Prof. Mo Yang Associate Head (Research) and Professor
Develops nanomaterials for sensing, imaging and therapy

Location ST419
Phone +852 2766 4946
mail mo.yang@polyu.edu.hk
stream Curriculum Vitae

Open Platform for University Scholars
ORCID ID
SCOPUS ID









Biography Prof. YANG Mo received the B.E. and M.S. degrees in Power Mechanical Engineering from Shanghai Jiaotong University, China, in 1998 and 2001, respectively. He received the Ph.D. degree in Mechanical Engineering from the University of California, Riverside, in 2004. From Jan 2005 to Oct 2005, he was a Postdoctoral Research Associate in Mechanical Engineering of Boston University. He is currently a Professor at Department of Biomedical Engineering, Faculty of Engineering in the Hong Kong Polytechnic University. Prof. Yang’s research focuses on microfluidic device for biosensing and nanomaterials based bioprobes for imaging, sensing and therapy. Prof. Yang has published more than 90 journal papers and is involved in 4 US patents and 1 China patent. He has been in charge of many research projects including 1 Hong Kong Research Grant Council Collaborative Research Fund (CRF) as Principle Coordinator, 8 Hong Kong Research Grant Council General Research Fund (GRF) as Principle Investigators, 2 National Natural Science Foundation of China (NSFC) fund and 1 Innovation and Technology Fund (ITF) as Principle Investigators, 1 深港澳科技計劃項目(c類) as Principle Investigator, and 1 Research Grant Council Collaborative Research Fund (CRF) as Co-PI.




Research Interests
Bio-nanotechnology
Biosensing
Theranostics
Lab-on-a-chip



Professional Qualifications Life Member of the World Association for Chinese Biomedical Engineers




Academic and Professional Experiences Professor, Department of Biomedical Engineering, Faculty of Engineering, the Hong Kong Polytechnic University, Jul 2018 - current
Associate Professor, Department of Biomedical Engineering, Faculty of Engineering, the Hong Kong Polytechnic University, Oct 2017 - Jun 2018
Associate Professor, Interdisciplinary Division of Biomedical Engineering, Faculty of Engineering, the Hong Kong Polytechnic University, Jul 2012 - Oct 2017
Assistant Professor, Interdisciplinary Division of Biomedical Engineering, Faculty of Engineering, the Hong Kong Polytechnic University, Apr 2012 - Jul 2012
Assistant Professor, Biomedical Engineering Programme, Department of Health Technology and Informatics, the Hong Kong Polytechnic University, Oct 2005 - Apr 2012
Postdoctoral Research Associate, Boston University, MA, United States, Jan 2005 - Oct2005




