Michael Addition Reactions
ACS Catalysis, v. 11, (10), May 2021, p. 6316-6324
Guo, Fangfang; Chen, Jiean; Huang, Yong Article
N-Heterocyclic Carbene-Catalyzed Four-Component Reaction: Chemoselective C_radical-C_radical Relay Coupling Involving the Homoenolate Intermediate
ACS Catalysis, v. 11, (16), July 2021, p. 10123-10130
Li, Zhen; Huang, Meirong; Zhang, Xinhao; Chen, Jiean; Huang, Yong Article
Synthesis of α-chiral phosphine sulfides via non-covalent organocatalysis
Cell Reports Physical Science, v. 2, (7), July 2021, article number 100490
Li, En; Wang, Qian; Cai, Yuxing; Chen, Jiean; Huang, Yong Article

2020 5

Direct Synthesis of Bicyclic Acetalsvia Visible Light Catalysis
iScience, v. 23, (8), August 2020, article number 101395
Wu, Fengjin; Wang, Leifeng; Ji, Ying; Zou, Ge; Shen, Hong; Nicewicz, David A.; Chen, Jiean; Huang, Yong Article
Enantioselective Intramolecular [2,3]-Sigmatropic Rearrangement of Aldehydes via a Sulfonium Enamine Intermediate
Angewandte Chemie - International Edition, v. 59, (47), 16 November 2020, p. 20904-20908
Li, Li; Chen, Baoli; Chen, Jiean; Huang, Yong Article
Ligand-Controlled C?O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights
Advanced Synthesis and Catalysis, v. 362, (1), January 2020, p. 126-132
Li, Li; Song, Feifei; Zhong, Xiumei; Wu, Yun Dong; Zhang, Xinhao; Chen, Jiean; Huang, Yong Article
Molecular Insights into Small‐Molecule Drug Discovery for SARS‐CoV‐2
Angewandte Chemie - International Edition, v. 60, 2021, p. 9789-9802
Su, Hailei; Zhou, Feng; Huang, Ziru; Ma, Xiaohua; Natarajan, Kathiresan; Zhang, Minchuan; Huang, Yong; Su, Haibin Article
Photo-induced energy transfer relay of N-heterocyclic carbene catalysis: An asymmetric α-fluorination/isomerization cascade
Chemical Communications, v. 57, (6), January 2021, p. 729-732
Jiang, Xinhang; Li, En; Chen, Jiean; Huang, Yong Article

2019 4

Alcohol-Directed ortho -C-H Alkenylation
Synlett, v. 30, (11), July 2019, p. 1366-1370
Li, Li; Liu, Qinglan; Chen, Jiean; Huang, Yong Article
Dehydrogenative Annulation of γ,δ-Unsaturated Amides and Alkynes via Double C-H Activation
Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica, v. 35, (9), 2019, p. 906-912
Wang, Zhen; Li, En; He, Zhiqi; Chen, Jiean; Huang, Yong Article
Enantio- and Diastereoselective Hydrofluorination of Enals by N-Heterocyclic Carbene Catalysis
Angewandte Chemie - International Edition, v. 58, (22), May 2019, p. 7410-7414
Wang, Leming; Jiang, Xinhang; Chen, Jiean; Huang, Yong Article
N-heterocyclic Carbenes as Bronsted Base Catalysts
N-Heterocyclic Carbenes in Organocatalysis / Editor, Akkattu T. Biju; With a Foreword by Ronald Breslow. Weinheim, Germany : Wiley, 2019, p. 261-286, Ch. 9
Chen, Jiean; Huang, Yong Book chapter

2018 11

Aerobic Oxidation/Annulation Cascades through Synergistic Catalysis of RuCl₃ and N-Heterocyclic Carbenes
Chemistry - A European Journal, v. 24, (49), September 2018, p. 12806-12810
Wang, Qian; Chen, Jiean; Huang, Yong Article
Direct Synthesis of Polysubstituted Aldehydes via Visible-Light Catalysis
Angewandte Chemie - International Edition, v. 57, (8), February 2018, p. 2174-2178
Wu, Fengjin; Wang, Leifeng; Chen, Jiean; Nicewicz, David A.; Huang, Yong Article
Enantioselective Cooperative Proton-transfer Catalysis Using Chiral Ammonium Phosphates
Chemical Communications, v. 54, (12), February 2018, p. 1473-1476
Zhang, Linrui; Yuan, Pengfei; Chen, Jiean; Huang, Yong Article
Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species
Angewandte Chemie - International Edition, v. 57, (28), July 2018, p. 8503-8507
Yuan, Pengfei; Chen, Jiean; Zhao, Jing; Huang, Yong Article
Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- And β-C-H bonds through an Allyl-Iridium Intermediate
Journal of the American Chemical Society, v. 140, (2), January 2018, p. 735-740
Wang, Zhen; He, Zhiqi; Zhang, Linrui; Huang, Yong Article
Lewis酸对氮杂环卡宾协同催化体系中反应途径的调控
研究通讯=Acta Chimica Sinica, v. 76, (11), November 2018, p. 850-856
王乐明; 王骞; 陈杰安; 黄涌 Article
One-pot Ligation Strategy for Atypical Ubiquitin Chains Synthesis by Using the Trifluoroacetamidomethyl-protected Isopeptide-linked Ub (Tfacm-isoUb) Unit
Tetrahedron Letters, v. 59, (3), January 2018, p. 268-271
Si, Yan-Yan; Liang, Lu-Jun; Tang, Shan; Qi, Yun-Kun; Huang, Yong; Zheng, Ji-Shen Article
Semi-synthesis of Disulfide-linked Branched Tri-ubiquitin Mimics
Science China Chemistry, v. 61, (4), April 2018, p. 412-417
Si, Yanyan; Liang, Lujun; Tang, Shan; Qi, Yunkun; Huang, Yong; Liu, Lei Article
Streamlined Asymmetric α-difunctionalization of Ynones
Nature Communications, v. 9, (1), December 2018, article number 375
Peng, Siyu; Wang, Zhaofeng; Zhang, Linxing; Zhang, Xinhao; Huang, Yong Article
Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo
Journal of Medicinal Chemistry, v. 61, (19), October 2018, p. 8613-8624
Huang, Yong; Pan, Peichen; Chen, Jiean; Li, Xijian; Li, Miyang; Yu, Huidong; Zhao, Jean J.; Ni, Jing; Wang, Xuwen; Sun, Huiyong; Tian, Sheng; Zhu, Feng; Liu, Feng; Hou, Tingjun Article
Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metalate Shift
Journal of the American Chemical Society, v. 140, (7), February 2018, p. 2693-2699
He, Zhiqi; Song, Feifei; Sun, Huan; Huang, Yong Article

