Academic and Professional Qualifications
MB ChB (CUHK), MRCP (UK), FHKCP, FHKAM (Medicine)
Contact Information
Tel.: (852) 3505 1853
Email: yanniesoo@cuhk.edu.hk
Biography
Dr. Yannie Soo graduated from the Faculty of Medicine at CUHK in 2000. She underwent her Neurology training at Prince of Wales Hospital and overseas training in stroke neuroimaging in Massachusetts General Hospital, Harvard Medical School, Boston. She has significant impact in steering stroke service development in Hong Kong. In 2012, she pioneered off-site intravenous thrombolysis using telestroke with iPad in Hong Kong, which won the Asia Pacific HIMSS Healthcare award in 2013. The technology and stroke service model has greatly facilitated the development of 24-hour thrombolytic service for acute stroke in other hospitals across the territory. Her research interests include cerebral microbleeds, ischaemic stroke related to atrial fibrillation and intracranial atherosclerosis, acute stroke therapies, stroke rehabilitation with external counterpulsation and robotic exoskeletal device, transmagnetic stimulation in stroke and Parkinson’s disease. Her research aims to explore how detection of cerebral microbleeds with MRI brain can help identify patients at risk of treatment-related intracerebral haemorrhage and guide treatment decisions, particularly in patients with atrial fibrillation. Her work with CT perfusion, MRI signal intensity ratio, MRA plague morphology and external counterpulsation have also improved stroke risk prediction and stroke recovery in patients with intracranial atherosclerosis, which is the major stroke mechanism in Chinese population. She is currently the Principal Investigator of many international clinical trials and is leading a number of research projects supported by competitive grants.
Dr. Yannie OY SOO
The Chinese University of Hong Kong
Specialist in Neurology, Department of Medicine & Therapeutics
Prince of Wales Hospital
Honorary Associate Consultant
Research Interests
- Clinical significance of cerebral microbleeds in ischaemic stroke
- Atrial fibrillation and stroke
- Stroke risk prediction and endovascular intervention for patients with intracranial atherosclerosis
- Thrombolytic therapy for acute ischaemic stroke
- Stroke rehabilitation with external counterpulsation and robotic exoskeleton devices
- Transmagnetic stimulation for stroke rehabilitation and Parkinson's disease
Awards
- Outstanding Team (PWH-CUHK Stroke Team), Hospital Authority (2019)
- Outstanding Team (PWH-CUHK Stroke Team), New Territories East Cluster, Hospital Authority(2018)
- Best Poster Award, Hong Kong Neurological Society (2018)
- Best Free Paper Award, Hong Kong Neurological Society (2014)
- Asia Pacific HIMSS-Elsevier Digital Healthcare Award, Outstanding ICT Achievement (2013)
- Young Investigator Award, The Hong Kong College of Physicians (2012)
- Best Free Paper Award, Hong Kong Neurological Society (2012)
- Best Teacher Award, Faculty of Medicine, CUHK (2011/12)
- Young Investigator Award, 5th International Conference on intracranial Atherosclerosis, Spain (2011)
- Best Thesis Award, Silver Medal, The Hong Kong College of Physicians (2007)
- Best Original Research Award, Hong Kong Academy of Medicine (2006)
- Best Free Paper Presentation, Hong Kong Neurological Society (2005)
Selected Publications
- Soo Y, Abrigo JM, Leung KT, Tsang SF, Ip HL, Ma SH, et al. Risk of intracerebral haemorrhage in Chinese patients with atrial fibrillation on warfarin with cerebral microbleeds: the IPAAC-Warfarin study. J Neurol Neurosurg Psychiatry. 2019;90(4):428-35.
- Wilson D, Ambler G, Lee KJ, Lim JS, Shiozawa M, Koga M, et al. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Lancet Neurol. 2019.
- Leng X, Lan L, Ip HL, Abrigo J, Scalzo F, Liu H, et al. Hemodynamics and stroke risk in intracranial atherosclerotic disease. Annals of neurology. 2019;85(5):752-64.
- Feng X, Chan KL, Lan L, Abrigo J, Liu J, Fang H, et al. Stroke Mechanisms in Symptomatic Intracranial Atherosclerotic Disease: Classification and Clinical Implications. Stroke. 2019;50(10):2692-9.
- Xiong L, Tian G, Leung HW, Chen XY, Lin WH, Leung TWH, et al. Autonomic dysfunction as measured by Ewing battery test to predict poor outcome after acute ischaemic stroke. Hong Kong Med J. 2019;25 Suppl 5(4):9-11.
- Tian G, Xiong L, Leung H, Soo Y, Leung T, Wong LK. Beat-to-beat blood pressure variability and heart rate variability in relation to autonomic dysregulation in patients with acute mild-moderate ischemic stroke. J Clin Neurosci. 2019.
