Yong HUANG
黄涌
PhD in Organic Chemistry
The University of Chicago, 2002
Associate Professor
Department of Chemistry
(852) 3469 2625
yonghuang@ust.hk
Room 4530
Personal Web
ORCID
0000-0001-8377-8923
Scopus ID
55061665600
Research Interest Publications Projects Teaching Assignment RPG Supervision Space used
Research Interest
Enantioselective reactions
Synthetic organic chemistry
Organic chemistry
Medicinal chemistry
Organometallic chemistry
Publications
All Years 85 2022 0 2021 3 2020 5 2019 4 2018 11 2017 9 2016 53
2021 3
A Bifunctional N-Heterocyclic Carbene as a Noncovalent Organocatalyst for Enantioselective Aza-Michael Addition Reactions
ACS Catalysis, v. 11, (10), May 2021, p. 6316-6324
Guo, Fangfang; Chen, Jiean; Huang, Yong Article
N-Heterocyclic Carbene-Catalyzed Four-Component Reaction: Chemoselective Cradical-Cradical Relay Coupling Involving the Homoenolate Intermediate
ACS Catalysis, v. 11, (16), July 2021, p. 10123-10130
Li, Zhen; Huang, Meirong; Zhang, Xinhao; Chen, Jiean; Huang, Yong Article
Synthesis of α-chiral phosphine sulfides via non-covalent organocatalysis
Cell Reports Physical Science, v. 2, (7), July 2021, article number 100490
Li, En; Wang, Qian; Cai, Yuxing; Chen, Jiean; Huang, Yong Article
2020 5
Direct Synthesis of Bicyclic Acetalsvia Visible Light Catalysis
iScience, v. 23, (8), August 2020, article number 101395
Wu, Fengjin; Wang, Leifeng; Ji, Ying; Zou, Ge; Shen, Hong; Nicewicz, David A.; Chen, Jiean; Huang, Yong Article
Enantioselective Intramolecular [2,3]-Sigmatropic Rearrangement of Aldehydes via a Sulfonium Enamine Intermediate
Angewandte Chemie - International Edition, v. 59, (47), 16 November 2020, p. 20904-20908
Li, Li; Chen, Baoli; Chen, Jiean; Huang, Yong Article
Ligand-Controlled C?O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights
Advanced Synthesis and Catalysis, v. 362, (1), January 2020, p. 126-132
Li, Li; Song, Feifei; Zhong, Xiumei; Wu, Yun Dong; Zhang, Xinhao; Chen, Jiean; Huang, Yong Article
Molecular Insights into Small‐Molecule Drug Discovery for SARS‐CoV‐2
Angewandte Chemie - International Edition, v. 60, 2021, p. 9789-9802
Su, Hailei; Zhou, Feng; Huang, Ziru; Ma, Xiaohua; Natarajan, Kathiresan; Zhang, Minchuan; Huang, Yong; Su, Haibin Article
Photo-induced energy transfer relay of N-heterocyclic carbene catalysis: An asymmetric α-fluorination/isomerization cascade
Chemical Communications, v. 57, (6), January 2021, p. 729-732
Jiang, Xinhang; Li, En; Chen, Jiean; Huang, Yong Article
2019 4
Alcohol-Directed ortho -C-H Alkenylation
Synlett, v. 30, (11), July 2019, p. 1366-1370
Li, Li; Liu, Qinglan; Chen, Jiean; Huang, Yong Article
Dehydrogenative Annulation of γ,δ-Unsaturated Amides and Alkynes via Double C-H Activation
Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica, v. 35, (9), 2019, p. 906-912
Wang, Zhen; Li, En; He, Zhiqi; Chen, Jiean; Huang, Yong Article
Enantio- and Diastereoselective Hydrofluorination of Enals by N-Heterocyclic Carbene Catalysis
Angewandte Chemie - International Edition, v. 58, (22), May 2019, p. 7410-7414
Wang, Leming; Jiang, Xinhang; Chen, Jiean; Huang, Yong Article
N-heterocyclic Carbenes as Bronsted Base Catalysts
N-Heterocyclic Carbenes in Organocatalysis / Editor, Akkattu T. Biju; With a Foreword by Ronald Breslow. Weinheim, Germany : Wiley, 2019, p. 261-286, Ch. 9
Chen, Jiean; Huang, Yong Book chapter
2018 11
Aerobic Oxidation/Annulation Cascades through Synergistic Catalysis of RuCl3 and N-Heterocyclic Carbenes
Chemistry - A European Journal, v. 24, (49), September 2018, p. 12806-12810
Wang, Qian; Chen, Jiean; Huang, Yong Article
Direct Synthesis of Polysubstituted Aldehydes via Visible-Light Catalysis
Angewandte Chemie - International Edition, v. 57, (8), February 2018, p. 2174-2178
Wu, Fengjin; Wang, Leifeng; Chen, Jiean; Nicewicz, David A.; Huang, Yong Article
Enantioselective Cooperative Proton-transfer Catalysis Using Chiral Ammonium Phosphates
Chemical Communications, v. 54, (12), February 2018, p. 1473-1476
Zhang, Linrui; Yuan, Pengfei; Chen, Jiean; Huang, Yong Article
Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species
Angewandte Chemie - International Edition, v. 57, (28), July 2018, p. 8503-8507
Yuan, Pengfei; Chen, Jiean; Zhao, Jing; Huang, Yong Article
Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- And β-C-H bonds through an Allyl-Iridium Intermediate
Journal of the American Chemical Society, v. 140, (2), January 2018, p. 735-740
Wang, Zhen; He, Zhiqi; Zhang, Linrui; Huang, Yong Article
Lewis酸对氮杂环卡宾协同催化体系中反应途径的调控
研究通讯=Acta Chimica Sinica, v. 76, (11), November 2018, p. 850-856
王乐明; 王骞; 陈杰安; 黄涌 Article
One-pot Ligation Strategy for Atypical Ubiquitin Chains Synthesis by Using the Trifluoroacetamidomethyl-protected Isopeptide-linked Ub (Tfacm-isoUb) Unit
Tetrahedron Letters, v. 59, (3), January 2018, p. 268-271
Si, Yan-Yan; Liang, Lu-Jun; Tang, Shan; Qi, Yun-Kun; Huang, Yong; Zheng, Ji-Shen Article
Semi-synthesis of Disulfide-linked Branched Tri-ubiquitin Mimics
Science China Chemistry, v. 61, (4), April 2018, p. 412-417
Si, Yanyan; Liang, Lujun; Tang, Shan; Qi, Yunkun; Huang, Yong; Liu, Lei Article
Streamlined Asymmetric α-difunctionalization of Ynones
Nature Communications, v. 9, (1), December 2018, article number 375
Peng, Siyu; Wang, Zhaofeng; Zhang, Linxing; Zhang, Xinhao; Huang, Yong Article
Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo
Journal of Medicinal Chemistry, v. 61, (19), October 2018, p. 8613-8624
Huang, Yong; Pan, Peichen; Chen, Jiean; Li, Xijian; Li, Miyang; Yu, Huidong; Zhao, Jean J.; Ni, Jing; Wang, Xuwen; Sun, Huiyong; Tian, Sheng; Zhu, Feng; Liu, Feng; Hou, Tingjun Article
Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metalate Shift
Journal of the American Chemical Society, v. 140, (7), February 2018, p. 2693-2699
He, Zhiqi; Song, Feifei; Sun, Huan; Huang, Yong Article
2017 9
Amine-Triggered 6π-Electrocyclization–Aromatization Cascade of Ynedienamines
Advanced Synthesis and Catalysis, v. 359, (8), April 2017, p. 1379-1387
Li, Xijian; Yu, Huidong; Huang, Yong Article
Chemical Synthesis of Histone H2A with Methylation at Gln104
Science China Chemistry, v. 60, (5), May 2017, p. 621-627
He, Qiaoqiao; Li, Jiabin; Qi, Yunkun; Wang, Zhipeng; Huang, Yong; Liu, Lei Article
Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation
ACS Central Science, v. 3, (11), November 2017, p. 1208-1220
Liu, Qi; Pan, Peichen; Yu, Huidong; Liu, Qinglan; Kong, Xiaotian; Chen, Hu; Chen, Jiean; Li, Dan; Kang, Yu; Sun, Huiyong; Zhou, Wenfang; Tian, Sheng; Cui, Sunliang; Zhu, Feng; Li, Youyong; Huang, Yong; Hou, Tingjun Article
Comparative Pharmacokinetic Profile of Cyclosporine (CsA) With A Decapeptide and A Linear Analogue