2017 9

Amine-Triggered 6π-Electrocyclization–Aromatization Cascade of Ynedienamines
Advanced Synthesis and Catalysis, v. 359, (8), April 2017, p. 1379-1387
Li, Xijian; Yu, Huidong; Huang, Yong Article
Chemical Synthesis of Histone H2A with Methylation at Gln104
Science China Chemistry, v. 60, (5), May 2017, p. 621-627
He, Qiaoqiao; Li, Jiabin; Qi, Yunkun; Wang, Zhipeng; Huang, Yong; Liu, Lei Article
Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation
ACS Central Science, v. 3, (11), November 2017, p. 1208-1220
Liu, Qi; Pan, Peichen; Yu, Huidong; Liu, Qinglan; Kong, Xiaotian; Chen, Hu; Chen, Jiean; Li, Dan; Kang, Yu; Sun, Huiyong; Zhou, Wenfang; Tian, Sheng; Cui, Sunliang; Zhu, Feng; Li, Youyong; Huang, Yong; Hou, Tingjun Article
Comparative Pharmacokinetic Profile of Cyclosporine (CsA) With A Decapeptide and A Linear Analogue
Organic and Biomolecular Chemistry, v. 15, (12), March 2017, p. 2501-2506
Price, David A.; Eng, Heather; Farley, Kathleen A.; Goetz, Gilles H.; Huang, Yong; Jiao, Zhaodong; Kalgutkar, Amit S.; Kablaoui, Natasha M.; Khunte, Bhagyashree A.; Liras, Spiros; Limberakis, Chris; Mathiowetz, Alan M.; Ruggeri, Roger B.; Quan, Junming Min; Yang, Zhen Article
Construction of Pyridazine Analogues via Rhodium-mediated C-H Activation
Advanced Synthesis and Catalysis, v. 359, (20), October 2017, p. 3496-3502
Yang, Chao; Song, Feifei; Chen, Jiean; Huang, Yong Article
Enantioselective β-Protonation of Enals via a Shuttling Strategy
Journal of the American Chemical Society, v. 139, (20), May 2017, p. 7045-7051
Chen, Jiean; Yuan, Pengfei; Wang, Leming; Huang, Yong Article
Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells
American Journal of Reproductive Immunology, v. 77, (3), March 2017, article number UNSP e12618
Diao, Liang-Hui; Li, Guan-Gui; Zhu, Yuan-Chang; Tu, Wen-Wei; Huang, Chun-Yu; Lian, Ruo-Chun; Chen, Xian; Li, Yu-Ye; Zhang, Tao; Huang, Yong; Zeng, Yong Article
Synthesis of Optically Active Oxazolines by an Organocatalytic Isocyanoacetate Aldol Reaction with α-Keto Esters
Synlett, v. 28, (11), July 2017, p. 1300-1304
Wang, Fei; Chen, Jiean; Huang, Yong Article
Visible-Light-Mediated [4+2] Cycloaddition of Styrenes: Synthesis of Tetralin Derivatives
Angewandte Chemie - International Edition, v. 56, (24), June 2017, p. 6896-6900
Wang, Leifeng; Wu, Fengjin; Chen, Jiean; Nicewicz, David A.; Huang, Yong Article

2016 6

A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics
Angewandte Chemie - International Edition, v. 55, (46), November 2016, p. 14340-14344
Jiang, Hao; Xu, Liping; Fang, Yan; Zhang, Zhenxing; Yang, Zhen; Huang, Yong Article
Advances in the Development of Catalytic Tethering Directing Groups for C-H Functionalization Reactions
Organic and Biomolecular Chemistry, v. 14, (36), 2016, p. 8389-8397
Sun, Huan; Guimond, Nicolas; Huang, Yong Article
Asymmetric Sulfa-Michael Addition of α,β-Unsaturated Esters/Amides Using a Chiral N-Heterocyclic Carbene as a Noncovalent Organocatalyst
Synlett, v. 27, (7), April 2016, p. 1068-1072
Yuan, Pengfei; Meng, Sixuan; Chen, Jiean; Huang, Yong Article
Diverting C?H Annulation Pathways: Nickel-Catalyzed Dehydrogenative Homologation of Aromatic Amides
ACS Catalysis, v. 6, (11), November 2016, p. 7814-7823
He, Zhiqi; Huang, Yong Article
Ligand-Assisted Palladium(II)/(IV) Oxidation for sp ³ CH Fluorination
Advanced Synthesis and Catalysis, v. 358, (12), June 2016, p. 1946-1957
Sun, Huan; Zhang, Yi; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong Article
New Frontiers of N-heterocyclic Carbene Catalysis
Science China Chemistry, v. 59, (3), March 2016, p. 251-254
Chen, Jiean; Huang, Yong Article

2015 8

A Copper-catalyzed Aerobic Domino Process for the Synthesis of Isoindolin-1-ylidene Derivatives
Tetrahedron, v. 71, (22), June 2015, p. 3632-3636
Chen, Hu; Wang, Qian; Huang, Yong Article
Asymmetric Intramolecular α-cyclopropanation of Aldehydes Using A Donor/acceptor Carbene Mimetic
Nature Communications, v. 6, December 2015, article number 10041
Luo, Chaosheng; Wang, Zhen; Huang, Yong Article
Asymmetric Synthesis of Hydrocarbazoles Catalyzed by an Octahedral Chiral-at-Rhodium Lewis Acid
Chemistry - An Asian Journal, v. 10, (12), December 2015, p. 2738-2743
Huang, Yong; Song, Liangliang; Gong, Lei; Meggers, Eric Article
Direct Fluorination of Styrenes
Chemical Communications, v. 51, (30), April 2015, p. 6584-6586
Shao, Qian; Huang, Yong Article
Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins
Angewandte Chemie - International Edition, v. 54, (51), December 2015, p. 15414-15418
Wang, Leming; Chen, Jiean; Huang, Yong Article
Highly Enantioselective Sulfa-Michael Addition Reactions Using N-heterocyclic Carbene as A Non-covalent Organocatalyst
Chemical Science, v. 6, (7), July 2015, p. 4184-4189
Chen, Jiean; Meng, Sixuan; Wang, Leming; Tang, Hongmei; Huang, Yong Article
Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions
Synlett, v. 26, (20), December 2015, article number st-2015-a0376-a, p. 2751-2762
Sun, Huan; Huang, Yong Article
Synthesis of tetrasubstituted 1-silyloxy-3-aminobutadienes and chemistry beyond Diels-Alder reactions
Nature Communications, v. 6, April 2015, article number 6913
Li, Xijian; Peng, Siyu; Li, Li; Huang, Yong Article

2014 11

A General Synthesis of Ynones From Aldehydes via Oxidative C-C Bond Cleavage Under Aerobic Conditions
Journal of the American Chemical Society, v. 136, (35), September 2014, p. 12233-12236
Wang, Zhaofeng; Li, Li; Huang, Yong Article
A Multitasking Functional Group Leads to Structural Diversity Using Designer C-H Activation Reaction Cascades
Nature Communications, v. 5, August 2014, article number 4610
Chen, Ying; Wang, Dongqi; Duan, Pingping; Ben, Rong; Dai, Lu; Shao, Xiaoru; Hong, Mei; Zhao, Jing; Huang, Yong Article
Asymmetric Catalysis With N-heterocyclic Carbenes as Non-covalent Chiral Templates
Nature Communications, v. 5, March 2014, article number 3437
Chen, Jiean; Huang, Yong Article
Directed Arene/alkyne Annulation Reactions via Aerobic Copper Catalysis
Organic and Biomolecular Chemistry, v. 12, (44), November 2014, p. 8844-8850
Zhang, Yi; Wang, Qian; Yu, Huidong; Huang, Yong Article
Highly Ortho-selective Trifluoromethyl-thiolation Reactions Using A Ligand Exchange Strategy
Advanced Synthesis & Catalysis, v. 356, (14-15), October 2014, p. 2998-3006
Yin, Weiyu; Wang, Zhaofeng; Huang, Yong Article
Metal-templated Chiral Br?nsted Base Organocatalysis
Nature Communications, v. 5, July 2014, article number 4531
Ma, Jiajia; Ding, Xiaobing; Hu, Ying; Huang, Yong; Gong, Lei; Meggers, Eric Article
New Semi-synthesis of Ubiquitin C-terminal Conjugate With 7-amino-4-methylcoumarin
Journal of Peptide Science, v. 20, (2), February 2014, p. 102-107
Li, Yitong; Liang, Jun; Li, Jiabin; Fang, Gemin; Huang, Yong; Liu, Lei Article
Palladium Catalyzed Acetoxylation of Benzylic C-H Bonds Using a Bidentate Picolinamide Directing Group
Organic and Biomolecular Chemistry, v. 12, (9), March 2014, p. 1405-1411
Cheng, Tao; Yin, Weiyu; Zhang, Yi; Zhang, Yingnan; Huang, Yong Article
Ruthenium-catalyzed Redox-neutral C-H Activation via N-N Cleavage: Synthesis of N-substituted Indoles
Organic Letters, v. 16, (22), November 2014, p. 5976-5979
Zhang, Zhenxing; Jiang, Hao; Huang, Yong Article
Selective Synthesis of Indazoles and Indoles via Triazene-alkyne Cyclization Switched by Different Metals
Organic and Biomolecular Chemistry, v. 12, (7), February 2014, p. 1061-1071
Fang, Yan; Wang, Chengming; Su, Shengqin; Yu, Haizhu; Huang, Yong Article
Synthesis of Indolo[2,1-a]isoquinolines via a Triazene-directed C-H Annulation Cascade
Journal of Organic Chemistry, v. 79, (24), December 2014, p. 11863-11872
Sun, Huan; Wang, Chengming; Yang, Yunfang; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong Article

