Professor TSANG Suk Ying Faye
Address
(Office): Rm 607, Mong Man Wai Building
(Lab): Rm 612B, Mong Man Wai Building


Phone
(Office): (852) 3943 1020
(Lab): (852) 3943 8071

Fax (852) 2603 7732
Email This email address is being protected from spambots. You need JavaScript enabled to view it.

Web -


Education2003 Ph.D. Chinese University of Hong Kong
1999 B.Sc. Chinese University of Hong Kong (1st class honor)
PositionAssociate Professor, School of Life Sciences
Investigator, State Key Laboratory in Agrobiotechnology
Investigator, Ministry of Education (MOE) Key Laboratories for Regenerative Medicine
Investigator, Institute for Tissue Engineering and Regenerative Medicine (iTERM), CUHK
Program Director, Food and Nutritional Sciences Program. CUHK
Research Interests1. Embryonic stem cells and their cardiac derivatives:
a. Mechanisms for maintaining the self-renewal and pluripotent characteristics of embryonic stem cells.
b. Mechanisms controlling the cardiac differentiation of embryonic stem cells.
c. Mechanisms of automaticity of embryonic stem cell-derived cardiomyocytes.
2. Ion channels and cardiovascular physiology.
3. Adult stem cells and cancer stem cells.
Representative PublicationsLiu X, Zhao R, Ding Q, Yao X, Tsang SY(2021) TRPC7 regulates the electrophysiological functions and structures of embryonic stem cell-derived cardiomyocytes. Stem Cell Res Ther. 12(1):262.
Zhao R, Liu X, Qi Z, Yao X, Tsang SY(2021) TRPV1 channels regulate the automaticity of embryonic stem cells-derived cardiomyocytes through stimulating the Na+/Ca2+ exchanger current. J Cell Physiol. Online ahead of print.
Chan HC, Lau YT, Ding Q, Li CK, Wong CM, Shaw PC, Waye MMY,Tsang SY (2020) PinX1t, a novel PinX1 transcript variant, positively regulates cardiogenesis of embryonic stem cells. J Am Heart Assoc. 9:e010240.
Chan YW, So C, Yau KL, Chiu KC, Wang X, Chan FL,Tsang SY (2020). Adipose-derived stem cells and cancer cells fuse to generate cancer stem cell-like cells with increased tumorigenicity. J Cell Physiol. 235:6794-6807.
Qi Z,Chen M, Song Y, Wang X, Chen ZF, Tsang SY*, and Cai Z* (2019) Acute exposure to Triphenyl Phosphate (TPHP) inhibits the proliferation and cardiac differentiation of mouse embryonic stem cells and zebrafish. J Cell Physiol. 234(11):21235-21248.
Wang Y, Qi YX, Qi Z, Tsang SY (2019) TRPC3 regulates the proliferation and apoptosis resistance of triple negative breast cancer cells through the TRPC3/RASA4/MAPK pathway. Cancers. 11:558.
Xu Y, So C, Lam HM, Fung MC, Tsang SY (2018) Apoptosis reversal promotes cancer stem-like cell formation. Neoplasia. 20:295-303.
Zhao R, and Tsang SY (2017) Versatile roles of intracellularly located TRPV1 channel. J Cell Physiol. 232:1957-65.
Qi Z, Wong CK, Suen CH, Wang J, Long C, Sauer H, Yao XQ, Tsang SY (2016). TRPC3 regulates the automaticity of embryonic stem cell-derived cardiomyocytes. Int J Cardiol. 203:169-81.
Lo IC, Chan HC, Qi Z, Ng KL, So C, Tsang SY (2016) TRPV3 channel negatively regulates cell cycle progression and safeguards the pluripotency of embryonic stem cells. J Cell Physiol. 231:403-13.
Qi Y, Qi Z, Li Z, Wong CK, So C, Lo IC, Huang Y, Yao XQ, Tsang SY (2015). Role of TRPV1 in the differentiation of mouse embryonic stem cells into cardiomyocytes. PLoS One. 10(7):e0133211.
Law SK, Leung CSL, Yau KL, Tse CL, Wong CK, Leung FP, Huang Y, Sauer H and Tsang SY (2013) Regulation of multiple transcription factors by reactive oxygen species and effects of pro-inflammatory cytokines released during myocardial infarction on cardiac differentiation of embryonic stem cells. Int J of Cardiol. 168:3458-72.
Yang C, Chen ZY, Wong SL, Liu J, Liang YT, Lau CW, Lee HK, Huang Y, Tsang SY (2012) Beta-sitosterol oxidation products attenuated vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2. Cardiovascular Res. 97:520-32.