Organic and Biomolecular Chemistry, v. 15, (12), March 2017, p. 2501-2506
Price, David A.; Eng, Heather; Farley, Kathleen A.; Goetz, Gilles H.; Huang, Yong; Jiao, Zhaodong; Kalgutkar, Amit S.; Kablaoui, Natasha M.; Khunte, Bhagyashree A.; Liras, Spiros; Limberakis, Chris; Mathiowetz, Alan M.; Ruggeri, Roger B.; Quan, Junming Min; Yang, Zhen Article
Construction of Pyridazine Analogues via Rhodium-mediated C-H Activation
Advanced Synthesis and Catalysis, v. 359, (20), October 2017, p. 3496-3502
Yang, Chao; Song, Feifei; Chen, Jiean; Huang, Yong Article
Enantioselective β-Protonation of Enals via a Shuttling Strategy
Journal of the American Chemical Society, v. 139, (20), May 2017, p. 7045-7051
Chen, Jiean; Yuan, Pengfei; Wang, Leming; Huang, Yong Article
Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells
American Journal of Reproductive Immunology, v. 77, (3), March 2017, article number UNSP e12618
Diao, Liang-Hui; Li, Guan-Gui; Zhu, Yuan-Chang; Tu, Wen-Wei; Huang, Chun-Yu; Lian, Ruo-Chun; Chen, Xian; Li, Yu-Ye; Zhang, Tao; Huang, Yong; Zeng, Yong Article
Synthesis of Optically Active Oxazolines by an Organocatalytic Isocyanoacetate Aldol Reaction with α-Keto Esters
Synlett, v. 28, (11), July 2017, p. 1300-1304
Wang, Fei; Chen, Jiean; Huang, Yong Article
Visible-Light-Mediated [4+2] Cycloaddition of Styrenes: Synthesis of Tetralin Derivatives
Angewandte Chemie - International Edition, v. 56, (24), June 2017, p. 6896-6900
Wang, Leifeng; Wu, Fengjin; Chen, Jiean; Nicewicz, David A.; Huang, Yong Article
2016 6
A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics
Angewandte Chemie - International Edition, v. 55, (46), November 2016, p. 14340-14344
Jiang, Hao; Xu, Liping; Fang, Yan; Zhang, Zhenxing; Yang, Zhen; Huang, Yong Article
Advances in the Development of Catalytic Tethering Directing Groups for C-H Functionalization Reactions
Organic and Biomolecular Chemistry, v. 14, (36), 2016, p. 8389-8397
Sun, Huan; Guimond, Nicolas; Huang, Yong Article
Asymmetric Sulfa-Michael Addition of α,β-Unsaturated Esters/Amides Using a Chiral N-Heterocyclic Carbene as a Noncovalent Organocatalyst
Synlett, v. 27, (7), April 2016, p. 1068-1072
Yuan, Pengfei; Meng, Sixuan; Chen, Jiean; Huang, Yong Article
Diverting C?H Annulation Pathways: Nickel-Catalyzed Dehydrogenative Homologation of Aromatic Amides
ACS Catalysis, v. 6, (11), November 2016, p. 7814-7823
He, Zhiqi; Huang, Yong Article
Ligand-Assisted Palladium(II)/(IV) Oxidation for sp 3 CH Fluorination
Advanced Synthesis and Catalysis, v. 358, (12), June 2016, p. 1946-1957
Sun, Huan; Zhang, Yi; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong Article
New Frontiers of N-heterocyclic Carbene Catalysis
Science China Chemistry, v. 59, (3), March 2016, p. 251-254
Chen, Jiean; Huang, Yong Article
2015 8
A Copper-catalyzed Aerobic Domino Process for the Synthesis of Isoindolin-1-ylidene Derivatives
Tetrahedron, v. 71, (22), June 2015, p. 3632-3636
Chen, Hu; Wang, Qian; Huang, Yong Article
Asymmetric Intramolecular α-cyclopropanation of Aldehydes Using A Donor/acceptor Carbene Mimetic
Nature Communications, v. 6, December 2015, article number 10041
Luo, Chaosheng; Wang, Zhen; Huang, Yong Article
Asymmetric Synthesis of Hydrocarbazoles Catalyzed by an Octahedral Chiral-at-Rhodium Lewis Acid
Chemistry - An Asian Journal, v. 10, (12), December 2015, p. 2738-2743
Huang, Yong; Song, Liangliang; Gong, Lei; Meggers, Eric Article
Direct Fluorination of Styrenes
Chemical Communications, v. 51, (30), April 2015, p. 6584-6586
Shao, Qian; Huang, Yong Article
Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins
Angewandte Chemie - International Edition, v. 54, (51), December 2015, p. 15414-15418
Wang, Leming; Chen, Jiean; Huang, Yong Article
Highly Enantioselective Sulfa-Michael Addition Reactions Using N-heterocyclic Carbene as A Non-covalent Organocatalyst
Chemical Science, v. 6, (7), July 2015, p. 4184-4189
Chen, Jiean; Meng, Sixuan; Wang, Leming; Tang, Hongmei; Huang, Yong Article
Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions
Synlett, v. 26, (20), December 2015, article number st-2015-a0376-a, p. 2751-2762
Sun, Huan; Huang, Yong Article
Synthesis of tetrasubstituted 1-silyloxy-3-aminobutadienes and chemistry beyond Diels-Alder reactions
Nature Communications, v. 6, April 2015, article number 6913
Li, Xijian; Peng, Siyu; Li, Li; Huang, Yong Article
2014 11
A General Synthesis of Ynones From Aldehydes via Oxidative C-C Bond Cleavage Under Aerobic Conditions
Journal of the American Chemical Society, v. 136, (35), September 2014, p. 12233-12236
Wang, Zhaofeng; Li, Li; Huang, Yong Article
A Multitasking Functional Group Leads to Structural Diversity Using Designer C-H Activation Reaction Cascades
Nature Communications, v. 5, August 2014, article number 4610
Chen, Ying; Wang, Dongqi; Duan, Pingping; Ben, Rong; Dai, Lu; Shao, Xiaoru; Hong, Mei; Zhao, Jing; Huang, Yong Article
Asymmetric Catalysis With N-heterocyclic Carbenes as Non-covalent Chiral Templates
Nature Communications, v. 5, March 2014, article number 3437
Chen, Jiean; Huang, Yong Article
Directed Arene/alkyne Annulation Reactions via Aerobic Copper Catalysis
Organic and Biomolecular Chemistry, v. 12, (44), November 2014, p. 8844-8850
Zhang, Yi; Wang, Qian; Yu, Huidong; Huang, Yong Article
Highly Ortho-selective Trifluoromethyl-thiolation Reactions Using A Ligand Exchange Strategy
Advanced Synthesis & Catalysis, v. 356, (14-15), October 2014, p. 2998-3006
Yin, Weiyu; Wang, Zhaofeng; Huang, Yong Article
Metal-templated Chiral Br?nsted Base Organocatalysis
Nature Communications, v. 5, July 2014, article number 4531
Ma, Jiajia; Ding, Xiaobing; Hu, Ying; Huang, Yong; Gong, Lei; Meggers, Eric Article
New Semi-synthesis of Ubiquitin C-terminal Conjugate With 7-amino-4-methylcoumarin
Journal of Peptide Science, v. 20, (2), February 2014, p. 102-107
Li, Yitong; Liang, Jun; Li, Jiabin; Fang, Gemin; Huang, Yong; Liu, Lei Article
Palladium Catalyzed Acetoxylation of Benzylic C-H Bonds Using a Bidentate Picolinamide Directing Group
Organic and Biomolecular Chemistry, v. 12, (9), March 2014, p. 1405-1411
Cheng, Tao; Yin, Weiyu; Zhang, Yi; Zhang, Yingnan; Huang, Yong Article
Ruthenium-catalyzed Redox-neutral C-H Activation via N-N Cleavage: Synthesis of N-substituted Indoles
Organic Letters, v. 16, (22), November 2014, p. 5976-5979
Zhang, Zhenxing; Jiang, Hao; Huang, Yong Article
Selective Synthesis of Indazoles and Indoles via Triazene-alkyne Cyclization Switched by Different Metals
Organic and Biomolecular Chemistry, v. 12, (7), February 2014, p. 1061-1071
