Dr CHIU Chi Ming Lawrence
Address
(Office): Rm EG01C, Science Centre East Block
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Phone
(Office): (852) 3943 4466
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Fax (852) 2603 5646
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Web https://www.researchgate.net/profile/Lawrence_Chiu/?ev=prf_act


Education1998 Ph. D. University of Hong Kong
1994 M. Phil. Chinese University of Hong Kong
1992 B. Sc. Chinese University of Hong Kong
PositionSenior Lecturer, School of Life Sciences
AwardsFaculty Exemplary Teaching Award 2012
SCGE Exemplary Teaching Award in General Education 2012
Research InterestsCell signaling in apoptosis
Cancer chemoprevention and chemotherapy with natural products targeting the molecular pathways in carcinogenesis
Applications of flow cytometry
Representative PublicationsRen SX, Cheng AS, To KF, Tong JH, Li MS, Shen J, Wong CC, Zhang L, Chan RL, Wang XJ, Ng SS, Chiu LCM, Marquez VE, Gallo R, Chan FK, Yu J, Sung JJ, Wu WK, Cho CH: Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res 2012, 72:6512-6513.
Wang H, Chiu LCM, Ooi VEC, Ang P: A potent antitumor polysaccharide from edible brown seaweed Hydroclathrus clathratus. Botanica Marina 2010, 53:265-274.
Kong CKL, Lam WS, Chiu LCM, Ooi VEC, Sun SSM, Wong YS: A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. Biochem Pharmacol 2009, 77:1487-1496.
Leung KT, Li K, Sun SSM, Chan PKS, Ooi VEC, Chiu LCM: Activation of the JNK pathway promotes phosphorylation and degradation of BimEL – A novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia. Carcinogenesis 2008, 29:544-551.
Lam WY, Tang JW, Yeung ACM, Chiu LCM, Sung JJY, Chan PKS: Avian influenza A H5N1 NS1 protein induces apoptosis in human airway epithelial cells. J Virol 2008, 82:2741-2751.
Li K, Ooi VEC, Chuen CKY, Lam AC, Ooi LSM, Zhang XB, Tsang KS, Chiu LCM , Chan KYY, Li CK, Fok TF, Yuen PMP, Ng PC: The plant mannose-binding lectin NTL preserves cord blood hematopoietic stem/progenitor cells in culture and enhances their ex vivo expansion. Br J Haematol 2008, 140:90-98.
Lee WYW, Chiu LCM, Yeung JHK: Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation. Food Chem Toxicol 2008, 46:328-338.
Ho TS, Ho YP, Wong WY, Chiu LCM, Wong YS, Ooi VEC: Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells. Biomed Pharmacother 2007, 61:578-587.
Shih C-H, Siu S-O, Wong E, Chiu LCM, Chu IK, Lo C: Sorghum 3-deoxyanthocyanidins: Inhibition of cancer cell proliferation and mass spectrometric analysis. J Agric Food Chem 2007, 55:254-259.
Wong SM, Wong KK, Chiu LCM, Cheung PCK: Non-starch polysaccharides from different developmental stages of Pleurotus tuber-regium inhibited the growth of human acute promyelocytic leukemia HL-60 cells by cell-cycle arrest and/or apoptotic induction. Carbohydr Polym 2007, 68:206-217.
Chiu LCM, Ho TS, Wong EYL, Ooi VEC: Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-XL expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation. J Ethnopharmacol 2006, 105:263-268.
Chiu LCM, Zhu W, Ooi VEC: A polysaccharide fraction from medicinal herb Prunella vulgaris downregulates the expression of herpes simplex virus antigen in Vero cells.J Ethnopharmacol 2004, 93:63-68.
Research Grants2009-2012, Teaching Devlopment Grants 2009-12 Triennium, Development of Online Self-learning Systems with Multimedia-enriched Pre-laboratory Talks and Pre-class Tests for Biology Laboratory Courses, $250,000 (Principal Investigator)
2009-2012, Teaching Development Grants 2009-12 Triennium, Developing an integrative teaching strategy for large class students to learn cell biology and beyond, $250,000 (Co-investigator)
2007-2010, Research Grants Council (Earmarked Grants), Role of the brownish shiitake mycelia exudate on the cell death of leukemia cell line and its role as an antioxidant and a functional food colorant, $920,500 (Co-investigator)
2006-2008, Research Fund for the Control of Infectious Diseases, Studies on antiviral activities of Chinese medicine-derived phytochemicals active against SARS-associated coronavirus or avian influenza A (H5N1), $798,930 (Co-investigator)
2006-2007, CUHK Research Committee Funding (Direct Grants), Antiproliferative effects of three active compounds isolated from the Chinese medicinal herbs, $54,125 (Co-investigator)
2005-2007, CUHK Research Committee Funding (Direct Grants), The cell death induced by SARS-CoV, $54,735 (Co-investigator)
2003-2006, Research Grants Council (Earmarked Grants), Molecular cloning of cDNA encoding a novel potent antiviral protein isolated from the Chinese medicinal herb and its transgenic expression in plants, $524,000 (Co-investigator)
2003-2005, CUHK Research Committee Funding (Direct Grants), Mechanistic studies of apoptotic cell death induced by respiratory syncytial virus (RSV) in human lung epithelium cells, $22,157
2002-2005, Research Grants Council (Earmarked Grants), A mechanistic study of the immunopotentiating and antitumor effects of native and chemically modified nonstarch polysaccharides [(1→3)-β-D-glucans] from mushroom sclerotia, $1,036,000 (Co-investigator)
2003-2004, CUHK Research Committee Funding (Direct Grants), Quantitative analysis for antiviral activity of Prunella vulgarisand related medicinal herbs with flow cytometry, $36,853
2002-2004, Research Grants Council (Earmarked Grants), In vitro and in vivoanticancer studies of novel polyunsaturated fatty acids (DHA, EPA) purified and characterized from several enriched microalgae, $876,000 (Co-investigator)
2001-2004, Research Grants Council (Earmarked Grants), Isolation, characterization and mode of action of novel antiviral agents from seaweeds in Hong Kong, $699,600 (Co-investigator)
2001-2003, CUHK Research Committee Funding (Direct Grants), Flow cytometric studies on anticancer and immunomodulatory activities of microalgal DHA and EPA, $80,000 (Co-investigator)
PatentsExtract of a medicinal mushroom, Polyporus rhinoceros Cooke and composition of the same having antiprofieration of cancer cells and immune enhancing activity. Chinese Patent CN 2.4 (2005 October)
Professional ActivitiesRegular Member, American Society for Cell Biology
OthersCommunity Services
Interviewee, “Interview with the Scientists” organized by Education and Manpower Bureau
Mentor, “Cyber Learning and Mentoring Platform (CLAMP), Support Measures for the Exceptionally Gifted Students Scheme” organized by Education and Manpower Bureau and Hong Kong University of Science and Technology
Advisors and Judges, “Hong Kong Student Science Project Competition” organized by Innovation and Technology Commission, Hong Kong Federation of Youth Groups, and Education and Manpower Bureau