2013 12

A Highly Diastereo- and Enantioselective Synthesis of Tetrahydroquinolines: Quaternary Stereogenic Center Inversion and Functionalization
Journal of the American Chemical Society, v. 135, (22), June 2013, p. 8193-8196
Luo, Chaosheng; Huang, Yong Article
A Highly Diastereoselective and Enantioselective Synthesis of Polysubstituted Pyrrolidines via an Organocatalytic Dynamic Kinetic Resolution Cascade
Organic Letters, v. 15, (8), April 2013, p. 1958-1961
Cheng, Tao; Meng, Sixuan; Huang, Yong Article
Computational Study on Mechanism of Rh(III)-catalyzed Oxidative Heck Coupling of Phenol Carbamates With Alkenes
Dalton Transactions, v. 42, (12), March 2013, p. 4175-4184
Zhang, Qi; Yu, Haizhu; Li, Yitong; Liu, Lei; Huang, Yong; Fu, Yao Article
Direct α-vinylidenation of Aldehydes and Subsequent Cascade: Gold and Amine Catalysts Work Synergistically
Angewandte Chemie - International Edition, v. 52, (52), December 2013, p. 14219-14223
Wang, Zhaofeng; Li, Xijian; Huang, Yong Article
Enantioselective Synthesis of 1,2,4-triazolines Catalyzed by A Cinchona Alkaloid-derived Organocatalyst
Chemical Communications, v. 49, (94), December 2013, p. 11098-11100
Shao, Qian; Chen, Jiean; Tu, Meihua; Piotrowski, David W.; Huang, Yong Article
Expanding Structural Diversity; Removable and Manipulable Directing Groups for C-H Activation
Synlett, v. 24, (2), January 2013, article number ST-2012-P0768-SP, p. 145-149
Wang, Chengming; Huang, Yong Article
General and Efficient Synthesis of Indoles Through Triazene-directed C-H Annulation
Angewandte Chemie - International Edition, v. 52, (22), May 2013, p. 5795-5798
Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong Article
Highly Practical Synthesis of Nitriles and Heterocycles From Alcohols Under Mild Conditions by Aerobic Double Dehydrogenative Catalysis
Organic Letters, v. 15, (8), April 2013, p. 1850-1853
Yin, Weiyu; Wang, Chengming; Huang, Yong Article
Highly Trans- Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper-catalyzed Triple Cascade Catalysis
Journal of Organic Chemistry, v. 78, (7), April 2013, p. 3503-3509
Chen, Hu; Wang, Zhaofeng; Zhang, Yingnan; Huang, Yong Article
Mechanism-based Design of a Photoactivatable Firefly Luciferase
Journal of the American Chemical Society, v. 135, (20), May 2013, p. 7410-7413
Zhao, Jing; Zhao, Jingyi; Lin, Shixian; Huang, Yong; Chen, Peng R. Article
Synthesis of α,β-unsaturated Carbonyl Compounds via a Visible-light-promoted Organocatalytic Aerobic Oxidation
Chemical Communications, v. 49, (99), November 2013, p. 11662-11664
Zhang, Junlin; Wang, Leming; Liu, Qi; Yang, Zhen; Huang, Yong Article
Traceless directing strategy: Efficient synthesis of N-alkyl indoles via redox-neutral C-H activation
Organic Letters, v. 15, (20), October 2013, p. 5294-5297
Wang, Chengming; Huang, Yong Article

2012 4

An Air-State Fe₃S₄ Complex with Properties Similar to Those of The H_OXair State of The Diiron Hydrogenases
European Journal of Inorganic Chemistry, (27), September 2012, p. 4259-4263
Huang, Yong; Gao, Weiming; ?kermark, Torbj?rn N.; Li, Mingrun; ?kermark, Bjǒrn Article
General Palladium-catalyzed Aerobic Dehydrogenation to Generate Double Bonds
Chemical Science, v. 3, (3), March 2012, p. 883-886
Gao, Weiming; He, Zhiqi; Qian, Yong; Zhao, Jing; Huang, Yong Article
One-pot Synthesis of Useful Heterocycles in Medicinal Chemistry Using A Cascade Strategy
Green Chemistry, v. 14, (3), March 2012, p. 580-585
Wu, Guiyong; Yin, Weiyu; Shen, Hong C.; Huang, Yong Article
Rhodium(III)-catalyzed C-H Activation of Arenes Using a Versatile and Removable Triazene Directing Group
Angewandte Chemie - International Edition, v. 51, (29), July 2012, p. 7242-7245
Wang, Chengming; Chen, Hu; Wang, Zhaofeng; Chen, Jiean; Huang, Yong Article

2011 1

Design of Potent and Selective GPR119 Agonists for Type II Diabetes
Bioorganic and Medicinal Chemistry Letters, v. 21, (9), May 2011, p. 2665-2669
Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B. Article

2010 1

A Thiourea-Oxazoline Library with Axial Chirality: Ligand Synthesis and Studies of the Palladium-Catalyzed Enantioselective Bis(methoxycarbonylation) of Terminal Olefin
Advanced Synthesis and Catalysis, v. 352, (11-12), August 2010, p. 1955-1966
Gao, Ying-Xiang; Chang, Le; Shi, Hang; Liang, Bo; Wongkhan, Kittiya; Chaiyaveij, Duangduan; Batsanov, Andrei S.; Marder, Todd B.; Li, Chuang-Chuang; Yang, Zhen; Huang, Yong Article

2007 1

Expedient, High-yielding Synthesis of Silyl-substituted Salen Ligands
Organic Letters, v. 9, (20), September 2007, p. 3873-3876
Thadani, Avinash N.; Huang, Yong; Rawal, Viresh H. Article

2005 1

Enantioselective Organo-cascade Catalysis
Journal of the American Chemical Society, v. 127, (43), November 2005, p. 15051-15053
Huang, Yong; Walji, Abbas M.; Larsen, Catharine H.; MacMillan, David W.C. Article

2003 1

Single Enantiomers From a Chiral-alcohol Catalyst
Nature, v. 424, (6945), July 2003, p. 146
Huang, Yong; Unni, Aditya K.; Thadani, Avinash N.; Rawal, Viresh H. Article

2002 5

An Efficient Approach to Aspidosperma Alkaloids via [4 + 2] Cycloadditions of Aminosiloxydienes: Stereocontrolled Total Synthesis of (±)-tabersonine. Gram-scale Catalytic Asymmetric Syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric Syntheses of (+)-aspidospermidine and (-)-quebrachamine
Journal of the American Chemical Society, v. 124, (17), May 2002, p. 4628-4641
Kozmin, Sergey A.; Iwama, Tetsuo; Huang, Yong; Rawal, Viresh H. Article
Broadly Effective Enantioselective Diels-Alder Reactions of 1-Amino-substituted-1,3-butadienes
Organic Letters, v. 4, (7), April 2002, p. 1163-1164
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article
Design and Development of Highly Effective Lewis Acid Catalysts for Enantioselective Diels-alder Reactions
Journal of the American Chemical Society, v. 124, (21), May 2002, p. 5950-5951
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article
Hydrogen-bond-promoted Hetero-diels-alder Reactions of Unactivated Ketones
Journal of the American Chemical Society, v. 124, (33), August 2002, p. 9662-9663
Huang, Yong; Rawal, Viresh H. Article
The First Catalytic Enantioselective Diels-alder Reactions of 1,2-dihydropyridine: Efficient Syntheses of Optically Active 2-azabicyclo[2.2.2]octanes With Chiral Binam Derived Cr(III) Salen Complexes
Tetrahedron, v. 58, (41), October 2002, p. 8299-8305
Takenaka, Norito; Huang, Yong; Rawal, Viresh H. Article

2000 2

Hetero Diels-alder Reactions of 1-amino-3-siloxy-1,3-butadienes Under Strictly Thermal Conditions
Organic Letters, v. 2, (21), October 2000, p. 3321-3323
Huang, Yong; Rawal, Viresh H. Article
Highly Enantioselective Diels-Alder Reactions of 1-Amino-3-siloxy-dienes Catalyzed by Cr(III)-Salen Complexes
Journal of the American Chemical Society, v. 122, (32), August 2000, p. 7843-7844
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article


