Zhihong GUO
郭志宏
PhD in Biological Chemistry
University of Minnesota, 1998
Associate Professor
Department of Chemistry
(852) 2358 7352
chguo@ust.hk
Room 4519
Personal Web
ORCID
0000-0003-0374-8412
Scopus ID
7404658303
Research Interest Publications Projects Teaching Assignment RPG Supervision Space used
Research Interest
Bioorganic chemistry
Biophysical chemistry
Biosynthesis of menaquinone
Chemical biology
Structural biology
Publications
All Years 223 2022 0 2021 1 2020 1 2019 5 2018 7 2017 16 2016 193
2021 1
Listeria monocytogenes MenI Encodes a DHNA-CoA thioesterase necessary for menaquinone biosynthesis, cytosolic survival, and virulence
Infection and Immunity, v. 89, (5), May 2021, article number e00792-20
Smith, Hans B.; Li, Tin Lok; Liao, Man Kit; Chen, Grischa Y.; Guo, Zhihong; Sauer, John-Demian Article
2020 1
Substrate recognition and catalytic mechanism of the phosphate acyltransferase PlsX from Bacillus subtilis
ChemBioChem, v. 21, 2020
Jiang, Yiping; Qin, Mingming; Guo, Zhihong Article
2019 5
Identification of an amphipathic peptide sensor of the Bacillus subtilis fluid membrane microdomains
Communications Biology, v. 2, (1), August 2019, article number 316
Jiang, Yiping; Dai, Xin; Qin, Mingming; Guo, Zhihong Article
Biochemical and structural characterization of CGI-58
The 26th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 4 May 2019
Ha, Thi Thuy Hoa; Shi, Jie; Guo, Zhihong Conference paper
Identification of an amphipathic peptide sensor of the fluid membrane microdomains in Bacillus subtilis
The 26th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 4 May 2019
Jiang, Yiping; Dai, Xin; Qin, Mingming; Guo, Zhihong Conference paper
Mechanism-based inhibition of the essential thiamine-dependent enzyme of the vitamin K2 biosynthesis
The 26th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 4 May 2019
Li, Tin Lok; Guo, Zhihong Conference paper
Structural and kinetic investigation of the thiamine-dependent MenD from the Escherichia coli menaquinone biosynthetic pathway
The 26th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 4 May 2019
Qin, Mingming; Song, Haigang; Guo, Zhihong Conference paper
2018 7
Single-Turnover Kinetics Reveal a Distinct Mode of Thiamine Diphosphate-Dependent Catalysis in VitaminK Biosynthesis
ChemBioChem, v. 19, (14), July 2018, p. 1514-1522
Qin, Mingming; Song, Haigang; Dai, Xin; Chan, Chi Kong; Chan, Wan; Guo, Zhihong Article
Two Active Site Arginines Are Critical Determinants of Substrate Binding and Catalysis in MenD: A Thiamine-dependent Enzyme in Menaquinone Biosynthesis
Biochemical Journal, v. 475, (22), November 2018, p. 3651-3667
Qin, Mingming; Song, Haigang; Dai, Xin; Chen, Yaozong; Guo, Zhihong Article
Development of inhibitors against the alternate active site of the thiamine-dependent enzyme in menaquinone biosynthesis
The 25th Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong University of Science and Technology, Hong Kong, 28 April 2018
Li, Tin Lok; Qin, Mingming; Guo, Zhihong Conference paper
Lipid-associated nonfibrillar α-helical oligomers of α-synuclein by unsaturated fatty acid sensing in vitro
The 25th Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong University of Science and Technology, Hong Kong, 28 April 2018
Dai, Xin; Chen, Xiaolei; Sun, Yueru; Zheng, Qingbing; Li, Shaowei; Guo, Zhihong Conference paper
Structural and mechanistic investigation of the monotopic membrane localization of the methyltransferase UbiE in quinone biosynthesis
The 25th Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong University of Science and Technology, Hong Kong, 28 April 2018
Ha, Thi Thuy Hoa; Jiang, Yiping; Guo, Zhihong Conference paper
Structural basis for peripheral sensing of the membrane regions of increased fluidity
The 25th Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong University of Science and Technology, 28 April 2018
Jiang, Yiping; Dai, Xin; Guo, Zhihong Conference paper
Structure and membrane interaction of the lipid II synthase MurG in Bacillus subtilis
The 25th Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong University of Science and Technology, Hong Kong, 28 April 2018
Qin, Mingming; Guo, Zhihong Conference paper
2017 16
Crystal Structure of the Thioesterification Conformation of Bacillus Subtilis O-succinylbenzoyl-CoA Synthetase Reveals a Distinct Substrate-binding Mode
Journal of Biological Chemistry, v. 292, (29), July 2017, p. 12296-12310
Chen, Yaozong; Li, Tin Lok; Lin, Xingbang; Li, Xin; Li, Xiang David; Guo, Zhihong Article
Facile Formation of a Microporous Chitosan Hydrogel Based on Self-crosslinking
Journal of Materials Chemistry B, v. 5, (47), December 2017, p. 9291-9299
Chen, Yin; Huang, Lu; Dai, Xin; Tian, Qian; Yu, Miao; Agheb, Maria; Chan, Ho Nam; Poon, ellen; Guo, Zhihong; Boheler,kenneth richard; Wu, Hongkai Article
A new mode of thiamine disphosphate-dependent catalysis in vitamin K biosynthesis
International Symposium on Bioorganic Chemistry (ISBOC-11) Konstanz Symposium Chemical Biology, University of Konstanz, Konstanz, Germany, 27-29 September 2017
Song, Haigang; Qin, Mingming; Chen, Dong; Dai, Xin; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Wan; Guo, Zhihong Conference paper
Conformational intermediates in the domain-alteration catalysis of an adenylating enzyme in vitamin K biosynthesis
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, Hong Kong, May, 2017
Guo, Zhihong; Chen, Yaozong; Sun, Yueru; Song, Haigang; Jiang, Yiping; Li, Tin Lok Conference paper
Generality of the novel thiamine-dependent catalysis medicated by an active tetrahedral intermediate in menaquinone biosynthesis
The Fifth South China Symposium of Structural Biology (SCSBS2017) 第五届华南结构生物学论坛会议, Fuzhou University, Fuzhou, Fujian, China, 24-26 November 2017
Li, Tin Lok; Qin, Mingming; Song, Haigang; Guo, Zhihong Conference paper
Investigation on the interaction between acyl-ACP and Bacillus subtilus PlsX from glycerophospholipid biosynthetic pathway
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Li, Tin Lok; Jiang, Yiping Conference paper
Mechanism of thiocarboxylate formation in thiosugar biosynthesis revealed by the MoeZ-SCP complex
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Qin, Xiaoyu; Dai, Xin; Liu, Hung-wen Conference paper
Mechanistic investigation on the thiocarboxylate formation in thiosugar biosynthesis
The Fifth South China Symposium of Structural Biology (SCSBS2017) 第五届华南结构生物学论坛会议, Fuzhou University, Fuzhou, Fujian, China., 24-26 November 2017
Qin, Xiaoyu; Dai, Xin; Liu, hung-wen; Guo, Zhihong Conference paper
Overcoming the solubility limit of recombinant protein with chaperone co-expression to produce high soluble yield of Arabidopsis CGI-58
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Ha, Thi Thuy Hoa; Shi, Jie Conference paper
Role of two conserved arginine residues in the new thiamine catalysis mediated by a tetrahedral intermediate in menaquinone biosynthesis
The Fifth South China Symposium of Structural Biology (SCSBS2017) 第五届华南结构生物学论坛会议, Fuzhou University, China, 24-26 November 2017
Qin, Mingming; Song, Haigang; Guo, Zhihong Conference paper
Structural and mechanistic investigation of the UbiE monotopic membrane localization in coenzyme Q and vitamin K biosynthesis
The Fifth South China Symposium of Structural Biology (SCSBS2017) 第五届华南结构生物学论坛会议, Fuzhou University, Fuzhou, Fujian, China, 24-26 November 2017
Ha, Thi Thuy Hoa; Jiang, Yiping; Guo, Zhihong Conference paper
Structural basis for peripheral sensing of membrane regions of increased fluidity
2017年华南结构生物学论坛 South China Symposium of Structural Biology, 福州, 中国, 24 - 26 November 2017
Jiang, Yiping; Dai, Xin; Guo, Zhihong Conference paper
Structural basis of the membrane association of phosphate acyltransferase PlsX
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Jiang, Yiping Conference paper
Structural determinants for the formation of the tetrahedral intermediate in the thiamine-dependent catalysis of Escherichia coli MenD from the menaquinone biosynthetic pathway
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Qin, Mingming; Song, haigang Conference paper
Two-staged interaction of α-synuclein with unsaturated fatty acids
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Dai, Xin; Cheung, Shuk Wa; Mak, Kar Kei Conference paper
α-Synuclein senses unsaturated fatty acid in vitro to form lipid-associated nonfibrillar α-helical oligomers
The Fifth South China Symposium of Structural Biology (SCSBS2017) 第五届华南结构生物学论坛会议, Fuzhou University, Fuzhou, Fujian, China, 24-26 November 2017
Dai, Xin; Chen, xiaolei; Sun, Yueru; Zheng, qingbing; Li, shaowei; Guo, Zhihong Conference paper
2016 14
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition
Autophagy, v. 12, (8), August 2016, p. 1372-1389
Song, Juxian; Sun, Yueru; Peluso, Ivana; Zeng, Yu; Yu, Xing; Lu, Jiahong; Xu, Zheng; Wang, Mingzhong; Liu, Liangfeng; Huang, Yingyu; Chen, Leilei; Durairajan, Siva Sundara Kumar Kumar; Zhang, Hongjie; Zhou, Bo; Zhang, Hongqi; Lu, Aiping; Ballabio, Andrea; Medina, Diego Luis; Guo, Zhihong; Li, Min Article
A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis
Journal of the American Chemical Society, v. 138, (23), June 2016, p. 7244-7247
Song, Haigang; Dong, Chen; Qin, Mingming; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Simon Wan; Guo, Zhihong Article
An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus Influenzae
Biochemistry, v. 55, (48), December 2016, p. 6705-6717
Shi, Jie; Cao, Xinyun; Chen, Yaozong; Cronan, John E.; Guo, Zhihong Article
Mechanistic Insights from the Crystal Structure of Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase Complexed with the Adenylate Intermediate
Biochemistry, v. 55, (48), December 2016, p. 6685-6695
Chen, Yaozong; Jiang, Yiping; Guo, Zhihong Article
Conformational intermediates in the domain-alteration catalysis of an adenylating enzyme in vitamin K biosynthesis
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Li, Tin Lok; Jiang, Yiping; Chen, Yaozong; Guo, Zhihong; Song, Haigang; Sun, Yueru Conference paper
Mechanism of thiocarboxylate formation in thiosugar biosynthesis revealed by the MoeZ-SCP complex
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Qin, Xiaoyu; Dai, Xin; Guo, Zhihong; Liu, Hung-wen Conference paper
Mechanistic investigation of the MoeZ-catalyzed thiocarboxylate formation in thiosugar biosynthesis
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23 April 2016
Dai, Xin; Liu, Hung-wen; Guo, Zhihong Conference paper
Structural and kinetic investigation of the thiamine-dependent MenD from the Escherichia coli menaquinone biosynthetic pathway
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Qin, Mingming; Guo, Zhihong; Song, Haigang Conference paper
Structural and kinetic investigation of the thiamine-dependent MenD from the menaquinone biosynthetic pathway in Escherichia coli
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23 April 2016
Qin, Mingming; Song, Haigang; Guo, Zhihong Conference paper
Structural and mechanistic investigation of the membrane associated phosphate acyltransferase PlsX
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Jiang, Yiping; Guo, Zhihong Conference paper
Structural basis of substrate recognition of Bacillus subtilis BioF in biotin biosynthesis
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Shi, Jie; Guo, Zhihong Conference paper
Structural characterization of H. influenzae BioG reveals a conserved active site within a novel three-layered of α/β hydrolase fold
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23 April 2016
Shi, Jie; Guo, Zhihong Conference paper
Structural elucidation and biochemical investigation of multi-functional states of Bacillus subtilis o-succinylbenzoyl-CoA synthetase
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23th April 2016
Chen, Yaozong; Sun, Yueru; Song, Haigang; Guo, Zhihong Conference paper
Structural Evdience for Negative Cooperativity in Substrate Binding of Hexameric Staphylococcus aureus 1,4-Dihydroxy-2-Naphthoyl-CoA Synthase
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, 15 April 2015
Jiang, Yiping; Chen, Yaozong; Guo, Zhihong Conference paper
2015 13
A Universal and Facile Approach for the Formation of a Protein Hydrogel for 3D Cell Encapsulation
Advanced Functional Materials, v. 25, (39), October 2015, p. 6189-6198
Chen, Yin; Dai, Xin; Huang, Lu; Sun, Yang; Chan, Ho Nam; Shen, Bo; Zeng, Xiaoqian; Wu, Zhenguo; Hsing, I-Ming; Guo, Zhihong; Wu, Hongkai Article
Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora
ChemBioChem, v. 16, (1), 2015, p. 100-109
Song, Haigang; Xu, Ri; Guo, Zhihong Article
Microsecond Protein Folding Events Revealed by Time-Resolved Fluorescence Resonance Energy Transfer in a Microfluidic Mixer
Analytical Chemistry, v. 87, (11), June 2015, p. 5589-5595
Jiang, Liguo; Zeng, Yan; Sun, Qiqi; Sun, Yueru; Guo, Zhihong; Qu, Jianan; Yao, Shuhuai Article
Structural basis for the atp-dependent configuration of adenylation active site in bacillus subtilis o-succinylbenzoyl-coa synthetase
Journal of Biological Chemistry, v. 290, (39), September 2015, p. 23971-23983
Chen, Yaozong; Sun, Yueru; Song, Haigang; Guo, Zhihong Article
Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Conference paper
Observation of an unusual intermediate in SEPHCHC synthase (MenD) in the biosynthesis of menaquinone
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 18 April 2015
Song, Haigang; Dong, Chen; Guo, Zhihong Conference paper
Structural and kinetic evidence of a large conformational movement in formation of the first Michaelis complex of o-succinylbenzoyl-CoA synthetase.
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Chen, Yaozong; Guo, Zhihong Conference paper
Structural and mechanistic investigation of the transmembrane sn-glycerol-3-phosphate acyltransferase PlsY from Escherichia coli
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Jiang, Yiping; Guo, Zhihong Conference paper
Structural basis for the ATP-dependent configuration of adenylation active site in Bacillus subtilis o-succinylbenzoyl-CoA synthetase
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Chen, Yaozong; Sun, Yueru; Song, Haigang; Guo, Zhihong Conference paper
Structural characterization of a small basic protein: the human G0/G1 switch gene 2 protein (hG0S2)
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 18 April 2015
Shi, Jie; Guo, Zhihong Conference paper
Structural investigation of an atypical acyl-CoA synthase involved in biotin synthesis of Bacillus subtilis
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Shi, Jie; Guo, Zhihong Conference paper
Structural investigation of the 'hot dog' folded thioesterase YbaW
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Dai, Xin; Guo, Zhihong Conference paper
Structure of the Escherichia coli hotdog thioesterase YbaW
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Dai, Xin; Guo, Zhihong Conference paper
2014 18
A comparison of the diet and fine-scale distribution of sympatric Tibetan and red foxes in Qinghai, PR China
Wildlife Biology, v. 20, (6), December 2014, p. 356-361
Tsukada, Hideharu; Li, Wei; Duo, Hong; Guo, Zhihong; Fu, Yong; Peng, Mao; Shen, Xiuying; Jing, Jianwu; Yuan, Aishan; Ni, Ma; He, Shengde; Huang, Fu Qiang; Feng, Kai; Ishikawa, Keisuke; Kobayashi, Ikuo; Shinohara, Akio; Nonaka, Nariaki Article
Cascade Biocatalysis by Multienzyme-Nanoparticle Assemblies
Bioconjugate Chemistry, v. 25, (8), August 2014, p. 1387-1394
Kang, Wei; Liu, Jiahui; Wang, Jianpeng; Nie, Yunyu; Guo, Zhihong; Xia, Jiang Article
Discovery of Pentacyclic Triterpenoids as Potential Entry Inhibitors of Influenza Viruses
Journal of Medicinal Chemistry, v. 57, (23), December 2014, p. 10058-10071
Yu, Maorong; Si, Longlong; Wang, Yufei; Wu, Yiming; Yu, Fei; Jiao, Pingxuan; Shi, Yongying; Wang, Han; Xiao, Sulong; Fu, Ge; Tian, Ke; Wang, Yitao; Guo, Zhihong; Ye, Xinshan; Zhang, Lihe; Zhou, Demin Article
Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues
Acta Crystallographica Section D: Biological Crystallography, v. 70, (11), November 2014, p. 2959-2969
Song, Haigang; Sung, Hoi Pang; Tse, Yuk Sing; Jiang, Ming; Guo, Zhihong Article
Molecular basis of the general base catalysis of an α/β- hydrolase catalytic triad
Journal of Biological Chemistry, v. 289, (22), May 2014, p. 15867-15879
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Article
Beta-Synuclein forms various alpha-helix and alpha-pleated sheet structures with different unsaturated fatty acids
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Shi, Jie; Guo, Zhihong Conference paper
Characterization of the alpha-helical oligomer of alpha-synuclein formed in the presence of oleic acid
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Dai, Xin; Chen, Xiaolei; Wong, Chun Wa; Guo, Zhihong Conference paper
Crystal structures of the type II M. tuberculosis MenB support a unified induced-fit catalytic mechanism for the crotonase fold enzyme family
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Song, Haigang; Tse, Yuk Sing; Sung, Hoi Pang; Guo, Zhihong Conference paper
Ligand-dependent active site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogs
The Third Asian Chemical Biology Conference, National University of Singapore, Singapore, 14-17 December 2014
Song, Haigang; Sung, Hoi Pang; Tse, Yuk Sing; Jiang, Ming; Guo, Zhihong Conference paper
Molecular Basis of the General Base Catalysis of an α/β-Hydrolase Catalytic Triad
The 2nd South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Conference paper
Observation of an Unusual Tetrahedral Intermediate in SEPHCHC Synthase (MenD) in the Biosynthesis of Menaquinone
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Song, Haigang; Dong, Chen; Guo, Zhihong Conference paper
Structural and catalytic roles of the NC-loop of the α/β-hydrolase MenH
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Xu, Zheng; Sun, Yueru; Guo, Zhihong Conference paper
Structural and kinetic characterization of a large conformational movement in the two-step catalysis of o-succinylbenzoyl-CoA synthetase
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Chen, Yaozong; Guo, Zhihong Conference paper
Structural and Kinetic Evidence of A Large Conformational Movement in Formation of the First Michaelis Complex of O-Succinylbenzoyl-CoA Synthetase
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Chen, Yaozong; Guo, Zhihong Conference paper
Structural and pre-steady state kinetic study of the ligand recognition mechanism of a noncanonical α/β-hydrolase fold enzyme MenH
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Sun, Yueru; Guo, Zhihong Conference paper
Structural Evdience for Negative Cooperativity in Substrate Binding of Hexameric Staphylococcus aureus 1,4-Dihydroxy-2-Naphthoyl-CoA Synthase
The Second South China Structural Biology Symposium 华南结构生物学论坛, 福州, 5 - 7 December 2014
Jiang, Yiping; Chen, Yaozong; Guo, Zhihong Conference paper
Structure of the Escherichia coli Hotdog Thioesterase Ybaw
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Dai, Xin; Guo, Zhihong Conference paper
α/β Hydrolase fold enzymes exhibit both open and closed conformations: a case study with BioH
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Shi, Jie; Guo, Zhihong Conference paper
2013 5
Crystal Structures of E. coli Native MenH and Two Active Site Mutants
PLoS ONE, v. 8, (4), April 2013, article number e61325
Johnston, Jodie M.; Jiang, Ming; Guo, Zhihong; Baker, Edward N. Article
Identification of a Hotdog Fold Thioesterase Involved in the Biosynthesis of Menaquinone in Escherichia coli
Journal of Bacteriology, v. 195, (12), 2013, p. 2768-2775
Chen, Minjiao; Ma, Xinyu; Chen, Xiaolei; Jiang, Ming; Song, Haigang; Guo, Zhihong Article
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase from the crotonase fold superfamily
PLoS ONE, v. 8, (4), April 2013, article number e63095
Sun, Yueru; Song, Haigang; Li, Jie; Li, Yan; Jiang, Ming; Zhou, Jiahai; Guo, Zhihong Article
The thiamine-dependent enzyme of the vitamin K biosynthesis catalyzes reductive C-N bond ligation between nitroarenes and alpha-ketoacids
SCIENCE CHINA Chemistry, v. 56, (3), March 2013, p. 312-320
Chen, Minjiao; Jiang, Ming; Guo, ZhiHong Article
Molecular Basis of the General Base Catalysis of an α/β-hydrolase Catalytic Triad
The 12th Meeting of the Asian Crystallographic Association, Hong Kong, 7-10 December 2013
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Guo, Zhihong Conference paper
2012 12
Active Site Binding and Catalytic Role of Bicarbonate in 1,4-Dihydroxy-2-naphthoyl Coenzyme A Synthases from Vitamin K Biosynthetic Pathways
Biochemistry, v. 51, (22), June 2012, p. 4580-4589
Sun, Yueru; Song, Haigang; Li, Jie; Jiang, Ming; Li, Yan; Zhou, Jiahai; Guo, Zhihong Article
Characterization of 1,4-dihydroxy-2-naphthoyl-coenzyme A synthase (MenB) in phylloquinone biosynthesis of Synechocystis sp. PCC 6803
SCIENCE CHINA Chemistry, v. 55, (1), 2012, p. 98-105
Song, Haigang; Guo, Zhihong Article
Interactions between Artemisinins and other Antimalarial Drugs in Relation to the Cofactor Model-A Unifying Proposal for Drug Action
ChemMedChem, v. 7, (12), December 2012, p. 2204-2226
Haynes, Richard K.; Cheu, Kwan-Wing; Chan, Ho-Wai; Wong, Ho-Ning; Li, Ka-Yan; Tang, Maggie Mei-Ki; Chen, Min-Jiao; Guo, Zu-Feng; Guo, Zhi-Hong; Sinniah, Kumar; Witte, Amanda B.; Coghi, Paolo; Monti, Diego Article
Alpha-Synuclein forms an oligomeric alpha-helical structure in the presence of unsaturated fatty acids.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013, O-56
Dai, Xin; Chen, Xiaolei; Wong, Chung Wa; Guo, Zhihong Conference paper
Crowding effect on calmodulin bakcbone dynamics
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Feng, Yitao; Liu, Changdong; Wu, Qinglin; Zhu, Guang; Guo, Zhihong Conference paper
Crystal structure of E. coli (1R, 6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (MenH) and its product complex.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Sun, Yueru; Yin, Shuhui; Li, Jie; Zhou, Jiahai; Guo, Zhihong Conference paper
Differentiation of solvation effect and macromolecular crowding effect
The Second Asian Chemical Biology Conference, Itoman, Okinawa, Japan, 4-6 July 2012