Fang, Yan; Wang, Chengming; Su, Shengqin; Yu, Haizhu; Huang, Yong Article
Synthesis of Indolo[2,1-a]isoquinolines via a Triazene-directed C-H Annulation Cascade
Journal of Organic Chemistry, v. 79, (24), December 2014, p. 11863-11872
Sun, Huan; Wang, Chengming; Yang, Yunfang; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong Article
2013 12
A Highly Diastereo- and Enantioselective Synthesis of Tetrahydroquinolines: Quaternary Stereogenic Center Inversion and Functionalization
Journal of the American Chemical Society, v. 135, (22), June 2013, p. 8193-8196
Luo, Chaosheng; Huang, Yong Article
A Highly Diastereoselective and Enantioselective Synthesis of Polysubstituted Pyrrolidines via an Organocatalytic Dynamic Kinetic Resolution Cascade
Organic Letters, v. 15, (8), April 2013, p. 1958-1961
Cheng, Tao; Meng, Sixuan; Huang, Yong Article
Computational Study on Mechanism of Rh(III)-catalyzed Oxidative Heck Coupling of Phenol Carbamates With Alkenes
Dalton Transactions, v. 42, (12), March 2013, p. 4175-4184
Zhang, Qi; Yu, Haizhu; Li, Yitong; Liu, Lei; Huang, Yong; Fu, Yao Article
Direct α-vinylidenation of Aldehydes and Subsequent Cascade: Gold and Amine Catalysts Work Synergistically
Angewandte Chemie - International Edition, v. 52, (52), December 2013, p. 14219-14223
Wang, Zhaofeng; Li, Xijian; Huang, Yong Article
Enantioselective Synthesis of 1,2,4-triazolines Catalyzed by A Cinchona Alkaloid-derived Organocatalyst
Chemical Communications, v. 49, (94), December 2013, p. 11098-11100
Shao, Qian; Chen, Jiean; Tu, Meihua; Piotrowski, David W.; Huang, Yong Article
Expanding Structural Diversity; Removable and Manipulable Directing Groups for C-H Activation
Synlett, v. 24, (2), January 2013, article number ST-2012-P0768-SP, p. 145-149
Wang, Chengming; Huang, Yong Article
General and Efficient Synthesis of Indoles Through Triazene-directed C-H Annulation
Angewandte Chemie - International Edition, v. 52, (22), May 2013, p. 5795-5798
Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong Article
Highly Practical Synthesis of Nitriles and Heterocycles From Alcohols Under Mild Conditions by Aerobic Double Dehydrogenative Catalysis
Organic Letters, v. 15, (8), April 2013, p. 1850-1853
Yin, Weiyu; Wang, Chengming; Huang, Yong Article
Highly Trans- Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper-catalyzed Triple Cascade Catalysis
Journal of Organic Chemistry, v. 78, (7), April 2013, p. 3503-3509
Chen, Hu; Wang, Zhaofeng; Zhang, Yingnan; Huang, Yong Article
Mechanism-based Design of a Photoactivatable Firefly Luciferase
Journal of the American Chemical Society, v. 135, (20), May 2013, p. 7410-7413
Zhao, Jing; Zhao, Jingyi; Lin, Shixian; Huang, Yong; Chen, Peng R. Article
Synthesis of α,β-unsaturated Carbonyl Compounds via a Visible-light-promoted Organocatalytic Aerobic Oxidation
Chemical Communications, v. 49, (99), November 2013, p. 11662-11664
Zhang, Junlin; Wang, Leming; Liu, Qi; Yang, Zhen; Huang, Yong Article
Traceless directing strategy: Efficient synthesis of N-alkyl indoles via redox-neutral C-H activation
Organic Letters, v. 15, (20), October 2013, p. 5294-5297
Wang, Chengming; Huang, Yong Article
2012 4
An Air-State Fe3S4 Complex with Properties Similar to Those of The HOXair State of The Diiron Hydrogenases
European Journal of Inorganic Chemistry, (27), September 2012, p. 4259-4263
Huang, Yong; Gao, Weiming; ?kermark, Torbj?rn N.; Li, Mingrun; ?kermark, Bjǒrn Article
General Palladium-catalyzed Aerobic Dehydrogenation to Generate Double Bonds
Chemical Science, v. 3, (3), March 2012, p. 883-886
Gao, Weiming; He, Zhiqi; Qian, Yong; Zhao, Jing; Huang, Yong Article
One-pot Synthesis of Useful Heterocycles in Medicinal Chemistry Using A Cascade Strategy
Green Chemistry, v. 14, (3), March 2012, p. 580-585
Wu, Guiyong; Yin, Weiyu; Shen, Hong C.; Huang, Yong Article
Rhodium(III)-catalyzed C-H Activation of Arenes Using a Versatile and Removable Triazene Directing Group
Angewandte Chemie - International Edition, v. 51, (29), July 2012, p. 7242-7245
Wang, Chengming; Chen, Hu; Wang, Zhaofeng; Chen, Jiean; Huang, Yong Article
2011 1
Design of Potent and Selective GPR119 Agonists for Type II Diabetes
Bioorganic and Medicinal Chemistry Letters, v. 21, (9), May 2011, p. 2665-2669
Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B. Article
2010 1
A Thiourea-Oxazoline Library with Axial Chirality: Ligand Synthesis and Studies of the Palladium-Catalyzed Enantioselective Bis(methoxycarbonylation) of Terminal Olefin
Advanced Synthesis and Catalysis, v. 352, (11-12), August 2010, p. 1955-1966
Gao, Ying-Xiang; Chang, Le; Shi, Hang; Liang, Bo; Wongkhan, Kittiya; Chaiyaveij, Duangduan; Batsanov, Andrei S.; Marder, Todd B.; Li, Chuang-Chuang; Yang, Zhen; Huang, Yong Article
2007 1
Expedient, High-yielding Synthesis of Silyl-substituted Salen Ligands
Organic Letters, v. 9, (20), September 2007, p. 3873-3876
Thadani, Avinash N.; Huang, Yong; Rawal, Viresh H. Article
2005 1
Enantioselective Organo-cascade Catalysis
Journal of the American Chemical Society, v. 127, (43), November 2005, p. 15051-15053
Huang, Yong; Walji, Abbas M.; Larsen, Catharine H.; MacMillan, David W.C. Article
2003 1
Single Enantiomers From a Chiral-alcohol Catalyst
Nature, v. 424, (6945), July 2003, p. 146
Huang, Yong; Unni, Aditya K.; Thadani, Avinash N.; Rawal, Viresh H. Article
2002 5
An Efficient Approach to Aspidosperma Alkaloids via [4 + 2] Cycloadditions of Aminosiloxydienes: Stereocontrolled Total Synthesis of (±)-tabersonine. Gram-scale Catalytic Asymmetric Syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric Syntheses of (+)-aspidospermidine and (-)-quebrachamine
Journal of the American Chemical Society, v. 124, (17), May 2002, p. 4628-4641
Kozmin, Sergey A.; Iwama, Tetsuo; Huang, Yong; Rawal, Viresh H. Article
Broadly Effective Enantioselective Diels-Alder Reactions of 1-Amino-substituted-1,3-butadienes
Organic Letters, v. 4, (7), April 2002, p. 1163-1164
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article
Design and Development of Highly Effective Lewis Acid Catalysts for Enantioselective Diels-alder Reactions
Journal of the American Chemical Society, v. 124, (21), May 2002, p. 5950-5951
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article
Hydrogen-bond-promoted Hetero-diels-alder Reactions of Unactivated Ketones
Journal of the American Chemical Society, v. 124, (33), August 2002, p. 9662-9663
Huang, Yong; Rawal, Viresh H. Article
The First Catalytic Enantioselective Diels-alder Reactions of 1,2-dihydropyridine: Efficient Syntheses of Optically Active 2-azabicyclo[2.2.2]octanes With Chiral Binam Derived Cr(III) Salen Complexes
