Kenny K CHUNG
锺家健
PhD in Neuroscience
University of Cambridge, 2001

Associate Professor
Division of Life Science

Program Director of BSc in Biotechnology and Business Program



(852) 2358 8019
bckchung@ust.hk
Room 5439
Personal Web

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ORCID
0000-0002-4002-1338

Scopus ID
23970042200




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Molecular mechanisms of neurodegeneration



Publications

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All Years 42 2022 0 2021 0 2020 1 2019 0 2018 1 2017 2 2016 38

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2020 1

S-Nitrosylation of G Protein-Coupled Receptor Kinase 6 and Casein Kinase 2 Alpha Modulates Their Kinase Activity Toward Alpha-Synuclein Phosphorylation in an Animal Model of Parkinson's Disease
PLoS ONE, v. 15, (4), 28 April 2020, article number e.0232019
Wu, Weiwei; Sung, Chun Chau; Yu, Peichun; Li, Jiahua; Chung, Kenny K Article

2018 1

PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect.
Proceedings of the National Academy of Sciences of the United States of America, v. 115, (30), July 2018, p. E7193-E7201
He, Jing; Xia, Mengying; Yeung, Patrick KK; Li, Jiahua; Li, Zhifang; Chung, Ka Kin Kenny; Chung, Sookja K; Xia, Jun Article

2017 2

Novel Enhancement Mechanism of Tyrosine Hydroxylase Enzymatic Activity by Nitric Oxide through S-nitrosylation
Scientific Reports, v. 7, March 2017, article number 44154
Wang, Yuanyuan; Sung, Chunchau; Chung, Kenny K K Article
The role of nitric oxide signaling in the pathogenesis of Parkinson's disease
International Conference Genetics, Mechanisms and Therapies of Neurodegenerative and Psychiatric Disorders, Harbin Institute of Technology, Harbin, China, 6-7 July 2017
Wu, Weiwei; Wang, Yuanyuan; Chung, Kenny K Conference paper

2015 2

S-nitrosylation of XIAP at Cys 213 of BIR2 Domain Impairs XIAP's Anti-caspase 3 Activity and Anti-apoptotic Function
Apoptosis, v. 20, (4), 2015, p. 491-499
Wu, Weiwei; Wan, Oi Wan; Chung, Kenny Ka Kin Article
Studying Nitrosative Stress in Parkinson’s Disease
Stress Responses / Editors: Christine M. Oslowski. New York : Humana Press, New York, NY, 2015, p. 195-201, Series: Methods in Molecular Biology
Chung, Kenny K K Book chapter

2012 2

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease
Journal of neurochemistry, v. 122, (2), July 2012, p. 404-414
Xie, Weilin; Chung, Kenny K.K. Article
The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson's Disease
PLoS ONE, v. 7, (6), June 2012
Wan, Oi Wan; Chung, Kenny K.K. Article

2011 4

P32 regulates mitochondrial morphology and dynamics through parkin
Neuroscience, v. 199, 2011, p. 346-358
Li, Youjun; Wan, Oi Wan; Xie, W.; Chung, Kenny K.K. Article
Involvement of S-nitrosylation in neurodegeneration
Post-translational modifications in health and disease / Edited by Cecilio J. Vidal. New York : Springer, 2011, p. 79-95
Chung, Kenny K.K.; Li, Y. Book chapter
S-Nitrosylation of Cdk5 Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development
The 9th Biennial Conference of the Chinese Neuroscience Society, Henan, China, 29 July - 1 August 2011
Zhang, P.; Yu,P-C; Tsang, A.H.; Chen, Y.; Fu, Kit Yu; Fu, WY; Chung, Kenny Ka Kin; Ip, Nancy Yuk-Yu Conference paper
The role of alpha-synuclein aggregation in Parkinson's disease
13th International Neuroscience Winter Conference, S?lden Austria, 2011
Wan, Oi Wan; Chung, Kenny Conference paper

2010 5

Emerging roles of nitric oxide in neurodegeneration
Nitric oxide-biology and CHEMISTRY, v. 22, (4), 2010, MAY 15, p. 290-295
Chung, Kenny K.K.; David, Karen K. Article
Modulation of pro-survival proteins by S-nitrosylation: implications for neurodegeneration
Apoptosis, v. 15, (11), Nov 2010, p. 1364-1370
Chung, Kenny KK Article
New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease
BIOCHIMICA ET BIOPHYSICA acta-molecular Basis OF Disease, v. 1802, (11), 2010, NOV, p. 935-941
Xie, Weilin; Wan, Oi Wan; Chung, Kenny K.K. Article
S-nitrosylation of cyclin-dependent kinase 5 (Cdk5) regulates its kinase activity and dendrite growth during neuronal development
Journal of Neuroscience, v. 30, (43), Ocotber 2010, p. 14366-14370
Zhang, Peng; Yu, Peichun; Tsang, Anthony H.K.; Chen, Yu; Fu, Kit Yu; Fu, Wing Yu; Chung, Kenny K.K.; Ip, Nancy Yuk-Yu Article
Regulation of Cyclin-Dependent Kinase-5 Activity by S-Nitrosylation
The 40th Annual Meeting of the Society for Neuroscience, San Diego, USA, 13 - 17 November 2010
Fu, Wing Yu; Zhang, Peng; Tsang, Anthony H.K.; Xie, S.Y.; Fu, Kit Yu; Chung, Kenny K K; Ip, Nancy Yuk-Yu Conference paper