Guo, Zhihong Conference paper
Discovery and characterization of an L-methionine gamma-lyase involved in Calicheamicin biosynthesis.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27, Apr, 2013, p. 111
Song, Haigang; Xu, Ri; Guo, Zhihong Conference paper
Investigation of the abnormal electrophoretic behavior of the hotdog thioesterase YbaW.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Ma, Xingyu; Chen, Xiaolei; Guo, Zhihong Conference paper
Structural and kinetic characterization of o-succinylbenzoyl-CoA synthetase in the menaquinone biosynthesis of Escherichia coli.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013, O-55
Chen, Yaozong; Guo, Zhihong Conference paper
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase of the crotonase fold superfamily
第四届中国结构生物学学术讨论会, 中国重庆, 31 Mar-3 Apr 2013
Sun, Yueru; Song, Haigang; Li, Jie; Li, Yan; Jiang, Ming; Zhou, Jiahai; Guo, Zhihong Conference paper
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase of the crotonase fold superfamily
The 7th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-7), Nanyang Technological University, Singapore, December 11-14 2012
Sun, Yueru; Song, Haigang; Li, Jie; Li, Yan; Jiang, Ming; Zhou, Jiahai; Guo, Zhihong Conference paper
2011 12
A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine
ChemMedChem, v. 6, (9), September 2011, p. 1603-1615
Haynes, Richard K.; Cheu, Kwan-Wing; Li, Ka-Yan; Tang, Maggie Mei-Ki; Wong, Ho-Ning; Chen, Min-Jiao; Guo, Zu-Feng; Guo, Zhi-Hong; Coghi, Paolo; Monti, Diego Article
Reactions of Antimalarial Peroxides with Each of Leucomethylene Blue and Dihydroflavins: Flavin Reductase and the Cofactor Model Exemplified
ChemMedChem, v. 6, (2), 2011, p. 279-291
Haynes, Richard Kingston; Cheu, Kwan-Wing; Tang, Maggie Mei-Ki; Chen, Min-Jiao; Guo, Zu-Feng; Guo, Zhi-Hong; Coghi, Paolo; Monti, Diego Article
Stabilization of the Second Oxyanion Intermediate by 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase of the Menaquinone Pathway: Spectroscopic Evidence of the Involvement of a Conserved Aspartic Acid
Biochemistry, v. 50, (26), July 2011, p. 5893-5904
Chen, Minjiao; Jiang, Ming; Sun, Yueru; Guo, Zu-Feng; Guo, Zhihong Article
A general synthesis of 6-substituted 5,6-dihydro-4-hydroxy-2H- pyran-2-ones and NMR studies in different solvents
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-45
Li, Huoming; Wang, Yuan; Chen, Xiaolei; Guo, Zhihong; Dai, Wei-Min Conference paper
Characterization of 1,4-dihydroxy-2-naphthoyl-CoA synthase in the phylloquinone biosynthesis of Synechocystis
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, 30 April 2011, City University of Hong Kong, 30 April 2011,The Abstract Book, O-51
Song, Haigang; Guo, Zhihong Conference paper
Characterization of the non-heme catalase activity of an α/β fold protein from Mycobacterium tuberculosis
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-52
Sun, Yueru; Wu, Wenzhan; Li, Xiao-Yuan; Johnston, Jodie M.; Baker, Edward N.; Guo, Zhihong Conference paper
Characterization of the type II hot-dog thioesterase in biosynthesis of the nine-membered enediyne core of C-1027
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-50
Keung, Bowie P.Y.; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong Conference paper
Effects of macromolecular crowding on selected protein systems
2011 Telluride Workshop on Macromolecular Crowding, Telluride Science Research Center, Telluride, Colorado, the United States of America, 20-24 June 2011
Guo, Zhihong Conference paper
Identification of active site residues involved in the second oxyanion hole in the catalysis of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB)
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-47
Chen, Minjiao; Jiang, Ming; Guo, Zhihong Conference paper
New Products for the Iterative Enediyne Core Polyketide Synthase
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011, The Abstract Book, O-53
Xu, Ri; Chen, Xiaolei; Feng, Yitao; Song, Haigang; Guo, Zhihong Conference paper
Production of a nonaketide by the iterative ten-membered enediyne core polyketide synthase in biosynthesis of calicheamicin
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-49
Feng, Yitao; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong Conference paper
Recognition of the acyl carrier protein by the phosphopanteheinyl transferase domain of the enediyne polykeide synthase SgcE
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-48
Chen, Xiaolei; Guo, Zhihong Conference paper
2010 13
A Bicarbonate Cofactor Modulates 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase in Menaquinone Biosynthesis of Escherichia coli
Journal of biological chemistry, v. 285, (39), 2010, SEP 24, p. 30159-30169
Jiang, Ming; Chen, Minjiao; Guo, Zu-Feng; Guo, Zhihong Article
Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027
Angewandte Chemie - International Edition, v. 49, (43), 2010, p. 7926-7928
Chen, Xiaolei; Guo, Zu-Feng; Lai, Pok Man; Sze, Kong Hung; Guo, Zhihong Article
Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis
ACTA crystallographica Section d-biological Crystallography, v. 66, (Part 8), 2010, AUG, p. 909-917
Johnston, Jodie M.; Jiang, Ming; Guo, Zhihong; Baker, Edward N. Article
Structural change of the enterobactin synthetase in crowded solution and its relation to crowding-enhanced product specificity in nonribosomal enterobactin biosynthesis
Bioorganic & medicinal chemistry letters, v. 20, (13), 2010, JUL 1, p. 3855-3858
Guo, Zu-Feng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Article
Structure and Reactivity of Bacillus subtilis MenD Catalyzing the First Committed Step in Menaquinone Biosynthesis
Journal of Molecular Biology, v. 401, (2), 2010, AUG 13, p. 253-264
Dawson, Alice; Chen, Minjiao; Fyfe, Paul K.; Guo, Zhihong; Hunter, William N. Article
Bicarbonate dependence in vitamin K biosynthesis
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-59
Jiang, Ming; Chen, Minjiao; Guo, Zu-Feng; Guo, Zhihong Conference paper
Characterization of a nonaketide precursor in biosynthesis of the nine-membered enediyne core of the antitumor antibiotic C-1027
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-57
Chen, Xiaolei; Guo, Zu-Feng; Lai, Pok Man; Sze, Kung Hung; Guo, Zhihong Conference paper
Characterization of a type II hot-dog thioesterase in Calicheamicin biosynthesis
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-57
Keung, Po Yee; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong Conference paper
Chemoenzymatic synthesis of N-hydroxyamides from nitro- or nitroso- compounds using a thiamine-dependent enzyme from the menaquinone biosynthetic pathway
The 5th International Conference on Cutting-Edge Organic Chemistry in Asia, Hsinchu, Taiwan, Nov. 7 - Nov. 11, PB-60, Abstract Book of The 5th International Conference on Cutting-Edge Organic Chemistry in Asia, 2010
Chen, Minjiao; Jiang, Ming; Guo, Zhihong Conference paper
Evidence for a new precursor in the biosynthesis of the ten-membered enediyne antitumor antibiotic Calicheamicin
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-61
Feng, Yitao; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong Conference paper
New insights into the catalytic mechanism of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) gained from the deuterium exchange of its substrate analogs
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-66
Chen, Minjiao; Jiang, Ming; Guo, Zhihong Conference paper
Search for the second enzyme in biosynthesis of the enediyne core of the antitumor antibiotic C-1027
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-58
Guo, Zu-Feng; Chen, Xiaolei; Feng, Yitao; Xu, Ri; Guo, Zhihong Conference paper
Searching for enzymes in the biosynthesis of the ten-membered enediyne core of Calicheamicin γI1
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-57
Xu, Ri; Guo, Zu-Feng; Guo, Zhihong Conference paper
2009 12
Catalytic Mechanism of SHCHC Synthase in the Menaquinone Biosynthesis of Escherichia coli: Identification and Mutational Analysis of the Active Site Residues
Biochemistry, v. 48, (29), 2009, JUL 28, p. 6921-6931
Jiang, Ming; Chen, Xiaolei; Wu, Xian-Hui; Chen, Minjiao; Wo, Yun-Dong; Guo, Zhihong Article
Combination of beta-elimination and liquid chromatography/quadrupole time-of-flight mass spectrometry for the determination of O-glycosylation sites
Talanta, v. 78, (2), 2009, APR 30, p. 358-363
Zheng, Yufang; Guo, Zhihong; Cai, Zongwei Article
Conjugation of Latent Membrane Protein (LMP)-2 Epitope to Gold Nanoparticles as Highly Immunogenic Multiple Antigenic Peptides for Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses in Vitro
Bioconjugate Chemistry, v. 20, (1), January 2009, p. 24-31
Cheung, Wai-Hung; Chan, Vera Sau-Fong; Pang, Heung-Wing; Wong, Man-Kin; Guo, Zhi-Hong; Tam, Paul Kwong-Hang; Che, Chi-Ming; Lin, Chen-Lung; Yu, Wing-Yiu Article
Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative
Journal of the American Chemical Society, v. 131, (38), September 2009, p. 13576-13577
Gao, Yuan; Kuang, Yi; Guo, Zufeng; Guo, Zhihong; Krauss, Isaac J.; Xu, Bing Article
Preferential Hydrolysis of Aberrant Intermediates by the Type II Thioesterase in Escherichia coli Nonribosomal Enterobactin Synthesis: Substrate Specificities and Mutagenic Studies on the Active-Site Residues
Biochemistry, v. 48, (8), 2009, MAR 3, p. 1712-1722
Guo, Zu-Feng; Sun, Yueru; Zheng, Suilan; Guo, Zhihong Article
Crowding Effect on Protein Side Chain Dynamics
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-63
Feng, Yitao; Cho, Chi Kong; Sze, Kong Hung; Guo, Zhihong Conference paper
Evidence for a New Precursor in the Biosynthesis of the Nine-membered Enediyne Core of the Antitumor Antibiotics C-1027
4th International Conference on Cutting-Edge Organic Chemistry in Asia, Chulabhorn Research Institute, Bangkok, Thailand, 29 Nov. - 3 Dec. 2009
Chen, Xiaolei; Guo, Zhihong Conference paper
Explorative investigation of protein organization in the enterobactin biosynthetic pathway
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-64
Guo, Zufeng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Conference paper
In vitro reconstitution of iterative type I polyketide synthases
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-61
Chen, Xiaolei; Feng, Yitao; Guo, Zhihong Conference paper
Mutational studies on the active site residues of MenD in Bacillus subtilis menaquinone biosynthesis
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-60
Chen, Minjiao; Jiang, Ming; Dawson, Alice; Hunter, William N.; Guo, Zhihong Conference paper
Re-examination of the activity of 1, 4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in the menaquinone biosynthesis
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-66
Jiang, Ming; Chen, Minjiao; Guo, Zhihong Conference paper
The viral 3a protein plays a role in the cellular immune response to the SARS coronavirus infection
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-68
Liu, Fuli; Guo, Zhihong Conference paper
2008 12
Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli
Biochemistry, v. 47, (11), 2008, MAR 18, p. 3426-3434
Jiang, Ming; Chen, Xiaolei; Guo, Zu-Feng; Cao, Yang; Chen, Minjiao; Guo, Zhihong Article
Suppression of linear side products by macromolecular crowding in nonribosomal enterobactin biosynthesis
Organic letters, v. 10, (4), 2008, FEB 21, p. 649-652
Guo, Zu-Feng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Article
A new activity of the serine-histidine-aspartate catalytic triad: ?-Proton abstraction from a carbon acid in a reaction involved in menaquinonone biosynthesis
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-37
Jiang, Ming; Chen, Xiaolei; Chen, Minjiao; Feng, Yitao; Guo, Zhihong Conference paper
Comparative advantages conferred by an enzyme with a nanomolar Michaelis constant in the menaquinonone biosynthesis of Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-35
Chen, Minjiao; Jiang, Ming; Guo, Zhihong Conference paper
Identification and characterization of a new intermediate and a new enzyme in the menaquinonone biosynthesis of Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, Oral-4
Jiang, Ming; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong Conference paper
Pre-steady-state characterization of the reaction catalyzed by (1R, 6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-36
Chen, Xiaolei; Qiao, Yuqin; Li, Ding; Jiang, Ming; Guo, Zhihong Conference paper
Quantitative characterization of the proofreading activity of a Type II thioesterase in nonribosomal enterobactin biosynthesis in Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-42
Guo, Zu-Feng; Zheng, Suilan; Guo, Zhihong Conference paper
Signals for the SARS coronavirus 3a protein intracellular localization and extracellular secretion
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-40
Liu, Fuli; Zhong, Xiaofen; Wu, Jie; Yang, Yanzhen; Cheng, Chak-Sum Samuel; Xie, Yong; Guo, Zhihong Conference paper
Structural changes in nonribosomal enterobactin synthetase under crowding conditions inherent to intracellular environment
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-38
Guo, Zu-Feng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Conference paper
The role of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in the menaquinonone biosynthesis of Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-39
Jiang, Ming; Guo, Zu-Feng; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong Conference paper
The role of macromolecular crowding in the nonribosomal synthesis of enterobactin in Escherichia coli
12emes Rencontres de Chimie Organique Biologique, Aussois, France, O11, 16-20 March 2008
Guo, Zhihong Conference paper
The role of protein 3a in cellular inflammatory response to infection by SARS coronavirus
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-41
Liu, Fuli; Liu, Yingjie; Guo, Zhihong Conference paper
2007 15
Chip-based CE coupled to a quadrupole TOF mass spectrometer for the analysis of a glycopeptide
Electrophoresis, v. 28, (9), 2007, MAY, p. 1305-1311
Zheng, Yufang; Li, Haifang; Guo, Zhihong; Lin, Jin-Ming; Cai, Zongwei Article
Determination of the stereochemistry of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate, a key intermediate in menaquinone biosynthesis
Organic letters, v. 9, (23), 2007, NOV 8, p. 4765-4767
Jiang, Ming; Chen, Minjiao; Cao, Yang; Yang, Yinhua; Sze, Kong Hung; Chen, Xiaolei; Guo, Zhihong Article
Effects of macromolecular crowding on the intrinsic catalytic efficiency and structure of enterobactin-specific isochorismate synthase
Journal of the American Chemical Society, v. 129, (4), 2007, JAN 31, p. 730-731
Jiang, Ming; Guo, Zhihong Article
Induction of cytotoxic T cell response against HCA661 positive cancer cells through activation with novel HLA-A{*}0201 restricted epitopes
Cancer letters, v. 256, (2), 2007, OCT 28, p. 178-185
Pang, Paul Ha-Sang; Chan, Kin-Tak; Tse, Luigi Ying-Wai; Chan, Ray Chun-Fai; Cheung, Ying-Kit; Sin, Fion Wan-Yee; Guo, Zhi-Hong; Xie, Yong Article
Intracellular enzymatic formation of nanofibers results in hydrogelation and regulated cell death
Advanced materials, v. 19, (20), 2007, OCT 19, p. 3152+
Yang, Zhimou; Xu, Keming; Guo, Zufeng; Guo, Zhihong; Xu, Bing Article
Intracellular hydrogelation of small molecules inhibits bacterial growth
ANGEWANDTE chemie-international EDITION, v. 46, (43), 2007, p. 8216-8219
Yang, Zhimou; Liang, Gaolin; Guo, Zufeng; Guo, Zhihong; Xu, Bing Article
Menaquinone biosynthesis in Escherichia coli: Identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-l-carboxylate as a novel intermediate and re-evaluation of MenD activity
Biochemistry, v. 46, (38), 2007, SEP 25, p. 10979-10989
Jiang, Ming; Cao, Yang; Guo, Zu-Feng; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong Article
Solid-phase total synthesis and antimicrobial activities of loloatins A-D
Chemistry & biodiversity, v. 4, (12), 2007, p. 2827-2834
Ding, Yan; Qin, Chuanguang; Guo, Zhihong; Niu, Weining; Zhang, Ruijie; Li, Yang Article
Using beta-lactamase to trigger supramolecular hydrogelation
Journal of the American Chemical Society, v. 129, (2), 2007, JAN 17, p. 266-267
Yang, Zhimou; Ho, Pak-Leung; Liang, Gaolin; Chow, Kin Hung; Wang, Qigang; Cao, Yang; Guo, Zhihong; Xu, Bing Article
A phenylalanine-rich signal is required for localization of the SARS coronavirus 3a protein to plasma membrane and its extracellular release
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong, CUHK, Hong Kong, O-61, 28 April 2007
Liu, Fuli; Zhong, Xiaofen; Wu, Jie; Yang, Yanzhen; Cheng, Chak-Sum Samuel; Xie, Yong; Guo, Zhihong Conference paper
Coordinative Effects of Macromolecular Crowding on the Two Functional Domains of Chorismate Mutase-Prephenate Dehydratase in the Bacterial Biosynthesis of Phenylalanine
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong, CUHK, Hong Kong, O-59, 28 April 2007
Zheng, Suilan; Jiang, Ming; Guo, Zu-Feng; Guo, Zhihong Conference paper
Determination of the Stereochemistry of 2-Succinyl-5-Enolpyruvyl-6- Hydroxy -3-Cyclohexene-1-Carboxylic Acid (SEPHCHC), a Key Intermediate in Menaquinone Biosynthesis.
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, Hong Kong, O-63, 28 April 2007
Jiang, Ming; Chen, Minjiao; Cao, Yang; Chen, Xiaolei; Yang, Yinhua; Sze, Kong Hung; Guo, Zhihong Conference paper
In Vivo Evidence for Interaction of the SARS Coronavirus 3a Protein with an Unknown Host Protein
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong,CUHK, Hong Kong, O-60, 28 April 2007
Liu, Fuli; Yang, Yanzhen; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Conference paper
Menaquinone Biosynthesis in Escherichia coli: Identification and Characterization of (1R, 6R)-2-Succinyl-6-Hydroxy-2,4- Cyclohexadiene-1-Carboxylate (SHCHC) Synthase
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong,CUHK, Hong Kong, O-62, 28 April 2007
Jiang, Ming; Guo, Zu-Feng; Chen, Xiaolei; Chen, Minjiao; Guo, Zhihong Conference paper
Menaquinone Biosynthesis in Escherichia coli: Identification of 2-Succinyl-5-Enolpyruvyl-6-Hydroxy-3-Cyclohexene-1-Carboxylate (SEPHCHC) as a Novel Intermediate and Re-evaluation of MenD Activity
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong,CUHK, Hong Kong, O-58, 28 April 2007
Jiang, Ming; Cao, Yang; Guo, Zu-Feng; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong Conference paper
2006 10
Amino terminus of the SARS coronavirus protein 3a elicits strong, potentially protective humoral responses in infected patients
Journal of general virology, v. 87, (Part 2), 2006, FEB, p. 369-374
Zhong, Xiaofen; Guo, Zufeng; Yang, Huanghao; Peng, Lisheng; Xie, Yong; Wong, Tinyau; Lai, Sikto; Guo, Zhihong Article
Fluorescent "light-up" bioprobes based on tetraphenylethylene derivatives with aggregation-induced emission characteristics
Chemical communications, (35), 2006, p. 3705-3707
Tong, Hui; Hong, Yuning; Dong, Yongqiang; Haeussler, Matthias; Lam, Jacky Wing Yip; Li, Zhen; Guo, Zufeng; Guo, Zhihong; Tang, Ben Zhong Article
Channeling of Isochorismate by a Dynamic Enzyme Complex in Escherichia coli Biosynthesis of Menaquinone
Thirteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-58
Jiang, Ming; Guo, Zu-Feng; Zheng, Suilan; Cao, Yang; Liu, Fuli; Guo, Zhihong Conference paper
Complete elucidation of the biosynthesis of menaquinone and utilization of the biosynthetic enzymes as targets for antibiotic development
2006 International Symposium on Chemical Biology and Combinatorial Chemistry, Shandong University, Jinan, China, IL-21, 28-30 December 2006
Jiang, Ming; Cao, Yang; Chen, Xiaolei; Chen, Minjiao; Guo, Zhihong Conference paper
Conjugation of Arginine Oligomers to Anti-cancer Drugs Sensitizes Multidrug Resistant Cancer Cells
Thirteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-92
Guo, Zu-Feng; Zhou, Ronghui; Guo, Zhihong Conference paper
Macromolecular Crowding Significantly Enhances the Intrinsic Catalytic Efficiency of Enterobactin-Specific Isochorismate Synthase
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-69
Jiang, Ming; Guo, Zhihong Conference paper
Protein 3a of SARS Coronavirus Interacts with an Unknown Human Host Protein, DKFZP434H132
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-91
Liu, Fuli; Yang, Yanzhen; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Conference paper
SARS Coronavirus Protein 3a Contains Distinct Targeting Signals for Localization to a Perinuclear Region and the Plasma Membrane
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-74
Zhong, Xiaofen; Liu, Fuli; Wu, Jie; Yang, Yanzhen; Cheng, Chak-Sum Samuel; Xie, Yong; Guo, Zhihong Conference paper
Sensing of Macromolecular Crowding by Fluorescence Resonance Energy Transfer between Two Variants of Green Fluorescent Protein
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-66
Guo, Zu-Feng; Lee, Kwok Pong; Guo, Zhihong Conference paper
Towards complete elucidation of the biosynthesis of menaquinone and its utilization as a drug target
The Fifth International Symposium for Chinese Medicinal Chemists. China Pharmaceutical University, Nanjing, China, IL-05, 2-7 November 2006
Jiang, Ming; Cao, Yang; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong Conference paper
2005 7
B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein
Journal of virology, v. 79, (6), 2005, MAR, p. 3401-3408
Zhong, Xiaofen; Yang, Huanghao; Guo, Zufeng; Sin, W.Y.F.; Chen, Wei; Xu, Junjie; Fu, Ling; Wu, Jie; Mak, Chun Kit Gannon; Cheng, Chak Sum Samuel; Yang, Yanzhen; Cao, Shuyong; Wong, Tinyau; Lai, Sikto; Xie, Yong; Guo, Zhihong Article
Macrolactonization catalyzed by the terminal thioesterase domain of the nonribosomal peptide synthetase responsible for lichenysin biosynthesis
Bioorganic & medicinal chemistry letters, v. 15, (10), 2005, MAY 16, p. 2595-2599
Cao, Shuyong; Yang, Yanzhen; Ng, Na Lee; Guo, Zhihong Article
A Preformed Conformation Guides the Thermal Head-to-tail Macrocyclization of an Unactivated Linear Peptide in Solid State
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-63
An, Linkun; Guo, Zhihong Conference paper
Amino Terminus of the SARS Coronavirus Protein 3a Elicited Protective Humoral Responses in Patients Who Had Recovered from SARS.