Wong CK, So WY, Law SK, Leung FP, Yau KL, Yao X, Huang Y, Li X, Tsang SY (2012) Estrogen controls embryonic stem cell proliferation via store-operated calcium entry & the nuclear factor of activated T-cells (NFAT). J Cell Physiol. 227:2519-30. (this article was selected to appear in the highlighted section)
Ng SY, Chin CH, Lau YT, Luo J, Wong CK, Bian ZX, Tsang SY (2010) Role of voltage-gated potassium channels in the fate determination of embryonic stem cells. J Cell Physiol. 224:165-77. (this article was selected to appear in the highlighted section)
Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA (2005) Functional integration of electrically-active cardiac derivatives from genetically-engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: Insights into the development of cell-based pacemakers. Circulation 111:11-20.
Tsang SY, Lesso H, Li RA (2004) Dissecting the structural and functional roles of the S3-S4 linker of pacemaker (HCN) channels by systematic length alterations. J Biol Chem 279:43752-9.
Tsang SY, Yao XQ, Chan FL, Wong CM, Chen ZY, Laher I, Huang Y (2004) Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats. Hypertension 44:1-5.
Tsang SY, Yao XQ, Essin K, Wong CM, Chan FL, Gollasch M, Huang Y (2004) Raloxifene relaxes rat cerebral arteries in vitro and inhibits L-type voltage-sensitive Ca2+ channels. Stroke 35:1709-14.
Research Grants2021-2023, GRF, Role of TRPA1 channels in regulating the functions and maturation of embryonic stem cell-derived cardiomyocytes through mediating mitochondrial biogenesis and/or dynamics, HKD $ 996,285
2018-2020, GRF, The role of TRPC7 channels in regulating the functions and maturation of embryonic stem cell-derived cardiomyocytes, HKD $ 854,494
2017-2019, GRF, The role of TRPV1 channels in regulating the functions of embryonic stem cell-derived cardiomyocytes, HKD $ 893,792
2014-2016, GRF, The role of Angiotensin II and the underlying mechanisms in the regulation of calcium transients in embryonic stem cell-derived cardiomyocytes, HK$ 744,788
2013-2014, RGC Germany/Hong Kong Joint Research Scheme, Role of transient receptor potential (TRP) channels in mediating cardiotrophin-1-induced cardiac differentiation in embryonic stem cells, HKD $ 28,600
2013-2014, GRF, The role of TRPC3 in the regulation of calcium transients in embryonic stem cell-derived cardiomyocytes, HK$ 650,000
2012-2013, RGC Germany/Hong Kong Joint Research Scheme, Effects of Inflammatory Cytokines on the Cardiac Differentiation of Embryonic Stem Cells: Role of Reactive Oxygen Species, HKD$ 59,200
2011-2014, GRF, Characterization of PinX1 and a novel truncated form of PinX1: their role in maintaining the characteristics of embryonic stem cells, HK$ 752,321
2007-2011, GRF, Directed differentiation of human embryonic stem cells into cardiac lineage and the molecular mechanisms involved, HK$ 1,136,464
2004-2006, Croucher Foundation, Genetic engineering of human embryonic stem cells to create a self-renewable ex vivo library of “custom-tailored” heart cells for transplantation, US$ 71,728
Awards2017, The Faculty Exemplary Teaching Award, CUHK
2004-2006, The Croucher Foundation Fellowship
Professional ActivitiesCroucher Foundation Scholar
https://scholars.croucher.org.hk/scholars/tsang-suk-ying-faye
Member, International Society for Stem Cell Research (United States)
Member, Physiology Society (United Kingdom)
Member, Biophysical Society (United States)
Member, American Heart Association (United States)
Activities for Science PromotionCroucher Science Week
https://croucherscienceweek.hk/facilitators/croucher-scholars/
https://croucherscienceweek.hk/ask-our-scientists/dr-faye-tsangs-science-adventure/
https://croucherscienceweek.hk/hk/multimedia-hub/the-beating-hearts-secret/

RTHK podcase one on Stem Cells
https://podcast.rthk.hk/podcast/item.php?pid=1556&eid=146615&year=2019&lang=en-US