2009 4

Oxidative stress and nitrosative stress in Parkinson's disease
Biochim Biophys Acta., 1792, 643-650
Tsang, Anthony H.K.; Chung, Kenny K.K. Article
S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease
Proceedings of the National Academy of Sciences of the United States of America, v. 106, (12), 2009, MAR 24, p. 4900-4905
Tsang, Anthony H.K.; Lee, Yun-Il; Ko, Han Seok; Savitt, Joseph M.; Pletnikova, Olga; Troncoso, Juan C.; Dawson, Valina L.; Dawson, Ted M.; Chung, Kenny K.K. Article
The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease
Journal of neurochemistry, v. 110, (1), 2009, JUL, p. 208-219
Lee, F.K.M.; Wong, A.K.Y.; Lee, Y.W.; Wan, Oi Wan; Chan, H.Y.E.; Chung, Kenny K.K. Article
Characterization of p32 as an interactor of parkin
Society for Neuroscience, Chicago
Li, Yihang; Chung, Kenny K.K. Conference paper

2008 3

Modification of X-linked Inhibitor of Apoptosis Protein by Nitric Oxide
38th Annual Meeting, Society for Neuroscience, Washington DC, 15-19 Nov 2008
Tsang, Anthony H.K.; Chung, Kenny K.K. Conference paper
S-nitrosylation of x-linked inhibitor of apoptosis protein (xIAP): Implication to the pathogenesis of Parkinson's disease (PD)
Gordon Research Conference, Molecular and Cellular Neurobiology, 8-13/June/2008
Tsang, Anthony; Chung, Kenny Conference paper
The role of alpha-synuclein aggregation in the pathogenesis of Parkinson's disease
Gordon Research Conference, Molecular and cellular neurobiology, 8-13/June/2008
Wan, Oi Wan; Chung, Kenny K.K. Conference paper

2007 1

Gaseous Signaling: Nitric Oxide and Carbon Monoxide as Messenger Molecules
Handbook of Contemporary Neuropharmacology / Editor David Robert Sibley. Hoboken, N.J. : John Wiley & Sons, 2007
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M. Book chapter

2006 2

Say NO to neurodegeneration: Role of S-nitrosylation in neurodegenerative disorders
NeuroSignals, v. 15, (6), 2006, p. 307-313
Chung, Kenny K.K. Article
Functional study of parkin: insights into the pathogenesis of Parkinson's disease
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, The Hong Kong Society of Neuroscience, Hong Kong, Symposium VI
Chung, Kenny K. Conference paper

2005 5

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.
Journal of Neuroscience, 25: 7968-7978
Ko, Han S.; Coelln, Rainer V.; Sriram, Sathya R.; Kim, Seong W.; Chung, Kenny K.K.; Pletnikova, Olga; Troncoso, Juan; Johnson, Brett; Saffary, Roya; Goh, Eyleen L.; Song, Hongjun; Park, Bum-Joon; Kim, Min J.; Kim, Sunghoon; Dawson, Valina L.; Dawson, Ted M. Article
Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.
Human Molecular Genetics, 14: 2571-2586
Sriram, Sathya R.; Li, Xiaojie; Ko, Han S.; Chung, Kenny K.K.; Wong, Esther; Lim, Kah L.; Dawson, Valina L.; Dawson, Ted M. Article
Nitric oxide, S-nitrosylation and neurodegeneration.
Cellular and Molecular Biology, 51: 247-254
Chung, Kenny K.K.; Dawson, Ted M.; Dawson, Valina L. Article
Parkin mediates non-classical, proteasomal-independent, ubiquitination of Synphilin-1: Implications for Lewy Body formation
J. Neurosci., v. 25, 2005, p. 2002-2009
Lim, K.L.; Chew, K.C.M.; Tan, J.M.M.; Wang, C.; Chung, Kenny K.K.; Zhang, Y.; Tanaka, Y.; Wei, W.L.; Engelender, S.; Ross, C.A.; Dawson, V.L.; Dawson, T.M. Article
S-nitrosylation in Parkinson's disease and related neurodegenerative disorders.
Methods in Enzymology, 396: 139-150
Chung, Kenny K.K.; Dawson, Valina L.; Dawson, Ted M. Article