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-67
Zhong, Xiaofen; Guo, Zufeng; Yang, Huanghao; Peng, Lisheng; Xie, Yong; Wong, Tin-Yau; Lai, Sik-To; Guo, Zhihong Conference paper
Identification of Interactions between SARS ORF 3a and Human Host Proteins by a Yeast Two-Hybrid System
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-66
Yang, Yanzhen; Guo, Zhihong Conference paper
Macrolactonization Catalysed by the Terminal Thioesterase Domain of the Nonribosomal Peptide Synthetase Responsible for Lichenysin Biosynthesis
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-64
Cao, Shuyong; Yang, Yanzhen; Ng, Na Lee Joyce; Guo, Zhihong Conference paper
Solid-State Biomimetic Synthesis of Gramicidin S and Analogues
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-65
Liu, Zhao; An, Linkun; Guo, Zhihong Conference paper
2004 13
Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles
Journal of the American Chemical Society, v. 126, (32), 2004, AUG 18, p. 9938-9939
Xu, Chenjie; Xu, Keming; Gu, Hongwei; Zheng, Rongkun; Liu, Hui; Zhang, Xixiang; Guo, Zhihong; Xu, Bing Article
Facile solid-phase synthesis of cyclic decapeptide antibiotic streptocidins A-D
Tetrahedron letters, v. 45, (1), 2004, JAN 1, p. 217-220
Qin, Chuanguang; Zhong, Xiaofen; Ng, Na Lee; Bu, Xianzhang; Chan, Wing Sze; Guo, Zhihong Article
Nitrilotriacetic acid-modified magnetic nanoparticles as a general agent to bind histidine-tagged proteins
Journal of the American Chemical Society, v. 126, (11), 2004, MAR 24, p. 3392-3393
Xu, Chenjie; Xu, Keming; Gu, Hongwei; Zhong, Xiaofen; Guo, Zhihong; Zheng, Rongkun; Zhang, Xixiang; Xu, Bing Article
Optimization of antibacterial cyclic decapeptides
Journal of combinatorial chemistry, v. 6, (3), 2004, MAY-JUN, p. 398-406
Qin, Chuanguang; Bu, Xianzhang; Zhong, Xiaofen; Ng, Joice Na Lee; Guo, Zhihong Article
Synthesis and Cytotoxicity of Enediyne Prodrugs with 3-Hydroxy-4-(arylmethylidene)cyclodeca-1,5-diyne Scaffolds
Letters in Drug Design & Discovery, 1, 69-72
Dai, Wei-Min; Tachi, Yukihiro; Nishimoto, Sei-ichi; Zhong, Xiaofen; Guo, Zhihong Article
Synthesis of gramicidin S and its analogues via an on-resin macrolactamization assisted by a predisposed conformation of the linear precursors
Journal of organic chemistry, v. 69, (8), 2004, APR 16, p. 2681-2685
Bu, Xianzhang; Wu, Xiaoming; Ng, Na Lee Joyce; Mak, Chun Kit; Qin, Chuanguang; Guo, Zhihong Article
T-cell epitopes in Severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS
Journal of Virology, v. 78, (11), June 2004, p. 5612-5618
Wang, Yue Dan; Sin, Wan Yee; Xu, Guo-Bing; Yang, Huang Hua; Wong, Tin-yau; Pang, Xue-Wen; He, Xiao-Yan; Zhang, Hua-Gang; Ng, Joice Na Lee; Cheng, Chak-Sum Samuel; Yu, Jing; Meng, Li; Yang, Rui-Feng; Lai, Sikto; Guo, Zhi-Hong; Xie, Yong; Chen, Wei-Feng Article
A Novel Phage-Based Approach to Discovery of Immunogenic Peptides for Immunotherapy of Nasopharyngeal Carcinoma
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong
Wu, Jie; Yang, Huanghao; Chen, Yongxiong; To, Leo Y.F.; Zhong, Xiaofen; Ng, Na Lee; Bu, Xianzhang; Wong, Man-Kin; Yu, Wing-Yiu; Che, Chi-Ming; Lin, Chen-Lung; Guo, Zhihong Conference paper
Biofunctional nanomagnets: Synthesis and Applications
227th ACS National Meeting, Anaheim, United States, Mar.
Gu, Hongwei; Xu, Chenjie; Xu, Keming; Ho, P.L.; Zhong, X.; Guo, Zhihong; Xu, Bing Conference paper
Optimization of Cyclic Peptide Antibiotic Gramicidin S
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong
Ng, Na Lee; Wu, Xiaoming; Zhong, Xiaofen; Guo, Zhihong Conference paper
Optimizing natural cyclic peptides to counter microbial resistance
The Fourth Conference for Worldwide Young Chinese Chemists, Sichuan University, Chengdu, China, p134
Qin, Chuanguang; Bu, Xianzhang; Zhong, Xiaofen; Wu, Xiaoming; Ng, Na Lee Joyce; Guo, Zhihong Conference paper
Preorganization in cyclic peptide synthesis and its application to the optimization of natural antibacterial peptide products
The 8th Korean Peptide Symposim: Peptide science in post-genomic era, Korean Peptide Society, Seoul, South Korea., IL04
Guo, Zhihong Conference paper
Roles of Terminal Condensation Domain in Cyclosporine Biosynthesis
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong
Cao, Shuyong; Yang, Yanzhen; Zhong, Xiaofen; Yang, Huanghao; Guo, Zhihong Conference paper
2003 7
A chemical approach to generate molecular diversity based on the scaffold of cyclic decapeptide antibiotic tyrocidine A
Journal of combinatorial chemistry, v. 5, (4), 2003, JUL-AUG, p. 353-355
Qin, Chuanguang; Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong Article
Biomimetic synthesis of gramicidin S and analogues by enzymatic cyclization of linear precursors on solid support
Organic letters, v. 5, (10), 2003, MAY 15, p. 1749-1752
Wu, Xiaoming; Bu, Xianzhang; Wong, Ka Man; Yan, Weili; Guo, Zhihong Article
Dissociation of antibacterial and hemolytic activities of an amphipathic peptide antibiotic
Journal of medicinal chemistry, v. 46, (23), 2003, NOV 6, p. 4830-4833
Qin, Chuanguang; Zhong, Xiaofen; Bu, Xianzhang; Ng, Na Lee Joyce; Guo, Zhihong Article
The biosynthesis of GDP-L-colitose: C-3 deoxygenation is catalyzed by a unique coenzyme B6-dependent enzyme
Journal of the American Chemical Society, v. 125, (19), 2003, p. 5584-5585
Beyer, Noelle; Alam, Jenefer; Hallis, Tina M.; Guo, Zhihong; Liu, Hung-wen Article
Evolve Cyclic Peptide Antibiotics to Contain Microbial Resistance
Singapore International Chemical Conference III: Frontiers in Physical and Analytical Chemistry, Singapore, 15-17 December
Guo, Zhihong Conference paper
Exploring Pre-organized Conformation of the Linear Gramicidin Precursor for Biomimetic Synthesis of Cyclopeptide Libraries
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-51
Wu, Xiaoming; Mak, Chun Kit; Qin, Chuanguang; Guo, Zhihong Conference paper
Identification of Viral Epitopes for Immunoglobulins from SARS Patients
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong, 2004.
Zhong, Xiaofen; Yang, Huanghao; Guo, Zufeng; Wu, Jie; Yang, Yanzhen; Cao, Shuyong; Xie, Yong; Guo, Zhihong Conference paper
2002 19
An improved deblocking agent for direct Fmoc solid-phase synthesis of peptide thioesters
Tetrahedron letters, v. 43, (13), 2002, MAR 25, p. 2419-2422
Bu, Xianzhang; Xie, Guiyang; Law, Chi Wang; Guo, Zhihong Article
Substrate spectrum of tyrocidine thioesterase probed with randomized peptide N-acetylcysteamine thioesters
Bioorganic & medicinal chemistry letters, v. 12, (6), 2002, MAR 25, p. 989-992
Xie, Guiyang; Uttamchandani, Mahesh; Chen, Grace Y.J.; Bu, Xianzhang; Lin, San San; Wong, Ka Man; Yan, Weili; Yao, Shao Q.; Guo, Zhihong Article
Synthesis of tyrocidine A and its analogues by spontaneous cyclization in aqueous solution
Organic letters, v. 4, (17), 2002, AUG 22, p. 2893-2895
Bu, Xianzhang; Wu, Xiaoming; Xie, Guiyang; Guo, Zhihong Article
A Chemical Approach to Engineering of the Cyclic Decapeptide Antibiotic Tyrocidine A
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-48
Qin, Chuanguang; Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong Conference paper
A modified Fmoc method for direct solid-state synthesis of peptide thioesters and its application to total synthesis of Tyrocidine A
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, o-53
Bu, Xianzhang; Xie, Guiyang; Wang, Chi Wang; Guo, Zhihong Conference paper
A-beta amyloidosis inhibitors from traditional Chinese medicines
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, O-58
Peng, Tuohua; Wong, Ka Man; Guo, Zhihong Conference paper
Biomimetic Combinatorial Synthesis of Cyclic Peptide Libraries for Drug Discovery
Frontiers in Biomedical Research, The University of Hong Kong, 6 December, p. 85
Guo, Zhihong Conference paper
Biomimetic Combinatorial Synthesis of Cyclic Peptide Libraries for Drug Discovery
Third International Symposium for Chinese Medicinal Chemists, Hong Kong, China, December 28-31, OP-8
Guo, Zhihong Conference paper
Combinatorial Synthesis and Screening of a Cyclopeptide Library based on the Tyrocidine Scaffold
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-50
Qin, Chuanguang; Bu, Xianzhang; Zhong, Xiaofen; Guo, Zhihong Conference paper
Oligomeric intermediates in amyloid-beta peptides fibrillogenesis arrested by N-terminal fusion are not neurotoxic
Ninth symposium on chemistry postgraduate research in Hong Kong, Book of Abstracts, O-57
Wei, Jianwen; Yan, Weili; Wong, Kan Man; Bu, Xianzhang; Lai, Lo Ming; Ng, Na Lee; Xie, Guiyang; Guo, Zhihong Conference paper
Parallel Solid-phase Synthesis of Streptocidins A~D through Spontaneous Self-cyclization of Their Linear Precursors
Third International Symposium for Chinese Medicinal Chemists, pp. 57
Qin, Chuanguang; Chan, Wing Sze; Guo, Zhihong Conference paper
Parallel synthesis of Tyrocidine A analogues through spontaneous cyclization of peptide thioesters
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, o-55
Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong Conference paper
Synthesis of Gramicidin S Analogues: Chemical versus Chemoenzymatic Approach
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-46
Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong Conference paper
Synthesis of Gramicidin S by Conformation-dependent Cyclization of Its Linear Biosynthetic Precursor
Third International Symposium for Chinese Medicinal Chemists, pp. 59
Wu, Xiaoming; Mak, Chun Kit; Bu, Xianzhang; So, Sau Man; Guo, Zhihong Conference paper
Synthesis, characterization, and screening of positional scanning cyclopeptide libraries based on Tyrocidine scaffold
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, O-56
Xie, Guiyang; Uttamchandani, Mahesh; Chen, Grace Y.J.; Bu, Xianzhang; Lin, San San; Wong, Ka Man; Yan, Weili; Wei, Jianwen; Yao, Shao Q.; Guo, Zhihong Conference paper
Traceless Biomimetic Synthesis of Tyrocidines
Third International Symposium for Chinese Medicinal Chemists, pp. 56
Qin, Chuanguang; Chan, Wing Sze; Wu, Xiaoming; Guo, Zhihong Conference paper
Traceless Solid-phase Synthesis of Streptocidins
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-47
Qin, Chuanguang; Chan, Wing Sze; Guo, Zhihong Conference paper
Utilization of a substrate intramolecular hydrogen bond in catalysis by enterobactin thioesterase
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, O-54
Xie, Guiyang; Wu, Xiaoming; Wong, Kan Man; Yan, Weili; Ng, Na Lee; Guo, Zhihong Conference paper
Utilization of Thioesterase from Non-ribosomal Peptide Synthase in Biomimetic Synthesis of Gramicidin S
Third International Symposium for Chinese Medicinal Chemists, pp. 58
Wu, Xiaoming; Mak, Chun Kit; So, Sauman; Guo, Zhihong Conference paper
2001 3
Insights into the branched-chain formation of mycarose: Methylation catalyzed by an (S)-adenosylmethionine-dependent methyltransferase
Angewandte Chemie (International ed.), v. 40, (3), 2001, p. 607-610
Chen, Huawei; Zhao, Zongbao; Hallis, Tina M.; Guo, Zhihong; Liu, Hung-wen Article
Phage display: A powerful tool in biomedical research
Frontiers of Biotechnology & Pharmaceuticals / Edited by Huang, Z., Guo, M., Reiner, J., Zhao, K.. Beijing. Science Press, v. 2, 2001, p. 32–58
Guo, Zhihong Book chapter
Recent Development on novel ZnS-based UV detectors
The proceedings of the Symposium on recent advances in photonics technology, 6 December, Hong Kong, sou-1-4
Sou, I.K.; Wu, Marcus C.W.; Lai, L.S.; Guo, Z.; Wong, G.K.L. Conference paper
2000 1
Designing small-molecule switches for protein-protein interactions
Science, v. 288, (5473), 2000, p. 2042-2045
Guo, Z.; Zhou, D.; Schultz, P.G. Article
1999 1
Biosynthesis of mycarose: Isolation and characterization of enzymes involved in the C-2 deoxygenation
Journal of the American Chemical Society, v. 121, (35), September 1999, p. 8124-8125
Chen, Huawei; Agnihotri, Gautam; Guo, Zhihong; Que, Nanette L.S.; Chen, Xuemei H.; Liu, Hung-wen Article
1998 2
Biosynthesis of yersiniose: Attachment of the two-carbon branched-chain is catalyzed by a thiamine pyrophosphate-dependent flavoprotein
Journal of the American Chemical Society, v. 120, (45), November 1998, p. 11796-11797
Chen, Huawei; Guo, Zhihong; Liu, Hung-wen Article
Expression, purification, and characterization of TyIM1, an N,N-dimethyltransferase involved in the biosynthesis of mycaminose
Journal of the American Chemical Society, v. 120, (38), September 1998, p. 9951-9952
Chen, Huawei; Guo, Zhihong; Liu, Hung-wen Article
1996 2
Mechanistic studies of the inactivation of crotonase by (methylenecyclopropyl)formyl-CoA
Journal of the American Chemical Society, v. 118, (1), January 1996, p. 275-276
Li, Ding; Guo, Zhihong; Liu, Hung-wen Article
Synthesis and phase-transition of 4-alkoxycarbonylphenyl 4'-n-alkoxy-2,3,5,6-tetrafluorobiphenyl-4-carboxylates
Molecular crystals and liquid crystals science and technology. Section A, Molecular crystals and liquid crystals, v. 275, 1996, p. 27-36
Wen, J.; Tian, M.; Guo, Z.; Chen, Q. Article
1995 1
Mechanistic studies of the biosynthesis of 3,6-dideoxy sugars: Stereochemical analysis of C-3 deoxygenation
Journal of the American Chemical Society, v. 117, (18), May 1995, p. 5158-5159
Pieper, Pieper A.; Guo, Zhifong; Liu, Hung-wen Article
1994 1
Novel fluorinated liquid crystals. Part 9. Synthesis and memomorphic properties of 4-(alkoxycarbonyl) phenyl 4-[(4-alkoxy-2,3,5,6-tetrafluorophenyl)ethynyl]benzoates
J. Mater. Chem., v. 4, 1994, p. 327–330
Wen, J.; Tian, M.; Yu, H.; Guo, Zhihong; Chen, Q. Article
Article 1
Listeria monocytogenes MenI Encodes a DHNA-CoA thioesterase necessary for menaquinone biosynthesis, cytosolic survival, and virulence
Infection and Immunity, v. 89, (5), May 2021, article number e00792-20
Smith, Hans B.; Li, Tin Lok; Liao, Man Kit; Chen, Grischa Y.; Guo, Zhihong; Sauer, John-Demian
Article 1
Substrate recognition and catalytic mechanism of the phosphate acyltransferase PlsX from Bacillus subtilis
ChemBioChem, v. 21, 2020
Jiang, Yiping; Qin, Mingming; Guo, Zhihong
Article 1
Identification of an amphipathic peptide sensor of the Bacillus subtilis fluid membrane microdomains
Communications Biology, v. 2, (1), August 2019, article number 316
Jiang, Yiping; Dai, Xin; Qin, Mingming; Guo, Zhihong
Conference paper 4
Biochemical and structural characterization of CGI-58
The 26th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 4 May 2019
Ha, Thi Thuy Hoa; Shi, Jie; Guo, Zhihong
Identification of an amphipathic peptide sensor of the fluid membrane microdomains in Bacillus subtilis
The 26th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 4 May 2019
Jiang, Yiping; Dai, Xin; Qin, Mingming; Guo, Zhihong
Mechanism-based inhibition of the essential thiamine-dependent enzyme of the vitamin K2 biosynthesis
The 26th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 4 May 2019
Li, Tin Lok; Guo, Zhihong
Structural and kinetic investigation of the thiamine-dependent MenD from the Escherichia coli menaquinone biosynthetic pathway
The 26th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 4 May 2019
Qin, Mingming; Song, Haigang; Guo, Zhihong
Article 2
Single-Turnover Kinetics Reveal a Distinct Mode of Thiamine Diphosphate-Dependent Catalysis in VitaminK Biosynthesis
ChemBioChem, v. 19, (14), July 2018, p. 1514-1522
Qin, Mingming; Song, Haigang; Dai, Xin; Chan, Chi Kong; Chan, Wan; Guo, Zhihong
Two Active Site Arginines Are Critical Determinants of Substrate Binding and Catalysis in MenD: A Thiamine-dependent Enzyme in Menaquinone Biosynthesis
Biochemical Journal, v. 475, (22), November 2018, p. 3651-3667
Qin, Mingming; Song, Haigang; Dai, Xin; Chen, Yaozong; Guo, Zhihong
Conference paper 5
Development of inhibitors against the alternate active site of the thiamine-dependent enzyme in menaquinone biosynthesis
The 25th Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong University of Science and Technology, Hong Kong, 28 April 2018
Li, Tin Lok; Qin, Mingming; Guo, Zhihong
Lipid-associated nonfibrillar α-helical oligomers of α-synuclein by unsaturated fatty acid sensing in vitro
The 25th Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong University of Science and Technology, Hong Kong, 28 April 2018
Dai, Xin; Chen, Xiaolei; Sun, Yueru; Zheng, Qingbing; Li, Shaowei; Guo, Zhihong
Structural and mechanistic investigation of the monotopic membrane localization of the methyltransferase UbiE in quinone biosynthesis
The 25th Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong University of Science and Technology, Hong Kong, 28 April 2018
Ha, Thi Thuy Hoa; Jiang, Yiping; Guo, Zhihong
Structural basis for peripheral sensing of the membrane regions of increased fluidity
The 25th Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong University of Science and Technology, 28 April 2018
Jiang, Yiping; Dai, Xin; Guo, Zhihong
Structure and membrane interaction of the lipid II synthase MurG in Bacillus subtilis
The 25th Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong University of Science and Technology, Hong Kong, 28 April 2018
Qin, Mingming; Guo, Zhihong
Article 2
Crystal Structure of the Thioesterification Conformation of Bacillus Subtilis O-succinylbenzoyl-CoA Synthetase Reveals a Distinct Substrate-binding Mode
Journal of Biological Chemistry, v. 292, (29), July 2017, p. 12296-12310
Chen, Yaozong; Li, Tin Lok; Lin, Xingbang; Li, Xin; Li, Xiang David; Guo, Zhihong
Facile Formation of a Microporous Chitosan Hydrogel Based on Self-crosslinking
Journal of Materials Chemistry B, v. 5, (47), December 2017, p. 9291-9299
Chen, Yin; Huang, Lu; Dai, Xin; Tian, Qian; Yu, Miao; Agheb, Maria; Chan, Ho Nam; Poon, ellen; Guo, Zhihong; Boheler,kenneth richard; Wu, Hongkai
Conference paper 14
A new mode of thiamine disphosphate-dependent catalysis in vitamin K biosynthesis
International Symposium on Bioorganic Chemistry (ISBOC-11) Konstanz Symposium Chemical Biology, University of Konstanz, Konstanz, Germany, 27-29 September 2017
Song, Haigang; Qin, Mingming; Chen, Dong; Dai, Xin; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Wan; Guo, Zhihong
Conformational intermediates in the domain-alteration catalysis of an adenylating enzyme in vitamin K biosynthesis
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, Hong Kong, May, 2017
Guo, Zhihong; Chen, Yaozong; Sun, Yueru; Song, Haigang; Jiang, Yiping; Li, Tin Lok
Generality of the novel thiamine-dependent catalysis medicated by an active tetrahedral intermediate in menaquinone biosynthesis
The Fifth South China Symposium of Structural Biology (SCSBS2017) 第五届华南结构生物学论坛会议, Fuzhou University, Fuzhou, Fujian, China, 24-26 November 2017
Li, Tin Lok; Qin, Mingming; Song, Haigang; Guo, Zhihong
Investigation on the interaction between acyl-ACP and Bacillus subtilus PlsX from glycerophospholipid biosynthetic pathway
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Li, Tin Lok; Jiang, Yiping
Mechanism of thiocarboxylate formation in thiosugar biosynthesis revealed by the MoeZ-SCP complex
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Qin, Xiaoyu; Dai, Xin; Liu, Hung-wen
Mechanistic investigation on the thiocarboxylate formation in thiosugar biosynthesis
The Fifth South China Symposium of Structural Biology (SCSBS2017) 第五届华南结构生物学论坛会议, Fuzhou University, Fuzhou, Fujian, China., 24-26 November 2017
Qin, Xiaoyu; Dai, Xin; Liu, hung-wen; Guo, Zhihong
Overcoming the solubility limit of recombinant protein with chaperone co-expression to produce high soluble yield of Arabidopsis CGI-58
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Ha, Thi Thuy Hoa; Shi, Jie
Role of two conserved arginine residues in the new thiamine catalysis mediated by a tetrahedral intermediate in menaquinone biosynthesis
The Fifth South China Symposium of Structural Biology (SCSBS2017) 第五届华南结构生物学论坛会议, Fuzhou University, China, 24-26 November 2017
Qin, Mingming; Song, Haigang; Guo, Zhihong
