Aifang CHENG
程爱芳
PhD in Life Science
The Hong Kong University of Science and Technology, 2018

Research Assistant Professor
Department of Ocean Science



chengaf@ust.hk
Room 3642

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ORCID
0000-0002-5022-418X

Scopus ID
56493908600




Research Interest Publications Teaching Assignment




Research Interest

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Neuroscience
Neurodegenerative disease
Marine bacteria
Cellular and molecular mechanisms
Molecular medicine



Publications

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All Years 19 2022 0 2021 3 2020 1 2019 3 2018 3 2017 1 2016 8

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2021 3

Discovery, Bioactivity Evaluation, Biosynthetic Gene Cluster Identification, and Heterologous Expression of Novel Albofungin Derivatives
Frontiers in Microbiology, v. 12, February 2021, article number 635268
She, Weiyi; Ye, Wenkang; Cheng, Aifang; Liu, Xin; Tang, JianWei; Lan, Yi; Chen, Feng; Qian, Peiyuan Article
Global Genome Mining Reveals a Cytochrome P450-Catalyzed Cyclization of Crownlike Cyclodipeptides with Neuroprotective Activity
Organic Letters, v. 23, (17), April 2021, p. 6601-6605
Malit, Jessie James Limlingan; Liu, Wenchao; Cheng, Aifang; Saha, Subhasish; Liu, Lingli; Qian, Peiyuan Article
Hologenome analysis reveals dual symbiosis in the deep-sea hydrothermal vent snail Gigantopelta aegis
Nature Communications, v. 12, (1), February 2021, article number 1165
Lan, Yi; Sun, Jin; Chen, Chong; Sun, Yanan; Zhou, Yadong; Yang, Yi; Zhang, Weipeng; Li, Runsheng; Zhou, Kun; Wong, Wai Chuen; Kwan, Yick Hang; Cheng, Aifang; Bougouffa, Salim; Van Dover, Cindy Lee; Qiu, Jian-Wen; Qian, Peiyuan Article

2020 1

ATM loss disrupts the autophagy-lysosomal pathway
Autophagy, August 2020
Cheng, Aifang; Tse, Kai-Hei; Chow, Hei-Man; Gan, Yunqiao; Song, Xuan; Ma, Fulin; Qian, Yi Xuan Yvonne; She, Weiyi; Herrup, Karl Article

2019 3

Age-related Hyperinsulinemia Leads to Insulin Resistance in Neurons and Cell-cycle-induced Senescence
Nature Neuroscience, v. 22, (11), November 2019, p. 1806-1819
Chow, Hei Man; Shi, Meng; Cheng, Aifang; Gao, Yuehong; Chen, Guimiao; Song, Yixuan; So, Wai Lam Raphaella; Zhang, Jie; Herrup, Karl Article
ATM is Activated by ATP Depletion and Modulates Mitochondrial Function Through NRF1
Journal of Cell Biology, v. 218, (3), March 2019, p. 909-928
Chow, Hei Man; Cheng, Aifang; Song, Xuan; Swerdel, Mavis R.; Hart, Ronald, P.; Herrup, Karl Article
Insulin resistant neurons arisen from peripheral hyperinsulinemia are senescent and correlate with memory impairment and cognitive decline: implications for Alzheimer's disease
Alzheimer's and Dementia, v. 15, (7S, pt. 6), July 2019, article number P-184, p. 307
Chow, Hei Man; Shi, Meng; Zhang, Jie; Chen, Guimiao; Cheng, Aifang; Song, Xuan; So, Raphaella Wai Lam; Herrup, Karl Conference paper

2018 3

ATM and ATR Play Complementary Roles in the Behavior of Excitatory and Inhibitory Vesicle Populations
Proceedings of the National Academy of Sciences of the United States of America (PNAS), v. 115, (2), January 2017, article number pnas.1716892115, p. E292-E301
Cheng, Aifang; Zhao, Teng; Tse, Kai Hei; Chow, Hei Man; Cui, Yong; Jiang, Liwen; Du, Shengwang; Loy, Michael Ming-tak; Herrup, Karl Article
DNA Damage-associated Oligodendrocyte Degeneration Precedes Amyloid Pathology and Contributes to Alzheimer's Disease and Dementia
Alzheimers & Dementia, v. 14, (5), May 2018, p. 664-679
Tse, Kai Hei; Cheng, Aifang; Ma, Fulin; Herrup, Karl Article
ATM is activated by ATP depletion and modulates mitochondrial function through NRF1
48th Annual Meeting of the Society for Neuroscience, San Diego, CA, 3-7 November 2018
Chow, Hei Man; Cheng, Aifang; Song, Xuan; Swerdel, M.; Hart, Ronald P.; Herrup, Karl Conference paper