Tetrahedron, v. 58, (41), October 2002, p. 8299-8305
Takenaka, Norito; Huang, Yong; Rawal, Viresh H. Article
2000 2
Hetero Diels-alder Reactions of 1-amino-3-siloxy-1,3-butadienes Under Strictly Thermal Conditions
Organic Letters, v. 2, (21), October 2000, p. 3321-3323
Huang, Yong; Rawal, Viresh H. Article
Highly Enantioselective Diels-Alder Reactions of 1-Amino-3-siloxy-dienes Catalyzed by Cr(III)-Salen Complexes
Journal of the American Chemical Society, v. 122, (32), August 2000, p. 7843-7844
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article
Article 3
A Bifunctional N-Heterocyclic Carbene as a Noncovalent Organocatalyst for Enantioselective Aza-Michael Addition Reactions
ACS Catalysis, v. 11, (10), May 2021, p. 6316-6324
Guo, Fangfang; Chen, Jiean; Huang, Yong
N-Heterocyclic Carbene-Catalyzed Four-Component Reaction: Chemoselective Cradical-Cradical Relay Coupling Involving the Homoenolate Intermediate
ACS Catalysis, v. 11, (16), July 2021, p. 10123-10130
Li, Zhen; Huang, Meirong; Zhang, Xinhao; Chen, Jiean; Huang, Yong
Synthesis of α-chiral phosphine sulfides via non-covalent organocatalysis
Cell Reports Physical Science, v. 2, (7), July 2021, article number 100490
Li, En; Wang, Qian; Cai, Yuxing; Chen, Jiean; Huang, Yong
Article 5
Direct Synthesis of Bicyclic Acetalsvia Visible Light Catalysis
iScience, v. 23, (8), August 2020, article number 101395
Wu, Fengjin; Wang, Leifeng; Ji, Ying; Zou, Ge; Shen, Hong; Nicewicz, David A.; Chen, Jiean; Huang, Yong
Enantioselective Intramolecular [2,3]-Sigmatropic Rearrangement of Aldehydes via a Sulfonium Enamine Intermediate
Angewandte Chemie - International Edition, v. 59, (47), 16 November 2020, p. 20904-20908
Li, Li; Chen, Baoli; Chen, Jiean; Huang, Yong
Ligand-Controlled C?O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights
Advanced Synthesis and Catalysis, v. 362, (1), January 2020, p. 126-132
Li, Li; Song, Feifei; Zhong, Xiumei; Wu, Yun Dong; Zhang, Xinhao; Chen, Jiean; Huang, Yong
Molecular Insights into Small‐Molecule Drug Discovery for SARS‐CoV‐2
Angewandte Chemie - International Edition, v. 60, 2021, p. 9789-9802
Su, Hailei; Zhou, Feng; Huang, Ziru; Ma, Xiaohua; Natarajan, Kathiresan; Zhang, Minchuan; Huang, Yong; Su, Haibin
Photo-induced energy transfer relay of N-heterocyclic carbene catalysis: An asymmetric α-fluorination/isomerization cascade
Chemical Communications, v. 57, (6), January 2021, p. 729-732
Jiang, Xinhang; Li, En; Chen, Jiean; Huang, Yong
Article 3
Alcohol-Directed ortho -C-H Alkenylation
Synlett, v. 30, (11), July 2019, p. 1366-1370
Li, Li; Liu, Qinglan; Chen, Jiean; Huang, Yong
Dehydrogenative Annulation of γ,δ-Unsaturated Amides and Alkynes via Double C-H Activation
Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica, v. 35, (9), 2019, p. 906-912
Wang, Zhen; Li, En; He, Zhiqi; Chen, Jiean; Huang, Yong
Enantio- and Diastereoselective Hydrofluorination of Enals by N-Heterocyclic Carbene Catalysis
Angewandte Chemie - International Edition, v. 58, (22), May 2019, p. 7410-7414
Wang, Leming; Jiang, Xinhang; Chen, Jiean; Huang, Yong
Book chapter 1
N-heterocyclic Carbenes as Bronsted Base Catalysts
N-Heterocyclic Carbenes in Organocatalysis / Editor, Akkattu T. Biju; With a Foreword by Ronald Breslow. Weinheim, Germany : Wiley, 2019, p. 261-286, Ch. 9
Chen, Jiean; Huang, Yong
Article 11
Aerobic Oxidation/Annulation Cascades through Synergistic Catalysis of RuCl3 and N-Heterocyclic Carbenes
Chemistry - A European Journal, v. 24, (49), September 2018, p. 12806-12810
Wang, Qian; Chen, Jiean; Huang, Yong
Direct Synthesis of Polysubstituted Aldehydes via Visible-Light Catalysis
Angewandte Chemie - International Edition, v. 57, (8), February 2018, p. 2174-2178
Wu, Fengjin; Wang, Leifeng; Chen, Jiean; Nicewicz, David A.; Huang, Yong
Enantioselective Cooperative Proton-transfer Catalysis Using Chiral Ammonium Phosphates
Chemical Communications, v. 54, (12), February 2018, p. 1473-1476
Zhang, Linrui; Yuan, Pengfei; Chen, Jiean; Huang, Yong
Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species
Angewandte Chemie - International Edition, v. 57, (28), July 2018, p. 8503-8507
Yuan, Pengfei; Chen, Jiean; Zhao, Jing; Huang, Yong
Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- And β-C-H bonds through an Allyl-Iridium Intermediate
Journal of the American Chemical Society, v. 140, (2), January 2018, p. 735-740
Wang, Zhen; He, Zhiqi; Zhang, Linrui; Huang, Yong
Lewis酸对氮杂环卡宾协同催化体系中反应途径的调控
研究通讯=Acta Chimica Sinica, v. 76, (11), November 2018, p. 850-856
王乐明; 王骞; 陈杰安; 黄涌
One-pot Ligation Strategy for Atypical Ubiquitin Chains Synthesis by Using the Trifluoroacetamidomethyl-protected Isopeptide-linked Ub (Tfacm-isoUb) Unit
Tetrahedron Letters, v. 59, (3), January 2018, p. 268-271
Si, Yan-Yan; Liang, Lu-Jun; Tang, Shan; Qi, Yun-Kun; Huang, Yong; Zheng, Ji-Shen
Semi-synthesis of Disulfide-linked Branched Tri-ubiquitin Mimics
Science China Chemistry, v. 61, (4), April 2018, p. 412-417
Si, Yanyan; Liang, Lujun; Tang, Shan; Qi, Yunkun; Huang, Yong; Liu, Lei
Streamlined Asymmetric α-difunctionalization of Ynones
Nature Communications, v. 9, (1), December 2018, article number 375
Peng, Siyu; Wang, Zhaofeng; Zhang, Linxing; Zhang, Xinhao; Huang, Yong
Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo
Journal of Medicinal Chemistry, v. 61, (19), October 2018, p. 8613-8624
Huang, Yong; Pan, Peichen; Chen, Jiean; Li, Xijian; Li, Miyang; Yu, Huidong; Zhao, Jean J.; Ni, Jing; Wang, Xuwen; Sun, Huiyong; Tian, Sheng; Zhu, Feng; Liu, Feng; Hou, Tingjun
Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metalate Shift
Journal of the American Chemical Society, v. 140, (7), February 2018, p. 2693-2699
He, Zhiqi; Song, Feifei; Sun, Huan; Huang, Yong
Article 9
Amine-Triggered 6π-Electrocyclization–Aromatization Cascade of Ynedienamines
Advanced Synthesis and Catalysis, v. 359, (8), April 2017, p. 1379-1387
Li, Xijian; Yu, Huidong; Huang, Yong
Chemical Synthesis of Histone H2A with Methylation at Gln104
Science China Chemistry, v. 60, (5), May 2017, p. 621-627
He, Qiaoqiao; Li, Jiabin; Qi, Yunkun; Wang, Zhipeng; Huang, Yong; Liu, Lei
Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type-I1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation
ACS Central Science, v. 3, (11), November 2017, p. 1208-1220
Liu, Qi; Pan, Peichen; Yu, Huidong; Liu, Qinglan; Kong, Xiaotian; Chen, Hu; Chen, Jiean; Li, Dan; Kang, Yu; Sun, Huiyong; Zhou, Wenfang; Tian, Sheng; Cui, Sunliang; Zhu, Feng; Li, Youyong; Huang, Yong; Hou, Tingjun
Comparative Pharmacokinetic Profile of Cyclosporine (CsA) With A Decapeptide and A Linear Analogue
Organic and Biomolecular Chemistry, v. 15, (12), March 2017, p. 2501-2506