Research Output

Publications & Bibliometris

H-index:32 (ISI Web of Knowledge, Research ID: K-1274-2012) / 33 (Scopus, ID: 7404927250) /37 (Google Scholar) ORCID: (0000-0002-3863-8187)
The paper"Ultrasensitive detection of ebola virus oligonucleotide based on upconversion nanoprobe/nanoporous membrane" (ACS Nano 10(1) 598-605, 2016) is “Highly Cited Paper” in Essential Science Indicators (ESI) ( top 1% of the academic field of Chemistry)
The paper"J.Y. Shi, C.Y. Chan, Y.T. Pang, W.W. Ye, F. Tian, J. Lyu, Y. Zhang, M. Yang, "A fluorescence resonance energy transfer (FRET) biosensor based on graphene quantum dots (GQDs) and gold nanoparticles (AuNPs) for the detection of mecA gene sequence of Staphylococcus aureus
is “Highly Cited Paper” in Essential Science Indicators (ESI) ( top 1% of the academic field of Chemistry)
The paper"F. Tian, J. Lyu, J.Y Shi, M. Yang* Graphene and graphene-like two-denominational materials based fluorescence resonance energy transfer (FRET) assays for biological applications, Biosensors and Bioelectronics, 89(1), 123-135, 2017." is "Highly Cited Paper" in Essential Science Indicators (ESI) ( top 1% of the academic field of Chemistry)
The paper"Nanoparticle based fluorescence resonance energy transfer (FRET) for biosensing applications
false" data-toggle="collapse" href="#!" role="button">Journal Papers
M.T. Au^#, J.Y. Shi^#, Y.D. Fan, J.G. Ni, C.Y. Wen^*, M. Yang^*, Nerve growth factor-targeted molecular theranostics based on molybdenum disulfide nanosheet coated gold nanorods (MoS₂-AuNR) for osteoarthritis pain, ACS Nano (In Press, # Co-first authors) (IF: 15.881)
D. Jiang, C.Q. Yang, Y.D. Fan, P. H.M. Leung, I. Kiao, Y. Zhang, Z.Y. Li, M. Yang*, Ultra-sensitive photoelectrochemical aptamer biosensor for detecting E. coli O157:H7 based on nonmetallic plasmonic two-dimensional hydrated defective tungsten oxide nanosheets coupling with nitrogen-doped graphene quantum dots (dWO3·H2O@N-GQDs), Biosensors and Bioelectronics, 183, 113214, 2021 (IF:10.618)
G. Oudeng, M. Benz, A. Popova, Y. Zhang, C.Q. Yi, L. Pavel*, M. Yang*, Droplet-Microarray Based on Nanosensing Probe Patterns for Simultaneous Detection of Multiple HIV Retroviral Nucleic Acids, ACS Applied Materials & Interfaces, 12, 50, 55614–55623, 2020. (IF:9.229)
C.M. Cheng, R.L. Zhang, J.H. Wang, Y, Zhang, S.S. Xiong, Y. Huang*,M. Yang*, Porphyrinic Metal-Organic Framework Nanorod-Based Dual-Modal Nanoprobe for Sensing and Bioimaging of Phosphate, ACS Applied Materials & Interfaces, 12, 26391−26398, 2020. (IF:9.229)
G. Oudeng, M.T. Au, J.Y. Shi, C.Y. Wen*,M. Yang*, One-step in-situ detection of miRNA-21 expression in single cancer cells based on biofunctionalized MoS₂nanosheets,ACS Applied Materials & Interfaces,10(1), 350-360, 2018(IF:9.229)
J.H. Wang, Y.D. Fan, Y.H. Tan, X. Zhao, Y. Zhang, C.M. Cheng,M. Yang*, Porphyrinic metal–organic framework PCN-224 nanoparticles for near-infrared-induced attenuation of aggregation and neurotoxicity of Alzheimer’s amyloid-β peptide,ACS Applied Materials & Interfaces,10(43), 36615-36621, 2018.(IF:9.229)
X.Q. Su, C.Y. Chan, J.Y. Shi, M.K. Tsang, Y. Pan, C.M. Cheng, O.D. Gerile,M. Yang*, A graphene quantum dot@Fe₃O₄@SiO₂based nanoprobe for drug delivery sensing and dual modal fluorescence and MRI imaging in cancer cells,Biosensors and Bioelectronics. 92, 489–495, 2017 (IF: 10.618)
J.Y Shi, J. Lyu, F. Tian,M. Yang*, A fluorescence turn-on biosensor based on graphene quantum dots (GQDs) and molybdenum disulfide (MoS₂) nanosheets for epithelial cell adhesion molecule (EpCAM) detection,Biosensors and Bioelectronics, 93, 182–188, 2017 (IF: 10.618)