2004 2

Parkin and HSP70 sacked by BAG5
Neuron 44, 2004, p. 899-901
Chung, Kenny K.K.; Dawson, T.M. Article
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
Science, v. 304, (5675), 2004, p. 1328-1331
Chung, Kenny K.K.; Thomas, B.; Li, X.; Pletnikova, O.; Troncoso, J.C.; Marsh, L.; Dawson, V.L.; Dawson, T.M. Article

2003 2

New insights into Parkinson's disease
J Neurol 250 Suppl 3, 2003, p. 15-24
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M. Article
SEPT5_v2 is a parkin-binding protein
Brain Res Mol Brain Res, v. 117, (2), 2003, p. 179-189
Choi, Peter; Snyder, Heather M.; Petrucelli, Leonard; Theisler, Catherine M.; Chong, Matthew; Zhang, Yongjie; Kah Leong, Lim; Chung, Kenny K.K.; Kehoe, Kathryn; D'Adamio, Luciano D.; Lee, John; Cochran, Elizabeth J.; Bowser, Robert P.; Dawson, Ted Murray; Wolozin, Benjamin L. Article

2001 2

Parkin ubiquitinates the alpha-synuclein interacting protein, synphilin-1: implications for Lewy body formation in Parkinson"s disease
Nature Med., v. 7, (10), 2001, p. 1144-1150
Chung, Kenny K.K.; Zhang, Y.; Lim, K.L.; Tanaka, Y.; Huang, H.; Gao, J.; Ross, C.; Dawson, V.L.; Dawson, T.M. Article
The role of the ubiquitin proteasomal pathway in Parkinson's Disease and other neurodegenerative disorders
TINS., v. 24, (11), 2001, p. S7-S14
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M. Article

2000 2

C-fos expression, behavioural, endocrine and autonomic responses to acute social stress in male rats after chronic restraint: modulation by serotonin
Neuroscience, v. 95, (2), 2000, p. 453-463
Chung, Kenny K.K.; Martinez, M.; Herbert,J Article
Parkin functions as an E3-dependent ubiquitin-protein ligase and promotes the degradation of synaptic vesicle associated protein
CDCrel-1. Proc .Natl. Acad. Sci. USA, v. 97, (24), 2000, p. 13354-13359
Zhang, Y.; Gao, J.; Chung, Kenny K.K.; Huang, H.; Dawson, V.L.; Dawson, T.M. Article

1999 1

Central serotonin depletion modulates the behavioural tendocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats
Neuroscience, v, 92, (2), 1999, p. 613-625.
Chung, Kenny K.K.; Martinez, M.; Herbert, J. Article

1997 1

The antigenic sites of trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties
Life Sciences, v. 61, (23), 1997, p. 2291-2303
Mulot, S.; Chung, Kenny K.K.; Li, X.B.; Wong, C.C.; Ng, T.B.; Shaw, P.C. Article


Expand All Collapse All


Article 1

S-Nitrosylation of G Protein-Coupled Receptor Kinase 6 and Casein Kinase 2 Alpha Modulates Their Kinase Activity Toward Alpha-Synuclein Phosphorylation in an Animal Model of Parkinson's Disease
PLoS ONE, v. 15, (4), 28 April 2020, article number e.0232019
Wu, Weiwei; Sung, Chun Chau; Yu, Peichun; Li, Jiahua; Chung, Kenny K


Expand All Collapse All


Article 1

PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect.
Proceedings of the National Academy of Sciences of the United States of America, v. 115, (30), July 2018, p. E7193-E7201
He, Jing; Xia, Mengying; Yeung, Patrick KK; Li, Jiahua; Li, Zhifang; Chung, Ka Kin Kenny; Chung, Sookja K; Xia, Jun


Expand All Collapse All


Article 1

Novel Enhancement Mechanism of Tyrosine Hydroxylase Enzymatic Activity by Nitric Oxide through S-nitrosylation
Scientific Reports, v. 7, March 2017, article number 44154
Wang, Yuanyuan; Sung, Chunchau; Chung, Kenny K K

Conference paper 1

The role of nitric oxide signaling in the pathogenesis of Parkinson's disease
International Conference Genetics, Mechanisms and Therapies of Neurodegenerative and Psychiatric Disorders, Harbin Institute of Technology, Harbin, China, 6-7 July 2017
Wu, Weiwei; Wang, Yuanyuan; Chung, Kenny K


Expand All Collapse All


Article 1

S-nitrosylation of XIAP at Cys 213 of BIR2 Domain Impairs XIAP's Anti-caspase 3 Activity and Anti-apoptotic Function
Apoptosis, v. 20, (4), 2015, p. 491-499
Wu, Weiwei; Wan, Oi Wan; Chung, Kenny Ka Kin

