Professor WONG Wing Tak Jack
Address
(Office): Rm 503B, Mong Man Wai Building, CUHK
(Lab): Rm 505, Mong Man Wai Building, CUHK

Phone
(Office): (852) 3943 5021
(Lab): - (852) 3943 5018

Fax (852) 2603 6382
Email This email address is being protected from spambots. You need JavaScript enabled to view it.

Web http://www.cuhk.edu.hk/lifesciences/jackwonglab
Education8/2005 - 7/2009 Ph.D. The Chinese University of Hong Kong
9/2000 - 7/2005 BCM & BSc Hong Kong Baptist University
PositionAssistant Professor, School of Life Sciences, CUHK
Research InterestsVascular and metabolic biology
Stem cell biology
Cardiovascular regeneration
Representative PublicationsMa S, Tian XY, Zhang Y, Mu C, Shen H, Bismuth J, Pownall HJ, Huang Y, Wong WT (2016). E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis. Sci Rep. 9;6:22910.
Sayed N, *Wong WT, Ospino F, Meng S, Lee J, Jha A, Dexheimer P, Aronow B, Cooke JP (2015). Transdifferentiation of Human Fibroblasts to Endothelial Cells: Role of Innate Immunity. Circulation. 131(3):300-9. *Co-first author.
Cooke JP, Sayed N, Lee J, Wong WT (2014). Innate immunity and epigenetic plasticity in cellular reprogramming. Current Opinion in Genetics & Development. 28:89-91.
Wong WT, Huang NF, Botham CM, Sayed N, Cooke JP (2012). Endothelial cells derived from nuclear reprogramming. Circ Res. 111(10):1363-75.
Tian XY, *Wong WT, Wang NP, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SS, Chen ZY, Cooke JP, Yao X, Huang Y (2012). PPARδ activation protects endothelial function in diabetic mice. Diabetes 61(12):3285-93. *Co-first author.
Tian XY,*Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X,Huang Y (2012). Uncoupling Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice. Circ Res. 110(9):1211-6. *Co-first author.
Tian XY, *Wong WT^#, Wang YX, Leung FP, Ng CF, Lee HK, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP, Huang Y (2012). ROS-stimulated production of cyclooxygenase-2-derived prostaglandin F2a cause endothelial dysfunction and impaired renal blood flow in renovascular hypertensive rats. Antioxid Redox Signal. 16(4):363-73. #Co-corresponding author.
Wong WT, Tian XY, Xu A, Yu J, Lau CW, Hoo RL, Wang Y, Lee VWY, Lam KS, Vanhoutte PM, Huang Y (2011). Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metab. 6;14(1):104-15.
Wong WT^#, *Tian XY, Chen YC, Leung FP, Liu LM, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL, Huang Y (2010). Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension. Circ Res. 107(8):984-91. #Co-corresponding author
Wong WT, Tian XY, Xu A, Ng CF, Lee HK, Chen ZY, Au, CL, Yao X, Huang Y (2010). Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in diabetic mice. Antioxid Redox Signal. 13(6):757-68.
Research Grants2018-2020, Hong Kong Research Grants Council (RGC) Early Career Scheme (ECS), PPARδ activation attenuates endothelial inflammation by up-regulating miR-181b, Project number: 24163117, HKD$1,263,098 (PI)
2017-2018, National Natural Science Foundation of China (NSFC)/ Research Grants Council (RGC) Joint Research Scheme (Conference Grant), Cardiovascular calcium signaling pathway: Role in health and disease, Project number: N_CUHK453/17, HKD$250,000 (PI)
2013-2017, American Heart Association (AHA) Scientist Development Grant, Novel Determinants of Differentiation to Endothelial Lineage, USD$308,000 (PI)
2014-2015, Kostas Research Center for Cardiovascular Nanomedicine, Targeted Delivery of miRNAs by Nanoparticles as a Novel Therapeutic Strategy in the Treatment of Vulnerable and Unstable Plaque, USD$100,000 (PI)
2013-2014, NIH/NHLBI Progenitor Cell Biology Consortium PCBC Jump Start Award, Heterokaryon as a Model for Identifying Novel Determinants of Endothelial Lineage, USD$7,000 (PI)

2012-2013, American Heart Association (AHA) Postdoctoral Research Fellowship, Identification of Novel Determinants Towards Endothelial Differentiation Using a Heterokaryon Approach, USD$90,000 (PI)
Awards11/2011 ATVB Early Career Investigator Award
1/2012 – 12/2013 AHA Postdoctoral Fellowship
11/2012 Los Angeles AHA meeting AHA NPAM Young Investigator Award Finalist
4/2013 NIH/NHLBI PCBC Jump Start Award
7/2013 – 6/2017 The American Heart Association (AHA) Scientist Development Grant
Professional Activities
2010 - Member of Editorial Board, Food and Nutrition Sciences
2011 - Member of Editorial Board, World Journal of Pharmacology
2012 - Member of Editorial Board, Dataset Papers in Medicine
2014 - Member of Editorial Board, Vascular Medicine
2014 - Member of Editorial Board, Annals of Vascular Medicine and Research
2014 - Peer Review Committee Member, Regenerative Cell Biology (RCB)1 Committee Study Section, American Heart
Association

2014 - External Reviewer for University of Macao Research Grant, Macao, China
2014 - External Peer Reviewer for The National Natural Science Foundation of China
2014 - Committee Member, NIH PCBC Bioinformatics Committee
12/2014 Invited Session Chair/Speaker at the Cold Spring Harbor Laboratory meeting
2014 - Academic Editor, Achives of Current Research International
2015 - Abstract Grader for American Heart Association Scientific Sessions