Price, David A.; Eng, Heather; Farley, Kathleen A.; Goetz, Gilles H.; Huang, Yong; Jiao, Zhaodong; Kalgutkar, Amit S.; Kablaoui, Natasha M.; Khunte, Bhagyashree A.; Liras, Spiros; Limberakis, Chris; Mathiowetz, Alan M.; Ruggeri, Roger B.; Quan, Junming Min; Yang, Zhen
Construction of Pyridazine Analogues via Rhodium-mediated C-H Activation
Advanced Synthesis and Catalysis, v. 359, (20), October 2017, p. 3496-3502
Yang, Chao; Song, Feifei; Chen, Jiean; Huang, Yong
Enantioselective β-Protonation of Enals via a Shuttling Strategy
Journal of the American Chemical Society, v. 139, (20), May 2017, p. 7045-7051
Chen, Jiean; Yuan, Pengfei; Wang, Leming; Huang, Yong
Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells
American Journal of Reproductive Immunology, v. 77, (3), March 2017, article number UNSP e12618
Diao, Liang-Hui; Li, Guan-Gui; Zhu, Yuan-Chang; Tu, Wen-Wei; Huang, Chun-Yu; Lian, Ruo-Chun; Chen, Xian; Li, Yu-Ye; Zhang, Tao; Huang, Yong; Zeng, Yong
Synthesis of Optically Active Oxazolines by an Organocatalytic Isocyanoacetate Aldol Reaction with α-Keto Esters
Synlett, v. 28, (11), July 2017, p. 1300-1304
Wang, Fei; Chen, Jiean; Huang, Yong
Visible-Light-Mediated [4+2] Cycloaddition of Styrenes: Synthesis of Tetralin Derivatives
Angewandte Chemie - International Edition, v. 56, (24), June 2017, p. 6896-6900
Wang, Leifeng; Wu, Fengjin; Chen, Jiean; Nicewicz, David A.; Huang, Yong
Article 6
A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics
Angewandte Chemie - International Edition, v. 55, (46), November 2016, p. 14340-14344
Jiang, Hao; Xu, Liping; Fang, Yan; Zhang, Zhenxing; Yang, Zhen; Huang, Yong
Advances in the Development of Catalytic Tethering Directing Groups for C-H Functionalization Reactions
Organic and Biomolecular Chemistry, v. 14, (36), 2016, p. 8389-8397
Sun, Huan; Guimond, Nicolas; Huang, Yong
Asymmetric Sulfa-Michael Addition of α,β-Unsaturated Esters/Amides Using a Chiral N-Heterocyclic Carbene as a Noncovalent Organocatalyst
Synlett, v. 27, (7), April 2016, p. 1068-1072
Yuan, Pengfei; Meng, Sixuan; Chen, Jiean; Huang, Yong
Diverting C?H Annulation Pathways: Nickel-Catalyzed Dehydrogenative Homologation of Aromatic Amides
ACS Catalysis, v. 6, (11), November 2016, p. 7814-7823
He, Zhiqi; Huang, Yong
Ligand-Assisted Palladium(II)/(IV) Oxidation for sp 3 CH Fluorination
Advanced Synthesis and Catalysis, v. 358, (12), June 2016, p. 1946-1957
Sun, Huan; Zhang, Yi; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong
New Frontiers of N-heterocyclic Carbene Catalysis
Science China Chemistry, v. 59, (3), March 2016, p. 251-254
Chen, Jiean; Huang, Yong
Article 8
A Copper-catalyzed Aerobic Domino Process for the Synthesis of Isoindolin-1-ylidene Derivatives
Tetrahedron, v. 71, (22), June 2015, p. 3632-3636
Chen, Hu; Wang, Qian; Huang, Yong
Asymmetric Intramolecular α-cyclopropanation of Aldehydes Using A Donor/acceptor Carbene Mimetic
Nature Communications, v. 6, December 2015, article number 10041
Luo, Chaosheng; Wang, Zhen; Huang, Yong
Asymmetric Synthesis of Hydrocarbazoles Catalyzed by an Octahedral Chiral-at-Rhodium Lewis Acid
Chemistry - An Asian Journal, v. 10, (12), December 2015, p. 2738-2743
Huang, Yong; Song, Liangliang; Gong, Lei; Meggers, Eric
Direct Fluorination of Styrenes
Chemical Communications, v. 51, (30), April 2015, p. 6584-6586
Shao, Qian; Huang, Yong
Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins
Angewandte Chemie - International Edition, v. 54, (51), December 2015, p. 15414-15418
Wang, Leming; Chen, Jiean; Huang, Yong
Highly Enantioselective Sulfa-Michael Addition Reactions Using N-heterocyclic Carbene as A Non-covalent Organocatalyst
Chemical Science, v. 6, (7), July 2015, p. 4184-4189
Chen, Jiean; Meng, Sixuan; Wang, Leming; Tang, Hongmei; Huang, Yong
Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions
Synlett, v. 26, (20), December 2015, article number st-2015-a0376-a, p. 2751-2762
Sun, Huan; Huang, Yong
Synthesis of tetrasubstituted 1-silyloxy-3-aminobutadienes and chemistry beyond Diels-Alder reactions
Nature Communications, v. 6, April 2015, article number 6913
Li, Xijian; Peng, Siyu; Li, Li; Huang, Yong
Article 11
A General Synthesis of Ynones From Aldehydes via Oxidative C-C Bond Cleavage Under Aerobic Conditions
Journal of the American Chemical Society, v. 136, (35), September 2014, p. 12233-12236
Wang, Zhaofeng; Li, Li; Huang, Yong
A Multitasking Functional Group Leads to Structural Diversity Using Designer C-H Activation Reaction Cascades
Nature Communications, v. 5, August 2014, article number 4610
Chen, Ying; Wang, Dongqi; Duan, Pingping; Ben, Rong; Dai, Lu; Shao, Xiaoru; Hong, Mei; Zhao, Jing; Huang, Yong
Asymmetric Catalysis With N-heterocyclic Carbenes as Non-covalent Chiral Templates
Nature Communications, v. 5, March 2014, article number 3437
Chen, Jiean; Huang, Yong
Directed Arene/alkyne Annulation Reactions via Aerobic Copper Catalysis
Organic and Biomolecular Chemistry, v. 12, (44), November 2014, p. 8844-8850
Zhang, Yi; Wang, Qian; Yu, Huidong; Huang, Yong
Highly Ortho-selective Trifluoromethyl-thiolation Reactions Using A Ligand Exchange Strategy
Advanced Synthesis & Catalysis, v. 356, (14-15), October 2014, p. 2998-3006
Yin, Weiyu; Wang, Zhaofeng; Huang, Yong
Metal-templated Chiral Br?nsted Base Organocatalysis
Nature Communications, v. 5, July 2014, article number 4531
Ma, Jiajia; Ding, Xiaobing; Hu, Ying; Huang, Yong; Gong, Lei; Meggers, Eric
New Semi-synthesis of Ubiquitin C-terminal Conjugate With 7-amino-4-methylcoumarin
Journal of Peptide Science, v. 20, (2), February 2014, p. 102-107
Li, Yitong; Liang, Jun; Li, Jiabin; Fang, Gemin; Huang, Yong; Liu, Lei
Palladium Catalyzed Acetoxylation of Benzylic C-H Bonds Using a Bidentate Picolinamide Directing Group
Organic and Biomolecular Chemistry, v. 12, (9), March 2014, p. 1405-1411
Cheng, Tao; Yin, Weiyu; Zhang, Yi; Zhang, Yingnan; Huang, Yong
Ruthenium-catalyzed Redox-neutral C-H Activation via N-N Cleavage: Synthesis of N-substituted Indoles
Organic Letters, v. 16, (22), November 2014, p. 5976-5979
Zhang, Zhenxing; Jiang, Hao; Huang, Yong
Selective Synthesis of Indazoles and Indoles via Triazene-alkyne Cyclization Switched by Different Metals
Organic and Biomolecular Chemistry, v. 12, (7), February 2014, p. 1061-1071
Fang, Yan; Wang, Chengming; Su, Shengqin; Yu, Haizhu; Huang, Yong
Synthesis of Indolo[2,1-a]isoquinolines via a Triazene-directed C-H Annulation Cascade
Journal of Organic Chemistry, v. 79, (24), December 2014, p. 11863-11872
Sun, Huan; Wang, Chengming; Yang, Yunfang; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong
Article 12