2017 1

Insulin resistance mediates neuronal cell cycle re-entry, dysfunction and degeneration
The 47th Annual Meeting of the Society for Neuroscience (Neuroscience 2017), Washington, DC, USA, 11-15 November
Chow, Hei Man; Cheng, Aifang; Herrup, Karl Conference paper

2016 4

ATM Protein is Located on Presynaptic Vesicles and its Deficit Leads to Failures in Synaptic Plasticity
Journal of Neurophysiology, v. 116, (1), July 2016, p. 201-209
Vail, Graham; Cheng, Aifang; Han, Yu Ray; Zhao, Teng; Du, Shengwang; Loy, Michael Ming-tak; Herrup, Karl; Plummer, Mark R. Article
Multicolor 4D fluorescence microscopy using ultrathin bessel light sheets
Scientific Reports, v. 6, May 2016, article number 26159
Zhao, Teng; Lau, Sze Cheung; Wang, Ying; Su, Yumian; Wang, Hao; Cheng, Aifang; Herrup, Karl; Ip, Nancy Y.; Du, Shengwang; Loy, M.M.T. Article
A Robust Two-Color Super-Resolution Localization Microscope
SPIE Photonics West: BIOS, Conference 9714: Single Molecule Spectroscopy and Superresolution Imaging IX, San Francisco, California, 13-18 February 2016
Loy, Michael Ming-tak; Du, Shengwang; Qu, Xiaoxuan; Cheng, Aifang; Zhai, Yuanliang; Wang, Ying; Zhao, Teng Conference paper
DNA damage--associated loss of cortical oligodendrocytes in dementia and Alzheimer's disease
48th Annual Meeting of the Society for Neuroscience, San Diego, CA, US, 12-16 November 2016
Tse, Kai Hei; Cheng, Aifang; Ma, Fulin; Chow, Hei Man; Herrup, Karl Conference paper

2015 2

A User-Friendly Two-Color Super-Resolution Localization Microscope
Optics Express, v. 23, (2), January 2015, p. 1879-1887
Zhao, Teng; Wang, Ying; Zhai, Yuanliang; Qu, Xiaoxuan; Cheng, Aifang; Du, Shengwang; Loy, Michael Ming-tak Article
White matter degeneration and aberrant oligodendrocyte differentiation during the progress of Alzheimer’s disease
45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015), Chicago, IL, US, 17-21 October 2015
Tse, Kai Hei; Cheng, Aifang; Chow, Hei Man; Herrup, Karl Conference paper

2014 1

Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress
Journal of Medicinal Food, v. 17, (5), May 2014, p. 535-542
Ai, Zhong; Cheng, Ai-Fang; Yu, Yuan-Tao; Yu, Long-Jiang; Jin, Wenwen Article

2012 1

国产玛咖芥子油苷的组分分析和含量测定
食品科技=Food Science and Technology, v. 37, (4), 2012, p. 182-186
艾中; 程爱芳; 孟际勇; 刘浩; 余龙江; 金文闻 Article


Expand All Collapse All


Article 3

Discovery, Bioactivity Evaluation, Biosynthetic Gene Cluster Identification, and Heterologous Expression of Novel Albofungin Derivatives
Frontiers in Microbiology, v. 12, February 2021, article number 635268
She, Weiyi; Ye, Wenkang; Cheng, Aifang; Liu, Xin; Tang, JianWei; Lan, Yi; Chen, Feng; Qian, Peiyuan
Global Genome Mining Reveals a Cytochrome P450-Catalyzed Cyclization of Crownlike Cyclodipeptides with Neuroprotective Activity
Organic Letters, v. 23, (17), April 2021, p. 6601-6605
Malit, Jessie James Limlingan; Liu, Wenchao; Cheng, Aifang; Saha, Subhasish; Liu, Lingli; Qian, Peiyuan
Hologenome analysis reveals dual symbiosis in the deep-sea hydrothermal vent snail Gigantopelta aegis
Nature Communications, v. 12, (1), February 2021, article number 1165
Lan, Yi; Sun, Jin; Chen, Chong; Sun, Yanan; Zhou, Yadong; Yang, Yi; Zhang, Weipeng; Li, Runsheng; Zhou, Kun; Wong, Wai Chuen; Kwan, Yick Hang; Cheng, Aifang; Bougouffa, Salim; Van Dover, Cindy Lee; Qiu, Jian-Wen; Qian, Peiyuan