F. Tian, J. Lyu, J.Y Shi, M. Yang* Graphene and graphene-like two-denominational materials based fluorescence resonance energy transfer (FRET) assays for biological applications, Biosensors and Bioelectronics, 89(1), 123-135, 2017(IF: 10.618)
M.K. Tsang, W.W. Ye, G.J. Wang, J.M. Li,M Yang*, JH Hao*, Ultrasensitive detection of ebola virus oligonucleotide based on upconversion nanoprobe/nanoporous membrane,ACS Nano10(1) 598-605, 2016. (IF: 15.881)
J.Y. Shi, C.Y. Chan, Y.T. Pang, W.W. Ye, F. Tian, J. Lyu, Y. Zhang,M. Yang*, A fluorescence resonance energy transfer (FRET) biosensor based on graphene quantum dots (GQDs) and gold nanoparticles (AuNPs) for the detection of mecA gene sequence of Staphylococcus aureus,Biosensors and Bioelectronics67, 595–600, 2015.(IF: 10.618)
J.Y. Shi, J.B. Guo, G.X. Bai, C.Y. Chan, X. Liu, W.W. Ye, J.H. Hao, S. Chen,M. Yang*, A graphene oxide based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection of botulinum neurotoxin A (BoNT/A) enzymatic activity,Biosensors and Bioelectronics, 65 238-244, 2015.(IF: 10.618)
W.W. Ye, M.K. Tsang, X. Liu,M. Yang*,Jianhua Hao*, Upconversion luminescence resonance Energy Transfer (LRET)-Based Biosensor for Rapid and Ultrasensitive Detection of Avian Influenza Virus H7 Subtype,Small, 10(12), 2390–2397, 2014.(IF: 13.281)
B.J. Xu, W.W. Ye, Y. Zhang, J.Y. Shi, C.Y. Chan, X.Q. Yao, M. Yang*, A hydrophilic polymer based microfluidic system with planar patch clamp electrode array for electrophysiological measurement from cells, Biosensors and Bioelectronics, 53, 187-192, 2014.(IF: 10.618)
C.Y. Hu, D. P. Yang, Z.H. Wang, P. Huang, X.S. Wang, D. Chen, D.X. Cui, M. Yang, N.Q. Jia, “Bio -mimetically synthesized Ag@BSA microspheres as a novel electrochemical biosensing interface for sensitive detection of tumor cells, Biosensors and Bioelectronics, 41, 656-662, (2013) (IF=10.618)
K. Y., Chan, W. W. Ye, Y. Zhang, L.D. Xiao, P.H.M. Leung, Y. Li, M. Yang*, “Ultrasensitive detection of E coli O157:H7 with biofunctional magnetic bead concentration via nanoporous membrane based electrochemical immunosensor”, Biosensors and Bioelectronics, 41,532–537 (2013) (IF=10.618)
P. Lin, F. Yan, J.J. Yu. H.L.W. Chan, M. Yang, The application of organic electrochemical transistors in cell-based biosensors, Advanced Materials, 22(33), 3655–3660 (2010) (IF: 30.849)
Y. Zhang,M. Yang, J.H. Park, J. Singelyn, H.Q. Ma, M.J. Sailor, E. Ruoslahti, M. Ozkan, C. Ozkan, A surface charge study on cellular uptake behaviors of F3 peptide conjugated iron oxide nanoparticles,Small, 5(17), 1990-1996, 2009.(IF: 13.281)
Q.J. Liu, J.J. Yu, L.D. Xiao, J.C.O. Tang, Y. Zhang, P. Wang, M. Yang*, Impedance studies of bio-behavior and chemosensitivity of cancer cells by micro-electrode arrays, Biosensors and Bioelectronics, 24(5), 1305-1310, 2009. (IF:10.618)
F. Yan, S.M. Mok, J.J. Yu, H.L.W. Chan, M. Yang, Label-free DNA sensor based on organic thin film transistors, Biosensors and Bioelectronics, 24(5), 1241-1245, 2009. (IF:10.618)
J.J. Yu., S.K. Jha, L.D. Xiao, Q.J. Liu, P. Wang, C. Surya, M. Yang*, AlGaN/GaN heterostructures for non-invasive cell electrophysiological measurements, Biosensors and Bioelectronics, 23, 513-519, 2007. (IF:10.618)
Q.J. Liu, H. Cai, Y. Xu, L.D. Xiao, M. Yang, P. Wang, Detection of heavy metal toxicity using cardiac cell-based biosensor, Biosensors and Bioelectronics, 22(12), 3224-3229, 2007. (IF:10.618)
M. Yang, C.C. Lim, R.L. Liao, X. Zhang, A novel microfluidic impedance assay for monitoring endothelin-induced cardiomyocyte hypertrophy, Biosensors and Bioelectronics 22(8),1688-1693, 2007. (IF:10.618)




