Shangyu DANG
党尚宇
Doctor of Natural Science in Biology
Tsinghua University, 2014

Assistant Professor
Division of Life Science



(852) 2358 5944
sdang@ust.hk
Room 5507
Personal Web

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ORCID
0000-0001-9141-1865

Scopus ID
26655423700




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Structural biology
Ion channels
Proteins



Publications

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All Years 10 2022 0 2021 0 2020 1 2019 2 2018 0 2017 1 2016 6

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2020 1

Structural insights into group II TRP channels
Cell Calcium, v. 86, March 2020, article number 102107
Fine, Michael; Li, Xiaochun; Dang, Shangyu Article

2019 2

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling
Cell Reports, v. 28, (2), July 2019, p. 567-579
Feng, Shengjie; Dang, Shangyu; Han, Tina Wei; Ye, Wen Lei; Jin, Peng; Cheng, Tong; Li, Junrui; Jan, Yuh Nung; Jan, Lily Yeh; Cheng, Yifan Article
Structural insight into TRPV5 channel function and modulation
Proceedings of the National Academy of Sciences of the United States of America, v. 116, (18), April 2019, p. 8869-8878
Dang, Shangyu; van Goor, Mark K.; Asarnow, Daniel; Wang, YongQiang; Julius, David; Cheng, Yifan; van der Wijst, Jenny Article

2017 1

Cryo-EM structures of the TMEM16A calciumactivated chloride channel
Nature, v. 552, (7685), December 2017, p. 426-429
Dang, Shangyu; Feng, Shengjie; Tien, Jason; Peters, Christian Joseph; Bulkley, David P.; Lolicato, Marco; Zhao, Jianhua; Zuberbühler, Kathrin; Ye, Wenlei; Qi, Lijun; Chen, Tingxu; Craik, Charles S.; Jan, Yuhnung; Minor, Daniel L.; Cheng, Yifan; Jan, L.Y. Article

2015 1

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH
Proceedings of the National Academy of Sciences of the United States of America, v. 112, (11), March 2015, p. 3344-3349
Dang, Shangyu; Wu, Shenjie; Wang, Jiawei; Li, Hongbo; Huang, Min; Hea, Wei; Li, Yueming; Wong, Catherine C.L.; Shi, Yi Gong Article

2013 2

Evolutionary mix-and-match with MFS transporters
Proceedings of the National Academy of Sciences of the United States of America, v. 110, (15), April 2013, p. 5870-5874
Gregor Madej, M.; Dang, Shangyu; Yan, Nieng; Ronald Kaback, H. Article
Structure of a presenilin family intramembrane aspartate protease
Nature, v. 493, (7430), January 2013, p. 56-61
Li, Xiaochun; Dang, Shangyu; Yan, Chuangye; Gong, Xinqi; Wang, Jiawei; Shi, Yi Gong Article

2011 1

Structure and mechanism of the uracil transporter UraA
Nature, v. 472, (7342), April 2011, p. 243-247
Lu, Feiran; Li, Shuo; Jiang, Yang; Jiang, Jing; Fan, He; Lu, Guifeng; Deng, Dong; Dang, Shangyu; Zhang, Xu.; Wang, Jiawei; Yan, Nieng Article

2010 1

Structure of a fucose transporter in an outward-open conformation
Nature, v. 467, (7316), October 2010, p. 734-738
Dang, Shangyu; Sun, Linfeng; Huang, Yongjian; Lu, Feiran; Liu, Yufeng; Gong, Haipeng; Wang, Jiawei; Yan, Nieng Article

2009 1

Structure and mechanism of an amino acid antiporter
Science, v. 324, (5934), June 2009, p. 1565-1568
Gao, Xiang; Lu, Feiran; Zhou, Lijun; Dang, Shangyu; Sun, Linfeng; Li, Xiaochun; Wang, Jiawei; Shi, Yi Gong Article


Expand All Collapse All


Article 1

Structural insights into group II TRP channels
Cell Calcium, v. 86, March 2020, article number 102107
Fine, Michael; Li, Xiaochun; Dang, Shangyu