Structural and mechanistic investigation of the UbiE monotopic membrane localization in coenzyme Q and vitamin K biosynthesis
The Fifth South China Symposium of Structural Biology (SCSBS2017) 第五届华南结构生物学论坛会议, Fuzhou University, Fuzhou, Fujian, China, 24-26 November 2017
Ha, Thi Thuy Hoa; Jiang, Yiping; Guo, Zhihong
Structural basis for peripheral sensing of membrane regions of increased fluidity
2017年华南结构生物学论坛 South China Symposium of Structural Biology, 福州, 中国, 24 - 26 November 2017
Jiang, Yiping; Dai, Xin; Guo, Zhihong
Structural basis of the membrane association of phosphate acyltransferase PlsX
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Jiang, Yiping
Structural determinants for the formation of the tetrahedral intermediate in the thiamine-dependent catalysis of Escherichia coli MenD from the menaquinone biosynthetic pathway
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Qin, Mingming; Song, haigang
Two-staged interaction of α-synuclein with unsaturated fatty acids
The 24th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 6 May 2017
Guo, Zhihong; Dai, Xin; Cheung, Shuk Wa; Mak, Kar Kei
α-Synuclein senses unsaturated fatty acid in vitro to form lipid-associated nonfibrillar α-helical oligomers
The Fifth South China Symposium of Structural Biology (SCSBS2017) 第五届华南结构生物学论坛会议, Fuzhou University, Fuzhou, Fujian, China, 24-26 November 2017
Dai, Xin; Chen, xiaolei; Sun, Yueru; Zheng, qingbing; Li, shaowei; Guo, Zhihong
Article 4
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition
Autophagy, v. 12, (8), August 2016, p. 1372-1389
Song, Juxian; Sun, Yueru; Peluso, Ivana; Zeng, Yu; Yu, Xing; Lu, Jiahong; Xu, Zheng; Wang, Mingzhong; Liu, Liangfeng; Huang, Yingyu; Chen, Leilei; Durairajan, Siva Sundara Kumar Kumar; Zhang, Hongjie; Zhou, Bo; Zhang, Hongqi; Lu, Aiping; Ballabio, Andrea; Medina, Diego Luis; Guo, Zhihong; Li, Min
A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis
Journal of the American Chemical Society, v. 138, (23), June 2016, p. 7244-7247
Song, Haigang; Dong, Chen; Qin, Mingming; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Simon Wan; Guo, Zhihong
An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus Influenzae
Biochemistry, v. 55, (48), December 2016, p. 6705-6717
Shi, Jie; Cao, Xinyun; Chen, Yaozong; Cronan, John E.; Guo, Zhihong
Mechanistic Insights from the Crystal Structure of Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase Complexed with the Adenylate Intermediate
Biochemistry, v. 55, (48), December 2016, p. 6685-6695
Chen, Yaozong; Jiang, Yiping; Guo, Zhihong
Conference paper 10
Conformational intermediates in the domain-alteration catalysis of an adenylating enzyme in vitamin K biosynthesis
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Li, Tin Lok; Jiang, Yiping; Chen, Yaozong; Guo, Zhihong; Song, Haigang; Sun, Yueru
Mechanism of thiocarboxylate formation in thiosugar biosynthesis revealed by the MoeZ-SCP complex
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Qin, Xiaoyu; Dai, Xin; Guo, Zhihong; Liu, Hung-wen
Mechanistic investigation of the MoeZ-catalyzed thiocarboxylate formation in thiosugar biosynthesis
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23 April 2016
Dai, Xin; Liu, Hung-wen; Guo, Zhihong
Structural and kinetic investigation of the thiamine-dependent MenD from the Escherichia coli menaquinone biosynthetic pathway
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Qin, Mingming; Guo, Zhihong; Song, Haigang
Structural and kinetic investigation of the thiamine-dependent MenD from the menaquinone biosynthetic pathway in Escherichia coli
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23 April 2016
Qin, Mingming; Song, Haigang; Guo, Zhihong
Structural and mechanistic investigation of the membrane associated phosphate acyltransferase PlsX
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Jiang, Yiping; Guo, Zhihong
Structural basis of substrate recognition of Bacillus subtilis BioF in biotin biosynthesis
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Shi, Jie; Guo, Zhihong
Structural characterization of H. influenzae BioG reveals a conserved active site within a novel three-layered of α/β hydrolase fold
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23 April 2016
Shi, Jie; Guo, Zhihong
Structural elucidation and biochemical investigation of multi-functional states of Bacillus subtilis o-succinylbenzoyl-CoA synthetase
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23th April 2016
Chen, Yaozong; Sun, Yueru; Song, Haigang; Guo, Zhihong
Structural Evdience for Negative Cooperativity in Substrate Binding of Hexameric Staphylococcus aureus 1,4-Dihydroxy-2-Naphthoyl-CoA Synthase
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, 15 April 2015
Jiang, Yiping; Chen, Yaozong; Guo, Zhihong
Article 4
A Universal and Facile Approach for the Formation of a Protein Hydrogel for 3D Cell Encapsulation
Advanced Functional Materials, v. 25, (39), October 2015, p. 6189-6198
Chen, Yin; Dai, Xin; Huang, Lu; Sun, Yang; Chan, Ho Nam; Shen, Bo; Zeng, Xiaoqian; Wu, Zhenguo; Hsing, I-Ming; Guo, Zhihong; Wu, Hongkai
Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora
ChemBioChem, v. 16, (1), 2015, p. 100-109
Song, Haigang; Xu, Ri; Guo, Zhihong
Microsecond Protein Folding Events Revealed by Time-Resolved Fluorescence Resonance Energy Transfer in a Microfluidic Mixer
Analytical Chemistry, v. 87, (11), June 2015, p. 5589-5595
Jiang, Liguo; Zeng, Yan; Sun, Qiqi; Sun, Yueru; Guo, Zhihong; Qu, Jianan; Yao, Shuhuai
Structural basis for the atp-dependent configuration of adenylation active site in bacillus subtilis o-succinylbenzoyl-coa synthetase
Journal of Biological Chemistry, v. 290, (39), September 2015, p. 23971-23983
Chen, Yaozong; Sun, Yueru; Song, Haigang; Guo, Zhihong
Conference paper 9
Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong
Observation of an unusual intermediate in SEPHCHC synthase (MenD) in the biosynthesis of menaquinone
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 18 April 2015
Song, Haigang; Dong, Chen; Guo, Zhihong
Structural and kinetic evidence of a large conformational movement in formation of the first Michaelis complex of o-succinylbenzoyl-CoA synthetase.
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Chen, Yaozong; Guo, Zhihong
Structural and mechanistic investigation of the transmembrane sn-glycerol-3-phosphate acyltransferase PlsY from Escherichia coli
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Jiang, Yiping; Guo, Zhihong
Structural basis for the ATP-dependent configuration of adenylation active site in Bacillus subtilis o-succinylbenzoyl-CoA synthetase
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Chen, Yaozong; Sun, Yueru; Song, Haigang; Guo, Zhihong
Structural characterization of a small basic protein: the human G0/G1 switch gene 2 protein (hG0S2)
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 18 April 2015
Shi, Jie; Guo, Zhihong
Structural investigation of an atypical acyl-CoA synthase involved in biotin synthesis of Bacillus subtilis
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Shi, Jie; Guo, Zhihong
Structural investigation of the 'hot dog' folded thioesterase YbaW
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Dai, Xin; Guo, Zhihong
Structure of the Escherichia coli hotdog thioesterase YbaW
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Dai, Xin; Guo, Zhihong
Article 5
A comparison of the diet and fine-scale distribution of sympatric Tibetan and red foxes in Qinghai, PR China
Wildlife Biology, v. 20, (6), December 2014, p. 356-361
Tsukada, Hideharu; Li, Wei; Duo, Hong; Guo, Zhihong; Fu, Yong; Peng, Mao; Shen, Xiuying; Jing, Jianwu; Yuan, Aishan; Ni, Ma; He, Shengde; Huang, Fu Qiang; Feng, Kai; Ishikawa, Keisuke; Kobayashi, Ikuo; Shinohara, Akio; Nonaka, Nariaki
Cascade Biocatalysis by Multienzyme-Nanoparticle Assemblies
Bioconjugate Chemistry, v. 25, (8), August 2014, p. 1387-1394
Kang, Wei; Liu, Jiahui; Wang, Jianpeng; Nie, Yunyu; Guo, Zhihong; Xia, Jiang
Discovery of Pentacyclic Triterpenoids as Potential Entry Inhibitors of Influenza Viruses
Journal of Medicinal Chemistry, v. 57, (23), December 2014, p. 10058-10071
Yu, Maorong; Si, Longlong; Wang, Yufei; Wu, Yiming; Yu, Fei; Jiao, Pingxuan; Shi, Yongying; Wang, Han; Xiao, Sulong; Fu, Ge; Tian, Ke; Wang, Yitao; Guo, Zhihong; Ye, Xinshan; Zhang, Lihe; Zhou, Demin
Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues
Acta Crystallographica Section D: Biological Crystallography, v. 70, (11), November 2014, p. 2959-2969
Song, Haigang; Sung, Hoi Pang; Tse, Yuk Sing; Jiang, Ming; Guo, Zhihong
Molecular basis of the general base catalysis of an α/β- hydrolase catalytic triad
Journal of Biological Chemistry, v. 289, (22), May 2014, p. 15867-15879
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong
Conference paper 13
Beta-Synuclein forms various alpha-helix and alpha-pleated sheet structures with different unsaturated fatty acids
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Shi, Jie; Guo, Zhihong
Characterization of the alpha-helical oligomer of alpha-synuclein formed in the presence of oleic acid
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Dai, Xin; Chen, Xiaolei; Wong, Chun Wa; Guo, Zhihong
Crystal structures of the type II M. tuberculosis MenB support a unified induced-fit catalytic mechanism for the crotonase fold enzyme family
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Song, Haigang; Tse, Yuk Sing; Sung, Hoi Pang; Guo, Zhihong
Ligand-dependent active site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogs
The Third Asian Chemical Biology Conference, National University of Singapore, Singapore, 14-17 December 2014
Song, Haigang; Sung, Hoi Pang; Tse, Yuk Sing; Jiang, Ming; Guo, Zhihong
Molecular Basis of the General Base Catalysis of an α/β-Hydrolase Catalytic Triad
The 2nd South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong
Observation of an Unusual Tetrahedral Intermediate in SEPHCHC Synthase (MenD) in the Biosynthesis of Menaquinone
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Song, Haigang; Dong, Chen; Guo, Zhihong
Structural and catalytic roles of the NC-loop of the α/β-hydrolase MenH
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Xu, Zheng; Sun, Yueru; Guo, Zhihong
Structural and kinetic characterization of a large conformational movement in the two-step catalysis of o-succinylbenzoyl-CoA synthetase
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Chen, Yaozong; Guo, Zhihong
Structural and Kinetic Evidence of A Large Conformational Movement in Formation of the First Michaelis Complex of O-Succinylbenzoyl-CoA Synthetase
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Chen, Yaozong; Guo, Zhihong
Structural and pre-steady state kinetic study of the ligand recognition mechanism of a noncanonical α/β-hydrolase fold enzyme MenH
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Sun, Yueru; Guo, Zhihong
Structural Evdience for Negative Cooperativity in Substrate Binding of Hexameric Staphylococcus aureus 1,4-Dihydroxy-2-Naphthoyl-CoA Synthase
The Second South China Structural Biology Symposium 华南结构生物学论坛, 福州, 5 - 7 December 2014
Jiang, Yiping; Chen, Yaozong; Guo, Zhihong
Structure of the Escherichia coli Hotdog Thioesterase Ybaw
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Dai, Xin; Guo, Zhihong
α/β Hydrolase fold enzymes exhibit both open and closed conformations: a case study with BioH
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Shi, Jie; Guo, Zhihong
Article 4
Crystal Structures of E. coli Native MenH and Two Active Site Mutants
PLoS ONE, v. 8, (4), April 2013, article number e61325
Johnston, Jodie M.; Jiang, Ming; Guo, Zhihong; Baker, Edward N.
Identification of a Hotdog Fold Thioesterase Involved in the Biosynthesis of Menaquinone in Escherichia coli
Journal of Bacteriology, v. 195, (12), 2013, p. 2768-2775
Chen, Minjiao; Ma, Xinyu; Chen, Xiaolei; Jiang, Ming; Song, Haigang; Guo, Zhihong
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase from the crotonase fold superfamily
PLoS ONE, v. 8, (4), April 2013, article number e63095
Sun, Yueru; Song, Haigang; Li, Jie; Li, Yan; Jiang, Ming; Zhou, Jiahai; Guo, Zhihong
The thiamine-dependent enzyme of the vitamin K biosynthesis catalyzes reductive C-N bond ligation between nitroarenes and alpha-ketoacids
SCIENCE CHINA Chemistry, v. 56, (3), March 2013, p. 312-320
Chen, Minjiao; Jiang, Ming; Guo, ZhiHong
Conference paper 1
Molecular Basis of the General Base Catalysis of an α/β-hydrolase Catalytic Triad
The 12th Meeting of the Asian Crystallographic Association, Hong Kong, 7-10 December 2013
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Guo, Zhihong
Article 3
Active Site Binding and Catalytic Role of Bicarbonate in 1,4-Dihydroxy-2-naphthoyl Coenzyme A Synthases from Vitamin K Biosynthetic Pathways
Biochemistry, v. 51, (22), June 2012, p. 4580-4589
Sun, Yueru; Song, Haigang; Li, Jie; Jiang, Ming; Li, Yan; Zhou, Jiahai; Guo, Zhihong
Characterization of 1,4-dihydroxy-2-naphthoyl-coenzyme A synthase (MenB) in phylloquinone biosynthesis of Synechocystis sp. PCC 6803
SCIENCE CHINA Chemistry, v. 55, (1), 2012, p. 98-105
Song, Haigang; Guo, Zhihong
Interactions between Artemisinins and other Antimalarial Drugs in Relation to the Cofactor Model-A Unifying Proposal for Drug Action
ChemMedChem, v. 7, (12), December 2012, p. 2204-2226
Haynes, Richard K.; Cheu, Kwan-Wing; Chan, Ho-Wai; Wong, Ho-Ning; Li, Ka-Yan; Tang, Maggie Mei-Ki; Chen, Min-Jiao; Guo, Zu-Feng; Guo, Zhi-Hong; Sinniah, Kumar; Witte, Amanda B.; Coghi, Paolo; Monti, Diego
Conference paper 9
Alpha-Synuclein forms an oligomeric alpha-helical structure in the presence of unsaturated fatty acids.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013, O-56
Dai, Xin; Chen, Xiaolei; Wong, Chung Wa; Guo, Zhihong
Crowding effect on calmodulin bakcbone dynamics
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Feng, Yitao; Liu, Changdong; Wu, Qinglin; Zhu, Guang; Guo, Zhihong
Crystal structure of E. coli (1R, 6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (MenH) and its product complex.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Sun, Yueru; Yin, Shuhui; Li, Jie; Zhou, Jiahai; Guo, Zhihong
Differentiation of solvation effect and macromolecular crowding effect
The Second Asian Chemical Biology Conference, Itoman, Okinawa, Japan, 4-6 July 2012
Guo, Zhihong
Discovery and characterization of an L-methionine gamma-lyase involved in Calicheamicin biosynthesis.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27, Apr, 2013, p. 111
Song, Haigang; Xu, Ri; Guo, Zhihong
Investigation of the abnormal electrophoretic behavior of the hotdog thioesterase YbaW.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Ma, Xingyu; Chen, Xiaolei; Guo, Zhihong
Structural and kinetic characterization of o-succinylbenzoyl-CoA synthetase in the menaquinone biosynthesis of Escherichia coli.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013, O-55
Chen, Yaozong; Guo, Zhihong
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase of the crotonase fold superfamily
第四届中国结构生物学学术讨论会, 中国重庆, 31 Mar-3 Apr 2013
Sun, Yueru; Song, Haigang; Li, Jie; Li, Yan; Jiang, Ming; Zhou, Jiahai; Guo, Zhihong
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase of the crotonase fold superfamily
The 7th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-7), Nanyang Technological University, Singapore, December 11-14 2012
Sun, Yueru; Song, Haigang; Li, Jie; Li, Yan; Jiang, Ming; Zhou, Jiahai; Guo, Zhihong
Article 3
A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine
ChemMedChem, v. 6, (9), September 2011, p. 1603-1615
Haynes, Richard K.; Cheu, Kwan-Wing; Li, Ka-Yan; Tang, Maggie Mei-Ki; Wong, Ho-Ning; Chen, Min-Jiao; Guo, Zu-Feng; Guo, Zhi-Hong; Coghi, Paolo; Monti, Diego
Reactions of Antimalarial Peroxides with Each of Leucomethylene Blue and Dihydroflavins: Flavin Reductase and the Cofactor Model Exemplified
ChemMedChem, v. 6, (2), 2011, p. 279-291
Haynes, Richard Kingston; Cheu, Kwan-Wing; Tang, Maggie Mei-Ki; Chen, Min-Jiao; Guo, Zu-Feng; Guo, Zhi-Hong; Coghi, Paolo; Monti, Diego
Stabilization of the Second Oxyanion Intermediate by 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase of the Menaquinone Pathway: Spectroscopic Evidence of the Involvement of a Conserved Aspartic Acid
Biochemistry, v. 50, (26), July 2011, p. 5893-5904
Chen, Minjiao; Jiang, Ming; Sun, Yueru; Guo, Zu-Feng; Guo, Zhihong
Conference paper 9
A general synthesis of 6-substituted 5,6-dihydro-4-hydroxy-2H- pyran-2-ones and NMR studies in different solvents
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-45
Li, Huoming; Wang, Yuan; Chen, Xiaolei; Guo, Zhihong; Dai, Wei-Min
Characterization of 1,4-dihydroxy-2-naphthoyl-CoA synthase in the phylloquinone biosynthesis of Synechocystis
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, 30 April 2011, City University of Hong Kong, 30 April 2011,The Abstract Book, O-51
Song, Haigang; Guo, Zhihong
Characterization of the non-heme catalase activity of an α/β fold protein from Mycobacterium tuberculosis
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-52
Sun, Yueru; Wu, Wenzhan; Li, Xiao-Yuan; Johnston, Jodie M.; Baker, Edward N.; Guo, Zhihong
Characterization of the type II hot-dog thioesterase in biosynthesis of the nine-membered enediyne core of C-1027
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-50
Keung, Bowie P.Y.; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong
Effects of macromolecular crowding on selected protein systems
2011 Telluride Workshop on Macromolecular Crowding, Telluride Science Research Center, Telluride, Colorado, the United States of America, 20-24 June 2011
Guo, Zhihong
Identification of active site residues involved in the second oxyanion hole in the catalysis of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB)
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-47
Chen, Minjiao; Jiang, Ming; Guo, Zhihong
New Products for the Iterative Enediyne Core Polyketide Synthase
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011, The Abstract Book, O-53
Xu, Ri; Chen, Xiaolei; Feng, Yitao; Song, Haigang; Guo, Zhihong
Production of a nonaketide by the iterative ten-membered enediyne core polyketide synthase in biosynthesis of calicheamicin
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-49
Feng, Yitao; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong
Recognition of the acyl carrier protein by the phosphopanteheinyl transferase domain of the enediyne polykeide synthase SgcE
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-48
Chen, Xiaolei; Guo, Zhihong
Article 5
A Bicarbonate Cofactor Modulates 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase in Menaquinone Biosynthesis of Escherichia coli
Journal of biological chemistry, v. 285, (39), 2010, SEP 24, p. 30159-30169
Jiang, Ming; Chen, Minjiao; Guo, Zu-Feng; Guo, Zhihong
Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027
Angewandte Chemie - International Edition, v. 49, (43), 2010, p. 7926-7928
Chen, Xiaolei; Guo, Zu-Feng; Lai, Pok Man; Sze, Kong Hung; Guo, Zhihong
Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis
ACTA crystallographica Section d-biological Crystallography, v. 66, (Part 8), 2010, AUG, p. 909-917
Johnston, Jodie M.; Jiang, Ming; Guo, Zhihong; Baker, Edward N.
Structural change of the enterobactin synthetase in crowded solution and its relation to crowding-enhanced product specificity in nonribosomal enterobactin biosynthesis
Bioorganic & medicinal chemistry letters, v. 20, (13), 2010, JUL 1, p. 3855-3858
Guo, Zu-Feng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong
Structure and Reactivity of Bacillus subtilis MenD Catalyzing the First Committed Step in Menaquinone Biosynthesis
Journal of Molecular Biology, v. 401, (2), 2010, AUG 13, p. 253-264
Dawson, Alice; Chen, Minjiao; Fyfe, Paul K.; Guo, Zhihong; Hunter, William N.