A Highly Diastereo- and Enantioselective Synthesis of Tetrahydroquinolines: Quaternary Stereogenic Center Inversion and Functionalization
Journal of the American Chemical Society, v. 135, (22), June 2013, p. 8193-8196
Luo, Chaosheng; Huang, Yong
A Highly Diastereoselective and Enantioselective Synthesis of Polysubstituted Pyrrolidines via an Organocatalytic Dynamic Kinetic Resolution Cascade
Organic Letters, v. 15, (8), April 2013, p. 1958-1961
Cheng, Tao; Meng, Sixuan; Huang, Yong
Computational Study on Mechanism of Rh(III)-catalyzed Oxidative Heck Coupling of Phenol Carbamates With Alkenes
Dalton Transactions, v. 42, (12), March 2013, p. 4175-4184
Zhang, Qi; Yu, Haizhu; Li, Yitong; Liu, Lei; Huang, Yong; Fu, Yao
Direct α-vinylidenation of Aldehydes and Subsequent Cascade: Gold and Amine Catalysts Work Synergistically
Angewandte Chemie - International Edition, v. 52, (52), December 2013, p. 14219-14223
Wang, Zhaofeng; Li, Xijian; Huang, Yong
Enantioselective Synthesis of 1,2,4-triazolines Catalyzed by A Cinchona Alkaloid-derived Organocatalyst
Chemical Communications, v. 49, (94), December 2013, p. 11098-11100
Shao, Qian; Chen, Jiean; Tu, Meihua; Piotrowski, David W.; Huang, Yong
Expanding Structural Diversity; Removable and Manipulable Directing Groups for C-H Activation
Synlett, v. 24, (2), January 2013, article number ST-2012-P0768-SP, p. 145-149
Wang, Chengming; Huang, Yong
General and Efficient Synthesis of Indoles Through Triazene-directed C-H Annulation
Angewandte Chemie - International Edition, v. 52, (22), May 2013, p. 5795-5798
Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong
Highly Practical Synthesis of Nitriles and Heterocycles From Alcohols Under Mild Conditions by Aerobic Double Dehydrogenative Catalysis
Organic Letters, v. 15, (8), April 2013, p. 1850-1853
Yin, Weiyu; Wang, Chengming; Huang, Yong
Highly Trans- Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper-catalyzed Triple Cascade Catalysis
Journal of Organic Chemistry, v. 78, (7), April 2013, p. 3503-3509
Chen, Hu; Wang, Zhaofeng; Zhang, Yingnan; Huang, Yong
Mechanism-based Design of a Photoactivatable Firefly Luciferase
Journal of the American Chemical Society, v. 135, (20), May 2013, p. 7410-7413
Zhao, Jing; Zhao, Jingyi; Lin, Shixian; Huang, Yong; Chen, Peng R.
Synthesis of α,β-unsaturated Carbonyl Compounds via a Visible-light-promoted Organocatalytic Aerobic Oxidation
Chemical Communications, v. 49, (99), November 2013, p. 11662-11664
Zhang, Junlin; Wang, Leming; Liu, Qi; Yang, Zhen; Huang, Yong
Traceless directing strategy: Efficient synthesis of N-alkyl indoles via redox-neutral C-H activation
Organic Letters, v. 15, (20), October 2013, p. 5294-5297
Wang, Chengming; Huang, Yong
Article 4
An Air-State Fe3S4 Complex with Properties Similar to Those of The HOXair State of The Diiron Hydrogenases
European Journal of Inorganic Chemistry, (27), September 2012, p. 4259-4263
Huang, Yong; Gao, Weiming; ?kermark, Torbj?rn N.; Li, Mingrun; ?kermark, Bjǒrn
General Palladium-catalyzed Aerobic Dehydrogenation to Generate Double Bonds
Chemical Science, v. 3, (3), March 2012, p. 883-886
Gao, Weiming; He, Zhiqi; Qian, Yong; Zhao, Jing; Huang, Yong
One-pot Synthesis of Useful Heterocycles in Medicinal Chemistry Using A Cascade Strategy
Green Chemistry, v. 14, (3), March 2012, p. 580-585
Wu, Guiyong; Yin, Weiyu; Shen, Hong C.; Huang, Yong
Rhodium(III)-catalyzed C-H Activation of Arenes Using a Versatile and Removable Triazene Directing Group
Angewandte Chemie - International Edition, v. 51, (29), July 2012, p. 7242-7245
Wang, Chengming; Chen, Hu; Wang, Zhaofeng; Chen, Jiean; Huang, Yong
Article 1
Design of Potent and Selective GPR119 Agonists for Type II Diabetes
Bioorganic and Medicinal Chemistry Letters, v. 21, (9), May 2011, p. 2665-2669
Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B.
Article 1
A Thiourea-Oxazoline Library with Axial Chirality: Ligand Synthesis and Studies of the Palladium-Catalyzed Enantioselective Bis(methoxycarbonylation) of Terminal Olefin
Advanced Synthesis and Catalysis, v. 352, (11-12), August 2010, p. 1955-1966
Gao, Ying-Xiang; Chang, Le; Shi, Hang; Liang, Bo; Wongkhan, Kittiya; Chaiyaveij, Duangduan; Batsanov, Andrei S.; Marder, Todd B.; Li, Chuang-Chuang; Yang, Zhen; Huang, Yong
Article 1
Expedient, High-yielding Synthesis of Silyl-substituted Salen Ligands
Organic Letters, v. 9, (20), September 2007, p. 3873-3876
Thadani, Avinash N.; Huang, Yong; Rawal, Viresh H.
Article 1
Enantioselective Organo-cascade Catalysis
Journal of the American Chemical Society, v. 127, (43), November 2005, p. 15051-15053
Huang, Yong; Walji, Abbas M.; Larsen, Catharine H.; MacMillan, David W.C.
Article 1
Single Enantiomers From a Chiral-alcohol Catalyst
Nature, v. 424, (6945), July 2003, p. 146
Huang, Yong; Unni, Aditya K.; Thadani, Avinash N.; Rawal, Viresh H.
Article 5
An Efficient Approach to Aspidosperma Alkaloids via [4 + 2] Cycloadditions of Aminosiloxydienes: Stereocontrolled Total Synthesis of (±)-tabersonine. Gram-scale Catalytic Asymmetric Syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric Syntheses of (+)-aspidospermidine and (-)-quebrachamine
Journal of the American Chemical Society, v. 124, (17), May 2002, p. 4628-4641
Kozmin, Sergey A.; Iwama, Tetsuo; Huang, Yong; Rawal, Viresh H.
Broadly Effective Enantioselective Diels-Alder Reactions of 1-Amino-substituted-1,3-butadienes
Organic Letters, v. 4, (7), April 2002, p. 1163-1164
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H.
Design and Development of Highly Effective Lewis Acid Catalysts for Enantioselective Diels-alder Reactions
Journal of the American Chemical Society, v. 124, (21), May 2002, p. 5950-5951
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H.
Hydrogen-bond-promoted Hetero-diels-alder Reactions of Unactivated Ketones
Journal of the American Chemical Society, v. 124, (33), August 2002, p. 9662-9663
Huang, Yong; Rawal, Viresh H.
The First Catalytic Enantioselective Diels-alder Reactions of 1,2-dihydropyridine: Efficient Syntheses of Optically Active 2-azabicyclo[2.2.2]octanes With Chiral Binam Derived Cr(III) Salen Complexes
Tetrahedron, v. 58, (41), October 2002, p. 8299-8305
Takenaka, Norito; Huang, Yong; Rawal, Viresh H.
Article 2
Hetero Diels-alder Reactions of 1-amino-3-siloxy-1,3-butadienes Under Strictly Thermal Conditions
Organic Letters, v. 2, (21), October 2000, p. 3321-3323
Huang, Yong; Rawal, Viresh H.
Highly Enantioselective Diels-Alder Reactions of 1-Amino-3-siloxy-dienes Catalyzed by Cr(III)-Salen Complexes
Journal of the American Chemical Society, v. 122, (32), August 2000, p. 7843-7844
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H.