Expand All Collapse All


Article 1

ATM loss disrupts the autophagy-lysosomal pathway
Autophagy, August 2020
Cheng, Aifang; Tse, Kai-Hei; Chow, Hei-Man; Gan, Yunqiao; Song, Xuan; Ma, Fulin; Qian, Yi Xuan Yvonne; She, Weiyi; Herrup, Karl


Expand All Collapse All


Article 2

Age-related Hyperinsulinemia Leads to Insulin Resistance in Neurons and Cell-cycle-induced Senescence
Nature Neuroscience, v. 22, (11), November 2019, p. 1806-1819
Chow, Hei Man; Shi, Meng; Cheng, Aifang; Gao, Yuehong; Chen, Guimiao; Song, Yixuan; So, Wai Lam Raphaella; Zhang, Jie; Herrup, Karl
ATM is Activated by ATP Depletion and Modulates Mitochondrial Function Through NRF1
Journal of Cell Biology, v. 218, (3), March 2019, p. 909-928
Chow, Hei Man; Cheng, Aifang; Song, Xuan; Swerdel, Mavis R.; Hart, Ronald, P.; Herrup, Karl

Conference paper 1

Insulin resistant neurons arisen from peripheral hyperinsulinemia are senescent and correlate with memory impairment and cognitive decline: implications for Alzheimer's disease
Alzheimer's and Dementia, v. 15, (7S, pt. 6), July 2019, article number P-184, p. 307
Chow, Hei Man; Shi, Meng; Zhang, Jie; Chen, Guimiao; Cheng, Aifang; Song, Xuan; So, Raphaella Wai Lam; Herrup, Karl


Expand All Collapse All


Article 2

ATM and ATR Play Complementary Roles in the Behavior of Excitatory and Inhibitory Vesicle Populations
Proceedings of the National Academy of Sciences of the United States of America (PNAS), v. 115, (2), January 2017, article number pnas.1716892115, p. E292-E301
Cheng, Aifang; Zhao, Teng; Tse, Kai Hei; Chow, Hei Man; Cui, Yong; Jiang, Liwen; Du, Shengwang; Loy, Michael Ming-tak; Herrup, Karl
DNA Damage-associated Oligodendrocyte Degeneration Precedes Amyloid Pathology and Contributes to Alzheimer's Disease and Dementia
Alzheimers & Dementia, v. 14, (5), May 2018, p. 664-679
Tse, Kai Hei; Cheng, Aifang; Ma, Fulin; Herrup, Karl

Conference paper 1

ATM is activated by ATP depletion and modulates mitochondrial function through NRF1
48th Annual Meeting of the Society for Neuroscience, San Diego, CA, 3-7 November 2018
Chow, Hei Man; Cheng, Aifang; Song, Xuan; Swerdel, M.; Hart, Ronald P.; Herrup, Karl


Expand All Collapse All


Conference paper 1

Insulin resistance mediates neuronal cell cycle re-entry, dysfunction and degeneration
The 47th Annual Meeting of the Society for Neuroscience (Neuroscience 2017), Washington, DC, USA, 11-15 November
Chow, Hei Man; Cheng, Aifang; Herrup, Karl


Expand All Collapse All


Article 2

ATM Protein is Located on Presynaptic Vesicles and its Deficit Leads to Failures in Synaptic Plasticity
Journal of Neurophysiology, v. 116, (1), July 2016, p. 201-209
Vail, Graham; Cheng, Aifang; Han, Yu Ray; Zhao, Teng; Du, Shengwang; Loy, Michael Ming-tak; Herrup, Karl; Plummer, Mark R.
Multicolor 4D fluorescence microscopy using ultrathin bessel light sheets
Scientific Reports, v. 6, May 2016, article number 26159
Zhao, Teng; Lau, Sze Cheung; Wang, Ying; Su, Yumian; Wang, Hao; Cheng, Aifang; Herrup, Karl; Ip, Nancy Y.; Du, Shengwang; Loy, M.M.T.