Expand All Collapse All


Article 2

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling
Cell Reports, v. 28, (2), July 2019, p. 567-579
Feng, Shengjie; Dang, Shangyu; Han, Tina Wei; Ye, Wen Lei; Jin, Peng; Cheng, Tong; Li, Junrui; Jan, Yuh Nung; Jan, Lily Yeh; Cheng, Yifan
Structural insight into TRPV5 channel function and modulation
Proceedings of the National Academy of Sciences of the United States of America, v. 116, (18), April 2019, p. 8869-8878
Dang, Shangyu; van Goor, Mark K.; Asarnow, Daniel; Wang, YongQiang; Julius, David; Cheng, Yifan; van der Wijst, Jenny


Expand All Collapse All


Article 1

Cryo-EM structures of the TMEM16A calciumactivated chloride channel
Nature, v. 552, (7685), December 2017, p. 426-429
Dang, Shangyu; Feng, Shengjie; Tien, Jason; Peters, Christian Joseph; Bulkley, David P.; Lolicato, Marco; Zhao, Jianhua; Zuberbühler, Kathrin; Ye, Wenlei; Qi, Lijun; Chen, Tingxu; Craik, Charles S.; Jan, Yuhnung; Minor, Daniel L.; Cheng, Yifan; Jan, L.Y.


Expand All Collapse All


Article 1

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH
Proceedings of the National Academy of Sciences of the United States of America, v. 112, (11), March 2015, p. 3344-3349
Dang, Shangyu; Wu, Shenjie; Wang, Jiawei; Li, Hongbo; Huang, Min; Hea, Wei; Li, Yueming; Wong, Catherine C.L.; Shi, Yi Gong


Expand All Collapse All


Article 2

Evolutionary mix-and-match with MFS transporters
Proceedings of the National Academy of Sciences of the United States of America, v. 110, (15), April 2013, p. 5870-5874
Gregor Madej, M.; Dang, Shangyu; Yan, Nieng; Ronald Kaback, H.
Structure of a presenilin family intramembrane aspartate protease
Nature, v. 493, (7430), January 2013, p. 56-61
Li, Xiaochun; Dang, Shangyu; Yan, Chuangye; Gong, Xinqi; Wang, Jiawei; Shi, Yi Gong


Expand All Collapse All


Article 1

Structure and mechanism of the uracil transporter UraA
Nature, v. 472, (7342), April 2011, p. 243-247
Lu, Feiran; Li, Shuo; Jiang, Yang; Jiang, Jing; Fan, He; Lu, Guifeng; Deng, Dong; Dang, Shangyu; Zhang, Xu.; Wang, Jiawei; Yan, Nieng


Expand All Collapse All


Article 1

Structure of a fucose transporter in an outward-open conformation
Nature, v. 467, (7316), October 2010, p. 734-738
Dang, Shangyu; Sun, Linfeng; Huang, Yongjian; Lu, Feiran; Liu, Yufeng; Gong, Haipeng; Wang, Jiawei; Yan, Nieng


Expand All Collapse All


Article 1

Structure and mechanism of an amino acid antiporter
Science, v. 324, (5934), June 2009, p. 1565-1568
Gao, Xiang; Lu, Feiran; Zhou, Lijun; Dang, Shangyu; Sun, Linfeng; Li, Xiaochun; Wang, Jiawei; Shi, Yi Gong


Expand All Collapse All


2015 1

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH
Proceedings of the National Academy of Sciences of the United States of America, v. 112, (11), March 2015, p. 3344-3349
Dang, Shangyu; Wu, Shenjie; Wang, Jiawei; Li, Hongbo; Huang, Min; Hea, Wei; Li, Yueming; Wong, Catherine C.L.; Shi, Yi Gong Article

