Academic and Professional Qualifications
MBBS (Syd), MD (CUHK), FRCP (Edin), FHKAM (Medicine), FHKCP, MRCP (UK)
Contact Information
Tel.: (852) 2558 7122
Biography
Prof. Vincent Mok's research aims to understand mechanisms of dementia and to investigate strategies that may help to prevent dementia. He is the first to report the association of cerebral small vessel disease (CSVD) and cognitive impairment in Asia and the first to report the community prevalence of CSVD among Asians (Chinese). Such findings have significantly increased the awareness that strategies targeting CSVD (e.g. blood pressure lowering) can help to prevent dementia in this region, where the burden of dementia is particularly huge. Prof. Mok conducted one of the largest single-centre studies investigating the prevalence and mechanisms of early and delayed cognitive decline in the context of stroke and found that concurrent presence of amyloid plaques as detected by in-vivo amyloid PET imaging and CSVD are important factors associated with early and delayed cognitive decline after stroke, respectively. Such findings provide a road map of how to prevent vascular cognitive impairment. Prof. Mok, along with Dr Adrian Wong (Clinical Psychologist) validated the Hong Kong-Montreal Cognitive Assessment (HK-MoCA) and developed norms for HK-MoCA performance according to age and education. HK-MoCA is currently the commonest brief cognitive assessment used for the assessment of cognitive function and the detection of mild cognitive impairment in HK.
Prof. Mok has been involved in the validation and clinical application of a novel Machine-Learning MRI-based Index, which was developed by a spin-off company of the Chinese University of Hong Kong (CUHK), for the detection of early Alzheimer’s disease. Such technology provides an easy screening method for early Alzheimer’s disease among subjects with mild cognitive impairment. Moreover, he also specializes in Parkinson's disease and was one of the pioneers of developing Deep Brain Stimulation programme in Asia for the treatment of Parkinson’s disease.
He received the Higher Education Outstanding Scientific Research Output Award (Science & Technology) in Natural Sciences (1st Class) from the Ministry of Education, People's Republic of China in 2011 for his research in cerebrovascular disease, Outstanding Fellow Award from the Faculty of Medicine of CUHK for his exceptional academic leadership in areas of research, education and service in 2016, Endowment as Mok Hing Yiu Professor of Medicine by CUHK in 2017, and the Excellent Research Award from the Food and Health Bureau of the Hong Kong Special Administrative Region for his research in vascular cognitive impairment in 2017. He received 7 times Teacher of the Year Award and the Master Teacher Award from the Faculty from the Faculty of Medicine, CUHK.
Prof. Mok has authored more than 300 publications in peer-reviewed international journals (with book chapters), with publications at Lancet, JAMA, Lancet Neurology, Nature Reviews Neurology, Alzheimer’s & Dementia, JAMA Neurology, JAMA Psychiatry, Journal of Neurology, Neurosurgery and Psychiatry (JNNP), Annals of Neurology, Neurology and Stroke.