Conference paper 8
Bicarbonate dependence in vitamin K biosynthesis
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-59
Jiang, Ming; Chen, Minjiao; Guo, Zu-Feng; Guo, Zhihong
Characterization of a nonaketide precursor in biosynthesis of the nine-membered enediyne core of the antitumor antibiotic C-1027
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-57
Chen, Xiaolei; Guo, Zu-Feng; Lai, Pok Man; Sze, Kung Hung; Guo, Zhihong
Characterization of a type II hot-dog thioesterase in Calicheamicin biosynthesis
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-57
Keung, Po Yee; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong
Chemoenzymatic synthesis of N-hydroxyamides from nitro- or nitroso- compounds using a thiamine-dependent enzyme from the menaquinone biosynthetic pathway
The 5th International Conference on Cutting-Edge Organic Chemistry in Asia, Hsinchu, Taiwan, Nov. 7 - Nov. 11, PB-60, Abstract Book of The 5th International Conference on Cutting-Edge Organic Chemistry in Asia, 2010
Chen, Minjiao; Jiang, Ming; Guo, Zhihong
Evidence for a new precursor in the biosynthesis of the ten-membered enediyne antitumor antibiotic Calicheamicin
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-61
Feng, Yitao; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong
New insights into the catalytic mechanism of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) gained from the deuterium exchange of its substrate analogs
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-66
Chen, Minjiao; Jiang, Ming; Guo, Zhihong
Search for the second enzyme in biosynthesis of the enediyne core of the antitumor antibiotic C-1027
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-58
Guo, Zu-Feng; Chen, Xiaolei; Feng, Yitao; Xu, Ri; Guo, Zhihong
Searching for enzymes in the biosynthesis of the ten-membered enediyne core of Calicheamicin γI1
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-57
Xu, Ri; Guo, Zu-Feng; Guo, Zhihong
Article 5
Catalytic Mechanism of SHCHC Synthase in the Menaquinone Biosynthesis of Escherichia coli: Identification and Mutational Analysis of the Active Site Residues
Biochemistry, v. 48, (29), 2009, JUL 28, p. 6921-6931
Jiang, Ming; Chen, Xiaolei; Wu, Xian-Hui; Chen, Minjiao; Wo, Yun-Dong; Guo, Zhihong
Combination of beta-elimination and liquid chromatography/quadrupole time-of-flight mass spectrometry for the determination of O-glycosylation sites
Talanta, v. 78, (2), 2009, APR 30, p. 358-363
Zheng, Yufang; Guo, Zhihong; Cai, Zongwei
Conjugation of Latent Membrane Protein (LMP)-2 Epitope to Gold Nanoparticles as Highly Immunogenic Multiple Antigenic Peptides for Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses in Vitro
Bioconjugate Chemistry, v. 20, (1), January 2009, p. 24-31
Cheung, Wai-Hung; Chan, Vera Sau-Fong; Pang, Heung-Wing; Wong, Man-Kin; Guo, Zhi-Hong; Tam, Paul Kwong-Hang; Che, Chi-Ming; Lin, Chen-Lung; Yu, Wing-Yiu
Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative
Journal of the American Chemical Society, v. 131, (38), September 2009, p. 13576-13577
Gao, Yuan; Kuang, Yi; Guo, Zufeng; Guo, Zhihong; Krauss, Isaac J.; Xu, Bing
Preferential Hydrolysis of Aberrant Intermediates by the Type II Thioesterase in Escherichia coli Nonribosomal Enterobactin Synthesis: Substrate Specificities and Mutagenic Studies on the Active-Site Residues
Biochemistry, v. 48, (8), 2009, MAR 3, p. 1712-1722
Guo, Zu-Feng; Sun, Yueru; Zheng, Suilan; Guo, Zhihong
Conference paper 7
Crowding Effect on Protein Side Chain Dynamics
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-63
Feng, Yitao; Cho, Chi Kong; Sze, Kong Hung; Guo, Zhihong
Evidence for a New Precursor in the Biosynthesis of the Nine-membered Enediyne Core of the Antitumor Antibiotics C-1027
4th International Conference on Cutting-Edge Organic Chemistry in Asia, Chulabhorn Research Institute, Bangkok, Thailand, 29 Nov. - 3 Dec. 2009
Chen, Xiaolei; Guo, Zhihong
Explorative investigation of protein organization in the enterobactin biosynthetic pathway
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-64
Guo, Zufeng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong
In vitro reconstitution of iterative type I polyketide synthases
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-61
Chen, Xiaolei; Feng, Yitao; Guo, Zhihong
Mutational studies on the active site residues of MenD in Bacillus subtilis menaquinone biosynthesis
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-60
Chen, Minjiao; Jiang, Ming; Dawson, Alice; Hunter, William N.; Guo, Zhihong
Re-examination of the activity of 1, 4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in the menaquinone biosynthesis
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-66
Jiang, Ming; Chen, Minjiao; Guo, Zhihong
The viral 3a protein plays a role in the cellular immune response to the SARS coronavirus infection
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-68
Liu, Fuli; Guo, Zhihong
Article 2
Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli
Biochemistry, v. 47, (11), 2008, MAR 18, p. 3426-3434
Jiang, Ming; Chen, Xiaolei; Guo, Zu-Feng; Cao, Yang; Chen, Minjiao; Guo, Zhihong
Suppression of linear side products by macromolecular crowding in nonribosomal enterobactin biosynthesis
Organic letters, v. 10, (4), 2008, FEB 21, p. 649-652
Guo, Zu-Feng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong
Conference paper 10
A new activity of the serine-histidine-aspartate catalytic triad: ?-Proton abstraction from a carbon acid in a reaction involved in menaquinonone biosynthesis
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-37
Jiang, Ming; Chen, Xiaolei; Chen, Minjiao; Feng, Yitao; Guo, Zhihong
Comparative advantages conferred by an enzyme with a nanomolar Michaelis constant in the menaquinonone biosynthesis of Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-35
Chen, Minjiao; Jiang, Ming; Guo, Zhihong
Identification and characterization of a new intermediate and a new enzyme in the menaquinonone biosynthesis of Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, Oral-4
Jiang, Ming; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong
Pre-steady-state characterization of the reaction catalyzed by (1R, 6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-36
Chen, Xiaolei; Qiao, Yuqin; Li, Ding; Jiang, Ming; Guo, Zhihong
Quantitative characterization of the proofreading activity of a Type II thioesterase in nonribosomal enterobactin biosynthesis in Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-42
Guo, Zu-Feng; Zheng, Suilan; Guo, Zhihong
Signals for the SARS coronavirus 3a protein intracellular localization and extracellular secretion
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-40
Liu, Fuli; Zhong, Xiaofen; Wu, Jie; Yang, Yanzhen; Cheng, Chak-Sum Samuel; Xie, Yong; Guo, Zhihong
Structural changes in nonribosomal enterobactin synthetase under crowding conditions inherent to intracellular environment
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-38
Guo, Zu-Feng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong
The role of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in the menaquinonone biosynthesis of Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-39
Jiang, Ming; Guo, Zu-Feng; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong
The role of macromolecular crowding in the nonribosomal synthesis of enterobactin in Escherichia coli
12emes Rencontres de Chimie Organique Biologique, Aussois, France, O11, 16-20 March 2008
Guo, Zhihong
The role of protein 3a in cellular inflammatory response to infection by SARS coronavirus
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-41
Liu, Fuli; Liu, Yingjie; Guo, Zhihong
Article 9
Chip-based CE coupled to a quadrupole TOF mass spectrometer for the analysis of a glycopeptide
Electrophoresis, v. 28, (9), 2007, MAY, p. 1305-1311
Zheng, Yufang; Li, Haifang; Guo, Zhihong; Lin, Jin-Ming; Cai, Zongwei
Determination of the stereochemistry of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate, a key intermediate in menaquinone biosynthesis
Organic letters, v. 9, (23), 2007, NOV 8, p. 4765-4767
Jiang, Ming; Chen, Minjiao; Cao, Yang; Yang, Yinhua; Sze, Kong Hung; Chen, Xiaolei; Guo, Zhihong
Effects of macromolecular crowding on the intrinsic catalytic efficiency and structure of enterobactin-specific isochorismate synthase
Journal of the American Chemical Society, v. 129, (4), 2007, JAN 31, p. 730-731
Jiang, Ming; Guo, Zhihong
Induction of cytotoxic T cell response against HCA661 positive cancer cells through activation with novel HLA-A{*}0201 restricted epitopes
Cancer letters, v. 256, (2), 2007, OCT 28, p. 178-185
Pang, Paul Ha-Sang; Chan, Kin-Tak; Tse, Luigi Ying-Wai; Chan, Ray Chun-Fai; Cheung, Ying-Kit; Sin, Fion Wan-Yee; Guo, Zhi-Hong; Xie, Yong
Intracellular enzymatic formation of nanofibers results in hydrogelation and regulated cell death
Advanced materials, v. 19, (20), 2007, OCT 19, p. 3152+
Yang, Zhimou; Xu, Keming; Guo, Zufeng; Guo, Zhihong; Xu, Bing
Intracellular hydrogelation of small molecules inhibits bacterial growth
ANGEWANDTE chemie-international EDITION, v. 46, (43), 2007, p. 8216-8219
Yang, Zhimou; Liang, Gaolin; Guo, Zufeng; Guo, Zhihong; Xu, Bing
Menaquinone biosynthesis in Escherichia coli: Identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-l-carboxylate as a novel intermediate and re-evaluation of MenD activity
Biochemistry, v. 46, (38), 2007, SEP 25, p. 10979-10989
Jiang, Ming; Cao, Yang; Guo, Zu-Feng; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong
Solid-phase total synthesis and antimicrobial activities of loloatins A-D
Chemistry & biodiversity, v. 4, (12), 2007, p. 2827-2834
Ding, Yan; Qin, Chuanguang; Guo, Zhihong; Niu, Weining; Zhang, Ruijie; Li, Yang
Using beta-lactamase to trigger supramolecular hydrogelation
Journal of the American Chemical Society, v. 129, (2), 2007, JAN 17, p. 266-267
Yang, Zhimou; Ho, Pak-Leung; Liang, Gaolin; Chow, Kin Hung; Wang, Qigang; Cao, Yang; Guo, Zhihong; Xu, Bing
Conference paper 6
A phenylalanine-rich signal is required for localization of the SARS coronavirus 3a protein to plasma membrane and its extracellular release
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong, CUHK, Hong Kong, O-61, 28 April 2007
Liu, Fuli; Zhong, Xiaofen; Wu, Jie; Yang, Yanzhen; Cheng, Chak-Sum Samuel; Xie, Yong; Guo, Zhihong
Coordinative Effects of Macromolecular Crowding on the Two Functional Domains of Chorismate Mutase-Prephenate Dehydratase in the Bacterial Biosynthesis of Phenylalanine
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong, CUHK, Hong Kong, O-59, 28 April 2007
Zheng, Suilan; Jiang, Ming; Guo, Zu-Feng; Guo, Zhihong
Determination of the Stereochemistry of 2-Succinyl-5-Enolpyruvyl-6- Hydroxy -3-Cyclohexene-1-Carboxylic Acid (SEPHCHC), a Key Intermediate in Menaquinone Biosynthesis.
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, Hong Kong, O-63, 28 April 2007
Jiang, Ming; Chen, Minjiao; Cao, Yang; Chen, Xiaolei; Yang, Yinhua; Sze, Kong Hung; Guo, Zhihong
In Vivo Evidence for Interaction of the SARS Coronavirus 3a Protein with an Unknown Host Protein
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong,CUHK, Hong Kong, O-60, 28 April 2007
Liu, Fuli; Yang, Yanzhen; Jiang, Ming; Zheng, Suilan; Guo, Zhihong
Menaquinone Biosynthesis in Escherichia coli: Identification and Characterization of (1R, 6R)-2-Succinyl-6-Hydroxy-2,4- Cyclohexadiene-1-Carboxylate (SHCHC) Synthase
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong,CUHK, Hong Kong, O-62, 28 April 2007
Jiang, Ming; Guo, Zu-Feng; Chen, Xiaolei; Chen, Minjiao; Guo, Zhihong
Menaquinone Biosynthesis in Escherichia coli: Identification of 2-Succinyl-5-Enolpyruvyl-6-Hydroxy-3-Cyclohexene-1-Carboxylate (SEPHCHC) as a Novel Intermediate and Re-evaluation of MenD Activity
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong,CUHK, Hong Kong, O-58, 28 April 2007
Jiang, Ming; Cao, Yang; Guo, Zu-Feng; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong
Article 2
Amino terminus of the SARS coronavirus protein 3a elicits strong, potentially protective humoral responses in infected patients
Journal of general virology, v. 87, (Part 2), 2006, FEB, p. 369-374
Zhong, Xiaofen; Guo, Zufeng; Yang, Huanghao; Peng, Lisheng; Xie, Yong; Wong, Tinyau; Lai, Sikto; Guo, Zhihong
Fluorescent "light-up" bioprobes based on tetraphenylethylene derivatives with aggregation-induced emission characteristics
Chemical communications, (35), 2006, p. 3705-3707
Tong, Hui; Hong, Yuning; Dong, Yongqiang; Haeussler, Matthias; Lam, Jacky Wing Yip; Li, Zhen; Guo, Zufeng; Guo, Zhihong; Tang, Ben Zhong
Conference paper 8
Channeling of Isochorismate by a Dynamic Enzyme Complex in Escherichia coli Biosynthesis of Menaquinone
Thirteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-58
Jiang, Ming; Guo, Zu-Feng; Zheng, Suilan; Cao, Yang; Liu, Fuli; Guo, Zhihong
Complete elucidation of the biosynthesis of menaquinone and utilization of the biosynthetic enzymes as targets for antibiotic development
2006 International Symposium on Chemical Biology and Combinatorial Chemistry, Shandong University, Jinan, China, IL-21, 28-30 December 2006
Jiang, Ming; Cao, Yang; Chen, Xiaolei; Chen, Minjiao; Guo, Zhihong
Conjugation of Arginine Oligomers to Anti-cancer Drugs Sensitizes Multidrug Resistant Cancer Cells
Thirteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-92
Guo, Zu-Feng; Zhou, Ronghui; Guo, Zhihong
Macromolecular Crowding Significantly Enhances the Intrinsic Catalytic Efficiency of Enterobactin-Specific Isochorismate Synthase
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-69
Jiang, Ming; Guo, Zhihong
Protein 3a of SARS Coronavirus Interacts with an Unknown Human Host Protein, DKFZP434H132
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-91
Liu, Fuli; Yang, Yanzhen; Jiang, Ming; Zheng, Suilan; Guo, Zhihong
SARS Coronavirus Protein 3a Contains Distinct Targeting Signals for Localization to a Perinuclear Region and the Plasma Membrane
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-74
Zhong, Xiaofen; Liu, Fuli; Wu, Jie; Yang, Yanzhen; Cheng, Chak-Sum Samuel; Xie, Yong; Guo, Zhihong
Sensing of Macromolecular Crowding by Fluorescence Resonance Energy Transfer between Two Variants of Green Fluorescent Protein
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-66
Guo, Zu-Feng; Lee, Kwok Pong; Guo, Zhihong
Towards complete elucidation of the biosynthesis of menaquinone and its utilization as a drug target
The Fifth International Symposium for Chinese Medicinal Chemists. China Pharmaceutical University, Nanjing, China, IL-05, 2-7 November 2006
Jiang, Ming; Cao, Yang; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong
Article 2
B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein
Journal of virology, v. 79, (6), 2005, MAR, p. 3401-3408
Zhong, Xiaofen; Yang, Huanghao; Guo, Zufeng; Sin, W.Y.F.; Chen, Wei; Xu, Junjie; Fu, Ling; Wu, Jie; Mak, Chun Kit Gannon; Cheng, Chak Sum Samuel; Yang, Yanzhen; Cao, Shuyong; Wong, Tinyau; Lai, Sikto; Xie, Yong; Guo, Zhihong
Macrolactonization catalyzed by the terminal thioesterase domain of the nonribosomal peptide synthetase responsible for lichenysin biosynthesis
Bioorganic & medicinal chemistry letters, v. 15, (10), 2005, MAY 16, p. 2595-2599
Cao, Shuyong; Yang, Yanzhen; Ng, Na Lee; Guo, Zhihong
Conference paper 5
A Preformed Conformation Guides the Thermal Head-to-tail Macrocyclization of an Unactivated Linear Peptide in Solid State
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-63
An, Linkun; Guo, Zhihong
Amino Terminus of the SARS Coronavirus Protein 3a Elicited Protective Humoral Responses in Patients Who Had Recovered from SARS.
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-67
Zhong, Xiaofen; Guo, Zufeng; Yang, Huanghao; Peng, Lisheng; Xie, Yong; Wong, Tin-Yau; Lai, Sik-To; Guo, Zhihong
Identification of Interactions between SARS ORF 3a and Human Host Proteins by a Yeast Two-Hybrid System
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-66
Yang, Yanzhen; Guo, Zhihong
Macrolactonization Catalysed by the Terminal Thioesterase Domain of the Nonribosomal Peptide Synthetase Responsible for Lichenysin Biosynthesis
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-64
Cao, Shuyong; Yang, Yanzhen; Ng, Na Lee Joyce; Guo, Zhihong
Solid-State Biomimetic Synthesis of Gramicidin S and Analogues
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-65
Liu, Zhao; An, Linkun; Guo, Zhihong
Article 7
Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles
Journal of the American Chemical Society, v. 126, (32), 2004, AUG 18, p. 9938-9939
Xu, Chenjie; Xu, Keming; Gu, Hongwei; Zheng, Rongkun; Liu, Hui; Zhang, Xixiang; Guo, Zhihong; Xu, Bing
Facile solid-phase synthesis of cyclic decapeptide antibiotic streptocidins A-D
Tetrahedron letters, v. 45, (1), 2004, JAN 1, p. 217-220
Qin, Chuanguang; Zhong, Xiaofen; Ng, Na Lee; Bu, Xianzhang; Chan, Wing Sze; Guo, Zhihong
Nitrilotriacetic acid-modified magnetic nanoparticles as a general agent to bind histidine-tagged proteins
Journal of the American Chemical Society, v. 126, (11), 2004, MAR 24, p. 3392-3393
Xu, Chenjie; Xu, Keming; Gu, Hongwei; Zhong, Xiaofen; Guo, Zhihong; Zheng, Rongkun; Zhang, Xixiang; Xu, Bing
Optimization of antibacterial cyclic decapeptides
Journal of combinatorial chemistry, v. 6, (3), 2004, MAY-JUN, p. 398-406
Qin, Chuanguang; Bu, Xianzhang; Zhong, Xiaofen; Ng, Joice Na Lee; Guo, Zhihong
Synthesis and Cytotoxicity of Enediyne Prodrugs with 3-Hydroxy-4-(arylmethylidene)cyclodeca-1,5-diyne Scaffolds
Letters in Drug Design & Discovery, 1, 69-72
Dai, Wei-Min; Tachi, Yukihiro; Nishimoto, Sei-ichi; Zhong, Xiaofen; Guo, Zhihong
Synthesis of gramicidin S and its analogues via an on-resin macrolactamization assisted by a predisposed conformation of the linear precursors
Journal of organic chemistry, v. 69, (8), 2004, APR 16, p. 2681-2685
Bu, Xianzhang; Wu, Xiaoming; Ng, Na Lee Joyce; Mak, Chun Kit; Qin, Chuanguang; Guo, Zhihong
T-cell epitopes in Severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS
Journal of Virology, v. 78, (11), June 2004, p. 5612-5618
Wang, Yue Dan; Sin, Wan Yee; Xu, Guo-Bing; Yang, Huang Hua; Wong, Tin-yau; Pang, Xue-Wen; He, Xiao-Yan; Zhang, Hua-Gang; Ng, Joice Na Lee; Cheng, Chak-Sum Samuel; Yu, Jing; Meng, Li; Yang, Rui-Feng; Lai, Sikto; Guo, Zhi-Hong; Xie, Yong; Chen, Wei-Feng
Conference paper 6
A Novel Phage-Based Approach to Discovery of Immunogenic Peptides for Immunotherapy of Nasopharyngeal Carcinoma
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong
Wu, Jie; Yang, Huanghao; Chen, Yongxiong; To, Leo Y.F.; Zhong, Xiaofen; Ng, Na Lee; Bu, Xianzhang; Wong, Man-Kin; Yu, Wing-Yiu; Che, Chi-Ming; Lin, Chen-Lung; Guo, Zhihong
Biofunctional nanomagnets: Synthesis and Applications
227th ACS National Meeting, Anaheim, United States, Mar.
Gu, Hongwei; Xu, Chenjie; Xu, Keming; Ho, P.L.; Zhong, X.; Guo, Zhihong; Xu, Bing
Optimization of Cyclic Peptide Antibiotic Gramicidin S
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong
Ng, Na Lee; Wu, Xiaoming; Zhong, Xiaofen; Guo, Zhihong
Optimizing natural cyclic peptides to counter microbial resistance
The Fourth Conference for Worldwide Young Chinese Chemists, Sichuan University, Chengdu, China, p134
Qin, Chuanguang; Bu, Xianzhang; Zhong, Xiaofen; Wu, Xiaoming; Ng, Na Lee Joyce; Guo, Zhihong
Preorganization in cyclic peptide synthesis and its application to the optimization of natural antibacterial peptide products
The 8th Korean Peptide Symposim: Peptide science in post-genomic era, Korean Peptide Society, Seoul, South Korea., IL04
Guo, Zhihong
Roles of Terminal Condensation Domain in Cyclosporine Biosynthesis
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong
Cao, Shuyong; Yang, Yanzhen; Zhong, Xiaofen; Yang, Huanghao; Guo, Zhihong
Article 4
A chemical approach to generate molecular diversity based on the scaffold of cyclic decapeptide antibiotic tyrocidine A
Journal of combinatorial chemistry, v. 5, (4), 2003, JUL-AUG, p. 353-355
Qin, Chuanguang; Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong
Biomimetic synthesis of gramicidin S and analogues by enzymatic cyclization of linear precursors on solid support
Organic letters, v. 5, (10), 2003, MAY 15, p. 1749-1752
Wu, Xiaoming; Bu, Xianzhang; Wong, Ka Man; Yan, Weili; Guo, Zhihong
Dissociation of antibacterial and hemolytic activities of an amphipathic peptide antibiotic
Journal of medicinal chemistry, v. 46, (23), 2003, NOV 6, p. 4830-4833
Qin, Chuanguang; Zhong, Xiaofen; Bu, Xianzhang; Ng, Na Lee Joyce; Guo, Zhihong
The biosynthesis of GDP-L-colitose: C-3 deoxygenation is catalyzed by a unique coenzyme B6-dependent enzyme
Journal of the American Chemical Society, v. 125, (19), 2003, p. 5584-5585
Beyer, Noelle; Alam, Jenefer; Hallis, Tina M.; Guo, Zhihong; Liu, Hung-wen
Conference paper 3
Evolve Cyclic Peptide Antibiotics to Contain Microbial Resistance
Singapore International Chemical Conference III: Frontiers in Physical and Analytical Chemistry, Singapore, 15-17 December
Guo, Zhihong
Exploring Pre-organized Conformation of the Linear Gramicidin Precursor for Biomimetic Synthesis of Cyclopeptide Libraries
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-51
Wu, Xiaoming; Mak, Chun Kit; Qin, Chuanguang; Guo, Zhihong
Identification of Viral Epitopes for Immunoglobulins from SARS Patients
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong, 2004.