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Article 3

A Bifunctional N-Heterocyclic Carbene as a Noncovalent Organocatalyst for Enantioselective Aza-Michael Addition Reactions
ACS Catalysis, v. 11, (10), May 2021, p. 6316-6324
Guo, Fangfang; Chen, Jiean; Huang, Yong
N-Heterocyclic Carbene-Catalyzed Four-Component Reaction: Chemoselective C_radical-C_radical Relay Coupling Involving the Homoenolate Intermediate
ACS Catalysis, v. 11, (16), July 2021, p. 10123-10130
Li, Zhen; Huang, Meirong; Zhang, Xinhao; Chen, Jiean; Huang, Yong
Synthesis of α-chiral phosphine sulfides via non-covalent organocatalysis
Cell Reports Physical Science, v. 2, (7), July 2021, article number 100490
Li, En; Wang, Qian; Cai, Yuxing; Chen, Jiean; Huang, Yong


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Article 5

Direct Synthesis of Bicyclic Acetalsvia Visible Light Catalysis
iScience, v. 23, (8), August 2020, article number 101395
Wu, Fengjin; Wang, Leifeng; Ji, Ying; Zou, Ge; Shen, Hong; Nicewicz, David A.; Chen, Jiean; Huang, Yong
Enantioselective Intramolecular [2,3]-Sigmatropic Rearrangement of Aldehydes via a Sulfonium Enamine Intermediate
Angewandte Chemie - International Edition, v. 59, (47), 16 November 2020, p. 20904-20908
Li, Li; Chen, Baoli; Chen, Jiean; Huang, Yong
Ligand-Controlled C?O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights
Advanced Synthesis and Catalysis, v. 362, (1), January 2020, p. 126-132
Li, Li; Song, Feifei; Zhong, Xiumei; Wu, Yun Dong; Zhang, Xinhao; Chen, Jiean; Huang, Yong
Molecular Insights into Small‐Molecule Drug Discovery for SARS‐CoV‐2
Angewandte Chemie - International Edition, v. 60, 2021, p. 9789-9802
Su, Hailei; Zhou, Feng; Huang, Ziru; Ma, Xiaohua; Natarajan, Kathiresan; Zhang, Minchuan; Huang, Yong; Su, Haibin
Photo-induced energy transfer relay of N-heterocyclic carbene catalysis: An asymmetric α-fluorination/isomerization cascade
Chemical Communications, v. 57, (6), January 2021, p. 729-732
Jiang, Xinhang; Li, En; Chen, Jiean; Huang, Yong


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Article 3

Alcohol-Directed ortho -C-H Alkenylation
Synlett, v. 30, (11), July 2019, p. 1366-1370
Li, Li; Liu, Qinglan; Chen, Jiean; Huang, Yong
Dehydrogenative Annulation of γ,δ-Unsaturated Amides and Alkynes via Double C-H Activation
Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica, v. 35, (9), 2019, p. 906-912
Wang, Zhen; Li, En; He, Zhiqi; Chen, Jiean; Huang, Yong
Enantio- and Diastereoselective Hydrofluorination of Enals by N-Heterocyclic Carbene Catalysis
Angewandte Chemie - International Edition, v. 58, (22), May 2019, p. 7410-7414
Wang, Leming; Jiang, Xinhang; Chen, Jiean; Huang, Yong

Book chapter 1

N-heterocyclic Carbenes as Bronsted Base Catalysts
N-Heterocyclic Carbenes in Organocatalysis / Editor, Akkattu T. Biju; With a Foreword by Ronald Breslow. Weinheim, Germany : Wiley, 2019, p. 261-286, Ch. 9
Chen, Jiean; Huang, Yong


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Article 11

Aerobic Oxidation/Annulation Cascades through Synergistic Catalysis of RuCl₃ and N-Heterocyclic Carbenes
Chemistry - A European Journal, v. 24, (49), September 2018, p. 12806-12810
Wang, Qian; Chen, Jiean; Huang, Yong
Direct Synthesis of Polysubstituted Aldehydes via Visible-Light Catalysis
Angewandte Chemie - International Edition, v. 57, (8), February 2018, p. 2174-2178
Wu, Fengjin; Wang, Leifeng; Chen, Jiean; Nicewicz, David A.; Huang, Yong
Enantioselective Cooperative Proton-transfer Catalysis Using Chiral Ammonium Phosphates
Chemical Communications, v. 54, (12), February 2018, p. 1473-1476
Zhang, Linrui; Yuan, Pengfei; Chen, Jiean; Huang, Yong
Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species
Angewandte Chemie - International Edition, v. 57, (28), July 2018, p. 8503-8507
Yuan, Pengfei; Chen, Jiean; Zhao, Jing; Huang, Yong
Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- And β-C-H bonds through an Allyl-Iridium Intermediate
Journal of the American Chemical Society, v. 140, (2), January 2018, p. 735-740
Wang, Zhen; He, Zhiqi; Zhang, Linrui; Huang, Yong
Lewis酸对氮杂环卡宾协同催化体系中反应途径的调控
研究通讯=Acta Chimica Sinica, v. 76, (11), November 2018, p. 850-856
王乐明; 王骞; 陈杰安; 黄涌
One-pot Ligation Strategy for Atypical Ubiquitin Chains Synthesis by Using the Trifluoroacetamidomethyl-protected Isopeptide-linked Ub (Tfacm-isoUb) Unit
Tetrahedron Letters, v. 59, (3), January 2018, p. 268-271
Si, Yan-Yan; Liang, Lu-Jun; Tang, Shan; Qi, Yun-Kun; Huang, Yong; Zheng, Ji-Shen
Semi-synthesis of Disulfide-linked Branched Tri-ubiquitin Mimics
Science China Chemistry, v. 61, (4), April 2018, p. 412-417
Si, Yanyan; Liang, Lujun; Tang, Shan; Qi, Yunkun; Huang, Yong; Liu, Lei
Streamlined Asymmetric α-difunctionalization of Ynones
Nature Communications, v. 9, (1), December 2018, article number 375
Peng, Siyu; Wang, Zhaofeng; Zhang, Linxing; Zhang, Xinhao; Huang, Yong
Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo
Journal of Medicinal Chemistry, v. 61, (19), October 2018, p. 8613-8624
Huang, Yong; Pan, Peichen; Chen, Jiean; Li, Xijian; Li, Miyang; Yu, Huidong; Zhao, Jean J.; Ni, Jing; Wang, Xuwen; Sun, Huiyong; Tian, Sheng; Zhu, Feng; Liu, Feng; Hou, Tingjun
Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metalate Shift
Journal of the American Chemical Society, v. 140, (7), February 2018, p. 2693-2699
He, Zhiqi; Song, Feifei; Sun, Huan; Huang, Yong


