Dr SIOW Lam Nina
Address
(Office): Rm 138, Science Centre North Block
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Phone
(Office): (852) 3943 1317
(Lab): ---

Fax (852) 2603 6510
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EducationPh.D., The Hong Kong University of Science and Technology
M.Phil., The Hong Kong University of Science and Technology
B. Sc., The Hong Kong University of Science and Technology
PositionLecturer, School of Life Sciences
Research InterestsMolecular and cellular neuroscience
Cell signaling and gene regulation
Representative PublicationsSiow, N.L., Choi, R.C., Xie, H.Q., Kong, L.W., Chu, G.C., Chan, G.K., Simon, J., Barnard, E.A. and Tsim, K.W. (2010) ATP Induces Synaptic Gene Expressions in Cortical Neurons: Transduction and Transcription Control Via P2Y1 Receptors. Mol. Pharmacol.78:1059-1071.
Doctor, B.P., Tsim, K.W. and Siow, N.L. (2008) The IXth International Meeting on Cholinesterases, Suzhou, People's Republic of China, 6 to 10 May 2007. Chem. Biol. Interact.175:1-2. (Preface of the conference proceedings)
Xie, H.Q., Choi, R.C., Leung, K.W., Siow, N.L., Kong, L.W., Lau, F.T., Peng, H.B. and Tsim, K.W. (2007) Regulation of a transcript-encoding the proline rich membrane anchor (PRiMA) of globular muscle acetylcholinesterase: the suppressive roles of myogenesis and innervating nerves. J. Biol. Chem.282:11765-75.
Siow, N.L., Xie, H.Q., Choi, R.C. and Tsim, K.W. (2005) ATP induces the post-synaptic gene expression in neuron-neuron synapses: Transcriptional regulation of AChE catalytic subunit. Chem Biol Interact.157-158:423-426.
Tung, E.K., Choi, R.C., Siow, N.L., Jiang, J.X., Ling, K.K., Simon, J., Barnard, E.A. and Tsim, K.W. (2004) P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions. Mol. Pharmacol.66:794-806.
Ling, K.K., Siow, N.L., Choi, R.C., Ting, A.K., Kong, L.W. and Tsim, K.W. (2004) ATP potentiates agrin-induced AChR aggregation in cultured myotubes: activation of RhoA in P2Y1 nucleotide receptor signaling at vertebrate neuromuscular junctions. J. Biol. Chem.279(30):31081-31088.
Lee, H.H., Choi, R.C., Ting, A.K., Siow, N.L., Jiang, J.X., Massoulie, J. and Tsim KW. (2004) Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: differential expression in fast and slow twitch muscle fibers is driven by distinct promoters. J. Biol. Chem.279(26):27098-27107.
Jiang, J.X., Choi, R.C., Siow, N.L., Lee, H.H., Wan, D. C. and Tsim, K.W. (2003): Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture: transcriptional regulation mediated by cAMP–dependent signaling. J. Biol. Chem.278:45435-45444.
Choi, R.C., Siow, N.L., Ling, K.K., Cheng, A.W., Tung, E.K., Simon, J., Barnard, E.A. and Tsim, K.W. (2003): ATP acts through the P2Y1 receptor to enhance the expression of muscle acetylcholinesterase and acetylcholine receptors: transduction pathways and control of transcription. J. Neurosci.23:4445-4456.
Siow, N.L., Choi, R.C., Cheng, A.W., Jiang, J.X., Wan, D.C., Zhu, S.Q. and Tsim, K.W. (2002) A cyclic AMP-dependent pathway regulates the expression of acetylcholinesterase during myogenic differentiation of C2C12 Cells. J. Biol. Chem. 277: 36129-36136.