Referred Conference Proceeding Papers
Jingyu Shi,Mo Yang*, "A fluorescence resonance energy transfer (FRET) biosensor based on graphene quantum dot (GQD) and graphene oxide (GO) for detection of circulating tumour cells in vitro". the 26^thAnniversary World Congress on Biosensors, , Gothenburg, Sweden, 25–27 May 2016.
Jing Lyu,Mo Yang*, "A graphene quantum dot based intracellular fluorescence resonance energy transfer (FRET) assay for monitoring caspase-3 protease activity during apoptosis process in single cells". the 26^thAnniversary World Congress on Biosensors, , Gothenburg, Sweden, 25–27 May 2016.
Xiaoqian Su,Mo Yang*, "Graphene quantum dot – magnetic nanoparticle conjugates for simultaneous dual modal imaging and drug delivery sensing based on fluorescence resonance energy transfer". the 26^thAnniversary World Congress on Biosensors, , Gothenburg, Sweden, 25–27 May 2016.
Jingyu Shi,Mo Yang*, "Graphene Oxide based Fluorescence Resonance Energy Transfer (FRET) Biosensor for Bacterial Protein Toxin Detection
Graphene Oxide based Fluorescence Resonance Energy Transfer (FRET) Biosensor for Bacterial Protein Toxin Detection
Biofunctionalized graphene field effect transistor for rapid and ultrasensitive detection of H5N1 Avian Influenza Virus
Nanoporous alumina membrane and nanoparticle based microfluidic sensing platform for direct DNA detection," 17^thInternational Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS 2013), Barcelona, Spain, June 16-20, 2013
WeiWei Ye,Mo. Yang*, "A functionalized nanoporous alumina membrane electrochemical sensor for DNA detection with gold nanoparticle amplification" Proceeding of PACRIM 10-The 10th Pacific Rim Conference on Ceramic and Glass Technology, San Diego, USA, June 2-7, 2013.
WeiWei Ye,Mo. Yang*, "Optimal surface functionalization of nanoporous alumina membrane for DNA detection
Nanoparticle Enhancement for Electrochemical DNA Detection using Nanoporous Alumina Membrane
false" data-toggle="collapse" href="#!" role="button">Invited Book Chapters
J.H. Wang,M. Yang, “Two-dimensional nanomaterials in cancer theranostics”, Theranostic Bionanomaterials, Elsevier, ISBN: 978, 2019
C.S. Ozkan, M. Ozkan,M. Yang, X. Zhang S. Prasad, "Bridging Microelectronics and Biotechnology: 9 Cell Based Microarray Biosensors". Encyclopedia of Sensors, American Scientific Publishers, United States, ISBN 158883056X, Vol. 1, 401-420, 2006.
C.S. Ozkan, M. Ozkan,M. Yang, X. Zhang, S. Prasad, A. Morgan, "Cell Based Sensors for Chemical Detection " BioMEMS and Biomedical Nanotechnology V4: Biomolecular Sensing, Processing and Analysis, Springer, New York, ISBN 978-0-387-25561-3, 55-89, 2006.
M. Ozkan. C.S. Ozkan, S. Prasad,M. Yang., X. Zhang,“ Microarray and Fluidic Chip for Extracellular Sensing”, BioMEMS and Biomedical Nanotechnology V2: Micro/Nano Technologies for Genomics and Proteomics, Springer, New York, ISBN 978-0-387-25561-3, 47-98, 2006.