2016 6
A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics
Angewandte Chemie - International Edition, v. 55, (46), November 2016, p. 14340-14344
Jiang, Hao; Xu, Liping; Fang, Yan; Zhang, Zhenxing; Yang, Zhen; Huang, Yong Article
Advances in the Development of Catalytic Tethering Directing Groups for C-H Functionalization Reactions
Organic and Biomolecular Chemistry, v. 14, (36), 2016, p. 8389-8397
Sun, Huan; Guimond, Nicolas; Huang, Yong Article
Asymmetric Sulfa-Michael Addition of α,β-Unsaturated Esters/Amides Using a Chiral N-Heterocyclic Carbene as a Noncovalent Organocatalyst
Synlett, v. 27, (7), April 2016, p. 1068-1072
Yuan, Pengfei; Meng, Sixuan; Chen, Jiean; Huang, Yong Article
Diverting C?H Annulation Pathways: Nickel-Catalyzed Dehydrogenative Homologation of Aromatic Amides
ACS Catalysis, v. 6, (11), November 2016, p. 7814-7823
He, Zhiqi; Huang, Yong Article
Ligand-Assisted Palladium(II)/(IV) Oxidation for sp 3 CH Fluorination
Advanced Synthesis and Catalysis, v. 358, (12), June 2016, p. 1946-1957
Sun, Huan; Zhang, Yi; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong Article
New Frontiers of N-heterocyclic Carbene Catalysis
Science China Chemistry, v. 59, (3), March 2016, p. 251-254
Chen, Jiean; Huang, Yong Article
2015 8
A Copper-catalyzed Aerobic Domino Process for the Synthesis of Isoindolin-1-ylidene Derivatives
Tetrahedron, v. 71, (22), June 2015, p. 3632-3636
Chen, Hu; Wang, Qian; Huang, Yong Article
Asymmetric Intramolecular α-cyclopropanation of Aldehydes Using A Donor/acceptor Carbene Mimetic
Nature Communications, v. 6, December 2015, article number 10041
Luo, Chaosheng; Wang, Zhen; Huang, Yong Article
Asymmetric Synthesis of Hydrocarbazoles Catalyzed by an Octahedral Chiral-at-Rhodium Lewis Acid
Chemistry - An Asian Journal, v. 10, (12), December 2015, p. 2738-2743
Huang, Yong; Song, Liangliang; Gong, Lei; Meggers, Eric Article
Direct Fluorination of Styrenes
Chemical Communications, v. 51, (30), April 2015, p. 6584-6586
Shao, Qian; Huang, Yong Article
Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins
Angewandte Chemie - International Edition, v. 54, (51), December 2015, p. 15414-15418
Wang, Leming; Chen, Jiean; Huang, Yong Article
Highly Enantioselective Sulfa-Michael Addition Reactions Using N-heterocyclic Carbene as A Non-covalent Organocatalyst
Chemical Science, v. 6, (7), July 2015, p. 4184-4189
Chen, Jiean; Meng, Sixuan; Wang, Leming; Tang, Hongmei; Huang, Yong Article
Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions
Synlett, v. 26, (20), December 2015, article number st-2015-a0376-a, p. 2751-2762
Sun, Huan; Huang, Yong Article
Synthesis of tetrasubstituted 1-silyloxy-3-aminobutadienes and chemistry beyond Diels-Alder reactions
Nature Communications, v. 6, April 2015, article number 6913
Li, Xijian; Peng, Siyu; Li, Li; Huang, Yong Article
2014 11
A General Synthesis of Ynones From Aldehydes via Oxidative C-C Bond Cleavage Under Aerobic Conditions
Journal of the American Chemical Society, v. 136, (35), September 2014, p. 12233-12236
Wang, Zhaofeng; Li, Li; Huang, Yong Article
A Multitasking Functional Group Leads to Structural Diversity Using Designer C-H Activation Reaction Cascades
Nature Communications, v. 5, August 2014, article number 4610
Chen, Ying; Wang, Dongqi; Duan, Pingping; Ben, Rong; Dai, Lu; Shao, Xiaoru; Hong, Mei; Zhao, Jing; Huang, Yong Article
Asymmetric Catalysis With N-heterocyclic Carbenes as Non-covalent Chiral Templates
Nature Communications, v. 5, March 2014, article number 3437
Chen, Jiean; Huang, Yong Article
Directed Arene/alkyne Annulation Reactions via Aerobic Copper Catalysis
Organic and Biomolecular Chemistry, v. 12, (44), November 2014, p. 8844-8850
Zhang, Yi; Wang, Qian; Yu, Huidong; Huang, Yong Article
Highly Ortho-selective Trifluoromethyl-thiolation Reactions Using A Ligand Exchange Strategy
Advanced Synthesis & Catalysis, v. 356, (14-15), October 2014, p. 2998-3006
Yin, Weiyu; Wang, Zhaofeng; Huang, Yong Article
Metal-templated Chiral Br?nsted Base Organocatalysis
Nature Communications, v. 5, July 2014, article number 4531
Ma, Jiajia; Ding, Xiaobing; Hu, Ying; Huang, Yong; Gong, Lei; Meggers, Eric Article
New Semi-synthesis of Ubiquitin C-terminal Conjugate With 7-amino-4-methylcoumarin
Journal of Peptide Science, v. 20, (2), February 2014, p. 102-107
Li, Yitong; Liang, Jun; Li, Jiabin; Fang, Gemin; Huang, Yong; Liu, Lei Article
Palladium Catalyzed Acetoxylation of Benzylic C-H Bonds Using a Bidentate Picolinamide Directing Group
Organic and Biomolecular Chemistry, v. 12, (9), March 2014, p. 1405-1411
Cheng, Tao; Yin, Weiyu; Zhang, Yi; Zhang, Yingnan; Huang, Yong Article
Ruthenium-catalyzed Redox-neutral C-H Activation via N-N Cleavage: Synthesis of N-substituted Indoles
Organic Letters, v. 16, (22), November 2014, p. 5976-5979
Zhang, Zhenxing; Jiang, Hao; Huang, Yong Article
Selective Synthesis of Indazoles and Indoles via Triazene-alkyne Cyclization Switched by Different Metals
Organic and Biomolecular Chemistry, v. 12, (7), February 2014, p. 1061-1071
Fang, Yan; Wang, Chengming; Su, Shengqin; Yu, Haizhu; Huang, Yong Article
Synthesis of Indolo[2,1-a]isoquinolines via a Triazene-directed C-H Annulation Cascade
Journal of Organic Chemistry, v. 79, (24), December 2014, p. 11863-11872
Sun, Huan; Wang, Chengming; Yang, Yunfang; Chen, Ping; Wu, Yundong; Zhang, Xinhao; Huang, Yong Article
2013 12
A Highly Diastereo- and Enantioselective Synthesis of Tetrahydroquinolines: Quaternary Stereogenic Center Inversion and Functionalization
Journal of the American Chemical Society, v. 135, (22), June 2013, p. 8193-8196
Luo, Chaosheng; Huang, Yong Article
A Highly Diastereoselective and Enantioselective Synthesis of Polysubstituted Pyrrolidines via an Organocatalytic Dynamic Kinetic Resolution Cascade
Organic Letters, v. 15, (8), April 2013, p. 1958-1961
Cheng, Tao; Meng, Sixuan; Huang, Yong Article
Computational Study on Mechanism of Rh(III)-catalyzed Oxidative Heck Coupling of Phenol Carbamates With Alkenes
Dalton Transactions, v. 42, (12), March 2013, p. 4175-4184
Zhang, Qi; Yu, Haizhu; Li, Yitong; Liu, Lei; Huang, Yong; Fu, Yao Article
Direct α-vinylidenation of Aldehydes and Subsequent Cascade: Gold and Amine Catalysts Work Synergistically
Angewandte Chemie - International Edition, v. 52, (52), December 2013, p. 14219-14223
Wang, Zhaofeng; Li, Xijian; Huang, Yong Article
Enantioselective Synthesis of 1,2,4-triazolines Catalyzed by A Cinchona Alkaloid-derived Organocatalyst
Chemical Communications, v. 49, (94), December 2013, p. 11098-11100
Shao, Qian; Chen, Jiean; Tu, Meihua; Piotrowski, David W.; Huang, Yong Article
Expanding Structural Diversity; Removable and Manipulable Directing Groups for C-H Activation
Synlett, v. 24, (2), January 2013, article number ST-2012-P0768-SP, p. 145-149
Wang, Chengming; Huang, Yong Article
