Prof. Weitian CHEN
Bsc, Msc, PhD
Associate Professor
Email: wtchen@cuhk.edu.hk
Tel: 3505 1036
Researcher ID (Q-3770-2016):
https://publons.com/researcher/1175542/weitian-chen/

Research Interests
I am interested in MRI technology innovations and relevant clinical studies. One of my main interests is quantitative MRI based on spin-lock techniques. The aim is to make it robust and reliable to detect certain biochemical symptoms of diseased tissue, which can be used for early detection and post-treatment monitoring of diseases. My other main interests include the development of MRI applications based on machine learning/deep learning technologies. We work closely with clinical colleagues to evaluate the diagnostic value of our technology inventions.

Education Profile
PhD. ??University of Virginia, Biomedical Engineering, ????2008
MSc. ?Stanford University, ??Geophysics, ??????????????????????2004
BSc. ??Peking University, ????Geophysics, ???????????????????????1998

Selected Publications
Selected publications:Hong J, Zhang YD, Chen W*. Source-free unsupervised domain adaptation for cross-modality abdominal multi-organ segmentation. arXiv preprint arXiv:2111.12221. 2021 Nov 24.
Khan S, Azam B, Yao Y, Chen W*. Multipath CNN with alpha matte inference for knee tissue segmentation from MRI. arXiv preprint arXiv:2109.14249. 2021 Sep 29.
Hong J, Yu SC, Chen W*. Unsupervised domain adaptation for cross-modality liver segmentation via joint adversarial learning and self-learning. arXiv preprint arXiv:2109.05664. 2021 Sep 13.
Liu Y, Ying L, Chen W, Cui ZX, Zhu Q, Liu X, Zheng H, Liang D, Zhu Y. Accelerating the 3D T1ρ mapping of cartilage using a signal-compensated robust tensor principal component analysis model. Quantitative Imaging in Medicine and Surgery. 2021 Aug;11(8):3376.
Au CK, Abrigo J, Liu C, Liu W, Lee J, Au LW, Chan Q, Chen S, Leung EY, Ho CL, Ko H, Mok V, Chen, W. Quantitative Susceptibility Mapping of the Hippocampal Fimbria in Alzheimer’s Disease. Journal of Magnetic Resonance Imaging. 2021 Jun;53(6):1823-32.
Hou J, Wong VW, Jiang B, Wang YX, Wong GL, Chan AW, Chu WC, Chen W*. Macromolecular proton fraction mapping based on spin‐lock magnetic resonance imaging. Magnetic Resonance in Medicine. 2020 Dec;84(6):3157-71.
Chen W*, Karampinos DC. Chemical‐shift encoding–based water–fat separation with multifrequency fat spectrum modeling in spin‐lock MRI. Magnetic Resonance in Medicine. 2020 May;83(5):1608
Ai QY, Chen W*, So TY, Lam WK, Jiang B, Poon DM, Qamar S, Mo FK, Blu T, Chan Q, Ma BB, Hui EP, Chan KCA, King AD*. Quantitative T1ρ MRI of the Head and Neck Discriminates Carcinoma and Benign Hyperplasia in the Nasopharynx. American Journal of Neuroradiology. 2020 Dec 1;41(12):2339-44.
Jiang B, Jin T, Blu T,?Chen W*. Probing chemical exchange using quantitative spin‐lock R1ρ asymmetry imaging with adiabatic RF pulses. Magnetic Resonance in Medicine. 2019 Nov;82(5):1767
Law BK, King AD, Ai QY, Poon DM,?Chen W, Bhatia KS, Ahuja AT, Ma BB, Ka-Wai Yeung D, Fai Mo FK, Wang YX. Head and neck tumors: amide proton transfer MRI. Radiology. 2018 Sep;288(3):782
Jiang B,?Chen W*. On‐resonance and off‐resonance continuous wave constant amplitude spin‐lock and T1ρ quantification in the presence of B1 and B0 inhomogeneities. NMR in Biomedicine. 2018 Jul;31(7):e3928
Wang YX, Deng M, Lo GG, Liang D, Yuan J,?Chen W. Breath-hold black-blood T1rho mapping improves liver T1rho quantification in healthy volunteers. Acta Radiologica. 2018 Mar;59(3):257
Villanueva-Meyer JE, Barajas Jr RF, Mabray MC,?Chen W, Shankaranarayanan A, Koon P, Barani IJ, Tihan T, Cha S. Differentiation of brain tumor-related edema based on 3D T1rho imaging. European journal of radiology. 2017 Jun 1;91:88
Chen W*. Artifacts correction for T1rho imaging with constant amplitude spin-lock. Journal of Magnetic Resonance. 2017 Jan 1;274:13
Tamir JI, Uecker M,?Chen W, Lai P, Alley MT, Vasanawala SS, Lustig M. T2 shuffling: sharp, multicontrast, volumetric fast spin‐echo imaging. Magnetic resonance in medicine. 2017 Jan;77(1):180
Bao S, Tamir JI, Young JL, Tariq U, Uecker M, Lai P,?Chen W, Lustig M, Vasanawala SS. Fast comprehensive single‐sequence four‐dimensional pediatric knee MRI with T2 shuffling. Journal of Magnetic Resonance Imaging. 2017 Jun;45(6):1700
Chen W*, Chan Q, Wáng YX. Breath-hold black blood quantitative T1rho imaging of liver using single shot fast spin echo acquisition. Quantitative Imaging in Medicine and Surgery. 2016 Apr;6(2):168.
Chen W*. Errors in quantitative T1rho imaging and the correction methods. Quantitative imaging in medicine and surgery. 2015 Aug;5(4):583.
Matzat SJ, McWalter EJ, Kogan F,?Chen W, Gold GE. T2 relaxation time quantitation differs between pulse sequences in articular cartilage. Journal of Magnetic Resonance Imaging. 2015 Jul;42(1):105-13.
Jordan CD, McWalter EJ, Monu UD, Watkins RD,?Chen W, Bangerter NK, Hargreaves BA, Gold GE. Variability of CubeQuant T1ρ, quantitative DESS T2, and cones sodium MRI in knee cartilage. Osteoarthritis and cartilage. 2014 Oct 1;22(10):1559
Li CQ,?Chen W, Rosenberg JK, Beatty PJ, Kijowski R, Hargreaves BA, Busse RF, Gold GE. Optimizing isotropic three‐dimensional fast spin‐echo methods for imaging the knee. Journal of Magnetic Resonance Imaging. 2014 Jun;39(6):1417
Li X, Wyatt C, Rivoire J, Han E,?Chen W, Schooler J, Liang F, Shet K, Souza R, Majumdar S. Simultaneous acquisition of T1ρ and T2 quantification in knee cartilage: repeatability and diurnal variation. Journal of Magnetic Resonance Imaging. 2014 May;39(5):1287
Chen W*, Takahashi A, Han E. Quantitative T1ρ imaging using phase cycling for B0 and B1 field inhomogeneity compensation. Magnetic resonance imaging. 2011 Jun 1;29(5):608
Chen CA,?Chen W, Goodman SB, Hargreaves BA, Koch KM, Lu W, Brau AC, Draper CE, Delp SL, Gold GE. New MR imaging methods for metallic implants in the knee: artifact correction and clinical impact. Journal of Magnetic Resonance Imaging. 2011 May;33(5):1121
Stevens KJ, Wallace CG,?Chen W, Rosenberg JK, Gold GE. Imaging of the wrist at 1.5 tesla using isotropic three‐dimensional fast spin echo cube. Journal of Magnetic Resonance Imaging. 2011 Apr;33(4):908
Koch KM, Brau AC,?Chen W, Gold GE, Hargreaves BA, Koff M, McKinnon GC, Potter HG, King KF. Imaging near metal with a MAVRIC‐SEMAC hybrid. Magnetic resonance in medicine. 2011 Jan;65(1):71
Koch KM, Hargreaves BA, Pauly KB,?Chen W, Gold GE, King KF. Magnetic resonance imaging near metal implants. Journal of Magnetic Resonance Imaging. 2010 Oct;32(4):773
Hargreaves BA,?Chen W, Lu W, Alley MT, Gold GE, Brau AC, Pauly JM, Pauly KB. Accelerated slice encoding for metal artifact correction. Journal of Magnetic Resonance Imaging: An Official Journal of the International Society for Magnetic Resonance in Medicine. 2010 Apr;31(4):987
Chen W, Sica CT, Meyer CH. Fast conjugate phase image reconstruction based on a Chebyshev approximation to correct for B0 field inhomogeneity and concomitant gradients. Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine. 2008 Nov;60(5):1104