Book chapter 1

Studying Nitrosative Stress in Parkinson’s Disease
Stress Responses / Editors: Christine M. Oslowski. New York : Humana Press, New York, NY, 2015, p. 195-201, Series: Methods in Molecular Biology
Chung, Kenny K K


Expand All Collapse All


Article 2

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease
Journal of neurochemistry, v. 122, (2), July 2012, p. 404-414
Xie, Weilin; Chung, Kenny K.K.
The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson's Disease
PLoS ONE, v. 7, (6), June 2012
Wan, Oi Wan; Chung, Kenny K.K.


Expand All Collapse All


Article 1

P32 regulates mitochondrial morphology and dynamics through parkin
Neuroscience, v. 199, 2011, p. 346-358
Li, Youjun; Wan, Oi Wan; Xie, W.; Chung, Kenny K.K.

Book chapter 1

Involvement of S-nitrosylation in neurodegeneration
Post-translational modifications in health and disease / Edited by Cecilio J. Vidal. New York : Springer, 2011, p. 79-95
Chung, Kenny K.K.; Li, Y.

Conference paper 2

S-Nitrosylation of Cdk5 Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development
The 9th Biennial Conference of the Chinese Neuroscience Society, Henan, China, 29 July - 1 August 2011
Zhang, P.; Yu,P-C; Tsang, A.H.; Chen, Y.; Fu, Kit Yu; Fu, WY; Chung, Kenny Ka Kin; Ip, Nancy Yuk-Yu
The role of alpha-synuclein aggregation in Parkinson's disease
13th International Neuroscience Winter Conference, S?lden Austria, 2011
Wan, Oi Wan; Chung, Kenny


Expand All Collapse All


Article 4

Emerging roles of nitric oxide in neurodegeneration
Nitric oxide-biology and CHEMISTRY, v. 22, (4), 2010, MAY 15, p. 290-295
Chung, Kenny K.K.; David, Karen K.
Modulation of pro-survival proteins by S-nitrosylation: implications for neurodegeneration
Apoptosis, v. 15, (11), Nov 2010, p. 1364-1370
Chung, Kenny KK
New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease
BIOCHIMICA ET BIOPHYSICA acta-molecular Basis OF Disease, v. 1802, (11), 2010, NOV, p. 935-941
Xie, Weilin; Wan, Oi Wan; Chung, Kenny K.K.
S-nitrosylation of cyclin-dependent kinase 5 (Cdk5) regulates its kinase activity and dendrite growth during neuronal development
Journal of Neuroscience, v. 30, (43), Ocotber 2010, p. 14366-14370
Zhang, Peng; Yu, Peichun; Tsang, Anthony H.K.; Chen, Yu; Fu, Kit Yu; Fu, Wing Yu; Chung, Kenny K.K.; Ip, Nancy Yuk-Yu

Conference paper 1

Regulation of Cyclin-Dependent Kinase-5 Activity by S-Nitrosylation
The 40th Annual Meeting of the Society for Neuroscience, San Diego, USA, 13 - 17 November 2010
Fu, Wing Yu; Zhang, Peng; Tsang, Anthony H.K.; Xie, S.Y.; Fu, Kit Yu; Chung, Kenny K K; Ip, Nancy Yuk-Yu


Expand All Collapse All


Article 3

Oxidative stress and nitrosative stress in Parkinson's disease
Biochim Biophys Acta., 1792, 643-650
Tsang, Anthony H.K.; Chung, Kenny K.K.
S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease
Proceedings of the National Academy of Sciences of the United States of America, v. 106, (12), 2009, MAR 24, p. 4900-4905
Tsang, Anthony H.K.; Lee, Yun-Il; Ko, Han Seok; Savitt, Joseph M.; Pletnikova, Olga; Troncoso, Juan C.; Dawson, Valina L.; Dawson, Ted M.; Chung, Kenny K.K.
The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease
Journal of neurochemistry, v. 110, (1), 2009, JUL, p. 208-219
Lee, F.K.M.; Wong, A.K.Y.; Lee, Y.W.; Wan, Oi Wan; Chan, H.Y.E.; Chung, Kenny K.K.

Conference paper 1

Characterization of p32 as an interactor of parkin
Society for Neuroscience, Chicago
Li, Yihang; Chung, Kenny K.K.