Prof. Vincent CT MOK
The Chinese University of Hong Kong
Head of Division of Neurology (Academic Affairs)
Endowed Mok Hing Yiu Professor of Medicine
Assistant Dean (Student Affairs, Admission), Faculty of Medicine
Programme Co-Director, MSc Programme in Stroke and Clinical Neurosciences (MCNS)
Director, Therese Pei Fong Chow Research Centre for Prevention of Dementia
Director, Margaret K.L. Cheung Research Centre for Management of Parkinsonism
Executive Committee Member, Chow Yuk Ho Technology Center for Innovative Medicine
Prince of Wales Hospital
Specialist in Neurology
Honorary Consultant, Department of Medicine and Therapeutics
Research Interests
- Vascular Cognitive Impairment, Poststroke Dementia, Mixed Dementia
- Cerebral Small Vessel Disease
- Multi-modal Brain and Retinal Imaging for stroke and cognitive impairment
- Parkinson's disease - premotor stage, genetics, neuroimaging, and Deep Brain Stimulation
Honorary Appointments in Other Professional Activities
- Advisory Council Member of Charles K. Kao Foundation for Alzheimer’s Disease
- Member of the Expert Committee on Clinical Events Assessment Following COVID-19 Immunisation, The Government of the Hong Kong Special Administrative Region, 2021 - present
- Chair of the Local Organizing Committee of the 9th International Meeting of the International Society of Vascular Behavioural and Cognitive Disorders, HKSAR, 2018
- Co-Chair of the Congress Scientific Program Committee of 2018 International Congress of the International Parkinson's Disease and Movement Disorder Society, HKSAR, 2018
- Secretary of the Neurology Specialty Board, Hong Kong College of Physicians, 2018 – present
- Advisory Council Member of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), 2018 – 2020
- Vice-Chair and Hong Kong Representative of the China Greater Bay Guang Zhou-Hong Kong-Macau Neurology Alliance, 2018
- Hong Kong Representative of the World Federation of Neurology, 2012 – 2021
- Executive Committee Member of the International Society of Vascular Behavioral and Cognitive Disorders, 2011 –Present
- Honorary Treasurer of the Asian Society Against Dementia, 2011 – Present
- Chair of the Scientific Program Committee of the 2017 Asia Pacific Stroke Conference, Nanjing China, 2017
- President of the Chinese Dementia Research Association, 2015 – 2016
- Member of Working Group of European Union-Joint Programme Neurodegenerative Disease (EU-JPND) Research in Longitudinal Cohorts, 2015
- Member of the Stroke Progress Review Group in Vascular Cognitive Member of the Stroke Progress Review Group in Vascular Cognitive Impairment of the National Institute of Neurological Diseases and Stroke of United States of America, 2012
- President of the Hong Kong Movement Disorder Society, 2011 – 2013
Awards
- 10th Health and Medical Research Fund Anniversary Award, HKSAR (2021)
- Excellent Research Award, Food & Health Bureau, HKSAR (2017)
- Outstanding Fellow of Faculty of Medicine, CUHK (2016)
- Ministry of Education Higher Education Outstanding Scientific Research Output Award - First-class Award in Natural Sciences (2011 )
- Master Teacher Award, CUHK (2012)
- Teacher of the Year Award for 7 times, CUHK (2005-2012)
Selected Publications
- Fan FSY, Yip TCF, Yiu B, Lam B, Au L, Lau AYL, Ip B, Soo Y, Leung TWH, Li T, Lui G, Wong GLH, Mok VCT. Neurological diseases and risk of mortality in patients with COVID-19 and SARS: a territory-wide study in Hong Kong. J Neurol Neurosurg Psychiatry. 2021 Apr 27;jnnp-2021-326286.
- Ho Sing Lo, Kenrie Pui Yan Hui, Hei-Ming Lai, Xu He, Khadija Shahed Khan, Simranjeet Kaur, Junzhe Huang, Zhongqi Li, Anthony K. N. Chan, Hayley Hei-Yin Cheung, Ka-Chun Ng, John Chi Wang Ho, Yu Wai Chen, Bowen Ma, Peter Man-Hin Cheung, Donghyuk Shin, Kaidao Wang, Meng-Hsuan Lee, Barbara Selisko, Cecilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Kuen-Phon Wu, Po-Huang Liang, Ivan Dikic, Zhong Zuo, Francis K. L. Chan, David S. C. Hui, Vincent C. T. Mok, Kam-Bo Wong, Chris Ka Pun Mok, Ho Ko, Wei Shen Aik, Michael Chi Wai Chan, and Wai-Lung Ng. Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir. ACS Cent Sci. 2021 April;doi.org/10.1021/acscentsci.0c01186.
- Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath P, GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim SY, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O’Brien J, Pai MC, Pantoni L, Sachdev P, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P. Tackling challenges in care of Alzheimer’s disease and other dementias amid the COVID-19 pandemic, now and in the future. Alzheimer's & Dementia. 2020 Aug 12;doi:10.1002/alz.12143.
- Kang D, Wong A, Fu J, Qun X, Liu W, Wang Z, Lin S, Kwan P, Lo E, Au LWC, Ko H, Lau AYL, Leung TWH, Abrigo J, Chu WCW, Mok VCT, Lam BYK. Can transcranial Doppler ultrasound be used for screening cerebral small vessel diseases in the community? J Neurol Sci. 2019 Aug 29;406:116439. doi: 10.1016/j.jns.2019.116439. [Epub ahead of print].
- Zhao L, Luo Y, Lew D, Liu W, Au L, Mok V, Shi L; Alzheimer Disease Neuroimaging Initiative. Risk estimation before progression to mild cognitive impairment and Alzheimer's disease: an AD resemblance atrophy index. Aging (Albany NY). 2019 Aug 29;11(16):6217-6236. doi: 10.18632/aging.102184. Epub 2019 Aug 29.
- Cummings J, Passmore P, McGuinness B, Mok V, Chen C, Engelborghs S, Woodward M, Manzano S, Garcia-Ribas G, Cappa S, Bertolucci P, Chu LW. Souvenaid in the management of mild cognitive impairment: an expert consensus opinion. Alzheimers Res Ther. 2019 Aug 17;11(1):73. doi: 10.1186/s13195-019-0528-6. Review.
- Wong A, Yiu S, Lam BYK, Leung KT, Shi L, Lo E, Abrigo J, Au LW, Lau A, Mok V. Physical activities attenuate the negative cognitive impact from white matter hyperintensities in stroke and TIA patients with low education. Int J Geriatr Psychiatry. 2019 Aug 13. doi: 10.1002/gps.5194. [Epub ahead of print]
- Au LWC, Chan AYY, Mok VCT. Teaching NeuroImages: X-linked adrenoleukodystrophy: Spinocerebellar variant. Neurology. 2019 Aug 13;93(7):e731-e732. doi: 10.1212/WNL.0000000000007958. No abstract available.
- Yu JT, Li JQ, Suckling J, Feng L, Pan A, Wang YJ, Song B, Zhu SL, Li DH, Wang HF, Tan CC, Dong Q, Tan L, Mok V, Aisen PS, Weiner MM; Alzheimer's Disease Neuroimaging Initiative. Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study. Alzheimers Dement. 2019 Sep;15(9):1208-1217. doi: 10.1016/j.jalz.2019.05.006. Epub 2019 Aug 6.
- Zhou X, Chen Y, Mok KY, Kwok TCY, Mok VCT, Guo Q, Ip FC, Chen Y, Mullapudi N; Alzheimer’s Disease Neuroimaging Initiative, Giusti-Rodríguez P, Sullivan PF, Hardy J, Fu AKY, Li Y, Ip NY. Non-coding variability at the APOE locus contributes to the Alzheimer's risk. Nat Commun. 2019 Jul 25;10(1):3310. doi: 10.1038/s41467-019-10945-z.