Zhong, Xiaofen; Yang, Huanghao; Guo, Zufeng; Wu, Jie; Yang, Yanzhen; Cao, Shuyong; Xie, Yong; Guo, Zhihong
Article 3
An improved deblocking agent for direct Fmoc solid-phase synthesis of peptide thioesters
Tetrahedron letters, v. 43, (13), 2002, MAR 25, p. 2419-2422
Bu, Xianzhang; Xie, Guiyang; Law, Chi Wang; Guo, Zhihong
Substrate spectrum of tyrocidine thioesterase probed with randomized peptide N-acetylcysteamine thioesters
Bioorganic & medicinal chemistry letters, v. 12, (6), 2002, MAR 25, p. 989-992
Xie, Guiyang; Uttamchandani, Mahesh; Chen, Grace Y.J.; Bu, Xianzhang; Lin, San San; Wong, Ka Man; Yan, Weili; Yao, Shao Q.; Guo, Zhihong
Synthesis of tyrocidine A and its analogues by spontaneous cyclization in aqueous solution
Organic letters, v. 4, (17), 2002, AUG 22, p. 2893-2895
Bu, Xianzhang; Wu, Xiaoming; Xie, Guiyang; Guo, Zhihong
Conference paper 16
A Chemical Approach to Engineering of the Cyclic Decapeptide Antibiotic Tyrocidine A
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-48
Qin, Chuanguang; Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong
A modified Fmoc method for direct solid-state synthesis of peptide thioesters and its application to total synthesis of Tyrocidine A
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, o-53
Bu, Xianzhang; Xie, Guiyang; Wang, Chi Wang; Guo, Zhihong
A-beta amyloidosis inhibitors from traditional Chinese medicines
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, O-58
Peng, Tuohua; Wong, Ka Man; Guo, Zhihong
Biomimetic Combinatorial Synthesis of Cyclic Peptide Libraries for Drug Discovery
Frontiers in Biomedical Research, The University of Hong Kong, 6 December, p. 85
Guo, Zhihong
Biomimetic Combinatorial Synthesis of Cyclic Peptide Libraries for Drug Discovery
Third International Symposium for Chinese Medicinal Chemists, Hong Kong, China, December 28-31, OP-8
Guo, Zhihong
Combinatorial Synthesis and Screening of a Cyclopeptide Library based on the Tyrocidine Scaffold
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-50
Qin, Chuanguang; Bu, Xianzhang; Zhong, Xiaofen; Guo, Zhihong
Oligomeric intermediates in amyloid-beta peptides fibrillogenesis arrested by N-terminal fusion are not neurotoxic
Ninth symposium on chemistry postgraduate research in Hong Kong, Book of Abstracts, O-57
Wei, Jianwen; Yan, Weili; Wong, Kan Man; Bu, Xianzhang; Lai, Lo Ming; Ng, Na Lee; Xie, Guiyang; Guo, Zhihong
Parallel Solid-phase Synthesis of Streptocidins A~D through Spontaneous Self-cyclization of Their Linear Precursors
Third International Symposium for Chinese Medicinal Chemists, pp. 57
Qin, Chuanguang; Chan, Wing Sze; Guo, Zhihong
Parallel synthesis of Tyrocidine A analogues through spontaneous cyclization of peptide thioesters
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, o-55
Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong
Synthesis of Gramicidin S Analogues: Chemical versus Chemoenzymatic Approach
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-46
Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong
Synthesis of Gramicidin S by Conformation-dependent Cyclization of Its Linear Biosynthetic Precursor
Third International Symposium for Chinese Medicinal Chemists, pp. 59
Wu, Xiaoming; Mak, Chun Kit; Bu, Xianzhang; So, Sau Man; Guo, Zhihong
Synthesis, characterization, and screening of positional scanning cyclopeptide libraries based on Tyrocidine scaffold
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, O-56
Xie, Guiyang; Uttamchandani, Mahesh; Chen, Grace Y.J.; Bu, Xianzhang; Lin, San San; Wong, Ka Man; Yan, Weili; Wei, Jianwen; Yao, Shao Q.; Guo, Zhihong
Traceless Biomimetic Synthesis of Tyrocidines
Third International Symposium for Chinese Medicinal Chemists, pp. 56
Qin, Chuanguang; Chan, Wing Sze; Wu, Xiaoming; Guo, Zhihong
Traceless Solid-phase Synthesis of Streptocidins
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-47
Qin, Chuanguang; Chan, Wing Sze; Guo, Zhihong
Utilization of a substrate intramolecular hydrogen bond in catalysis by enterobactin thioesterase
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, O-54
Xie, Guiyang; Wu, Xiaoming; Wong, Kan Man; Yan, Weili; Ng, Na Lee; Guo, Zhihong
Utilization of Thioesterase from Non-ribosomal Peptide Synthase in Biomimetic Synthesis of Gramicidin S
Third International Symposium for Chinese Medicinal Chemists, pp. 58
Wu, Xiaoming; Mak, Chun Kit; So, Sauman; Guo, Zhihong
Article 1
Insights into the branched-chain formation of mycarose: Methylation catalyzed by an (S)-adenosylmethionine-dependent methyltransferase
Angewandte Chemie (International ed.), v. 40, (3), 2001, p. 607-610
Chen, Huawei; Zhao, Zongbao; Hallis, Tina M.; Guo, Zhihong; Liu, Hung-wen
Book chapter 1
Phage display: A powerful tool in biomedical research
Frontiers of Biotechnology & Pharmaceuticals / Edited by Huang, Z., Guo, M., Reiner, J., Zhao, K.. Beijing. Science Press, v. 2, 2001, p. 32–58
Guo, Zhihong
Conference paper 1
Recent Development on novel ZnS-based UV detectors
The proceedings of the Symposium on recent advances in photonics technology, 6 December, Hong Kong, sou-1-4
Sou, I.K.; Wu, Marcus C.W.; Lai, L.S.; Guo, Z.; Wong, G.K.L.
Article 1
Designing small-molecule switches for protein-protein interactions
Science, v. 288, (5473), 2000, p. 2042-2045
Guo, Z.; Zhou, D.; Schultz, P.G.
Article 1
Biosynthesis of mycarose: Isolation and characterization of enzymes involved in the C-2 deoxygenation
Journal of the American Chemical Society, v. 121, (35), September 1999, p. 8124-8125
Chen, Huawei; Agnihotri, Gautam; Guo, Zhihong; Que, Nanette L.S.; Chen, Xuemei H.; Liu, Hung-wen
Article 2
Biosynthesis of yersiniose: Attachment of the two-carbon branched-chain is catalyzed by a thiamine pyrophosphate-dependent flavoprotein
Journal of the American Chemical Society, v. 120, (45), November 1998, p. 11796-11797
Chen, Huawei; Guo, Zhihong; Liu, Hung-wen
Expression, purification, and characterization of TyIM1, an N,N-dimethyltransferase involved in the biosynthesis of mycaminose
Journal of the American Chemical Society, v. 120, (38), September 1998, p. 9951-9952
Chen, Huawei; Guo, Zhihong; Liu, Hung-wen
Article 2
Mechanistic studies of the inactivation of crotonase by (methylenecyclopropyl)formyl-CoA
Journal of the American Chemical Society, v. 118, (1), January 1996, p. 275-276
Li, Ding; Guo, Zhihong; Liu, Hung-wen
Synthesis and phase-transition of 4-alkoxycarbonylphenyl 4'-n-alkoxy-2,3,5,6-tetrafluorobiphenyl-4-carboxylates
Molecular crystals and liquid crystals science and technology. Section A, Molecular crystals and liquid crystals, v. 275, 1996, p. 27-36
Wen, J.; Tian, M.; Guo, Z.; Chen, Q.
Article 1
Mechanistic studies of the biosynthesis of 3,6-dideoxy sugars: Stereochemical analysis of C-3 deoxygenation
Journal of the American Chemical Society, v. 117, (18), May 1995, p. 5158-5159
Pieper, Pieper A.; Guo, Zhifong; Liu, Hung-wen
Article 1
Novel fluorinated liquid crystals. Part 9. Synthesis and memomorphic properties of 4-(alkoxycarbonyl) phenyl 4-[(4-alkoxy-2,3,5,6-tetrafluorophenyl)ethynyl]benzoates
J. Mater. Chem., v. 4, 1994, p. 327–330
Wen, J.; Tian, M.; Yu, H.; Guo, Zhihong; Chen, Q.
2016 14
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition
Autophagy, v. 12, (8), August 2016, p. 1372-1389
Song, Juxian; Sun, Yueru; Peluso, Ivana; Zeng, Yu; Yu, Xing; Lu, Jiahong; Xu, Zheng; Wang, Mingzhong; Liu, Liangfeng; Huang, Yingyu; Chen, Leilei; Durairajan, Siva Sundara Kumar Kumar; Zhang, Hongjie; Zhou, Bo; Zhang, Hongqi; Lu, Aiping; Ballabio, Andrea; Medina, Diego Luis; Guo, Zhihong; Li, Min Article
A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis
Journal of the American Chemical Society, v. 138, (23), June 2016, p. 7244-7247
Song, Haigang; Dong, Chen; Qin, Mingming; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Simon Wan; Guo, Zhihong Article
An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus Influenzae
Biochemistry, v. 55, (48), December 2016, p. 6705-6717
Shi, Jie; Cao, Xinyun; Chen, Yaozong; Cronan, John E.; Guo, Zhihong Article
Mechanistic Insights from the Crystal Structure of Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase Complexed with the Adenylate Intermediate
Biochemistry, v. 55, (48), December 2016, p. 6685-6695
Chen, Yaozong; Jiang, Yiping; Guo, Zhihong Article
Conformational intermediates in the domain-alteration catalysis of an adenylating enzyme in vitamin K biosynthesis
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Li, Tin Lok; Jiang, Yiping; Chen, Yaozong; Guo, Zhihong; Song, Haigang; Sun, Yueru Conference paper
Mechanism of thiocarboxylate formation in thiosugar biosynthesis revealed by the MoeZ-SCP complex
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Qin, Xiaoyu; Dai, Xin; Guo, Zhihong; Liu, Hung-wen Conference paper
Mechanistic investigation of the MoeZ-catalyzed thiocarboxylate formation in thiosugar biosynthesis
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23 April 2016
Dai, Xin; Liu, Hung-wen; Guo, Zhihong Conference paper
Structural and kinetic investigation of the thiamine-dependent MenD from the Escherichia coli menaquinone biosynthetic pathway
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Qin, Mingming; Guo, Zhihong; Song, Haigang Conference paper
Structural and kinetic investigation of the thiamine-dependent MenD from the menaquinone biosynthetic pathway in Escherichia coli
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23 April 2016
Qin, Mingming; Song, Haigang; Guo, Zhihong Conference paper
Structural and mechanistic investigation of the membrane associated phosphate acyltransferase PlsX
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Jiang, Yiping; Guo, Zhihong Conference paper
Structural basis of substrate recognition of Bacillus subtilis BioF in biotin biosynthesis
The Fourth South China Structural Biology Symposium, Southern University of Science and Technology, Shenzhen, Guangdong, China, November 2016
Shi, Jie; Guo, Zhihong Conference paper
Structural characterization of H. influenzae BioG reveals a conserved active site within a novel three-layered of α/β hydrolase fold
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23 April 2016
Shi, Jie; Guo, Zhihong Conference paper
Structural elucidation and biochemical investigation of multi-functional states of Bacillus subtilis o-succinylbenzoyl-CoA synthetase
The 23rd Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 23th April 2016
Chen, Yaozong; Sun, Yueru; Song, Haigang; Guo, Zhihong Conference paper
Structural Evdience for Negative Cooperativity in Substrate Binding of Hexameric Staphylococcus aureus 1,4-Dihydroxy-2-Naphthoyl-CoA Synthase
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, The University of Hong Kong, 15 April 2015
Jiang, Yiping; Chen, Yaozong; Guo, Zhihong Conference paper
2015 13
A Universal and Facile Approach for the Formation of a Protein Hydrogel for 3D Cell Encapsulation
Advanced Functional Materials, v. 25, (39), October 2015, p. 6189-6198
Chen, Yin; Dai, Xin; Huang, Lu; Sun, Yang; Chan, Ho Nam; Shen, Bo; Zeng, Xiaoqian; Wu, Zhenguo; Hsing, I-Ming; Guo, Zhihong; Wu, Hongkai Article
Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora
ChemBioChem, v. 16, (1), 2015, p. 100-109
Song, Haigang; Xu, Ri; Guo, Zhihong Article
Microsecond Protein Folding Events Revealed by Time-Resolved Fluorescence Resonance Energy Transfer in a Microfluidic Mixer
Analytical Chemistry, v. 87, (11), June 2015, p. 5589-5595
Jiang, Liguo; Zeng, Yan; Sun, Qiqi; Sun, Yueru; Guo, Zhihong; Qu, Jianan; Yao, Shuhuai Article
Structural basis for the atp-dependent configuration of adenylation active site in bacillus subtilis o-succinylbenzoyl-coa synthetase
Journal of Biological Chemistry, v. 290, (39), September 2015, p. 23971-23983
Chen, Yaozong; Sun, Yueru; Song, Haigang; Guo, Zhihong Article
Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Conference paper
Observation of an unusual intermediate in SEPHCHC synthase (MenD) in the biosynthesis of menaquinone
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 18 April 2015
Song, Haigang; Dong, Chen; Guo, Zhihong Conference paper
Structural and kinetic evidence of a large conformational movement in formation of the first Michaelis complex of o-succinylbenzoyl-CoA synthetase.
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Chen, Yaozong; Guo, Zhihong Conference paper
Structural and mechanistic investigation of the transmembrane sn-glycerol-3-phosphate acyltransferase PlsY from Escherichia coli
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Jiang, Yiping; Guo, Zhihong Conference paper
Structural basis for the ATP-dependent configuration of adenylation active site in Bacillus subtilis o-succinylbenzoyl-CoA synthetase
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Chen, Yaozong; Sun, Yueru; Song, Haigang; Guo, Zhihong Conference paper
Structural characterization of a small basic protein: the human G0/G1 switch gene 2 protein (hG0S2)
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 18 April 2015
Shi, Jie; Guo, Zhihong Conference paper
Structural investigation of an atypical acyl-CoA synthase involved in biotin synthesis of Bacillus subtilis
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Shi, Jie; Guo, Zhihong Conference paper
Structural investigation of the 'hot dog' folded thioesterase YbaW
The Third South China Structural Biology Symposium, Xiamen University, Xiamen, Fujian, China, 18-20 December 2015
Dai, Xin; Guo, Zhihong Conference paper
Structure of the Escherichia coli hotdog thioesterase YbaW
The 22nd Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, Hong Kong, 18 April 2015
Dai, Xin; Guo, Zhihong Conference paper
2014 18
A comparison of the diet and fine-scale distribution of sympatric Tibetan and red foxes in Qinghai, PR China
Wildlife Biology, v. 20, (6), December 2014, p. 356-361
Tsukada, Hideharu; Li, Wei; Duo, Hong; Guo, Zhihong; Fu, Yong; Peng, Mao; Shen, Xiuying; Jing, Jianwu; Yuan, Aishan; Ni, Ma; He, Shengde; Huang, Fu Qiang; Feng, Kai; Ishikawa, Keisuke; Kobayashi, Ikuo; Shinohara, Akio; Nonaka, Nariaki Article
Cascade Biocatalysis by Multienzyme-Nanoparticle Assemblies
Bioconjugate Chemistry, v. 25, (8), August 2014, p. 1387-1394
Kang, Wei; Liu, Jiahui; Wang, Jianpeng; Nie, Yunyu; Guo, Zhihong; Xia, Jiang Article
Discovery of Pentacyclic Triterpenoids as Potential Entry Inhibitors of Influenza Viruses
Journal of Medicinal Chemistry, v. 57, (23), December 2014, p. 10058-10071
Yu, Maorong; Si, Longlong; Wang, Yufei; Wu, Yiming; Yu, Fei; Jiao, Pingxuan; Shi, Yongying; Wang, Han; Xiao, Sulong; Fu, Ge; Tian, Ke; Wang, Yitao; Guo, Zhihong; Ye, Xinshan; Zhang, Lihe; Zhou, Demin Article
Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues
Acta Crystallographica Section D: Biological Crystallography, v. 70, (11), November 2014, p. 2959-2969
Song, Haigang; Sung, Hoi Pang; Tse, Yuk Sing; Jiang, Ming; Guo, Zhihong Article
Molecular basis of the general base catalysis of an α/β- hydrolase catalytic triad
Journal of Biological Chemistry, v. 289, (22), May 2014, p. 15867-15879
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Article
Beta-Synuclein forms various alpha-helix and alpha-pleated sheet structures with different unsaturated fatty acids
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Shi, Jie; Guo, Zhihong Conference paper
Characterization of the alpha-helical oligomer of alpha-synuclein formed in the presence of oleic acid
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Dai, Xin; Chen, Xiaolei; Wong, Chun Wa; Guo, Zhihong Conference paper
Crystal structures of the type II M. tuberculosis MenB support a unified induced-fit catalytic mechanism for the crotonase fold enzyme family
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Song, Haigang; Tse, Yuk Sing; Sung, Hoi Pang; Guo, Zhihong Conference paper
Ligand-dependent active site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogs
The Third Asian Chemical Biology Conference, National University of Singapore, Singapore, 14-17 December 2014
Song, Haigang; Sung, Hoi Pang; Tse, Yuk Sing; Jiang, Ming; Guo, Zhihong Conference paper
Molecular Basis of the General Base Catalysis of an α/β-Hydrolase Catalytic Triad
The 2nd South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong Conference paper
Observation of an Unusual Tetrahedral Intermediate in SEPHCHC Synthase (MenD) in the Biosynthesis of Menaquinone
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Song, Haigang; Dong, Chen; Guo, Zhihong Conference paper
Structural and catalytic roles of the NC-loop of the α/β-hydrolase MenH
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Xu, Zheng; Sun, Yueru; Guo, Zhihong Conference paper
Structural and kinetic characterization of a large conformational movement in the two-step catalysis of o-succinylbenzoyl-CoA synthetase
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Chen, Yaozong; Guo, Zhihong Conference paper
Structural and Kinetic Evidence of A Large Conformational Movement in Formation of the First Michaelis Complex of O-Succinylbenzoyl-CoA Synthetase
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Chen, Yaozong; Guo, Zhihong Conference paper
Structural and pre-steady state kinetic study of the ligand recognition mechanism of a noncanonical α/β-hydrolase fold enzyme MenH
The 21st Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, 12 April 2014
Sun, Yueru; Guo, Zhihong Conference paper
Structural Evdience for Negative Cooperativity in Substrate Binding of Hexameric Staphylococcus aureus 1,4-Dihydroxy-2-Naphthoyl-CoA Synthase
The Second South China Structural Biology Symposium 华南结构生物学论坛, 福州, 5 - 7 December 2014
Jiang, Yiping; Chen, Yaozong; Guo, Zhihong Conference paper
Structure of the Escherichia coli Hotdog Thioesterase Ybaw
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Dai, Xin; Guo, Zhihong Conference paper
α/β Hydrolase fold enzymes exhibit both open and closed conformations: a case study with BioH
The Second South China Structural Biology Symposium, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 5-7 December 2014
Shi, Jie; Guo, Zhihong Conference paper
2013 5
Crystal Structures of E. coli Native MenH and Two Active Site Mutants
PLoS ONE, v. 8, (4), April 2013, article number e61325
Johnston, Jodie M.; Jiang, Ming; Guo, Zhihong; Baker, Edward N. Article
Identification of a Hotdog Fold Thioesterase Involved in the Biosynthesis of Menaquinone in Escherichia coli
Journal of Bacteriology, v. 195, (12), 2013, p. 2768-2775
Chen, Minjiao; Ma, Xinyu; Chen, Xiaolei; Jiang, Ming; Song, Haigang; Guo, Zhihong Article
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase from the crotonase fold superfamily
PLoS ONE, v. 8, (4), April 2013, article number e63095
Sun, Yueru; Song, Haigang; Li, Jie; Li, Yan; Jiang, Ming; Zhou, Jiahai; Guo, Zhihong Article
The thiamine-dependent enzyme of the vitamin K biosynthesis catalyzes reductive C-N bond ligation between nitroarenes and alpha-ketoacids
SCIENCE CHINA Chemistry, v. 56, (3), March 2013, p. 312-320
Chen, Minjiao; Jiang, Ming; Guo, ZhiHong Article
Molecular Basis of the General Base Catalysis of an α/β-hydrolase Catalytic Triad
The 12th Meeting of the Asian Crystallographic Association, Hong Kong, 7-10 December 2013
Sun, Yueru; Yin, Shuhui; Feng, Yitao; Guo, Zhihong Conference paper
2012 12
Active Site Binding and Catalytic Role of Bicarbonate in 1,4-Dihydroxy-2-naphthoyl Coenzyme A Synthases from Vitamin K Biosynthetic Pathways
Biochemistry, v. 51, (22), June 2012, p. 4580-4589
Sun, Yueru; Song, Haigang; Li, Jie; Jiang, Ming; Li, Yan; Zhou, Jiahai; Guo, Zhihong Article
Characterization of 1,4-dihydroxy-2-naphthoyl-coenzyme A synthase (MenB) in phylloquinone biosynthesis of Synechocystis sp. PCC 6803
SCIENCE CHINA Chemistry, v. 55, (1), 2012, p. 98-105
Song, Haigang; Guo, Zhihong Article
Interactions between Artemisinins and other Antimalarial Drugs in Relation to the Cofactor Model-A Unifying Proposal for Drug Action
ChemMedChem, v. 7, (12), December 2012, p. 2204-2226
Haynes, Richard K.; Cheu, Kwan-Wing; Chan, Ho-Wai; Wong, Ho-Ning; Li, Ka-Yan; Tang, Maggie Mei-Ki; Chen, Min-Jiao; Guo, Zu-Feng; Guo, Zhi-Hong; Sinniah, Kumar; Witte, Amanda B.; Coghi, Paolo; Monti, Diego Article
Alpha-Synuclein forms an oligomeric alpha-helical structure in the presence of unsaturated fatty acids.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013, O-56
Dai, Xin; Chen, Xiaolei; Wong, Chung Wa; Guo, Zhihong Conference paper
Crowding effect on calmodulin bakcbone dynamics
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Feng, Yitao; Liu, Changdong; Wu, Qinglin; Zhu, Guang; Guo, Zhihong Conference paper
Crystal structure of E. coli (1R, 6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (MenH) and its product complex.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Sun, Yueru; Yin, Shuhui; Li, Jie; Zhou, Jiahai; Guo, Zhihong Conference paper
Differentiation of solvation effect and macromolecular crowding effect
The Second Asian Chemical Biology Conference, Itoman, Okinawa, Japan, 4-6 July 2012
Guo, Zhihong Conference paper
Discovery and characterization of an L-methionine gamma-lyase involved in Calicheamicin biosynthesis.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27, Apr, 2013, p. 111
Song, Haigang; Xu, Ri; Guo, Zhihong Conference paper
Investigation of the abnormal electrophoretic behavior of the hotdog thioesterase YbaW.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013
Ma, Xingyu; Chen, Xiaolei; Guo, Zhihong Conference paper
Structural and kinetic characterization of o-succinylbenzoyl-CoA synthetase in the menaquinone biosynthesis of Escherichia coli.