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Article 9

Amine-Triggered 6π-Electrocyclization–Aromatization Cascade of Ynedienamines
Advanced Synthesis and Catalysis, v. 359, (8), April 2017, p. 1379-1387
Li, Xijian; Yu, Huidong; Huang, Yong
Chemical Synthesis of Histone H2A with Methylation at Gln104
Science China Chemistry, v. 60, (5), May 2017, p. 621-627
He, Qiaoqiao; Li, Jiabin; Qi, Yunkun; Wang, Zhipeng; Huang, Yong; Liu, Lei
Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation
ACS Central Science, v. 3, (11), November 2017, p. 1208-1220
Liu, Qi; Pan, Peichen; Yu, Huidong; Liu, Qinglan; Kong, Xiaotian; Chen, Hu; Chen, Jiean; Li, Dan; Kang, Yu; Sun, Huiyong; Zhou, Wenfang; Tian, Sheng; Cui, Sunliang; Zhu, Feng; Li, Youyong; Huang, Yong; Hou, Tingjun
Comparative Pharmacokinetic Profile of Cyclosporine (CsA) With A Decapeptide and A Linear Analogue
Organic and Biomolecular Chemistry, v. 15, (12), March 2017, p. 2501-2506
Price, David A.; Eng, Heather; Farley, Kathleen A.; Goetz, Gilles H.; Huang, Yong; Jiao, Zhaodong; Kalgutkar, Amit S.; Kablaoui, Natasha M.; Khunte, Bhagyashree A.; Liras, Spiros; Limberakis, Chris; Mathiowetz, Alan M.; Ruggeri, Roger B.; Quan, Junming Min; Yang, Zhen
Construction of Pyridazine Analogues via Rhodium-mediated C-H Activation
Advanced Synthesis and Catalysis, v. 359, (20), October 2017, p. 3496-3502
Yang, Chao; Song, Feifei; Chen, Jiean; Huang, Yong
Enantioselective β-Protonation of Enals via a Shuttling Strategy
Journal of the American Chemical Society, v. 139, (20), May 2017, p. 7045-7051
Chen, Jiean; Yuan, Pengfei; Wang, Leming; Huang, Yong
Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells
American Journal of Reproductive Immunology, v. 77, (3), March 2017, article number UNSP e12618
Diao, Liang-Hui; Li, Guan-Gui; Zhu, Yuan-Chang; Tu, Wen-Wei; Huang, Chun-Yu; Lian, Ruo-Chun; Chen, Xian; Li, Yu-Ye; Zhang, Tao; Huang, Yong; Zeng, Yong
Synthesis of Optically Active Oxazolines by an Organocatalytic Isocyanoacetate Aldol Reaction with α-Keto Esters
Synlett, v. 28, (11), July 2017, p. 1300-1304
Wang, Fei; Chen, Jiean; Huang, Yong
Visible-Light-Mediated [4+2] Cycloaddition of Styrenes: Synthesis of Tetralin Derivatives
Angewandte Chemie - International Edition, v. 56, (24), June 2017, p. 6896-6900
Wang, Leifeng; Wu, Fengjin; Chen, Jiean; Nicewicz, David A.; Huang, Yong


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Article 6

A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics
Angewandte Chemie - International Edition, v. 55, (46), November 2016, p. 14340-14344
Jiang, Hao; Xu, Liping; Fang, Yan; Zhang, Zhenxing; Yang, Zhen; Huang, Yong
Advances in the Development of Catalytic Tethering Directing Groups for C-H Functionalization Reactions
Organic and Biomolecular Chemistry, v. 14, (36), 2016, p. 8389-8397
Sun, Huan; Guimond, Nicolas; Huang, Yong
Asymmetric Sulfa-Michael Addition of α,β-Unsaturated Esters/Amides Using a Chiral N-Heterocyclic Carbene as a Noncovalent Organocatalyst
Synlett, v. 27, (7), April 2016, p. 1068-1072
Yuan, Pengfei; Meng, Sixuan; Chen, Jiean; Huang, Yong
Diverting C?H Annulation Pathways: Nickel-Catalyzed Dehydrogenative Homologation of Aromatic Amides
ACS Catalysis, v. 6, (11), November 2016, p. 7814-7823
He, Zhiqi; Huang, Yong
Ligand-Assisted Palladium(II)/(IV) Oxidation for sp ³ CH Fluorination
Advanced Synthesis and Catalysis, v. 358, (12), June 2016, p. 1946-1957
Sun, Huan; Zhang, Yi; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong
New Frontiers of N-heterocyclic Carbene Catalysis
Science China Chemistry, v. 59, (3), March 2016, p. 251-254
Chen, Jiean; Huang, Yong


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Article 8

A Copper-catalyzed Aerobic Domino Process for the Synthesis of Isoindolin-1-ylidene Derivatives
Tetrahedron, v. 71, (22), June 2015, p. 3632-3636
Chen, Hu; Wang, Qian; Huang, Yong
Asymmetric Intramolecular α-cyclopropanation of Aldehydes Using A Donor/acceptor Carbene Mimetic
Nature Communications, v. 6, December 2015, article number 10041
Luo, Chaosheng; Wang, Zhen; Huang, Yong
Asymmetric Synthesis of Hydrocarbazoles Catalyzed by an Octahedral Chiral-at-Rhodium Lewis Acid
Chemistry - An Asian Journal, v. 10, (12), December 2015, p. 2738-2743
Huang, Yong; Song, Liangliang; Gong, Lei; Meggers, Eric
Direct Fluorination of Styrenes
Chemical Communications, v. 51, (30), April 2015, p. 6584-6586
Shao, Qian; Huang, Yong
Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins
Angewandte Chemie - International Edition, v. 54, (51), December 2015, p. 15414-15418
Wang, Leming; Chen, Jiean; Huang, Yong
Highly Enantioselective Sulfa-Michael Addition Reactions Using N-heterocyclic Carbene as A Non-covalent Organocatalyst
Chemical Science, v. 6, (7), July 2015, p. 4184-4189
Chen, Jiean; Meng, Sixuan; Wang, Leming; Tang, Hongmei; Huang, Yong
Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions
Synlett, v. 26, (20), December 2015, article number st-2015-a0376-a, p. 2751-2762
Sun, Huan; Huang, Yong
Synthesis of tetrasubstituted 1-silyloxy-3-aminobutadienes and chemistry beyond Diels-Alder reactions
Nature Communications, v. 6, April 2015, article number 6913
Li, Xijian; Peng, Siyu; Li, Li; Huang, Yong


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Article 11

A General Synthesis of Ynones From Aldehydes via Oxidative C-C Bond Cleavage Under Aerobic Conditions
Journal of the American Chemical Society, v. 136, (35), September 2014, p. 12233-12236
Wang, Zhaofeng; Li, Li; Huang, Yong
A Multitasking Functional Group Leads to Structural Diversity Using Designer C-H Activation Reaction Cascades
Nature Communications, v. 5, August 2014, article number 4610
Chen, Ying; Wang, Dongqi; Duan, Pingping; Ben, Rong; Dai, Lu; Shao, Xiaoru; Hong, Mei; Zhao, Jing; Huang, Yong
Asymmetric Catalysis With N-heterocyclic Carbenes as Non-covalent Chiral Templates
Nature Communications, v. 5, March 2014, article number 3437
Chen, Jiean; Huang, Yong
Directed Arene/alkyne Annulation Reactions via Aerobic Copper Catalysis
Organic and Biomolecular Chemistry, v. 12, (44), November 2014, p. 8844-8850
Zhang, Yi; Wang, Qian; Yu, Huidong; Huang, Yong
Highly Ortho-selective Trifluoromethyl-thiolation Reactions Using A Ligand Exchange Strategy
Advanced Synthesis & Catalysis, v. 356, (14-15), October 2014, p. 2998-3006
Yin, Weiyu; Wang, Zhaofeng; Huang, Yong
Metal-templated Chiral Br?nsted Base Organocatalysis
Nature Communications, v. 5, July 2014, article number 4531
Ma, Jiajia; Ding, Xiaobing; Hu, Ying; Huang, Yong; Gong, Lei; Meggers, Eric
New Semi-synthesis of Ubiquitin C-terminal Conjugate With 7-amino-4-methylcoumarin
Journal of Peptide Science, v. 20, (2), February 2014, p. 102-107
Li, Yitong; Liang, Jun; Li, Jiabin; Fang, Gemin; Huang, Yong; Liu, Lei
Palladium Catalyzed Acetoxylation of Benzylic C-H Bonds Using a Bidentate Picolinamide Directing Group
Organic and Biomolecular Chemistry, v. 12, (9), March 2014, p. 1405-1411
Cheng, Tao; Yin, Weiyu; Zhang, Yi; Zhang, Yingnan; Huang, Yong
Ruthenium-catalyzed Redox-neutral C-H Activation via N-N Cleavage: Synthesis of N-substituted Indoles
Organic Letters, v. 16, (22), November 2014, p. 5976-5979
Zhang, Zhenxing; Jiang, Hao; Huang, Yong
Selective Synthesis of Indazoles and Indoles via Triazene-alkyne Cyclization Switched by Different Metals
Organic and Biomolecular Chemistry, v. 12, (7), February 2014, p. 1061-1071
Fang, Yan; Wang, Chengming; Su, Shengqin; Yu, Haizhu; Huang, Yong
Synthesis of Indolo[2,1-a]isoquinolines via a Triazene-directed C-H Annulation Cascade
Journal of Organic Chemistry, v. 79, (24), December 2014, p. 11863-11872
Sun, Huan; Wang, Chengming; Yang, Yunfang; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong


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Article 12

A Highly Diastereo- and Enantioselective Synthesis of Tetrahydroquinolines: Quaternary Stereogenic Center Inversion and Functionalization
Journal of the American Chemical Society, v. 135, (22), June 2013, p. 8193-8196
Luo, Chaosheng; Huang, Yong
A Highly Diastereoselective and Enantioselective Synthesis of Polysubstituted Pyrrolidines via an Organocatalytic Dynamic Kinetic Resolution Cascade
Organic Letters, v. 15, (8), April 2013, p. 1958-1961
Cheng, Tao; Meng, Sixuan; Huang, Yong
Computational Study on Mechanism of Rh(III)-catalyzed Oxidative Heck Coupling of Phenol Carbamates With Alkenes
Dalton Transactions, v. 42, (12), March 2013, p. 4175-4184
Zhang, Qi; Yu, Haizhu; Li, Yitong; Liu, Lei; Huang, Yong; Fu, Yao
Direct α-vinylidenation of Aldehydes and Subsequent Cascade: Gold and Amine Catalysts Work Synergistically
Angewandte Chemie - International Edition, v. 52, (52), December 2013, p. 14219-14223
Wang, Zhaofeng; Li, Xijian; Huang, Yong
Enantioselective Synthesis of 1,2,4-triazolines Catalyzed by A Cinchona Alkaloid-derived Organocatalyst
Chemical Communications, v. 49, (94), December 2013, p. 11098-11100
Shao, Qian; Chen, Jiean; Tu, Meihua; Piotrowski, David W.; Huang, Yong
Expanding Structural Diversity; Removable and Manipulable Directing Groups for C-H Activation
Synlett, v. 24, (2), January 2013, article number ST-2012-P0768-SP, p. 145-149
Wang, Chengming; Huang, Yong
General and Efficient Synthesis of Indoles Through Triazene-directed C-H Annulation
Angewandte Chemie - International Edition, v. 52, (22), May 2013, p. 5795-5798
Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong
Highly Practical Synthesis of Nitriles and Heterocycles From Alcohols Under Mild Conditions by Aerobic Double Dehydrogenative Catalysis
Organic Letters, v. 15, (8), April 2013, p. 1850-1853
Yin, Weiyu; Wang, Chengming; Huang, Yong
Highly Trans- Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper-catalyzed Triple Cascade Catalysis
Journal of Organic Chemistry, v. 78, (7), April 2013, p. 3503-3509
Chen, Hu; Wang, Zhaofeng; Zhang, Yingnan; Huang, Yong
Mechanism-based Design of a Photoactivatable Firefly Luciferase
Journal of the American Chemical Society, v. 135, (20), May 2013, p. 7410-7413
Zhao, Jing; Zhao, Jingyi; Lin, Shixian; Huang, Yong; Chen, Peng R.
Synthesis of α,β-unsaturated Carbonyl Compounds via a Visible-light-promoted Organocatalytic Aerobic Oxidation
Chemical Communications, v. 49, (99), November 2013, p. 11662-11664
Zhang, Junlin; Wang, Leming; Liu, Qi; Yang, Zhen; Huang, Yong
Traceless directing strategy: Efficient synthesis of N-alkyl indoles via redox-neutral C-H activation
Organic Letters, v. 15, (20), October 2013, p. 5294-5297
Wang, Chengming; Huang, Yong


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Article 4

An Air-State Fe₃S₄ Complex with Properties Similar to Those of The H_OXair State of The Diiron Hydrogenases
European Journal of Inorganic Chemistry, (27), September 2012, p. 4259-4263
Huang, Yong; Gao, Weiming; ?kermark, Torbj?rn N.; Li, Mingrun; ?kermark, Bjǒrn
General Palladium-catalyzed Aerobic Dehydrogenation to Generate Double Bonds
Chemical Science, v. 3, (3), March 2012, p. 883-886
Gao, Weiming; He, Zhiqi; Qian, Yong; Zhao, Jing; Huang, Yong
One-pot Synthesis of Useful Heterocycles in Medicinal Chemistry Using A Cascade Strategy
Green Chemistry, v. 14, (3), March 2012, p. 580-585
Wu, Guiyong; Yin, Weiyu; Shen, Hong C.; Huang, Yong
Rhodium(III)-catalyzed C-H Activation of Arenes Using a Versatile and Removable Triazene Directing Group
Angewandte Chemie - International Edition, v. 51, (29), July 2012, p. 7242-7245
Wang, Chengming; Chen, Hu; Wang, Zhaofeng; Chen, Jiean; Huang, Yong


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Article 1

Design of Potent and Selective GPR119 Agonists for Type II Diabetes
Bioorganic and Medicinal Chemistry Letters, v. 21, (9), May 2011, p. 2665-2669
Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B.


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Article 1

A Thiourea-Oxazoline Library with Axial Chirality: Ligand Synthesis and Studies of the Palladium-Catalyzed Enantioselective Bis(methoxycarbonylation) of Terminal Olefin
Advanced Synthesis and Catalysis, v. 352, (11-12), August 2010, p. 1955-1966
Gao, Ying-Xiang; Chang, Le; Shi, Hang; Liang, Bo; Wongkhan, Kittiya; Chaiyaveij, Duangduan; Batsanov, Andrei S.; Marder, Todd B.; Li, Chuang-Chuang; Yang, Zhen; Huang, Yong


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Article 1

Expedient, High-yielding Synthesis of Silyl-substituted Salen Ligands
Organic Letters, v. 9, (20), September 2007, p. 3873-3876
Thadani, Avinash N.; Huang, Yong; Rawal, Viresh H.


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Article 1

Enantioselective Organo-cascade Catalysis
Journal of the American Chemical Society, v. 127, (43), November 2005, p. 15051-15053
Huang, Yong; Walji, Abbas M.; Larsen, Catharine H.; MacMillan, David W.C.


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Article 1

Single Enantiomers From a Chiral-alcohol Catalyst
Nature, v. 424, (6945), July 2003, p. 146
Huang, Yong; Unni, Aditya K.; Thadani, Avinash N.; Rawal, Viresh H.


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Article 5

An Efficient Approach to Aspidosperma Alkaloids via [4 + 2] Cycloadditions of Aminosiloxydienes: Stereocontrolled Total Synthesis of (±)-tabersonine. Gram-scale Catalytic Asymmetric Syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric Syntheses of (+)-aspidospermidine and (-)-quebrachamine
Journal of the American Chemical Society, v. 124, (17), May 2002, p. 4628-4641
Kozmin, Sergey A.; Iwama, Tetsuo; Huang, Yong; Rawal, Viresh H.
Broadly Effective Enantioselective Diels-Alder Reactions of 1-Amino-substituted-1,3-butadienes
Organic Letters, v. 4, (7), April 2002, p. 1163-1164
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H.
Design and Development of Highly Effective Lewis Acid Catalysts for Enantioselective Diels-alder Reactions
Journal of the American Chemical Society, v. 124, (21), May 2002, p. 5950-5951
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H.
Hydrogen-bond-promoted Hetero-diels-alder Reactions of Unactivated Ketones
Journal of the American Chemical Society, v. 124, (33), August 2002, p. 9662-9663
Huang, Yong; Rawal, Viresh H.
The First Catalytic Enantioselective Diels-alder Reactions of 1,2-dihydropyridine: Efficient Syntheses of Optically Active 2-azabicyclo[2.2.2]octanes With Chiral Binam Derived Cr(III) Salen Complexes
Tetrahedron, v. 58, (41), October 2002, p. 8299-8305
Takenaka, Norito; Huang, Yong; Rawal, Viresh H.


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Article 2

Hetero Diels-alder Reactions of 1-amino-3-siloxy-1,3-butadienes Under Strictly Thermal Conditions
Organic Letters, v. 2, (21), October 2000, p. 3321-3323
Huang, Yong; Rawal, Viresh H.
Highly Enantioselective Diels-Alder Reactions of 1-Amino-3-siloxy-dienes Catalyzed by Cr(III)-Salen Complexes
Journal of the American Chemical Society, v. 122, (32), August 2000, p. 7843-7844
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H.