- Wilson D, Ambler G, Lee KJ, Lim JS, Shiozawa M, Koga M, Li L, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats-Sánchez L, Martínez-Domeño A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Schrooten M, Lemmens R, Eppinger S, Gattringer T, Uysal E, Tanriverdi Z, Bornstein NM, Assayag EB, Hallevi H, Tanaka J, Hara H, Coutts SB, Hert L, Polymeris A, Seiffge DJ, Lyrer P, Algra A, Kappelle J, Al-Shahi Salman R, Jäger HR, Lip GYH, Mattle HP, Panos LD, Mas JL, Legrand L, Karayiannis C, Phan T, Gunkel S, Christ N, Abrigo J, Leung T, Chu W, Chappell F, Makin S, Hayden D, Williams DJ, Kooi ME, van Dam-Nolen DHK, Barbato C, Browning S, Wiegertjes K, Tuladhar AM, Maaijwee N, Guevarra C, Yatawara C, Mendyk AM, Delmaire C, Köhler S, van Oostenbrugge R, Zhou Y, Xu C, Hilal S, Gyanwali B, Chen C, Lou M, Staals J, Bordet R, Kandiah N, de Leeuw FE, Simister R, van der Lugt A, Kelly PJ, Wardlaw JM, Soo Y, Fluri F, Srikanth V, Calvet D, Jung S, Kwa VIH, Engelter ST, Peters N, Smith EE, Yakushiji Y, Orken DN, Fazekas F, Thijs V, Heo JH, Mok V, Veltkamp R, Ay H, Imaizumi T, Gomez-Anson B, Lau KK, Jouvent E, Rothwell PM, Toyoda K, Bae HJ, Marti-Fabregas J, Werring DJ; Microbleeds International Collaborative Network. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Lancet Neurol. 2019 Jul;18(7):653-665. doi: 10.1016/S1474-4422(19)30197-8. Epub 2019 May 23.
- Shi L, Lou W, Wong A, Zhang F, Abrigo J, Chu WC, Kwok TC, Wong KK, Abbott D, Wang D, Mok VC. Neural evidence for long-term marriage shaping the functional brain network organization between couples. Neuroimage. 2019 Oct 1;199:87-92. doi: 10.1016/j.neuroimage.2019.05.058. Epub 2019 May 23.
- Kwok JYY, Kwan JCY, Auyeung M, Mok VCT, Lau CKY, Choi KC, Chan HYL. Effects of Mindfulness Yoga vs Stretching and Resistance Training Exercises on Anxiety and Depression for People With Parkinson Disease: A Randomized Clinical Trial. JAMA Neurol. 2019 Jul 1;76(7):755-763. doi: 10.1001/jamaneurol.2019.0534.
- Yakushiji Y, Wilson D, Ambler G, Charidimou A, Beiser A, van Buchem MA, DeCarli C, Ding D, Gudnason V, Hara H, Imaizumi T, Kohara K, Kwon HM, Launer LJ, Mok V, Phan T, Preis SR, Romero JR, Seshadri S, Srikanth V, Takashima Y, Tsushima Y, Wang Z, Wolf PA, Xiong Y, Yamaguchi S, Werring DJ. Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis. Neurology. 2019 Mar 5;92(10):e1086-e1097. doi: 10.1212/WNL.0000000000007039. Epub 2019 Feb 1. Erratum in: Neurology. 2019 Jul 2;93(1):46.
- Lau AY, Mok V, Lee J, Fan Y, Zeng J, Lam B, Wong A, Kwok C, Lai M, Zee B. Retinal image analytics detects white matter hyperintensities in healthy adults. Ann Clin Transl Neurol. 2018 Nov 15;6(1):98-105. doi: 10.1002/acn3.688. eCollection 2019 Jan.
- Abrigo J, Shi L, Luo Y, Chen Q, Chu WCW, Mok VCT; Alzheimer’s Disease Neuroimaging Initiative. Standardization of hippocampus volumetry using automated brain structure volumetry tool for an initial Alzheimer's disease imaging biomarker. Acta Radiol. 2019 Jun;60(6):769-776. doi: 10.1177/0284185118795327. Epub 2018 Sep 5.
- Shi L, Zhao L, Yeung FK, Wong SY, Chan RKT, Tse MF, Chan SC, Kwong YC, Li KC, Liu K, Abrigo JM, Lau AYL, Wong A, Lam BYK, Leung TWH, Fu J, Chu WCW, Mok VCT. Mapping the contribution and strategic distribution patterns of neuroimaging features of small vessel disease in poststroke cognitive impairment. J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):918-926. doi: 10.1136/jnnp-2017-317817. Epub 2018 Apr 17.