The 20th Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, 27 April 2013, O-55
Chen, Yaozong; Guo, Zhihong Conference paper
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase of the crotonase fold superfamily
第四届中国结构生物学学术讨论会, 中国重庆, 31 Mar-3 Apr 2013
Sun, Yueru; Song, Haigang; Li, Jie; Li, Yan; Jiang, Ming; Zhou, Jiahai; Guo, Zhihong Conference paper
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase of the crotonase fold superfamily
The 7th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-7), Nanyang Technological University, Singapore, December 11-14 2012
Sun, Yueru; Song, Haigang; Li, Jie; Li, Yan; Jiang, Ming; Zhou, Jiahai; Guo, Zhihong Conference paper
2011 12
A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine
ChemMedChem, v. 6, (9), September 2011, p. 1603-1615
Haynes, Richard K.; Cheu, Kwan-Wing; Li, Ka-Yan; Tang, Maggie Mei-Ki; Wong, Ho-Ning; Chen, Min-Jiao; Guo, Zu-Feng; Guo, Zhi-Hong; Coghi, Paolo; Monti, Diego Article
Reactions of Antimalarial Peroxides with Each of Leucomethylene Blue and Dihydroflavins: Flavin Reductase and the Cofactor Model Exemplified
ChemMedChem, v. 6, (2), 2011, p. 279-291
Haynes, Richard Kingston; Cheu, Kwan-Wing; Tang, Maggie Mei-Ki; Chen, Min-Jiao; Guo, Zu-Feng; Guo, Zhi-Hong; Coghi, Paolo; Monti, Diego Article
Stabilization of the Second Oxyanion Intermediate by 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase of the Menaquinone Pathway: Spectroscopic Evidence of the Involvement of a Conserved Aspartic Acid
Biochemistry, v. 50, (26), July 2011, p. 5893-5904
Chen, Minjiao; Jiang, Ming; Sun, Yueru; Guo, Zu-Feng; Guo, Zhihong Article
A general synthesis of 6-substituted 5,6-dihydro-4-hydroxy-2H- pyran-2-ones and NMR studies in different solvents
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-45
Li, Huoming; Wang, Yuan; Chen, Xiaolei; Guo, Zhihong; Dai, Wei-Min Conference paper
Characterization of 1,4-dihydroxy-2-naphthoyl-CoA synthase in the phylloquinone biosynthesis of Synechocystis
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, 30 April 2011, City University of Hong Kong, 30 April 2011,The Abstract Book, O-51
Song, Haigang; Guo, Zhihong Conference paper
Characterization of the non-heme catalase activity of an α/β fold protein from Mycobacterium tuberculosis
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-52
Sun, Yueru; Wu, Wenzhan; Li, Xiao-Yuan; Johnston, Jodie M.; Baker, Edward N.; Guo, Zhihong Conference paper
Characterization of the type II hot-dog thioesterase in biosynthesis of the nine-membered enediyne core of C-1027
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-50
Keung, Bowie P.Y.; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong Conference paper
Effects of macromolecular crowding on selected protein systems
2011 Telluride Workshop on Macromolecular Crowding, Telluride Science Research Center, Telluride, Colorado, the United States of America, 20-24 June 2011
Guo, Zhihong Conference paper
Identification of active site residues involved in the second oxyanion hole in the catalysis of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB)
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-47
Chen, Minjiao; Jiang, Ming; Guo, Zhihong Conference paper
New Products for the Iterative Enediyne Core Polyketide Synthase
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011, The Abstract Book, O-53
Xu, Ri; Chen, Xiaolei; Feng, Yitao; Song, Haigang; Guo, Zhihong Conference paper
Production of a nonaketide by the iterative ten-membered enediyne core polyketide synthase in biosynthesis of calicheamicin
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-49
Feng, Yitao; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong Conference paper
Recognition of the acyl carrier protein by the phosphopanteheinyl transferase domain of the enediyne polykeide synthase SgcE
The 18th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, 30 April 2011,The Abstract Book, O-48
Chen, Xiaolei; Guo, Zhihong Conference paper
2010 13
A Bicarbonate Cofactor Modulates 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase in Menaquinone Biosynthesis of Escherichia coli
Journal of biological chemistry, v. 285, (39), 2010, SEP 24, p. 30159-30169
Jiang, Ming; Chen, Minjiao; Guo, Zu-Feng; Guo, Zhihong Article
Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027
Angewandte Chemie - International Edition, v. 49, (43), 2010, p. 7926-7928
Chen, Xiaolei; Guo, Zu-Feng; Lai, Pok Man; Sze, Kong Hung; Guo, Zhihong Article
Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis
ACTA crystallographica Section d-biological Crystallography, v. 66, (Part 8), 2010, AUG, p. 909-917
Johnston, Jodie M.; Jiang, Ming; Guo, Zhihong; Baker, Edward N. Article
Structural change of the enterobactin synthetase in crowded solution and its relation to crowding-enhanced product specificity in nonribosomal enterobactin biosynthesis
Bioorganic & medicinal chemistry letters, v. 20, (13), 2010, JUL 1, p. 3855-3858
Guo, Zu-Feng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Article
Structure and Reactivity of Bacillus subtilis MenD Catalyzing the First Committed Step in Menaquinone Biosynthesis
Journal of Molecular Biology, v. 401, (2), 2010, AUG 13, p. 253-264
Dawson, Alice; Chen, Minjiao; Fyfe, Paul K.; Guo, Zhihong; Hunter, William N. Article
Bicarbonate dependence in vitamin K biosynthesis
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-59
Jiang, Ming; Chen, Minjiao; Guo, Zu-Feng; Guo, Zhihong Conference paper
Characterization of a nonaketide precursor in biosynthesis of the nine-membered enediyne core of the antitumor antibiotic C-1027
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-57
Chen, Xiaolei; Guo, Zu-Feng; Lai, Pok Man; Sze, Kung Hung; Guo, Zhihong Conference paper
Characterization of a type II hot-dog thioesterase in Calicheamicin biosynthesis
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-57
Keung, Po Yee; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong Conference paper
Chemoenzymatic synthesis of N-hydroxyamides from nitro- or nitroso- compounds using a thiamine-dependent enzyme from the menaquinone biosynthetic pathway
The 5th International Conference on Cutting-Edge Organic Chemistry in Asia, Hsinchu, Taiwan, Nov. 7 - Nov. 11, PB-60, Abstract Book of The 5th International Conference on Cutting-Edge Organic Chemistry in Asia, 2010
Chen, Minjiao; Jiang, Ming; Guo, Zhihong Conference paper
Evidence for a new precursor in the biosynthesis of the ten-membered enediyne antitumor antibiotic Calicheamicin
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-61
Feng, Yitao; Guo, Zu-Feng; Chen, Xiaolei; Guo, Zhihong Conference paper
New insights into the catalytic mechanism of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) gained from the deuterium exchange of its substrate analogs
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-66
Chen, Minjiao; Jiang, Ming; Guo, Zhihong Conference paper
Search for the second enzyme in biosynthesis of the enediyne core of the antitumor antibiotic C-1027
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-58
Guo, Zu-Feng; Chen, Xiaolei; Feng, Yitao; Xu, Ri; Guo, Zhihong Conference paper
Searching for enzymes in the biosynthesis of the ten-membered enediyne core of Calicheamicin γI1
The Seventeenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Hong Kong Polytechnic University, 24 April 2010, O-57
Xu, Ri; Guo, Zu-Feng; Guo, Zhihong Conference paper
2009 12
Catalytic Mechanism of SHCHC Synthase in the Menaquinone Biosynthesis of Escherichia coli: Identification and Mutational Analysis of the Active Site Residues
Biochemistry, v. 48, (29), 2009, JUL 28, p. 6921-6931
Jiang, Ming; Chen, Xiaolei; Wu, Xian-Hui; Chen, Minjiao; Wo, Yun-Dong; Guo, Zhihong Article
Combination of beta-elimination and liquid chromatography/quadrupole time-of-flight mass spectrometry for the determination of O-glycosylation sites
Talanta, v. 78, (2), 2009, APR 30, p. 358-363
Zheng, Yufang; Guo, Zhihong; Cai, Zongwei Article
Conjugation of Latent Membrane Protein (LMP)-2 Epitope to Gold Nanoparticles as Highly Immunogenic Multiple Antigenic Peptides for Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses in Vitro
Bioconjugate Chemistry, v. 20, (1), January 2009, p. 24-31
Cheung, Wai-Hung; Chan, Vera Sau-Fong; Pang, Heung-Wing; Wong, Man-Kin; Guo, Zhi-Hong; Tam, Paul Kwong-Hang; Che, Chi-Ming; Lin, Chen-Lung; Yu, Wing-Yiu Article
Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative
Journal of the American Chemical Society, v. 131, (38), September 2009, p. 13576-13577
Gao, Yuan; Kuang, Yi; Guo, Zufeng; Guo, Zhihong; Krauss, Isaac J.; Xu, Bing Article
Preferential Hydrolysis of Aberrant Intermediates by the Type II Thioesterase in Escherichia coli Nonribosomal Enterobactin Synthesis: Substrate Specificities and Mutagenic Studies on the Active-Site Residues
Biochemistry, v. 48, (8), 2009, MAR 3, p. 1712-1722
Guo, Zu-Feng; Sun, Yueru; Zheng, Suilan; Guo, Zhihong Article
Crowding Effect on Protein Side Chain Dynamics
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-63
Feng, Yitao; Cho, Chi Kong; Sze, Kong Hung; Guo, Zhihong Conference paper
Evidence for a New Precursor in the Biosynthesis of the Nine-membered Enediyne Core of the Antitumor Antibiotics C-1027
4th International Conference on Cutting-Edge Organic Chemistry in Asia, Chulabhorn Research Institute, Bangkok, Thailand, 29 Nov. - 3 Dec. 2009
Chen, Xiaolei; Guo, Zhihong Conference paper
Explorative investigation of protein organization in the enterobactin biosynthetic pathway
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-64
Guo, Zufeng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Conference paper
In vitro reconstitution of iterative type I polyketide synthases
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-61
Chen, Xiaolei; Feng, Yitao; Guo, Zhihong Conference paper
Mutational studies on the active site residues of MenD in Bacillus subtilis menaquinone biosynthesis
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-60
Chen, Minjiao; Jiang, Ming; Dawson, Alice; Hunter, William N.; Guo, Zhihong Conference paper
Re-examination of the activity of 1, 4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in the menaquinone biosynthesis
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-66
Jiang, Ming; Chen, Minjiao; Guo, Zhihong Conference paper
The viral 3a protein plays a role in the cellular immune response to the SARS coronavirus infection
The Sixteenth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong Baptist University, 2009, O-68
Liu, Fuli; Guo, Zhihong Conference paper
2008 12
Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli
Biochemistry, v. 47, (11), 2008, MAR 18, p. 3426-3434
Jiang, Ming; Chen, Xiaolei; Guo, Zu-Feng; Cao, Yang; Chen, Minjiao; Guo, Zhihong Article
Suppression of linear side products by macromolecular crowding in nonribosomal enterobactin biosynthesis
Organic letters, v. 10, (4), 2008, FEB 21, p. 649-652
Guo, Zu-Feng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Article
A new activity of the serine-histidine-aspartate catalytic triad: ?-Proton abstraction from a carbon acid in a reaction involved in menaquinonone biosynthesis
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-37
Jiang, Ming; Chen, Xiaolei; Chen, Minjiao; Feng, Yitao; Guo, Zhihong Conference paper
Comparative advantages conferred by an enzyme with a nanomolar Michaelis constant in the menaquinonone biosynthesis of Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-35
Chen, Minjiao; Jiang, Ming; Guo, Zhihong Conference paper
Identification and characterization of a new intermediate and a new enzyme in the menaquinonone biosynthesis of Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, Oral-4
Jiang, Ming; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong Conference paper
Pre-steady-state characterization of the reaction catalyzed by (1R, 6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-36
Chen, Xiaolei; Qiao, Yuqin; Li, Ding; Jiang, Ming; Guo, Zhihong Conference paper
Quantitative characterization of the proofreading activity of a Type II thioesterase in nonribosomal enterobactin biosynthesis in Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-42
Guo, Zu-Feng; Zheng, Suilan; Guo, Zhihong Conference paper
Signals for the SARS coronavirus 3a protein intracellular localization and extracellular secretion
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-40
Liu, Fuli; Zhong, Xiaofen; Wu, Jie; Yang, Yanzhen; Cheng, Chak-Sum Samuel; Xie, Yong; Guo, Zhihong Conference paper
Structural changes in nonribosomal enterobactin synthetase under crowding conditions inherent to intracellular environment
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-38
Guo, Zu-Feng; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Conference paper
The role of 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in the menaquinonone biosynthesis of Escherichia coli
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-39
Jiang, Ming; Guo, Zu-Feng; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong Conference paper
The role of macromolecular crowding in the nonribosomal synthesis of enterobactin in Escherichia coli
12emes Rencontres de Chimie Organique Biologique, Aussois, France, O11, 16-20 March 2008
Guo, Zhihong Conference paper
The role of protein 3a in cellular inflammatory response to infection by SARS coronavirus
The Fifteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKU, Hong Kong, O-41
Liu, Fuli; Liu, Yingjie; Guo, Zhihong Conference paper
2007 15
Chip-based CE coupled to a quadrupole TOF mass spectrometer for the analysis of a glycopeptide
Electrophoresis, v. 28, (9), 2007, MAY, p. 1305-1311
Zheng, Yufang; Li, Haifang; Guo, Zhihong; Lin, Jin-Ming; Cai, Zongwei Article
Determination of the stereochemistry of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate, a key intermediate in menaquinone biosynthesis
Organic letters, v. 9, (23), 2007, NOV 8, p. 4765-4767
Jiang, Ming; Chen, Minjiao; Cao, Yang; Yang, Yinhua; Sze, Kong Hung; Chen, Xiaolei; Guo, Zhihong Article
Effects of macromolecular crowding on the intrinsic catalytic efficiency and structure of enterobactin-specific isochorismate synthase
Journal of the American Chemical Society, v. 129, (4), 2007, JAN 31, p. 730-731
Jiang, Ming; Guo, Zhihong Article
Induction of cytotoxic T cell response against HCA661 positive cancer cells through activation with novel HLA-A{*}0201 restricted epitopes
Cancer letters, v. 256, (2), 2007, OCT 28, p. 178-185
Pang, Paul Ha-Sang; Chan, Kin-Tak; Tse, Luigi Ying-Wai; Chan, Ray Chun-Fai; Cheung, Ying-Kit; Sin, Fion Wan-Yee; Guo, Zhi-Hong; Xie, Yong Article
Intracellular enzymatic formation of nanofibers results in hydrogelation and regulated cell death
Advanced materials, v. 19, (20), 2007, OCT 19, p. 3152+
Yang, Zhimou; Xu, Keming; Guo, Zufeng; Guo, Zhihong; Xu, Bing Article
Intracellular hydrogelation of small molecules inhibits bacterial growth
ANGEWANDTE chemie-international EDITION, v. 46, (43), 2007, p. 8216-8219
Yang, Zhimou; Liang, Gaolin; Guo, Zufeng; Guo, Zhihong; Xu, Bing Article
Menaquinone biosynthesis in Escherichia coli: Identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-l-carboxylate as a novel intermediate and re-evaluation of MenD activity
Biochemistry, v. 46, (38), 2007, SEP 25, p. 10979-10989
Jiang, Ming; Cao, Yang; Guo, Zu-Feng; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong Article
Solid-phase total synthesis and antimicrobial activities of loloatins A-D
Chemistry & biodiversity, v. 4, (12), 2007, p. 2827-2834
Ding, Yan; Qin, Chuanguang; Guo, Zhihong; Niu, Weining; Zhang, Ruijie; Li, Yang Article
Using beta-lactamase to trigger supramolecular hydrogelation
Journal of the American Chemical Society, v. 129, (2), 2007, JAN 17, p. 266-267
Yang, Zhimou; Ho, Pak-Leung; Liang, Gaolin; Chow, Kin Hung; Wang, Qigang; Cao, Yang; Guo, Zhihong; Xu, Bing Article
A phenylalanine-rich signal is required for localization of the SARS coronavirus 3a protein to plasma membrane and its extracellular release
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong, CUHK, Hong Kong, O-61, 28 April 2007
Liu, Fuli; Zhong, Xiaofen; Wu, Jie; Yang, Yanzhen; Cheng, Chak-Sum Samuel; Xie, Yong; Guo, Zhihong Conference paper
Coordinative Effects of Macromolecular Crowding on the Two Functional Domains of Chorismate Mutase-Prephenate Dehydratase in the Bacterial Biosynthesis of Phenylalanine
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong, CUHK, Hong Kong, O-59, 28 April 2007
Zheng, Suilan; Jiang, Ming; Guo, Zu-Feng; Guo, Zhihong Conference paper
Determination of the Stereochemistry of 2-Succinyl-5-Enolpyruvyl-6- Hydroxy -3-Cyclohexene-1-Carboxylic Acid (SEPHCHC), a Key Intermediate in Menaquinone Biosynthesis.
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong, The Chinese University of Hong Kong, Hong Kong, O-63, 28 April 2007
Jiang, Ming; Chen, Minjiao; Cao, Yang; Chen, Xiaolei; Yang, Yinhua; Sze, Kong Hung; Guo, Zhihong Conference paper
In Vivo Evidence for Interaction of the SARS Coronavirus 3a Protein with an Unknown Host Protein
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong,CUHK, Hong Kong, O-60, 28 April 2007
Liu, Fuli; Yang, Yanzhen; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Conference paper
Menaquinone Biosynthesis in Escherichia coli: Identification and Characterization of (1R, 6R)-2-Succinyl-6-Hydroxy-2,4- Cyclohexadiene-1-Carboxylate (SHCHC) Synthase
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong,CUHK, Hong Kong, O-62, 28 April 2007
Jiang, Ming; Guo, Zu-Feng; Chen, Xiaolei; Chen, Minjiao; Guo, Zhihong Conference paper
Menaquinone Biosynthesis in Escherichia coli: Identification of 2-Succinyl-5-Enolpyruvyl-6-Hydroxy-3-Cyclohexene-1-Carboxylate (SEPHCHC) as a Novel Intermediate and Re-evaluation of MenD Activity
Fourteenth Symposium on Chemistry Postgraduate Research in Hong Kong,CUHK, Hong Kong, O-58, 28 April 2007
Jiang, Ming; Cao, Yang; Guo, Zu-Feng; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong Conference paper
2006 10
Amino terminus of the SARS coronavirus protein 3a elicits strong, potentially protective humoral responses in infected patients
Journal of general virology, v. 87, (Part 2), 2006, FEB, p. 369-374
Zhong, Xiaofen; Guo, Zufeng; Yang, Huanghao; Peng, Lisheng; Xie, Yong; Wong, Tinyau; Lai, Sikto; Guo, Zhihong Article
Fluorescent "light-up" bioprobes based on tetraphenylethylene derivatives with aggregation-induced emission characteristics
Chemical communications, (35), 2006, p. 3705-3707
Tong, Hui; Hong, Yuning; Dong, Yongqiang; Haeussler, Matthias; Lam, Jacky Wing Yip; Li, Zhen; Guo, Zufeng; Guo, Zhihong; Tang, Ben Zhong Article
Channeling of Isochorismate by a Dynamic Enzyme Complex in Escherichia coli Biosynthesis of Menaquinone
Thirteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-58
Jiang, Ming; Guo, Zu-Feng; Zheng, Suilan; Cao, Yang; Liu, Fuli; Guo, Zhihong Conference paper
Complete elucidation of the biosynthesis of menaquinone and utilization of the biosynthetic enzymes as targets for antibiotic development
2006 International Symposium on Chemical Biology and Combinatorial Chemistry, Shandong University, Jinan, China, IL-21, 28-30 December 2006
Jiang, Ming; Cao, Yang; Chen, Xiaolei; Chen, Minjiao; Guo, Zhihong Conference paper
Conjugation of Arginine Oligomers to Anti-cancer Drugs Sensitizes Multidrug Resistant Cancer Cells
Thirteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-92
Guo, Zu-Feng; Zhou, Ronghui; Guo, Zhihong Conference paper
Macromolecular Crowding Significantly Enhances the Intrinsic Catalytic Efficiency of Enterobactin-Specific Isochorismate Synthase
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-69
Jiang, Ming; Guo, Zhihong Conference paper
Protein 3a of SARS Coronavirus Interacts with an Unknown Human Host Protein, DKFZP434H132
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-91
Liu, Fuli; Yang, Yanzhen; Jiang, Ming; Zheng, Suilan; Guo, Zhihong Conference paper
SARS Coronavirus Protein 3a Contains Distinct Targeting Signals for Localization to a Perinuclear Region and the Plasma Membrane
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-74
Zhong, Xiaofen; Liu, Fuli; Wu, Jie; Yang, Yanzhen; Cheng, Chak-Sum Samuel; Xie, Yong; Guo, Zhihong Conference paper
Sensing of Macromolecular Crowding by Fluorescence Resonance Energy Transfer between Two Variants of Green Fluorescent Protein
Thirdteenth Symposium on Chemistry Postgraduate Research in Hong Kong, HKUST, Hong Kong, O-66
Guo, Zu-Feng; Lee, Kwok Pong; Guo, Zhihong Conference paper
Towards complete elucidation of the biosynthesis of menaquinone and its utilization as a drug target
The Fifth International Symposium for Chinese Medicinal Chemists. China Pharmaceutical University, Nanjing, China, IL-05, 2-7 November 2006
Jiang, Ming; Cao, Yang; Chen, Minjiao; Chen, Xiaolei; Guo, Zhihong Conference paper
2005 7
B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein
Journal of virology, v. 79, (6), 2005, MAR, p. 3401-3408
Zhong, Xiaofen; Yang, Huanghao; Guo, Zufeng; Sin, W.Y.F.; Chen, Wei; Xu, Junjie; Fu, Ling; Wu, Jie; Mak, Chun Kit Gannon; Cheng, Chak Sum Samuel; Yang, Yanzhen; Cao, Shuyong; Wong, Tinyau; Lai, Sikto; Xie, Yong; Guo, Zhihong Article
Macrolactonization catalyzed by the terminal thioesterase domain of the nonribosomal peptide synthetase responsible for lichenysin biosynthesis
Bioorganic & medicinal chemistry letters, v. 15, (10), 2005, MAY 16, p. 2595-2599
Cao, Shuyong; Yang, Yanzhen; Ng, Na Lee; Guo, Zhihong Article
A Preformed Conformation Guides the Thermal Head-to-tail Macrocyclization of an Unactivated Linear Peptide in Solid State
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-63
An, Linkun; Guo, Zhihong Conference paper
Amino Terminus of the SARS Coronavirus Protein 3a Elicited Protective Humoral Responses in Patients Who Had Recovered from SARS.