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2016 6

A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics
Angewandte Chemie - International Edition, v. 55, (46), November 2016, p. 14340-14344
Jiang, Hao; Xu, Liping; Fang, Yan; Zhang, Zhenxing; Yang, Zhen; Huang, Yong Article
Advances in the Development of Catalytic Tethering Directing Groups for C-H Functionalization Reactions
Organic and Biomolecular Chemistry, v. 14, (36), 2016, p. 8389-8397
Sun, Huan; Guimond, Nicolas; Huang, Yong Article
Asymmetric Sulfa-Michael Addition of α,β-Unsaturated Esters/Amides Using a Chiral N-Heterocyclic Carbene as a Noncovalent Organocatalyst
Synlett, v. 27, (7), April 2016, p. 1068-1072
Yuan, Pengfei; Meng, Sixuan; Chen, Jiean; Huang, Yong Article
Diverting C?H Annulation Pathways: Nickel-Catalyzed Dehydrogenative Homologation of Aromatic Amides
ACS Catalysis, v. 6, (11), November 2016, p. 7814-7823
He, Zhiqi; Huang, Yong Article
Ligand-Assisted Palladium(II)/(IV) Oxidation for sp ³ CH Fluorination
Advanced Synthesis and Catalysis, v. 358, (12), June 2016, p. 1946-1957
Sun, Huan; Zhang, Yi; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong Article
New Frontiers of N-heterocyclic Carbene Catalysis
Science China Chemistry, v. 59, (3), March 2016, p. 251-254
Chen, Jiean; Huang, Yong Article

2015 8

A Copper-catalyzed Aerobic Domino Process for the Synthesis of Isoindolin-1-ylidene Derivatives
Tetrahedron, v. 71, (22), June 2015, p. 3632-3636
Chen, Hu; Wang, Qian; Huang, Yong Article
Asymmetric Intramolecular α-cyclopropanation of Aldehydes Using A Donor/acceptor Carbene Mimetic
Nature Communications, v. 6, December 2015, article number 10041
Luo, Chaosheng; Wang, Zhen; Huang, Yong Article
Asymmetric Synthesis of Hydrocarbazoles Catalyzed by an Octahedral Chiral-at-Rhodium Lewis Acid
Chemistry - An Asian Journal, v. 10, (12), December 2015, p. 2738-2743
Huang, Yong; Song, Liangliang; Gong, Lei; Meggers, Eric Article
Direct Fluorination of Styrenes
Chemical Communications, v. 51, (30), April 2015, p. 6584-6586
Shao, Qian; Huang, Yong Article
Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins
Angewandte Chemie - International Edition, v. 54, (51), December 2015, p. 15414-15418
Wang, Leming; Chen, Jiean; Huang, Yong Article
Highly Enantioselective Sulfa-Michael Addition Reactions Using N-heterocyclic Carbene as A Non-covalent Organocatalyst
Chemical Science, v. 6, (7), July 2015, p. 4184-4189
Chen, Jiean; Meng, Sixuan; Wang, Leming; Tang, Hongmei; Huang, Yong Article
Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions
Synlett, v. 26, (20), December 2015, article number st-2015-a0376-a, p. 2751-2762
Sun, Huan; Huang, Yong Article
Synthesis of tetrasubstituted 1-silyloxy-3-aminobutadienes and chemistry beyond Diels-Alder reactions
Nature Communications, v. 6, April 2015, article number 6913
Li, Xijian; Peng, Siyu; Li, Li; Huang, Yong Article

2014 11

A General Synthesis of Ynones From Aldehydes via Oxidative C-C Bond Cleavage Under Aerobic Conditions
Journal of the American Chemical Society, v. 136, (35), September 2014, p. 12233-12236
Wang, Zhaofeng; Li, Li; Huang, Yong Article
A Multitasking Functional Group Leads to Structural Diversity Using Designer C-H Activation Reaction Cascades
Nature Communications, v. 5, August 2014, article number 4610
Chen, Ying; Wang, Dongqi; Duan, Pingping; Ben, Rong; Dai, Lu; Shao, Xiaoru; Hong, Mei; Zhao, Jing; Huang, Yong Article
Asymmetric Catalysis With N-heterocyclic Carbenes as Non-covalent Chiral Templates
Nature Communications, v. 5, March 2014, article number 3437
Chen, Jiean; Huang, Yong Article
Directed Arene/alkyne Annulation Reactions via Aerobic Copper Catalysis
Organic and Biomolecular Chemistry, v. 12, (44), November 2014, p. 8844-8850
Zhang, Yi; Wang, Qian; Yu, Huidong; Huang, Yong Article
Highly Ortho-selective Trifluoromethyl-thiolation Reactions Using A Ligand Exchange Strategy
Advanced Synthesis & Catalysis, v. 356, (14-15), October 2014, p. 2998-3006
Yin, Weiyu; Wang, Zhaofeng; Huang, Yong Article
Metal-templated Chiral Br?nsted Base Organocatalysis
Nature Communications, v. 5, July 2014, article number 4531
Ma, Jiajia; Ding, Xiaobing; Hu, Ying; Huang, Yong; Gong, Lei; Meggers, Eric Article
New Semi-synthesis of Ubiquitin C-terminal Conjugate With 7-amino-4-methylcoumarin
Journal of Peptide Science, v. 20, (2), February 2014, p. 102-107
Li, Yitong; Liang, Jun; Li, Jiabin; Fang, Gemin; Huang, Yong; Liu, Lei Article
Palladium Catalyzed Acetoxylation of Benzylic C-H Bonds Using a Bidentate Picolinamide Directing Group
Organic and Biomolecular Chemistry, v. 12, (9), March 2014, p. 1405-1411
Cheng, Tao; Yin, Weiyu; Zhang, Yi; Zhang, Yingnan; Huang, Yong Article
Ruthenium-catalyzed Redox-neutral C-H Activation via N-N Cleavage: Synthesis of N-substituted Indoles
Organic Letters, v. 16, (22), November 2014, p. 5976-5979
Zhang, Zhenxing; Jiang, Hao; Huang, Yong Article
Selective Synthesis of Indazoles and Indoles via Triazene-alkyne Cyclization Switched by Different Metals
Organic and Biomolecular Chemistry, v. 12, (7), February 2014, p. 1061-1071
Fang, Yan; Wang, Chengming; Su, Shengqin; Yu, Haizhu; Huang, Yong Article
Synthesis of Indolo[2,1-a]isoquinolines via a Triazene-directed C-H Annulation Cascade
Journal of Organic Chemistry, v. 79, (24), December 2014, p. 11863-11872
Sun, Huan; Wang, Chengming; Yang, Yunfang; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong Article

2013 12

A Highly Diastereo- and Enantioselective Synthesis of Tetrahydroquinolines: Quaternary Stereogenic Center Inversion and Functionalization
Journal of the American Chemical Society, v. 135, (22), June 2013, p. 8193-8196
Luo, Chaosheng; Huang, Yong Article
A Highly Diastereoselective and Enantioselective Synthesis of Polysubstituted Pyrrolidines via an Organocatalytic Dynamic Kinetic Resolution Cascade
Organic Letters, v. 15, (8), April 2013, p. 1958-1961
Cheng, Tao; Meng, Sixuan; Huang, Yong Article
Computational Study on Mechanism of Rh(III)-catalyzed Oxidative Heck Coupling of Phenol Carbamates With Alkenes
Dalton Transactions, v. 42, (12), March 2013, p. 4175-4184
Zhang, Qi; Yu, Haizhu; Li, Yitong; Liu, Lei; Huang, Yong; Fu, Yao Article
Direct α-vinylidenation of Aldehydes and Subsequent Cascade: Gold and Amine Catalysts Work Synergistically
Angewandte Chemie - International Edition, v. 52, (52), December 2013, p. 14219-14223
Wang, Zhaofeng; Li, Xijian; Huang, Yong Article
Enantioselective Synthesis of 1,2,4-triazolines Catalyzed by A Cinchona Alkaloid-derived Organocatalyst
Chemical Communications, v. 49, (94), December 2013, p. 11098-11100
Shao, Qian; Chen, Jiean; Tu, Meihua; Piotrowski, David W.; Huang, Yong Article
Expanding Structural Diversity; Removable and Manipulable Directing Groups for C-H Activation
Synlett, v. 24, (2), January 2013, article number ST-2012-P0768-SP, p. 145-149
Wang, Chengming; Huang, Yong Article
General and Efficient Synthesis of Indoles Through Triazene-directed C-H Annulation
Angewandte Chemie - International Edition, v. 52, (22), May 2013, p. 5795-5798
Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong Article
Highly Practical Synthesis of Nitriles and Heterocycles From Alcohols Under Mild Conditions by Aerobic Double Dehydrogenative Catalysis
Organic Letters, v. 15, (8), April 2013, p. 1850-1853
Yin, Weiyu; Wang, Chengming; Huang, Yong Article
Highly Trans- Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper-catalyzed Triple Cascade Catalysis
Journal of Organic Chemistry, v. 78, (7), April 2013, p. 3503-3509
Chen, Hu; Wang, Zhaofeng; Zhang, Yingnan; Huang, Yong Article
Mechanism-based Design of a Photoactivatable Firefly Luciferase
Journal of the American Chemical Society, v. 135, (20), May 2013, p. 7410-7413
Zhao, Jing; Zhao, Jingyi; Lin, Shixian; Huang, Yong; Chen, Peng R. Article
Synthesis of α,β-unsaturated Carbonyl Compounds via a Visible-light-promoted Organocatalytic Aerobic Oxidation
Chemical Communications, v. 49, (99), November 2013, p. 11662-11664
Zhang, Junlin; Wang, Leming; Liu, Qi; Yang, Zhen; Huang, Yong Article
Traceless directing strategy: Efficient synthesis of N-alkyl indoles via redox-neutral C-H activation
Organic Letters, v. 15, (20), October 2013, p. 5294-5297
Wang, Chengming; Huang, Yong Article