General and Efficient Synthesis of Indoles Through Triazene-directed C-H Annulation
Angewandte Chemie - International Edition, v. 52, (22), May 2013, p. 5795-5798
Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong Article
Highly Practical Synthesis of Nitriles and Heterocycles From Alcohols Under Mild Conditions by Aerobic Double Dehydrogenative Catalysis
Organic Letters, v. 15, (8), April 2013, p. 1850-1853
Yin, Weiyu; Wang, Chengming; Huang, Yong Article
Highly Trans- Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper-catalyzed Triple Cascade Catalysis
Journal of Organic Chemistry, v. 78, (7), April 2013, p. 3503-3509
Chen, Hu; Wang, Zhaofeng; Zhang, Yingnan; Huang, Yong Article
Mechanism-based Design of a Photoactivatable Firefly Luciferase
Journal of the American Chemical Society, v. 135, (20), May 2013, p. 7410-7413
Zhao, Jing; Zhao, Jingyi; Lin, Shixian; Huang, Yong; Chen, Peng R. Article
Synthesis of α,β-unsaturated Carbonyl Compounds via a Visible-light-promoted Organocatalytic Aerobic Oxidation
Chemical Communications, v. 49, (99), November 2013, p. 11662-11664
Zhang, Junlin; Wang, Leming; Liu, Qi; Yang, Zhen; Huang, Yong Article
Traceless directing strategy: Efficient synthesis of N-alkyl indoles via redox-neutral C-H activation
Organic Letters, v. 15, (20), October 2013, p. 5294-5297
Wang, Chengming; Huang, Yong Article
2012 4
An Air-State Fe3S4 Complex with Properties Similar to Those of The HOXair State of The Diiron Hydrogenases
European Journal of Inorganic Chemistry, (27), September 2012, p. 4259-4263
Huang, Yong; Gao, Weiming; ?kermark, Torbj?rn N.; Li, Mingrun; ?kermark, Bjǒrn Article
General Palladium-catalyzed Aerobic Dehydrogenation to Generate Double Bonds
Chemical Science, v. 3, (3), March 2012, p. 883-886
Gao, Weiming; He, Zhiqi; Qian, Yong; Zhao, Jing; Huang, Yong Article
One-pot Synthesis of Useful Heterocycles in Medicinal Chemistry Using A Cascade Strategy
Green Chemistry, v. 14, (3), March 2012, p. 580-585
Wu, Guiyong; Yin, Weiyu; Shen, Hong C.; Huang, Yong Article
Rhodium(III)-catalyzed C-H Activation of Arenes Using a Versatile and Removable Triazene Directing Group
Angewandte Chemie - International Edition, v. 51, (29), July 2012, p. 7242-7245
Wang, Chengming; Chen, Hu; Wang, Zhaofeng; Chen, Jiean; Huang, Yong Article
2011 1
Design of Potent and Selective GPR119 Agonists for Type II Diabetes
Bioorganic and Medicinal Chemistry Letters, v. 21, (9), May 2011, p. 2665-2669
Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B. Article
2010 1
A Thiourea-Oxazoline Library with Axial Chirality: Ligand Synthesis and Studies of the Palladium-Catalyzed Enantioselective Bis(methoxycarbonylation) of Terminal Olefin
Advanced Synthesis and Catalysis, v. 352, (11-12), August 2010, p. 1955-1966
Gao, Ying-Xiang; Chang, Le; Shi, Hang; Liang, Bo; Wongkhan, Kittiya; Chaiyaveij, Duangduan; Batsanov, Andrei S.; Marder, Todd B.; Li, Chuang-Chuang; Yang, Zhen; Huang, Yong Article
2007 1
Expedient, High-yielding Synthesis of Silyl-substituted Salen Ligands
Organic Letters, v. 9, (20), September 2007, p. 3873-3876
Thadani, Avinash N.; Huang, Yong; Rawal, Viresh H. Article
2005 1
Enantioselective Organo-cascade Catalysis
Journal of the American Chemical Society, v. 127, (43), November 2005, p. 15051-15053
Huang, Yong; Walji, Abbas M.; Larsen, Catharine H.; MacMillan, David W.C. Article
2003 1
Single Enantiomers From a Chiral-alcohol Catalyst
Nature, v. 424, (6945), July 2003, p. 146
Huang, Yong; Unni, Aditya K.; Thadani, Avinash N.; Rawal, Viresh H. Article
2002 5
An Efficient Approach to Aspidosperma Alkaloids via [4 + 2] Cycloadditions of Aminosiloxydienes: Stereocontrolled Total Synthesis of (±)-tabersonine. Gram-scale Catalytic Asymmetric Syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric Syntheses of (+)-aspidospermidine and (-)-quebrachamine
Journal of the American Chemical Society, v. 124, (17), May 2002, p. 4628-4641
Kozmin, Sergey A.; Iwama, Tetsuo; Huang, Yong; Rawal, Viresh H. Article
Broadly Effective Enantioselective Diels-Alder Reactions of 1-Amino-substituted-1,3-butadienes
Organic Letters, v. 4, (7), April 2002, p. 1163-1164
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article
Design and Development of Highly Effective Lewis Acid Catalysts for Enantioselective Diels-alder Reactions
Journal of the American Chemical Society, v. 124, (21), May 2002, p. 5950-5951
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article
Hydrogen-bond-promoted Hetero-diels-alder Reactions of Unactivated Ketones
Journal of the American Chemical Society, v. 124, (33), August 2002, p. 9662-9663
Huang, Yong; Rawal, Viresh H. Article
The First Catalytic Enantioselective Diels-alder Reactions of 1,2-dihydropyridine: Efficient Syntheses of Optically Active 2-azabicyclo[2.2.2]octanes With Chiral Binam Derived Cr(III) Salen Complexes
Tetrahedron, v. 58, (41), October 2002, p. 8299-8305
Takenaka, Norito; Huang, Yong; Rawal, Viresh H. Article
2000 2
Hetero Diels-alder Reactions of 1-amino-3-siloxy-1,3-butadienes Under Strictly Thermal Conditions
Organic Letters, v. 2, (21), October 2000, p. 3321-3323
Huang, Yong; Rawal, Viresh H. Article
Highly Enantioselective Diels-Alder Reactions of 1-Amino-3-siloxy-dienes Catalyzed by Cr(III)-Salen Complexes
Journal of the American Chemical Society, v. 122, (32), August 2000, p. 7843-7844
Huang, Yong; Iwama, Tetsuo; Rawal, Viresh H. Article
No Publications
Teaching Assignment
2021-22 Winter 0 2021-22 Fall 2 2020-21 Summer 1 2020-21 Spring 4 2020-21 Winter 0 2020-21 Fall 3
CHEM4140 Intermediate Organic Chemistry
CHEM4689 Capstone Project
CHEM4680 Undergraduate Research
CHEM4130 Medicinal Chemistry
CHEM4689 Capstone Project
CHEM4691 Capstone Research I
SCIE4500 IRE Research Project II
CHEM4140 Intermediate Organic Chemistry
CHEM4691 Capstone Research I
SCIE3500 IRE Research Project I
No Teaching Assignments
No Teaching Assignments
Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)
Current RPGs
Doctor of Philosophy ZHANG, Yichi
Chemistry( 2021 - )
CHAN, Cho Ying
Chemistry( 2020 - )
CHEN, Mengting
Chemistry( 2020 - )
CHING, Yin Cheung
Chemistry( 2020 - )
XING, Yajie
Chemistry( 2020 - )
ProjectsFrom January 2020 to December 2022
All Projects 3
No Projects.
The Development of Organocatalytic Cross-Coupling Reactions
发展有机催化的交叉偶联反应 Leading
RGC - General Research Fund
Project Team (HKUST)
HUANG Yong (Lead)
2022 -
Enantioselective Organocatalytic Sigmatropic Rearrangement
对映选择性有机催化sigmatropic重排反应 Leading
RGC - General Research Fund
Project Team (HKUST)
HUANG Yong (Lead)
2021 -
Medicinal Chemistry on Novel Type I1/2 ALK Inhibitors for Combating Drug-resistant Mutants
改善ALK突变体耐药性的I1/2型抑制剂的药物化学研究 Leading
Shenzhen Science and Technology Innovation Committee
Project Team (HKUST)
HUANG Yong (Lead)
2019 -
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香港科技大学理学院老师教师导师介绍简介-Yong HUANG
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