Expand All Collapse All


Conference paper 3

Modification of X-linked Inhibitor of Apoptosis Protein by Nitric Oxide
38th Annual Meeting, Society for Neuroscience, Washington DC, 15-19 Nov 2008
Tsang, Anthony H.K.; Chung, Kenny K.K.
S-nitrosylation of x-linked inhibitor of apoptosis protein (xIAP): Implication to the pathogenesis of Parkinson's disease (PD)
Gordon Research Conference, Molecular and Cellular Neurobiology, 8-13/June/2008
Tsang, Anthony; Chung, Kenny
The role of alpha-synuclein aggregation in the pathogenesis of Parkinson's disease
Gordon Research Conference, Molecular and cellular neurobiology, 8-13/June/2008
Wan, Oi Wan; Chung, Kenny K.K.


Expand All Collapse All


Book chapter 1

Gaseous Signaling: Nitric Oxide and Carbon Monoxide as Messenger Molecules
Handbook of Contemporary Neuropharmacology / Editor David Robert Sibley. Hoboken, N.J. : John Wiley & Sons, 2007
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.


Expand All Collapse All


Article 1

Say NO to neurodegeneration: Role of S-nitrosylation in neurodegenerative disorders
NeuroSignals, v. 15, (6), 2006, p. 307-313
Chung, Kenny K.K.

Conference paper 1

Functional study of parkin: insights into the pathogenesis of Parkinson's disease
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, The Hong Kong Society of Neuroscience, Hong Kong, Symposium VI
Chung, Kenny K.


Expand All Collapse All


Article 5

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.
Journal of Neuroscience, 25: 7968-7978
Ko, Han S.; Coelln, Rainer V.; Sriram, Sathya R.; Kim, Seong W.; Chung, Kenny K.K.; Pletnikova, Olga; Troncoso, Juan; Johnson, Brett; Saffary, Roya; Goh, Eyleen L.; Song, Hongjun; Park, Bum-Joon; Kim, Min J.; Kim, Sunghoon; Dawson, Valina L.; Dawson, Ted M.
Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.
Human Molecular Genetics, 14: 2571-2586
Sriram, Sathya R.; Li, Xiaojie; Ko, Han S.; Chung, Kenny K.K.; Wong, Esther; Lim, Kah L.; Dawson, Valina L.; Dawson, Ted M.
Nitric oxide, S-nitrosylation and neurodegeneration.
Cellular and Molecular Biology, 51: 247-254
Chung, Kenny K.K.; Dawson, Ted M.; Dawson, Valina L.
Parkin mediates non-classical, proteasomal-independent, ubiquitination of Synphilin-1: Implications for Lewy Body formation
J. Neurosci., v. 25, 2005, p. 2002-2009
Lim, K.L.; Chew, K.C.M.; Tan, J.M.M.; Wang, C.; Chung, Kenny K.K.; Zhang, Y.; Tanaka, Y.; Wei, W.L.; Engelender, S.; Ross, C.A.; Dawson, V.L.; Dawson, T.M.
S-nitrosylation in Parkinson's disease and related neurodegenerative disorders.
Methods in Enzymology, 396: 139-150
Chung, Kenny K.K.; Dawson, Valina L.; Dawson, Ted M.


Expand All Collapse All


Article 2

Parkin and HSP70 sacked by BAG5
Neuron 44, 2004, p. 899-901
Chung, Kenny K.K.; Dawson, T.M.
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
Science, v. 304, (5675), 2004, p. 1328-1331
Chung, Kenny K.K.; Thomas, B.; Li, X.; Pletnikova, O.; Troncoso, J.C.; Marsh, L.; Dawson, V.L.; Dawson, T.M.


Expand All Collapse All


Article 2

New insights into Parkinson's disease
J Neurol 250 Suppl 3, 2003, p. 15-24
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.
SEPT5_v2 is a parkin-binding protein
Brain Res Mol Brain Res, v. 117, (2), 2003, p. 179-189
Choi, Peter; Snyder, Heather M.; Petrucelli, Leonard; Theisler, Catherine M.; Chong, Matthew; Zhang, Yongjie; Kah Leong, Lim; Chung, Kenny K.K.; Kehoe, Kathryn; D'Adamio, Luciano D.; Lee, John; Cochran, Elizabeth J.; Bowser, Robert P.; Dawson, Ted Murray; Wolozin, Benjamin L.


Expand All Collapse All


Article 2

Parkin ubiquitinates the alpha-synuclein interacting protein, synphilin-1: implications for Lewy body formation in Parkinson"s disease
Nature Med., v. 7, (10), 2001, p. 1144-1150
Chung, Kenny K.K.; Zhang, Y.; Lim, K.L.; Tanaka, Y.; Huang, H.; Gao, J.; Ross, C.; Dawson, V.L.; Dawson, T.M.
The role of the ubiquitin proteasomal pathway in Parkinson's Disease and other neurodegenerative disorders
TINS., v. 24, (11), 2001, p. S7-S14
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M.