- Tang WK, Lau CG, Liang Y, Wang L, Mok V, Soo OYY, et al. Prevalence and Clinical Correlates of Poststroke Behavioral Dysexecutive Syndrome. J Am Heart Assoc. 2019;8(22):e013448.
- Soo Y, Abrigo J, Leung KT, Liu W, Lam B, Tsang SF, et al. Correlation of non-vitamin K antagonist oral anticoagulant exposure and cerebral microbleeds in Chinese patients with atrial fibrillation. J Neurol Neurosurg Psychiatry. 2018;0:1-7. ePub on March 29, 2018.
- Soo Y, Chan N, Leung KT, Chen XY, Mok V, Wong L, et al. Age-specific trends of atrial fibrillation-related ischaemic stroke and transient ischaemic attack, anticoagulant use and risk factor profile in Chinese population: a 15-year study. J Neurol Neurosurg Psychiatry. 2017;88(9):744-8.
- Soo YO, Siu DY, Abrigo J, Yu S, Ng N, Ahuja AT, et al. Risk of intracerebral hemorrhage in patients with cerebral microbleeds undergoing endovascular intervention. Stroke. 2012;43(6):1532-6.
- Soo YO, Yang SR, Lam WW, Wong A, Fan YH, Leung HH, et al. Risk vs benefit of anti-thrombotic therapy in ischaemic stroke patients with cerebral microbleeds. J Neurol. 2008;255(11):1679-86.
- Charidimou A, Soo Y, Heo JH, Srikanth V, Consortium M-M. A call for researchers to join the META-MICROBLEEDS Consortium. Lancet Neurol. 2016;15(9):900.
- Wang Z, Soo YO, Mok VC. Cerebral microbleeds: is antithrombotic therapy safe to administer? Stroke. 2014;45(9):2811-7.
- Sun J, Soo YO, Lam WW, Wong KS, Zeng JS, Fan YH. Different Distribution Patterns of Cerebral Microbleeds in Acute Ischemic Stroke Patients with and without Hypertension. Eur Neurol. 2009;62(5):298-303.
- Charidimou A, Karayiannis C, Song TJ, Orken DN, Thijs V, Lemmens R, et al. Brain microbleeds, anticoagulation, and hemorrhage risk: Meta-analysis in stroke patients with AF. Neurology. 2017;89(23):2317-26.
- Microbleeds International Collaborative N. Worldwide collaboration in the Microbleeds International Collaborative Network. Lancet Neurol. 2016;15(11):1113-4.
- Eckman MH, Wong LK, Soo YO, Lam W, Yang SR, Greenberg SM, et al. Patient-specific decision-making for warfarin therapy in nonvalvular atrial fibrillation: how will screening with genetics and imaging help? Stroke. 2008;39(12):3308-15.
- Chan KL, Leng XY, Zhang W, Dong WN, Qiu QL, Yang J, et al. Early Identification of High-Risk TIA or Minor Stroke Using Artificial Neural Network. Front Neurol. 2019;10.
- Xiong L, Tian G, Leung H, Soo YOY, Chen X, Ip VHL, et al. Autonomic Dysfunction Predicts Clinical Outcomes After Acute Ischemic Stroke: A Prospective Observational Study. Stroke. 2018;49(1):215-8.
- Wu X, Wang L, Zhong J, Ko J, Shi L, Soo Y, et al. Impact of intracranial artery calcification on cerebral hemodynamic changes. Neuroradiology. 2018;60(4):357-63.
- Wong A, Yiu S, Nasreddine Z, Leung KT, Lau A, Soo YOY, et al. Validity and reliability of two alternate versions of the Montreal Cognitive Assessment (Hong Kong version) for screening of Mild Neurocognitive Disorder. PLoS One. 2018;13(5):e0196344.
- Wong A, Black SE, Yiu SYP, Au LWC, Lau AYL, Soo YOY, et al. Converting MMSE to MoCA and MoCA 5-minute protocol in an educationally heterogeneous sample with stroke or transient ischemic attack. Int J Geriatr Psychiatry. 2018.
- Leng X, Lan L, Ip HL, Fan F, Ma SH, Ma K, et al. Translesional pressure gradient and leptomeningeal collateral status in symptomatic middle cerebral artery stenosis. Eur J Neural. 2018;25(2):404-10.
- Lan L, Leng X, Ip V, Soo Y, Abrigo J, Liu H, et al. Sustaining cerebral perfusion in intracranial atherosclerotic stenosis: The roles of antegrade residual flow and leptomeningeal collateral flow. J Cereb Blood Flow Metab. 2018:271678X18805209.