Keynote Talk in Conference
"Multifunctional Nanoprobes for Biosensing, Imaging and Therapeutics
Nanparticle based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection
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"Multifunctional 2D nanomaterials based nanoprobes for sensing, imaging and drug delivery
Two-dimensional materials based nanoprobe for bioimaging and sensing
Nanopore/nanoparticle based optical biosensor for biomolecule detection
Nanopore and nanoparticle based optical biosensor for biomolecule detection
Nanoparticle based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection
Nanoparticle based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection
Microfluidic devices with nanopore structures for ultrasensitive foodborne pathogen detection
Microfluidic devices with nanopore structures for ultrasensitive foodborne pathogen
Culturing rat mesenchymal stem cell on 2D and 3D poly(ethylene glycol) (PEG) hydrogel structure with various RGD-peptide concentrations
Micro chip with nanostructured membranes for anti cancer drug screening using impedance spectroscopy
false" data-toggle="collapse" href="#!" role="button">Invited Research Seminars
"Multifunctional 2D nanomaterials based nanoprobes for sensing, imaging and drug delivery
Multifunctional 2D nanomaterials based nanoprobes for sensing, imaging and drug delivery
Multifunctional 2D nanomaterials based nanoprobes for sensing, imaging and drug delivery
Microfluidic Devices Integrated with Micropore/Nanopore Structure for Bio-analytical Applications
Microfluidic Devices Integrated with Nanopore Structure for Foodborne Pathogen Detection
Microfluidic Devices Integrated with Micropore/Nanopore Structure for Bio-analytical Applications" invited by University of Sydney, Aug 30, 2011
"Microfluidic Devices for Bio-analytical Applications
Polymer Microfluidic Devices with biosensing applications
Polymer Microfluidic Devices with biosensing applications
Talk in the Television Programme of Open University of Hong Kong, for part of "Open for learning: Exploring Science: Development of Nanotechnology in Hong Kong
false" data-toggle="collapse" href="#!" role="button">Grants
External Competitive Grants as Principle Investigator (PI) /Co- Principle Investigator (Co-PI)
深港澳科技计划C类, “用于新冠病毒和流感病毒现场筛查的快速检测技术和便携式微纳机电系统”, RMB 1,000,000 (PI), 2021-2023.
Hong Kong Research Grants Council (RGC) General Research Fund (GRF), “Multiplexed single exosome analysis based on hybridization chain reaction (HCR) enhanced multi-color fluorescence resonance energy transfer (FRET) nanoprobes in a droplet optofluidic platform”, HK$, 815,601, 2022-2024 (PolyU 15217621, PI).
Hong Kong Research Grants Council (RGC) Collaborative Research Fund (CRF), “Multi-level synergistic COVID-19 point-of-care diagnostics based on upconversion luminescence biosensing platform” (C5110-20G), HK$8, 408,102, 2021-2024 (Co-PI sharing HK$ 2 million)
Hong Kong Research Grants Council (RGC) Collaborative Research Fund (CRF), "Multi-scale spatiotemporal single-cell in-situ analysis: Mechanism and biomedical applications
Development of an integrated microfluidic platform for high-throughput isolation of circulating tumor cells (CTCs) and on-chip detection of CTC-heterogeneity via multicolor nanoprobes
Hybrid ZnIn2S4/GQD nanointerface based artificial photoreceptors for restoring human-like colour sensitivity of degenerative retina
A hybrid nanosystem for photo-treatment of Alzheimer’s disease in a blood-brain barrier on-a-chip
A hybrid molybdenum disulfide (MoS2)/graphene quantum dot (GQD) nanosystem for imaging-guided combinatorial phototherapy targeting cancer stem cells
A graphene quantum dot based intracellular fluorescence resonance energy transfer (FRET) assay for monitoring caspase-3 protease activity during apoptosis process in single cells
A hydrophilic polymer based microfluidic patch clamp array system for simultaneous multiple cell recording
Simultaneous and rapid detection of multiple foodborne pathogens by nanoporous membrane based impedance arrays" (PolyU 535809), HK$ 607,000, 2010-2013 (PI).
Hong Kong Research Grants Council (RGC) General Research Fund (GRF) "An integrated microfluidic chip for single cell electrophysiological studies within picoliter volume
用於單細胞水平上檢測幹細胞內多種 miRNA 原位表達的多色納米感測探針的研究
false" data-toggle="collapse" href="#!" role="button">Patents & Technology Transfer
Patent 1: J.H. Hao,M. Yang, M.K. Tsang, W.W. Ye, "Heterogeneous Microarray Based Hybrid Upconversion nanoprobe/nanoporous membrane system
Innovative biosensors for chemical and biological assays
Microcantilevers for biological and chemical assays and method of making and using thereof
, US Patent, Publication No. US2006/0188904 A1 (Publication date: August 24, 2006)
Application Paradigm 1: "Nano biosensor for rapid detection of flu virus" Jianhua Hao,Mo Yang, Ming-Kiu Tsang, Weiwei Ye,Gold medal awardwith congratulations of Jury and special merit award from scientific community of Romania, the 45th International Exhibition of Inventions of Geneva Brussels, 2017
Link to public report:
http://www.sciencenewsline.com/news/2037.html
https://www.techinnovation.com.sg/technologies/detail/1241
http://www.qsnews2wow-u.com/dev/2016/08/05/polyus-nano-biosensor-virus-detection/
http://std.stheadline.com/yesterday/loc/0315ao07.html

Application Paradigm 2: "Biosensor to safeguard food safety
noopener noreferrer" rel="noopener noreferrer" href="http://paper.wenweipo.com/2009/12/15/HK.htm" target="_blank">http://paper.wenweipo.com/2009/12/15/HK.htm
http://orientaldaily.on.cc/cnt/news/20091215/00176_072.html
http://www.ouhk.edu.hk/wcsprd/Satellite?pagename=OUHK/tcOLE2_2004&OLE_YEAR=2016&OLE_MONTH=JUNE&OLE_DATE=19&CALENDA=true&TOB=true&SHOWPREV=true&c=C_ETPU&cid=191157083000&lang=eng&dis=1








Esteem Measures Honorary Appointments Special Merit Award from Scientific Community of Romania
Hao, Jianhua (Recipient), Yang, Mo (Recipient), Ming Kiu TSANG (Recipient) & Weiwei YE (Recipient), Mar 2017
Gold Medal with the Congratulations of Jury
Hao, Jianhua (Recipient), Yang, Mo (Recipient), Ming Kiu TSANG (Recipient) & Weiwei YE (Recipient), Mar 2017
The Faculty Merit Award for Outstanding Performance/Achievement in Research (Individual)
Yang, Mo (Recipient), 2015