Dr Thomas Lee Associate Head (Academic) and Associate Professor
Advances point-of-care nucleic acid testing through innovation in colorimetric nanoprobes

Location ST407
Phone +852 2766 4931
mail ming-hung.lee@polyu.edu.hk
stream Curriculum Vitae

Open Platform for University Scholars
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Biography Dr. Thomas Lee received his bachelor, master, and doctoral degrees in chemical engineering from The Hong Kong University of Science and Technology in 1998, 2000, and 2003, respectively. He worked on PCR microchip and electrochemical DNA sensors under the supervision of Prof. I-Ming Hsing. In 2004, he joined Prof. Joseph Wang’s group in New Mexico State University and Arizona State University as a postdoc and worked on inorganic nanocrystals-based electrochemical sensor for single-base mismatches detection as well as aptamer-based electrochemical sensor for protein detection. In 2005, he returned to Prof. I-Ming Hsing’s group and worked on electrochemical real-time PCR. In 2006, he joined The Hong Kong Polytechnic University (PolyU) biomedical engineering program as an Assistant Professor. He is now an Associate Professor and his current research focus is on nucleic acid testing in point-of-care and field settings by means of novel colorimetric nanoprobes.




Research Interests
Point-of-care and on-site nucleic acid testing
Nanomaterials for in vitro diagnostics



Academic and Professional Experiences Associate Professor, Department of Biomedical Engineering, The Hong Kong Polytechnic University, Jul 2014 - Current
Assistant Professor, Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Apr 2012 - Jun 2014
Assistant Professor, Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Aug 2006 - Mar 2012
Visiting Scholar, Department of Chemical Engineering, The Hong Kong University of Science and Technology, Feb 2005 - Jul 2006
Research Associate, Department of Chemistry and Biochemistry, Arizona State University and New Mexico State University, Jan 2004 - Jan 2005
Research Associate, Department of Chemical Engineering, The Hong Kong University of Science and Technology, Jul 2003 - Dec 2003




Research Output

Journal Papers
Qin, L. T. Fu, J. K. F. Wong, L. Y. Chau, S. P. Yip, T. M. H. Lee, Precipitation of PEG/Carboxyl-Modi?ed Gold Nanoparticles with Magnesium Pyrophosphate: A New Platform for Real-Time Monitoring of Loop-Mediated Isothermal Ampli?cation, ACS Appl. Mater. Interfaces, 2017, 9, 10472–10480. (Click hereto access the article in the publisher's website)
Y. Chau, Q. He, A. Qin, S. P. Yip, T. M. H. Lee, Platinum Nanoparticles on Reduced Graphene Oxide as Peroxidase Mimetics for the Colorimetric Detection of Specific DNA Sequence, J. Mater. Chem. B, 2016, 4, 4076–4083. (Click hereto access the article in the publisher's website)
K. F. Wong, S. P. Yip, T. M. H. Lee, Ultrasensitive and Closed-Tube Colorimetric Loop-Mediated Isothermal Amplification Assay Using Carboxyl-Modified Gold Nanoparticles, Small, 2014, 10, 1495–1499. (Click hereto access the article in the publisher's website)
K. F. Wong, S. P. Yip, T. M. H. Lee, Ultra-Stable Oligonucleotide-Gold and -Silver Nanoparticle Conjugates Prepared by a Facile Silica Reinforcement Method, Nano Res., 2012, 5, 585–594. (Click hereto access the article in the publisher's website)
K. F. Wong, S. P. Yip, T. M. H. Lee, Silica-Modified Oligonucleotide-Gold Nanoparticle Conjugate Enables Closed-Tube Colorimetric Polymerase Chain Reaction, Small, 2012, 8, 214–219. (Click hereto access the article in the publisher's website)




Patents
T. M. H. Lee, K. F. Wong, S. P. Yip, Ultra-Stable Oligonucleotide–Gold and–Silver Nanoparticle Conjugates Prepared by a Facile Silica Reinforcement Method, U.S. Patent Number: 9605304, Granted on 28 Mar 2017.
I-M. Hsing, T. M. H. Lee, S. W. Yeung, X. Luo, Method and System for Real-Time Quantification and Monitoring of Nucleic Acid Amplification Using Electroconductive or Electrochemically Active Labels, U.S. Patent Number: 8465926, Granted on 18 Jun 2013.








Teaching and Learning Teaching Awards Faculty Merit Award in Teaching (Individual), Faculty of Engineering, The Hong Kong Polytechnic University, 2018
Best Teacher Award, Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, 2016

Teaching and Learning Project Gongyeh講嘢app (https://www.gongyeh.com/; also a web platform); language enhancement grant; project title: using technology to improve students' presentation skills and enhance students' engagement in others' presentation; project team: Dr. Thomas Ming Hung Lee (project leader; BME), Dr. Hin Chung Lau (project leader; BME), Dr. Joe Wai Kin Ching (project leader; ELC), Ms. Vickie Wai Kei Li (ELC), and Mr. Mitesh Patel (EDC)