Expand All Collapse All


Article 2

C-fos expression, behavioural, endocrine and autonomic responses to acute social stress in male rats after chronic restraint: modulation by serotonin
Neuroscience, v. 95, (2), 2000, p. 453-463
Chung, Kenny K.K.; Martinez, M.; Herbert,J
Parkin functions as an E3-dependent ubiquitin-protein ligase and promotes the degradation of synaptic vesicle associated protein
CDCrel-1. Proc .Natl. Acad. Sci. USA, v. 97, (24), 2000, p. 13354-13359
Zhang, Y.; Gao, J.; Chung, Kenny K.K.; Huang, H.; Dawson, V.L.; Dawson, T.M.


Expand All Collapse All


Article 1

Central serotonin depletion modulates the behavioural tendocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats
Neuroscience, v, 92, (2), 1999, p. 613-625.
Chung, Kenny K.K.; Martinez, M.; Herbert, J.


Expand All Collapse All


Article 1

The antigenic sites of trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties
Life Sciences, v. 61, (23), 1997, p. 2291-2303
Mulot, S.; Chung, Kenny K.K.; Li, X.B.; Wong, C.C.; Ng, T.B.; Shaw, P.C.


Expand All Collapse All


2015 2

S-nitrosylation of XIAP at Cys 213 of BIR2 Domain Impairs XIAP's Anti-caspase 3 Activity and Anti-apoptotic Function
Apoptosis, v. 20, (4), 2015, p. 491-499
Wu, Weiwei; Wan, Oi Wan; Chung, Kenny Ka Kin Article
Studying Nitrosative Stress in Parkinson’s Disease
Stress Responses / Editors: Christine M. Oslowski. New York : Humana Press, New York, NY, 2015, p. 195-201, Series: Methods in Molecular Biology
Chung, Kenny K K Book chapter

2012 2

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease
Journal of neurochemistry, v. 122, (2), July 2012, p. 404-414
Xie, Weilin; Chung, Kenny K.K. Article
The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson's Disease
PLoS ONE, v. 7, (6), June 2012
Wan, Oi Wan; Chung, Kenny K.K. Article

2011 4

P32 regulates mitochondrial morphology and dynamics through parkin
Neuroscience, v. 199, 2011, p. 346-358
Li, Youjun; Wan, Oi Wan; Xie, W.; Chung, Kenny K.K. Article
Involvement of S-nitrosylation in neurodegeneration
Post-translational modifications in health and disease / Edited by Cecilio J. Vidal. New York : Springer, 2011, p. 79-95
Chung, Kenny K.K.; Li, Y. Book chapter
S-Nitrosylation of Cdk5 Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development
The 9th Biennial Conference of the Chinese Neuroscience Society, Henan, China, 29 July - 1 August 2011
Zhang, P.; Yu,P-C; Tsang, A.H.; Chen, Y.; Fu, Kit Yu; Fu, WY; Chung, Kenny Ka Kin; Ip, Nancy Yuk-Yu Conference paper
The role of alpha-synuclein aggregation in Parkinson's disease
13th International Neuroscience Winter Conference, S?lden Austria, 2011
Wan, Oi Wan; Chung, Kenny Conference paper

2010 5

Emerging roles of nitric oxide in neurodegeneration
Nitric oxide-biology and CHEMISTRY, v. 22, (4), 2010, MAY 15, p. 290-295
Chung, Kenny K.K.; David, Karen K. Article
Modulation of pro-survival proteins by S-nitrosylation: implications for neurodegeneration
Apoptosis, v. 15, (11), Nov 2010, p. 1364-1370
Chung, Kenny KK Article
New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease
BIOCHIMICA ET BIOPHYSICA acta-molecular Basis OF Disease, v. 1802, (11), 2010, NOV, p. 935-941
Xie, Weilin; Wan, Oi Wan; Chung, Kenny K.K. Article
S-nitrosylation of cyclin-dependent kinase 5 (Cdk5) regulates its kinase activity and dendrite growth during neuronal development
Journal of Neuroscience, v. 30, (43), Ocotber 2010, p. 14366-14370
Zhang, Peng; Yu, Peichun; Tsang, Anthony H.K.; Chen, Yu; Fu, Kit Yu; Fu, Wing Yu; Chung, Kenny K.K.; Ip, Nancy Yuk-Yu Article
Regulation of Cyclin-Dependent Kinase-5 Activity by S-Nitrosylation
The 40th Annual Meeting of the Society for Neuroscience, San Diego, USA, 13 - 17 November 2010
Fu, Wing Yu; Zhang, Peng; Tsang, Anthony H.K.; Xie, S.Y.; Fu, Kit Yu; Chung, Kenny K K; Ip, Nancy Yuk-Yu Conference paper