Research Grants
PI, Innovation and Technology Fund (ITF) Midstream Research Programme for Universities (MRP) 2020/2021Project title: Development of Fully Automated Non-Invasive MRI Applications for Diagnosis and Staging of Liver Fibrosis and Inflammation. Hong Kong Innovation and Technology Commission (ITC). HK$6,800,000. 01/07/2021-30/06/2024
PI, Hong Kong Health and Medical Research Fund (HMRF) 2018/2019Project title: Quantitative Rotating Frame Relaxometry for Early Detection of Liver Fibrosis in Presence of Hepatic Iron. Hong Kong Food and Health Bureau. HK$1,300,998. 01/08/2019-31/07/2021
PI, Innovation and Technology Fund (ITF) Midstream Research Programme for Universities (MRP) 2018/2019Project title: Development Of A Quantitative And Fully Automated Non-Contrast MRI Application For Early Detection And Monitoring Of Joint Diseases In Elderly Population. Hong Kong Innovation and Technology Commission (ITC). HK$7,838,528. 01/02/2019-31/01/2022
PI, Faculty Innovation Award 2018Project title: Develop Robust, Non-invasive, and Contrast-free Imaging Biomarkers Based on Magnetic Resonance Spin-lock Technology for Diagnosis of Biochemical Symptoms at The Early Stage of Human Diseases. Faculty of Medicine, The Chinese University of Hong Kong. HK$2,500,000. 01/01/2018-31/12/2022
PI, Innovation and Technology Fund (ITF) Innovation and Technology Support Programme (ITSP) 2017/2018Project title: Develop Magnetic Resonance Imaging Technology for Fat-Water Imaging and Simultaneous T1rho Quantification. Hong Kong Innovation and Technology Commission (ITC). HK$1,395,789. 01/01/2018-30/06/2019
PI, General Research Fund 2017/2018Project title: Develop and evaluate breathhold black blood magnetic resonance imaging technology for simultaneous acquisition of quantitative T1rho and its composite metric for early diagnosis of liver fibrosis. Hong Kong Research Grants Council (RGC). HK$466,667. 01/01/2018-31/06/2020
PI, Innovation and Technology Fund (ITF) Innovation and Technology Support Programme (ITSP) 2016/2017Project title: Develop A Magnetic Resonance Imaging Application of T1rho Relaxometry for Routine Clinical Use. Hong Kong Innovation and Technology Commission (ITC). HK$1,281,100. 01/03/2017-31/12/2018