2013 2

Evolutionary mix-and-match with MFS transporters
Proceedings of the National Academy of Sciences of the United States of America, v. 110, (15), April 2013, p. 5870-5874
Gregor Madej, M.; Dang, Shangyu; Yan, Nieng; Ronald Kaback, H. Article
Structure of a presenilin family intramembrane aspartate protease
Nature, v. 493, (7430), January 2013, p. 56-61
Li, Xiaochun; Dang, Shangyu; Yan, Chuangye; Gong, Xinqi; Wang, Jiawei; Shi, Yi Gong Article

2011 1

Structure and mechanism of the uracil transporter UraA
Nature, v. 472, (7342), April 2011, p. 243-247
Lu, Feiran; Li, Shuo; Jiang, Yang; Jiang, Jing; Fan, He; Lu, Guifeng; Deng, Dong; Dang, Shangyu; Zhang, Xu.; Wang, Jiawei; Yan, Nieng Article

2010 1

Structure of a fucose transporter in an outward-open conformation
Nature, v. 467, (7316), October 2010, p. 734-738
Dang, Shangyu; Sun, Linfeng; Huang, Yongjian; Lu, Feiran; Liu, Yufeng; Gong, Haipeng; Wang, Jiawei; Yan, Nieng Article

2009 1

Structure and mechanism of an amino acid antiporter
Science, v. 324, (5934), June 2009, p. 1565-1568
Gao, Xiang; Lu, Feiran; Zhou, Lijun; Dang, Shangyu; Sun, Linfeng; Li, Xiaochun; Wang, Jiawei; Shi, Yi Gong Article


No Publications


No Publications


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 5 2020-21 Summer 0 2020-21 Spring 6 2020-21 Winter 0 2020-21 Fall 4

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LIFS2210 Biochemistry I
LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS6111O Life Science Postgraduate Student Seminar
LIFS6113E Current Topics in Biochemistry and Biophysics
SCIE4500 IRE Research Project II


BIPH4010 Principles of Quantitative Instrumentation
LIFS3580 Bioinformatics
LIFS4540 Structure and Function of Proteins
LIFS4960 Biological Science Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS4983 Biotechnology Project Research II


LIFS2210 Biochemistry I
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4973 Biotechnology Project Research I
LIFS6113D Current Topics in Biochemistry and Biophysics


No Teaching Assignments


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy DENG, Siqi
Life Science( 2021 - )

QIN, Yuqi
Life Science( 2021 - )

QIU, Qinling
Life Science( 2021 - )

LI, Sirui
Life Science( 2019 - )

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Master of Philosophy TANG, Bingjie
Life Science( 2021 - )

LIU, Hang
Life Science( 2020 - )

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Graduated RPGs

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Master of Philosophy XU, Yixin
Life Science( Completed in 2021 )









ProjectsFrom January 2020 to December 2022

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All Projects 5 Leading Projects 4 Participating Projects 1

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Mechanism for the TMEM63B mechanosensitive ion channel, an osmosensor required for hearing


对机械敏感离子通道TMEM63B作为听力所需渗透传感器的机制研究 Leading


RGC - General Research Fund


Project Team (HKUST)
DANG Shangyu (Lead)


2022 -




Structure and molecular mechanisms of the eukaryotic replisome


真核生物复制机器的结构和分子机制研究 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
DANG Shangyu


2021 -




Application of gel-like branched polymer to improve particle distribution and orientation in single-particle cryo-EM


利用凝胶状支链聚合物改善单颗粒冷冻电子显微技术中颗粒的分布与取向 Leading


Shenzhen Science and Technology Innovation Strategy Research and Technology Transfer Promotion Center


Project Team (HKUST)
DANG Shangyu (Lead)


2021 -




Mechanism study of ABHD2, a key regulatory protein of sperm hyperactivated motility


精子超活化运动关键调控蛋白ABHD2的机理研究 Leading


Guangdong Natural Science Foundation


Project Team (HKUST)
DANG Shangyu (Lead)


2021 -




Investigation of calcium signaling in sperm cells


精子细胞中钙信号的研究 Leading


RGC - Early Career Scheme


Project Team (HKUST)
DANG Shangyu (Lead)


2020 -