2009 4

Oxidative stress and nitrosative stress in Parkinson's disease
Biochim Biophys Acta., 1792, 643-650
Tsang, Anthony H.K.; Chung, Kenny K.K. Article
S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease
Proceedings of the National Academy of Sciences of the United States of America, v. 106, (12), 2009, MAR 24, p. 4900-4905
Tsang, Anthony H.K.; Lee, Yun-Il; Ko, Han Seok; Savitt, Joseph M.; Pletnikova, Olga; Troncoso, Juan C.; Dawson, Valina L.; Dawson, Ted M.; Chung, Kenny K.K. Article
The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease
Journal of neurochemistry, v. 110, (1), 2009, JUL, p. 208-219
Lee, F.K.M.; Wong, A.K.Y.; Lee, Y.W.; Wan, Oi Wan; Chan, H.Y.E.; Chung, Kenny K.K. Article
Characterization of p32 as an interactor of parkin
Society for Neuroscience, Chicago
Li, Yihang; Chung, Kenny K.K. Conference paper

2008 3

Modification of X-linked Inhibitor of Apoptosis Protein by Nitric Oxide
38th Annual Meeting, Society for Neuroscience, Washington DC, 15-19 Nov 2008
Tsang, Anthony H.K.; Chung, Kenny K.K. Conference paper
S-nitrosylation of x-linked inhibitor of apoptosis protein (xIAP): Implication to the pathogenesis of Parkinson's disease (PD)
Gordon Research Conference, Molecular and Cellular Neurobiology, 8-13/June/2008
Tsang, Anthony; Chung, Kenny Conference paper
The role of alpha-synuclein aggregation in the pathogenesis of Parkinson's disease
Gordon Research Conference, Molecular and cellular neurobiology, 8-13/June/2008
Wan, Oi Wan; Chung, Kenny K.K. Conference paper

2007 1

Gaseous Signaling: Nitric Oxide and Carbon Monoxide as Messenger Molecules
Handbook of Contemporary Neuropharmacology / Editor David Robert Sibley. Hoboken, N.J. : John Wiley & Sons, 2007
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M. Book chapter

2006 2

Say NO to neurodegeneration: Role of S-nitrosylation in neurodegenerative disorders
NeuroSignals, v. 15, (6), 2006, p. 307-313
Chung, Kenny K.K. Article
Functional study of parkin: insights into the pathogenesis of Parkinson's disease
The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies, The Hong Kong Society of Neuroscience, Hong Kong, Symposium VI
Chung, Kenny K. Conference paper

2005 5

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.
Journal of Neuroscience, 25: 7968-7978
Ko, Han S.; Coelln, Rainer V.; Sriram, Sathya R.; Kim, Seong W.; Chung, Kenny K.K.; Pletnikova, Olga; Troncoso, Juan; Johnson, Brett; Saffary, Roya; Goh, Eyleen L.; Song, Hongjun; Park, Bum-Joon; Kim, Min J.; Kim, Sunghoon; Dawson, Valina L.; Dawson, Ted M. Article
Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.
Human Molecular Genetics, 14: 2571-2586
Sriram, Sathya R.; Li, Xiaojie; Ko, Han S.; Chung, Kenny K.K.; Wong, Esther; Lim, Kah L.; Dawson, Valina L.; Dawson, Ted M. Article
Nitric oxide, S-nitrosylation and neurodegeneration.
Cellular and Molecular Biology, 51: 247-254
Chung, Kenny K.K.; Dawson, Ted M.; Dawson, Valina L. Article
Parkin mediates non-classical, proteasomal-independent, ubiquitination of Synphilin-1: Implications for Lewy Body formation
J. Neurosci., v. 25, 2005, p. 2002-2009
Lim, K.L.; Chew, K.C.M.; Tan, J.M.M.; Wang, C.; Chung, Kenny K.K.; Zhang, Y.; Tanaka, Y.; Wei, W.L.; Engelender, S.; Ross, C.A.; Dawson, V.L.; Dawson, T.M. Article
S-nitrosylation in Parkinson's disease and related neurodegenerative disorders.
Methods in Enzymology, 396: 139-150
Chung, Kenny K.K.; Dawson, Valina L.; Dawson, Ted M. Article

2004 2

Parkin and HSP70 sacked by BAG5
Neuron 44, 2004, p. 899-901
Chung, Kenny K.K.; Dawson, T.M. Article
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
Science, v. 304, (5675), 2004, p. 1328-1331
Chung, Kenny K.K.; Thomas, B.; Li, X.; Pletnikova, O.; Troncoso, J.C.; Marsh, L.; Dawson, V.L.; Dawson, T.M. Article