Patents
A. Patents granted
1. W Chen, CH Meyer, Fast automatic linear off-resonance correction method for spiral imaging, US Patent 7,642,777, Filed 21/08/2007, Date of Patent 05/01/2010
2. W Chen, CH Meyer, CT Sica, System, Method and Computer Program Product for Fast Conjugate Phase Reconstruction Based on Polynomial Approximation, US Patent 8,094,907, Filed 02/05/2008, Date of Patent 10/01/2012
3. W Chen, P Hu, CH Meyer, Method and System for Off-Resonance Correction for Non-Cartesian Parallel Imaging Reconstruction, US Patent 8,306,289, Filed 25/02/2008, Date of Patent 06/11/2012
4. W Chen, CH Meyer, Efficient Off-Resonance Correction Method and System for Spiral Imaging with Improved Accuracy, US Patent 8,238,634, Filed 25/02/2008, Date of Patent 07/08/2012
5. W Chen, P Hu, CH Meyer, Rapid Auto-Calibrated Parallel Reconstruction Using Synthetic Target Coil, US Patent 8,026,720, Filed 25/03/2009, Date of Patent 27/09/2011
6. W Chen, ACS Brau, PJ Beatty, System and Method of Parallel Imaging for Magnetic Resonance Imaging Near Metallic Implants, US Patent 8,482,279, Filed 31/03/2010, Date of Patent 09/07/2013
7. W Chen, E Han, Composite Spin Locking Pulse Sequence and Method of Using the Same, US Patent 8,618,797, Filed 23/07/2010, Date of Patent 31/12/2013
8. P Lai, W Chen, Accelerated Multispectral Data Magnetic Resonance Imaging System and Method, US Patent 9,018,951, Filed 18/04/2011, Date of Patent 28/04/2015
9. W Chen, RD Peters, ZW Slavens, KM Koch, Method and apparatus for ring artifact repair of magnetic resonance images, US Patent 9,727,953, Filed 30/06/2015, Date of Patent 08/08/2017
10. W Chen, B Jiang, Y Wang, Quantitative Magnetic Resonance Imaging Relaxometry with Suppression of Blood Signal, US Patent 10,557,906, Filed 27/04/2017, Date of Patent 11/02/2020
11. W Chen. System and Method for Separation of Water and Fat Signals During Spin-lock Magnetic Resonance Imaging, US Patent 10,598,751, Filed 04/02/2019, Date of Patent 24/03/2020
12. K Gan, W Chen. System and Method for Patient Privacy Protection in Medical Images, US Patent 10,679,740, Filed 12/06/2018, Date of Patent 09/06/2020
13. W Chen, B Jiang. System and Method for Continuous Wave Constant Amplitude On-Resonance and Off-resonance Spin-Lock for Magnetic Resonance Imaging, US 11,137,463, USA patent, Filed 28/07/2017, Date of Patent 05/10/2021
B. Pending patent applications
14. W Chen, J Hou, B Jiang. System and Method for Quantitative Magnetization Transfer Imaging Based on Spin-Lock. US 15/929,627, USA patent, pending
15. 陈蔚天, 江柏言. 用於磁共振成像的连续波恒定振幅产生共振和偏共振自旋锁的系统和方法, CN 2.X, pending
16. 陈蔚天. 自旋锁磁共振成像中分离水和脂肪信号的系统和方法 CN2.5, pending
17. 陈蔚天, 候健，江柏言. 基於自旋锁的定量磁化传递成像的系统和方法 CN2.7, pending