Academic and Professional Qualifications
BMed, MMed, PhD
Biography
Dr. Leng's research focuses on stroke and intracranial atherosclerotic disease (ICAD). In the past few years, Dr. Leng has been utilizing multimodal neuroimaging and computational methods to study cerebral hemodynamics and plaque characteristics in ICAD and its clinical implications, using a cross-disciplinary approach. She also works on the efficacy and safety of medical and interventional treatment regimens in ischemic stroke, and investigates mechanisms of collateral circulation recruitment and its prognostic values in stroke patients. In these research areas, she has close collaboration with University of Oxford, University of California Los Angeles, Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences, and Beijing Tiantan Hospital of Capital Medical University.
Dr. Leng has been funded by the Research Grants Council of Hong Kong, Health and Medical Research Fund, the National Natural Science Foundation of China, China Association for Science and Technology, and the Lee Hysan Foundation. Since 2013, Dr. Leng has published more than 60 peer-reviewed articles in international academic journals, including Circulation, Ann Neurol, Neurology, J Neurol Neurosurg Psychiatry, Stroke, etc.
Dr. Cindy XY LENG
The Chinese University of Hong Kong
Assistant Professor, Department of Medicine & Therapeutics
Research Interests
- Imaging, treatment and prognosis of ischemic stroke and intracranial atherosclerotic disease
- Cerebral hemodynamics and plaque characteristics in intracranial atherosclerotic disease
- Collateral circulation in ischemic stroke and intracranial atherosclerotic disease
Honorary Appointments in Other Professional Activities
- Associate Editor, Stroke and Vascular Neurology
- Guest Editor, Frontiers in Neurology
- Editorial Board Member, Stroke
- Fellow, Chinese Society of Cerebral Blood Flow and Metabolism
Awards
- Outstanding Researcher of the Chinese Stroke Association (2020)
- Lee Hysan Postdoctoral Fellowship in Clinical Neurosciences (2018)
- World Heart Federation Emerging Leaders (2018)
- Young Elite Scientist, China Association for Science and Technology (2017)
Selected Publications
- Leng X, Hurford R, Feng X, Chan KL, Wolters FJ, Li L, Soo YOY, Mok VCT, Leung TW, Rothwell PM. Intracranial arterial stenosis in Caucasian versus Chinese patients with TIA and minor stroke: two contemporaneous cohorts and a systematic review. J Neurol Neurosurg Psychiatry. Published online before print on 30 Mar 2021.
- Leung TW, Wang L, Zou X, Soo Y, Pu Y, Ip HL, Chan A, Au LWC, Fan F, Ma SH, Ip B, Ma K, Lau AY, Leung H, Hui KF, Li R, Li SH, Fu M, Fong WC, Liu J, Mok V, Wong KSL, Miao Z, Ma N, Yu SCH, Leng X. Plaque morphology in acute symptomatic intracranial atherosclerotic disease. J Neurol Neurosurg Psychiatry. 2021;92:370-376.
- Lan L, Liu H, Ip V, Soo Y, Abrigo J, Fan F, Ma SH, Ma K, Ip BYM, Liu J, Fan Y, Zeng J, Mok VCT, Wong KS, Liebeskind DS, Leung TW, Leng X. Regional high wall shear stress associated with regression of luminal stenosis in symptomatic intracranial atherosclerotic disease. Stroke. 2020;51:3064-3073.
- Feng X, Chan KL, Lan L, Abrigo J, Ip VHL, Soo Y, Leung TW, Leng X. Translesional pressure gradient alters relationship between blood pressure and recurrent stroke in intracranial stenosis. Stroke. 2020; 51:1862-1864.
- Lan L, Leng X, Ip V, et al. Sustaining cerebral perfusion in intracranial atherosclerotic stenosis: the roles of antegrade residual flow and leptomeningeal collateral flow. J Cereb Blood Flow Metab. 2020;40:126-134.
- Feng X, Chan KL, Lan L, Abrigo J, Fang H, Xu Y, Soo Y, Leng X, Leung TW. Stroke mechanisms in symptomatic intracranial atherosclerotic disease: classification and clinical implications. Stroke. 2019. 2019;50:2692-2699.
- Leng X, Lan L (co-1st author), Ip HL, Abrigo J, Scalzo F, Liu H, Feng X, Chan KL, Fan FS, Ma SH, Fang H, Xu Y, Li J, Zhang B, Xu Y, Soo YO, Mok VC, Yu SC, Liebeskind DS, Wong KS, Leung TW. Hemodynamics and stroke risk in intracranial atherosclerotic disease. Ann Neurol. 2019;85:752-764.
- Leng X, Fang H, Leung TWH, et al. Impact of collaterals on the efficacy and safety of endovascular treatment in acute ischemic stroke: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2016;87:537-544.
- Leng X, Wong KS, Liebeskind DS. Evaluating intracranial atherosclerosis rather than intracranial stenosis. Stroke. 2014;45: 645-651.
- Leng XY, Chen XY, Chook P, et al. Correlation of large artery intracranial occlusive disease with carotid intima-media thickness and presence of carotid plaque. Stroke. 2013;44:68-72.