2003 2

New insights into Parkinson's disease
J Neurol 250 Suppl 3, 2003, p. 15-24
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M. Article
SEPT5_v2 is a parkin-binding protein
Brain Res Mol Brain Res, v. 117, (2), 2003, p. 179-189
Choi, Peter; Snyder, Heather M.; Petrucelli, Leonard; Theisler, Catherine M.; Chong, Matthew; Zhang, Yongjie; Kah Leong, Lim; Chung, Kenny K.K.; Kehoe, Kathryn; D'Adamio, Luciano D.; Lee, John; Cochran, Elizabeth J.; Bowser, Robert P.; Dawson, Ted Murray; Wolozin, Benjamin L. Article

2001 2

Parkin ubiquitinates the alpha-synuclein interacting protein, synphilin-1: implications for Lewy body formation in Parkinson"s disease
Nature Med., v. 7, (10), 2001, p. 1144-1150
Chung, Kenny K.K.; Zhang, Y.; Lim, K.L.; Tanaka, Y.; Huang, H.; Gao, J.; Ross, C.; Dawson, V.L.; Dawson, T.M. Article
The role of the ubiquitin proteasomal pathway in Parkinson's Disease and other neurodegenerative disorders
TINS., v. 24, (11), 2001, p. S7-S14
Chung, Kenny K.K.; Dawson, V.L.; Dawson, T.M. Article

2000 2

C-fos expression, behavioural, endocrine and autonomic responses to acute social stress in male rats after chronic restraint: modulation by serotonin
Neuroscience, v. 95, (2), 2000, p. 453-463
Chung, Kenny K.K.; Martinez, M.; Herbert,J Article
Parkin functions as an E3-dependent ubiquitin-protein ligase and promotes the degradation of synaptic vesicle associated protein
CDCrel-1. Proc .Natl. Acad. Sci. USA, v. 97, (24), 2000, p. 13354-13359
Zhang, Y.; Gao, J.; Chung, Kenny K.K.; Huang, H.; Dawson, V.L.; Dawson, T.M. Article

1999 1

Central serotonin depletion modulates the behavioural tendocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats
Neuroscience, v, 92, (2), 1999, p. 613-625.
Chung, Kenny K.K.; Martinez, M.; Herbert, J. Article

1997 1

The antigenic sites of trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties
Life Sciences, v. 61, (23), 1997, p. 2291-2303
Mulot, S.; Chung, Kenny K.K.; Li, X.B.; Wong, C.C.; Ng, T.B.; Shaw, P.C. Article


No Publications


No Publications


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 3 2020-21 Summer 1 2020-21 Spring 4 2020-21 Winter 0 2020-21 Fall 6

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BIBU4820 Biotechnology Entrepreneurship and Business Operations
LIFS4950 Neurochemistry
LIFS6112E Current Topics in Neuroscience


BTEC5210 Principles and Application in Biotechnology


BIBU1010 Biotechnology and Business Seminar
BIBU4850 Biotechnology and Business Project Research
LIFS4981 Biochemistry and Cell Biology Project Research II
LIFS4983 Biotechnology Project Research II


BIBU4840 Biotechnology and Business Capstone Project
LIFS4950 Neurochemistry
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS4973 Biotechnology Project Research I
LIFS6112D Current Topics in Neuroscience


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy NG, Ka Wai
Life Science( 2019 - )

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Graduated RPGs

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Doctor of Philosophy SUNG, Chun Chau
Life Science( Completed in 2021 )

LI, Jiahua
Life Science( Completed in 2019 )

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Master of Philosophy LAM, Wai Yun
Life Science( Completed in 2021 )









ProjectsFrom January 2020 to December 2022

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All Projects 3 Leading Projects 1 Participating Projects 2

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A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases


以干细胞方法解析神经退行性疾病的分子基础 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
CHUNG Kenny K
FU Amy Kit Yu
QI Robert Zhong
QU Jianan
TSIM Karl Wah Keung
WEN Zilong
WONG Yung Hou
WU Zhenguo
XIA Jun


2019 -




The establishment of a novel Parkinson's disease mouse model by conditional expression of aggregation-prone alpha-synuclein in dopaminergic neurons


新型帕金森氏病小鼠模型的构建：多巴胺神经元内条件性表达聚集型α核突触蛋白(α-synuclein) Leading


RGC - General Research Fund


Project Team (HKUST)
CHUNG Kenny K (Lead)


2018 - 2021




State Key Laboratory of Molecular Neuroscience (The Hong Kong University of Science and Technology)


分子神经科学国家重点实验室（香港科技大学） Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHOW King Lau
CHUNG Kenny K
DAI Wei Min
GUO Zhihong
HUANG Pingbo
LIANG Chun
MILLER Andrew Leitch
POON Randy Yat Choi
QI Robert Zhong
TSIM Karl Wah Keung
WEN Zilong
WONG Joseph Tin Yum
WONG Yung Hou
WU Zhenguo
ZHU Guang


2011 -