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-67
Zhong, Xiaofen; Guo, Zufeng; Yang, Huanghao; Peng, Lisheng; Xie, Yong; Wong, Tin-Yau; Lai, Sik-To; Guo, Zhihong Conference paper
Identification of Interactions between SARS ORF 3a and Human Host Proteins by a Yeast Two-Hybrid System
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-66
Yang, Yanzhen; Guo, Zhihong Conference paper
Macrolactonization Catalysed by the Terminal Thioesterase Domain of the Nonribosomal Peptide Synthetase Responsible for Lichenysin Biosynthesis
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-64
Cao, Shuyong; Yang, Yanzhen; Ng, Na Lee Joyce; Guo, Zhihong Conference paper
Solid-State Biomimetic Synthesis of Gramicidin S and Analogues
Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, O-65
Liu, Zhao; An, Linkun; Guo, Zhihong Conference paper
2004 13
Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles
Journal of the American Chemical Society, v. 126, (32), 2004, AUG 18, p. 9938-9939
Xu, Chenjie; Xu, Keming; Gu, Hongwei; Zheng, Rongkun; Liu, Hui; Zhang, Xixiang; Guo, Zhihong; Xu, Bing Article
Facile solid-phase synthesis of cyclic decapeptide antibiotic streptocidins A-D
Tetrahedron letters, v. 45, (1), 2004, JAN 1, p. 217-220
Qin, Chuanguang; Zhong, Xiaofen; Ng, Na Lee; Bu, Xianzhang; Chan, Wing Sze; Guo, Zhihong Article
Nitrilotriacetic acid-modified magnetic nanoparticles as a general agent to bind histidine-tagged proteins
Journal of the American Chemical Society, v. 126, (11), 2004, MAR 24, p. 3392-3393
Xu, Chenjie; Xu, Keming; Gu, Hongwei; Zhong, Xiaofen; Guo, Zhihong; Zheng, Rongkun; Zhang, Xixiang; Xu, Bing Article
Optimization of antibacterial cyclic decapeptides
Journal of combinatorial chemistry, v. 6, (3), 2004, MAY-JUN, p. 398-406
Qin, Chuanguang; Bu, Xianzhang; Zhong, Xiaofen; Ng, Joice Na Lee; Guo, Zhihong Article
Synthesis and Cytotoxicity of Enediyne Prodrugs with 3-Hydroxy-4-(arylmethylidene)cyclodeca-1,5-diyne Scaffolds
Letters in Drug Design & Discovery, 1, 69-72
Dai, Wei-Min; Tachi, Yukihiro; Nishimoto, Sei-ichi; Zhong, Xiaofen; Guo, Zhihong Article
Synthesis of gramicidin S and its analogues via an on-resin macrolactamization assisted by a predisposed conformation of the linear precursors
Journal of organic chemistry, v. 69, (8), 2004, APR 16, p. 2681-2685
Bu, Xianzhang; Wu, Xiaoming; Ng, Na Lee Joyce; Mak, Chun Kit; Qin, Chuanguang; Guo, Zhihong Article
T-cell epitopes in Severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS
Journal of Virology, v. 78, (11), June 2004, p. 5612-5618
Wang, Yue Dan; Sin, Wan Yee; Xu, Guo-Bing; Yang, Huang Hua; Wong, Tin-yau; Pang, Xue-Wen; He, Xiao-Yan; Zhang, Hua-Gang; Ng, Joice Na Lee; Cheng, Chak-Sum Samuel; Yu, Jing; Meng, Li; Yang, Rui-Feng; Lai, Sikto; Guo, Zhi-Hong; Xie, Yong; Chen, Wei-Feng Article
A Novel Phage-Based Approach to Discovery of Immunogenic Peptides for Immunotherapy of Nasopharyngeal Carcinoma
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong
Wu, Jie; Yang, Huanghao; Chen, Yongxiong; To, Leo Y.F.; Zhong, Xiaofen; Ng, Na Lee; Bu, Xianzhang; Wong, Man-Kin; Yu, Wing-Yiu; Che, Chi-Ming; Lin, Chen-Lung; Guo, Zhihong Conference paper
Biofunctional nanomagnets: Synthesis and Applications
227th ACS National Meeting, Anaheim, United States, Mar.
Gu, Hongwei; Xu, Chenjie; Xu, Keming; Ho, P.L.; Zhong, X.; Guo, Zhihong; Xu, Bing Conference paper
Optimization of Cyclic Peptide Antibiotic Gramicidin S
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong
Ng, Na Lee; Wu, Xiaoming; Zhong, Xiaofen; Guo, Zhihong Conference paper
Optimizing natural cyclic peptides to counter microbial resistance
The Fourth Conference for Worldwide Young Chinese Chemists, Sichuan University, Chengdu, China, p134
Qin, Chuanguang; Bu, Xianzhang; Zhong, Xiaofen; Wu, Xiaoming; Ng, Na Lee Joyce; Guo, Zhihong Conference paper
Preorganization in cyclic peptide synthesis and its application to the optimization of natural antibacterial peptide products
The 8th Korean Peptide Symposim: Peptide science in post-genomic era, Korean Peptide Society, Seoul, South Korea., IL04
Guo, Zhihong Conference paper
Roles of Terminal Condensation Domain in Cyclosporine Biosynthesis
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong
Cao, Shuyong; Yang, Yanzhen; Zhong, Xiaofen; Yang, Huanghao; Guo, Zhihong Conference paper
2003 7
A chemical approach to generate molecular diversity based on the scaffold of cyclic decapeptide antibiotic tyrocidine A
Journal of combinatorial chemistry, v. 5, (4), 2003, JUL-AUG, p. 353-355
Qin, Chuanguang; Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong Article
Biomimetic synthesis of gramicidin S and analogues by enzymatic cyclization of linear precursors on solid support
Organic letters, v. 5, (10), 2003, MAY 15, p. 1749-1752
Wu, Xiaoming; Bu, Xianzhang; Wong, Ka Man; Yan, Weili; Guo, Zhihong Article
Dissociation of antibacterial and hemolytic activities of an amphipathic peptide antibiotic
Journal of medicinal chemistry, v. 46, (23), 2003, NOV 6, p. 4830-4833
Qin, Chuanguang; Zhong, Xiaofen; Bu, Xianzhang; Ng, Na Lee Joyce; Guo, Zhihong Article
The biosynthesis of GDP-L-colitose: C-3 deoxygenation is catalyzed by a unique coenzyme B6-dependent enzyme
Journal of the American Chemical Society, v. 125, (19), 2003, p. 5584-5585
Beyer, Noelle; Alam, Jenefer; Hallis, Tina M.; Guo, Zhihong; Liu, Hung-wen Article
Evolve Cyclic Peptide Antibiotics to Contain Microbial Resistance
Singapore International Chemical Conference III: Frontiers in Physical and Analytical Chemistry, Singapore, 15-17 December
Guo, Zhihong Conference paper
Exploring Pre-organized Conformation of the Linear Gramicidin Precursor for Biomimetic Synthesis of Cyclopeptide Libraries
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-51
Wu, Xiaoming; Mak, Chun Kit; Qin, Chuanguang; Guo, Zhihong Conference paper
Identification of Viral Epitopes for Immunoglobulins from SARS Patients
Eleventh Symposium on Chemistry Postgraduate Research in Hong Kong, 2004.
Zhong, Xiaofen; Yang, Huanghao; Guo, Zufeng; Wu, Jie; Yang, Yanzhen; Cao, Shuyong; Xie, Yong; Guo, Zhihong Conference paper
2002 19
An improved deblocking agent for direct Fmoc solid-phase synthesis of peptide thioesters
Tetrahedron letters, v. 43, (13), 2002, MAR 25, p. 2419-2422
Bu, Xianzhang; Xie, Guiyang; Law, Chi Wang; Guo, Zhihong Article
Substrate spectrum of tyrocidine thioesterase probed with randomized peptide N-acetylcysteamine thioesters
Bioorganic & medicinal chemistry letters, v. 12, (6), 2002, MAR 25, p. 989-992
Xie, Guiyang; Uttamchandani, Mahesh; Chen, Grace Y.J.; Bu, Xianzhang; Lin, San San; Wong, Ka Man; Yan, Weili; Yao, Shao Q.; Guo, Zhihong Article
Synthesis of tyrocidine A and its analogues by spontaneous cyclization in aqueous solution
Organic letters, v. 4, (17), 2002, AUG 22, p. 2893-2895
Bu, Xianzhang; Wu, Xiaoming; Xie, Guiyang; Guo, Zhihong Article
A Chemical Approach to Engineering of the Cyclic Decapeptide Antibiotic Tyrocidine A
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-48
Qin, Chuanguang; Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong Conference paper
A modified Fmoc method for direct solid-state synthesis of peptide thioesters and its application to total synthesis of Tyrocidine A
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, o-53
Bu, Xianzhang; Xie, Guiyang; Wang, Chi Wang; Guo, Zhihong Conference paper
A-beta amyloidosis inhibitors from traditional Chinese medicines
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, O-58
Peng, Tuohua; Wong, Ka Man; Guo, Zhihong Conference paper
Biomimetic Combinatorial Synthesis of Cyclic Peptide Libraries for Drug Discovery
Frontiers in Biomedical Research, The University of Hong Kong, 6 December, p. 85
Guo, Zhihong Conference paper
Biomimetic Combinatorial Synthesis of Cyclic Peptide Libraries for Drug Discovery
Third International Symposium for Chinese Medicinal Chemists, Hong Kong, China, December 28-31, OP-8
Guo, Zhihong Conference paper
Combinatorial Synthesis and Screening of a Cyclopeptide Library based on the Tyrocidine Scaffold
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-50
Qin, Chuanguang; Bu, Xianzhang; Zhong, Xiaofen; Guo, Zhihong Conference paper
Oligomeric intermediates in amyloid-beta peptides fibrillogenesis arrested by N-terminal fusion are not neurotoxic
Ninth symposium on chemistry postgraduate research in Hong Kong, Book of Abstracts, O-57
Wei, Jianwen; Yan, Weili; Wong, Kan Man; Bu, Xianzhang; Lai, Lo Ming; Ng, Na Lee; Xie, Guiyang; Guo, Zhihong Conference paper
Parallel Solid-phase Synthesis of Streptocidins A~D through Spontaneous Self-cyclization of Their Linear Precursors
Third International Symposium for Chinese Medicinal Chemists, pp. 57
Qin, Chuanguang; Chan, Wing Sze; Guo, Zhihong Conference paper
Parallel synthesis of Tyrocidine A analogues through spontaneous cyclization of peptide thioesters
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, o-55
Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong Conference paper
Synthesis of Gramicidin S Analogues: Chemical versus Chemoenzymatic Approach
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-46
Bu, Xianzhang; Wu, Xiaoming; Guo, Zhihong Conference paper
Synthesis of Gramicidin S by Conformation-dependent Cyclization of Its Linear Biosynthetic Precursor
Third International Symposium for Chinese Medicinal Chemists, pp. 59
Wu, Xiaoming; Mak, Chun Kit; Bu, Xianzhang; So, Sau Man; Guo, Zhihong Conference paper
Synthesis, characterization, and screening of positional scanning cyclopeptide libraries based on Tyrocidine scaffold
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, O-56
Xie, Guiyang; Uttamchandani, Mahesh; Chen, Grace Y.J.; Bu, Xianzhang; Lin, San San; Wong, Ka Man; Yan, Weili; Wei, Jianwen; Yao, Shao Q.; Guo, Zhihong Conference paper
Traceless Biomimetic Synthesis of Tyrocidines
Third International Symposium for Chinese Medicinal Chemists, pp. 56
Qin, Chuanguang; Chan, Wing Sze; Wu, Xiaoming; Guo, Zhihong Conference paper
Traceless Solid-phase Synthesis of Streptocidins
Tenth Symposium on Chemistry Postgraduate Research in Hong Kong, O-47
Qin, Chuanguang; Chan, Wing Sze; Guo, Zhihong Conference paper
Utilization of a substrate intramolecular hydrogen bond in catalysis by enterobactin thioesterase
Ninth Symposium on Chemistry Postgraduate Research in Hong Kong, Book of Abstracts, O-54
Xie, Guiyang; Wu, Xiaoming; Wong, Kan Man; Yan, Weili; Ng, Na Lee; Guo, Zhihong Conference paper
Utilization of Thioesterase from Non-ribosomal Peptide Synthase in Biomimetic Synthesis of Gramicidin S
Third International Symposium for Chinese Medicinal Chemists, pp. 58
Wu, Xiaoming; Mak, Chun Kit; So, Sauman; Guo, Zhihong Conference paper
2001 3
Insights into the branched-chain formation of mycarose: Methylation catalyzed by an (S)-adenosylmethionine-dependent methyltransferase
Angewandte Chemie (International ed.), v. 40, (3), 2001, p. 607-610
Chen, Huawei; Zhao, Zongbao; Hallis, Tina M.; Guo, Zhihong; Liu, Hung-wen Article
Phage display: A powerful tool in biomedical research
Frontiers of Biotechnology & Pharmaceuticals / Edited by Huang, Z., Guo, M., Reiner, J., Zhao, K.. Beijing. Science Press, v. 2, 2001, p. 32–58
Guo, Zhihong Book chapter
Recent Development on novel ZnS-based UV detectors
The proceedings of the Symposium on recent advances in photonics technology, 6 December, Hong Kong, sou-1-4
Sou, I.K.; Wu, Marcus C.W.; Lai, L.S.; Guo, Z.; Wong, G.K.L. Conference paper
2000 1
Designing small-molecule switches for protein-protein interactions
Science, v. 288, (5473), 2000, p. 2042-2045
Guo, Z.; Zhou, D.; Schultz, P.G. Article
1999 1
Biosynthesis of mycarose: Isolation and characterization of enzymes involved in the C-2 deoxygenation
Journal of the American Chemical Society, v. 121, (35), September 1999, p. 8124-8125
Chen, Huawei; Agnihotri, Gautam; Guo, Zhihong; Que, Nanette L.S.; Chen, Xuemei H.; Liu, Hung-wen Article
1998 2
Biosynthesis of yersiniose: Attachment of the two-carbon branched-chain is catalyzed by a thiamine pyrophosphate-dependent flavoprotein
Journal of the American Chemical Society, v. 120, (45), November 1998, p. 11796-11797
Chen, Huawei; Guo, Zhihong; Liu, Hung-wen Article
Expression, purification, and characterization of TyIM1, an N,N-dimethyltransferase involved in the biosynthesis of mycaminose
Journal of the American Chemical Society, v. 120, (38), September 1998, p. 9951-9952
Chen, Huawei; Guo, Zhihong; Liu, Hung-wen Article
1996 2
Mechanistic studies of the inactivation of crotonase by (methylenecyclopropyl)formyl-CoA
Journal of the American Chemical Society, v. 118, (1), January 1996, p. 275-276
Li, Ding; Guo, Zhihong; Liu, Hung-wen Article
Synthesis and phase-transition of 4-alkoxycarbonylphenyl 4'-n-alkoxy-2,3,5,6-tetrafluorobiphenyl-4-carboxylates
Molecular crystals and liquid crystals science and technology. Section A, Molecular crystals and liquid crystals, v. 275, 1996, p. 27-36
Wen, J.; Tian, M.; Guo, Z.; Chen, Q. Article
1995 1
Mechanistic studies of the biosynthesis of 3,6-dideoxy sugars: Stereochemical analysis of C-3 deoxygenation
Journal of the American Chemical Society, v. 117, (18), May 1995, p. 5158-5159
Pieper, Pieper A.; Guo, Zhifong; Liu, Hung-wen Article
1994 1
Novel fluorinated liquid crystals. Part 9. Synthesis and memomorphic properties of 4-(alkoxycarbonyl) phenyl 4-[(4-alkoxy-2,3,5,6-tetrafluorophenyl)ethynyl]benzoates
J. Mater. Chem., v. 4, 1994, p. 327–330
Wen, J.; Tian, M.; Yu, H.; Guo, Zhihong; Chen, Q. Article
No Publications
Teaching Assignment
2021-22 Winter 0 2021-22 Fall 5 2020-21 Summer 0 2020-21 Spring 7 2020-21 Winter 0 2020-21 Fall 5
CHEM4120 Biomolecular Chemistry
CHEM4691 Capstone Research I
CHEM4692 Capstone Research II
CHEM6771 Professional Enrichment in Chemistry
CHEM6772 Professional Development in Chemistry
CHEM4130 Medicinal Chemistry
CHEM4691 Capstone Research I
CHEM6771 Professional Enrichment in Chemistry
CHEM6772 Professional Development in Chemistry
CHMS5112 Food and Drug Analysis
SCIE1500 Guided Study on Research I
SCIE4500 IRE Research Project II
CHEM4120 Biomolecular Chemistry
CHEM4689 Capstone Project
CHEM6771 Professional Enrichment in Chemistry
CHEM6772 Professional Development in Chemistry
SCIE3500 IRE Research Project I
No Teaching Assignments
No Teaching Assignments
No Teaching Assignments
Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)
All Supervisions Current RPGs Graduated RPGs
Current RPGs
Doctor of Philosophy LAW, Wai Kit
Chemistry( 2021 - )
LI, Keyao (co-supervision)
Chemistry( 2021 - )
LI, Xin
Chemistry( 2021 - )
LIU, Wenchao (co-supervision)
Earth, Ocean and Atmospheric Sciences( 2021 - )
MACHHUA, Pragyansree
Chemistry( 2021 - )
WANG, Xinnan
Chemistry( 2021 - )
XIA, Hui
Chemistry( 2021 - )
ZHANG, Chen
Chemistry( 2021 - )
LIU, Yu
Chemistry( 2020 - )
YE, Weijian
Chemistry( 2020 - )
Master of Philosophy MA, Yanyi
Chemistry( 2021 - )
UNNITHAN, Vignesh Gopalakrishnan
Chemistry( 2021 - )
WONG, Ting Hei
Chemistry( 2020 - )
Graduated RPGs
Doctor of Philosophy LI, Tin Lok
Chemistry( Completed in 2020 )
JIANG, Yiping
Chemistry( Completed in 2019 )
QIN, Mingming
Chemistry( Completed in 2019 )
ProjectsFrom January 2020 to December 2022
All Projects 9 Leading Projects 3 Participating Projects 6
Molecular basis of the influence of phosphatidylglycerol on daptomycin susceptibility and resistance
磷脂酰甘油对达托霉素药敏性与抗药性影响的结构基础研究 Leading
RGC - General Research Fund
Project Team (HKUST)
GUO Zhihong (Lead)
2022 -
New Aggregation-Induced Emission Systems: Solving the Existing Problems in Bioimaging and Developing New Biological Applications
聚集诱导发光新体系：解决生物成像中存在的问题并开发新的生物应用 Leading
RGC - Collaborative Research Fund
Project Team (HKUST)
GUO Zhihong (Lead)
KWOK Ryan Tsz Kin
LAM Wing Yip
2021 -
The Indium-Rich Metal Jet: A Bright Dual Wavelength X-ray Source for S-XRD and SAXS
富铟 MetalJet: 用於S-XRD和SAXS的明亮的双波长X射线源 Participating
RGC - Collaborative Research Fund
Project Team (HKUST)
WILLIAMS Ian Duncan (Lead)
GUO Zhihong
HALPERT Jonathan Eugene
2021 -
A Smart Theranostic System Based on Biomimetic Nanoaggregates
新型智能仿生聚集态纳米诊疗系统 Participating
Innovation and Technology Fund
Project Team (HKUST)
GUO Zhihong
KWOK Ryan Tsz Kin
SUN Jianwei
2021 -
Role of pangolins in the emergence of SARS-CoV-2 and other viruses in humans
穿山甲在新冠肺炎病毒和其他病毒出现於人类中的作用 Participating
RGC - Collaborative Research Fund
Project Team (HKUST)
GUO Zhihong
2021 -
Novel Antibiotics from Genome Mining and Diversity-oriented Synthesis
发现新型抗生素：基因组挖掘与多样性导向有机合成相结合的策略 Participating
RGC - Collaborative Research Fund
Project Team (HKUST)
TONG Rongbiao (Lead)
GUO Zhihong
QIAN Peiyuan
2020 -
Dynamic compartmentation of peptidoglycan biosynthesis in fluidic membrane microdomains and septum
肽聚糖生物合成在高流动性微膜区与隔膜区之间动态区域化进行的研究 Leading
National Natural Science Foundation of China
Project Team (HKUST)
GUO Zhihong (Lead)
2019 -
Hong Kong Branch of National Engineering Research Center for Tissue Restoration & Reconstruction
国家人体组织功能重建工程技术研究中心香港分中心 Participating
Innovation and Technology Fund
Project Team (HKUST)
SUN Jianwei (Lead)
CHAU Ying
GUO Zhihong
HSING I-ming
IP Nancy Yuk-Yu
JIA Guocheng
KO Robert Kam Ming
KWOK Ryan Tsz Kin
LAM Wing Yip
LIANG Chun
LIN Nian
LUO Zhengtang
MI Yongli
TSIM Karl Wah Keung
WILLIAMS Ian Duncan
WU Hongkai
WU Zhenguo
YAN Henry He
YAN Yan
YANG Jinglei
YAO Shuhuai
2015 -
State Key Laboratory of Molecular Neuroscience (The Hong Kong University of Science and Technology)
分子神经科学国家重点实验室（香港科技大学） Participating
Innovation and Technology Fund
Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHOW King Lau
CHUNG Kenny K
DAI Wei Min
GUO Zhihong
HUANG Pingbo
LIANG Chun
MILLER Andrew Leitch
POON Randy Yat Choi
QI Robert Zhong
TSIM Karl Wah Keung
WEN Zilong
WONG Joseph Tin Yum
WONG Yung Hou
WU Zhenguo
ZHU Guang
2011 -
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香港科技大学理学院老师教师导师介绍简介-Zhihong GUO
本站小编 Free考研考试/2022-01-30
相关话题/理学院 香港科技大学
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