2012 4

An Air-State Fe₃S₄ Complex with Properties Similar to Those of The H_OXair State of The Diiron Hydrogenases
European Journal of Inorganic Chemistry, (27), September 2012, p. 4259-4263
Huang, Yong; Gao, Weiming; ?kermark, Torbj?rn N.; Li, Mingrun; ?kermark, Bjǒrn Article
General Palladium-catalyzed Aerobic Dehydrogenation to Generate Double Bonds
Chemical Science, v. 3, (3), March 2012, p. 883-886
Gao, Weiming; He, Zhiqi; Qian, Yong; Zhao, Jing; Huang, Yong Article
One-pot Synthesis of Useful Heterocycles in Medicinal Chemistry Using A Cascade Strategy
Green Chemistry, v. 14, (3), March 2012, p. 580-585
Wu, Guiyong; Yin, Weiyu; Shen, Hong C.; Huang, Yong Article
Rhodium(III)-catalyzed C-H Activation of Arenes Using a Versatile and Removable Triazene Directing Group
Angewandte Chemie - International Edition, v. 51, (29), July 2012, p. 7242-7245
Wang, Chengming; Chen, Hu; Wang, Zhaofeng; Chen, Jiean; Huang, Yong Article

2011 1

Design of Potent and Selective GPR119 Agonists for Type II Diabetes
Bioorganic and Medicinal Chemistry Letters, v. 21, (9), May 2011, p. 2665-2669
Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B. Article

2010 1

A Thiourea-Oxazoline Library with Axial Chirality: Ligand Synthesis and Studies of the Palladium-Catalyzed Enantioselective Bis(methoxycarbonylation) of Terminal Olefin
Advanced Synthesis and Catalysis, v. 352, (11-12), August 2010, p. 1955-1966
Gao, Ying-Xiang; Chang, Le; Shi, Hang; Liang, Bo; Wongkhan, Kittiya; Chaiyaveij, Duangduan; Batsanov, Andrei S.; Marder, Todd B.; Li, Chuang-Chuang; Yang, Zhen; Huang, Yong Article

2007 1

Expedient, High-yielding Synthesis of Silyl-substituted Salen Ligands
Organic Letters, v. 9, (20), September 2007, p. 3873-3876
Thadani, Avinash N.; Huang, Yong; Rawal, Viresh H. Article

2005 1

Enantioselective Organo-cascade Catalysis
Journal of the American Chemical Society, v. 127, (43), November 2005, p. 15051-15053
Huang, Yong; Walji, Abbas M.; Larsen, Catharine H.; MacMillan, David W.C. Article

2003 1

Single Enantiomers From a Chiral-alcohol Catalyst
Nature, v. 424, (6945), July 2003, p. 146
Huang, Yong; Unni, Aditya K.; Thadani, Avinash N.; Rawal, Viresh H. Article

2002 5

An Efficient Approach to Aspidosperma Alkaloids via [4 + 2] Cycloadditions of Aminosiloxydienes: Stereocontrolled Total Synthesis of (±)-tabersonine. Gram-scale Catalytic Asymmetric Syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric Syntheses of (+)-aspidospermidine and (-)-quebrachamine
Journal of the American Chemical Society, v. 124, (17), May 2002, p. 4628-4641
Kozmin, Sergey A.; Iwama, Tetsuo; Huang, Yong; Rawal, Viresh H. Article
Broadly Effective Enantioselective Diels-Alder Reactions of 1-Amino-substituted-1,3-butadienes
Organic Letters, v. 4, (7), April 2002, p. 1163-1164
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article
Design and Development of Highly Effective Lewis Acid Catalysts for Enantioselective Diels-alder Reactions
Journal of the American Chemical Society, v. 124, (21), May 2002, p. 5950-5951
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article
Hydrogen-bond-promoted Hetero-diels-alder Reactions of Unactivated Ketones
Journal of the American Chemical Society, v. 124, (33), August 2002, p. 9662-9663
Huang, Yong; Rawal, Viresh H. Article
The First Catalytic Enantioselective Diels-alder Reactions of 1,2-dihydropyridine: Efficient Syntheses of Optically Active 2-azabicyclo[2.2.2]octanes With Chiral Binam Derived Cr(III) Salen Complexes
Tetrahedron, v. 58, (41), October 2002, p. 8299-8305
Takenaka, Norito; Huang, Yong; Rawal, Viresh H. Article

2000 2

Hetero Diels-alder Reactions of 1-amino-3-siloxy-1,3-butadienes Under Strictly Thermal Conditions
Organic Letters, v. 2, (21), October 2000, p. 3321-3323
Huang, Yong; Rawal, Viresh H. Article
Highly Enantioselective Diels-Alder Reactions of 1-Amino-3-siloxy-dienes Catalyzed by Cr(III)-Salen Complexes
Journal of the American Chemical Society, v. 122, (32), August 2000, p. 7843-7844
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 2 2020-21 Summer 1 2020-21 Spring 4 2020-21 Winter 0 2020-21 Fall 3

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CHEM4140 Intermediate Organic Chemistry
CHEM4689 Capstone Project


CHEM4680 Undergraduate Research


CHEM4130 Medicinal Chemistry
CHEM4689 Capstone Project
CHEM4691 Capstone Research I
SCIE4500 IRE Research Project II


CHEM4140 Intermediate Organic Chemistry
CHEM4691 Capstone Research I
SCIE3500 IRE Research Project I


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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Current RPGs

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Doctor of Philosophy ZHANG, Yichi
Chemistry( 2021 - )

CHAN, Cho Ying
Chemistry( 2020 - )

CHEN, Mengting
Chemistry( 2020 - )

CHING, Yin Cheung
Chemistry( 2020 - )

XING, Yajie
Chemistry( 2020 - )









ProjectsFrom January 2020 to December 2022

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All Projects 3

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No Projects.
The Development of Organocatalytic Cross-Coupling Reactions


发展有机催化的交叉偶联反应 Leading


RGC - General Research Fund


Project Team (HKUST)
HUANG Yong (Lead)


2022 -




Enantioselective Organocatalytic Sigmatropic Rearrangement


对映选择性有机催化sigmatropic重排反应 Leading


RGC - General Research Fund


Project Team (HKUST)
HUANG Yong (Lead)


2021 -




Medicinal Chemistry on Novel Type I1/2 ALK Inhibitors for Combating Drug-resistant Mutants


改善ALK突变体耐药性的I1/2型抑制剂的药物化学研究 Leading


Shenzhen Science and Technology Innovation Committee


Project Team (HKUST)
HUANG Yong (Lead)


2019 -