Conference paper 2

A Robust Two-Color Super-Resolution Localization Microscope
SPIE Photonics West: BIOS, Conference 9714: Single Molecule Spectroscopy and Superresolution Imaging IX, San Francisco, California, 13-18 February 2016
Loy, Michael Ming-tak; Du, Shengwang; Qu, Xiaoxuan; Cheng, Aifang; Zhai, Yuanliang; Wang, Ying; Zhao, Teng
DNA damage--associated loss of cortical oligodendrocytes in dementia and Alzheimer's disease
48th Annual Meeting of the Society for Neuroscience, San Diego, CA, US, 12-16 November 2016
Tse, Kai Hei; Cheng, Aifang; Ma, Fulin; Chow, Hei Man; Herrup, Karl


Expand All Collapse All


Article 1

A User-Friendly Two-Color Super-Resolution Localization Microscope
Optics Express, v. 23, (2), January 2015, p. 1879-1887
Zhao, Teng; Wang, Ying; Zhai, Yuanliang; Qu, Xiaoxuan; Cheng, Aifang; Du, Shengwang; Loy, Michael Ming-tak

Conference paper 1

White matter degeneration and aberrant oligodendrocyte differentiation during the progress of Alzheimer’s disease
45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015), Chicago, IL, US, 17-21 October 2015
Tse, Kai Hei; Cheng, Aifang; Chow, Hei Man; Herrup, Karl


Expand All Collapse All


Article 1

Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress
Journal of Medicinal Food, v. 17, (5), May 2014, p. 535-542
Ai, Zhong; Cheng, Ai-Fang; Yu, Yuan-Tao; Yu, Long-Jiang; Jin, Wenwen


Expand All Collapse All


Article 1

国产玛咖芥子油苷的组分分析和含量测定
食品科技=Food Science and Technology, v. 37, (4), 2012, p. 182-186
艾中; 程爱芳; 孟际勇; 刘浩; 余龙江; 金文闻


Expand All Collapse All


2016 4

ATM Protein is Located on Presynaptic Vesicles and its Deficit Leads to Failures in Synaptic Plasticity
Journal of Neurophysiology, v. 116, (1), July 2016, p. 201-209
Vail, Graham; Cheng, Aifang; Han, Yu Ray; Zhao, Teng; Du, Shengwang; Loy, Michael Ming-tak; Herrup, Karl; Plummer, Mark R. Article
Multicolor 4D fluorescence microscopy using ultrathin bessel light sheets
Scientific Reports, v. 6, May 2016, article number 26159
Zhao, Teng; Lau, Sze Cheung; Wang, Ying; Su, Yumian; Wang, Hao; Cheng, Aifang; Herrup, Karl; Ip, Nancy Y.; Du, Shengwang; Loy, M.M.T. Article
A Robust Two-Color Super-Resolution Localization Microscope
SPIE Photonics West: BIOS, Conference 9714: Single Molecule Spectroscopy and Superresolution Imaging IX, San Francisco, California, 13-18 February 2016
Loy, Michael Ming-tak; Du, Shengwang; Qu, Xiaoxuan; Cheng, Aifang; Zhai, Yuanliang; Wang, Ying; Zhao, Teng Conference paper
DNA damage--associated loss of cortical oligodendrocytes in dementia and Alzheimer's disease
48th Annual Meeting of the Society for Neuroscience, San Diego, CA, US, 12-16 November 2016
Tse, Kai Hei; Cheng, Aifang; Ma, Fulin; Chow, Hei Man; Herrup, Karl Conference paper

2015 2

A User-Friendly Two-Color Super-Resolution Localization Microscope
Optics Express, v. 23, (2), January 2015, p. 1879-1887
Zhao, Teng; Wang, Ying; Zhai, Yuanliang; Qu, Xiaoxuan; Cheng, Aifang; Du, Shengwang; Loy, Michael Ming-tak Article
White matter degeneration and aberrant oligodendrocyte differentiation during the progress of Alzheimer’s disease
45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015), Chicago, IL, US, 17-21 October 2015
Tse, Kai Hei; Cheng, Aifang; Chow, Hei Man; Herrup, Karl Conference paper

2014 1

Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress
Journal of Medicinal Food, v. 17, (5), May 2014, p. 535-542
Ai, Zhong; Cheng, Ai-Fang; Yu, Yuan-Tao; Yu, Long-Jiang; Jin, Wenwen Article

2012 1

国产玛咖芥子油苷的组分分析和含量测定
食品科技=Food Science and Technology, v. 37, (4), 2012, p. 182-186
艾中; 程爱芳; 孟际勇; 刘浩; 余龙江; 金文闻 Article


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 1 2020-21 Summer 0 2020-21 Spring 0 2020-21 Winter 0 2020-21 Fall 1

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OCES6011A Postgraduate Seminar


ENVS6011Q Postgraduate Seminar


No Teaching Assignments


No Teaching Assignments


No Teaching Assignments


No Teaching Assignments









ProjectsFrom January 2020 to December 2022

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