Dr. Lili Li






Name


Lili Li

Chinese Name


李力力

Rank


Research Assistant Professor

Email


lili_li@cuhk.edu.hk

Specific Research / Sites of Interest


Epigenetic disruption of cell signaling in tumorigenesis

Post-translation modifications (phosphorylation, ubiquitination, etc) of regulatory proteins in carcinogenesis


Short Biography


Dr. Li obtained her PhD in 2007 in Xiangya School of Medicine, Central South University, China, and did her postdoctoral training in the State Key Laboratory of Oncology in South China, Department of Clinical Oncology, the Chinese University of Hong Kong from 2009 to 2013. She was promoted to Research Assistant Professor in the Department of Clinical Oncology, CUHK in March 2014.
Dr. Li’s research work is focused on cancer epigenomics, including epigenetic disruption of cell signaling in tumorigenesis, and post-translation modifications of regulatory proteins in carcinogenesis. She got an Outstanding Scientific Research Achievement Award in Natural Science of the Institutions of Higher Education in the Ministry of Education, and a Natural Science Award in Hunan Province. She has published 76 papers in international journals including Oncogene, Clinical Cancer Res, Theranostics, Cell Res and Cell Cycle. She is a reviewer for China NSFC grants and several scientific journals including Oncogene, J Pathol and Cancer Letters, and also a Young Board member for the China Association of Pathophysiology.

Most Representative Publications


Li L, Xu J, Qiu G, Ying J, Du Z, Xiang T, Wong KY, Srivastava G, Zhu XF, Mok TS, Chan AT, Chan FK, Ambinder RF, Tao Q. Epigenomic characterization of a p53-regulated 3p22.2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently methylated in esophageal and other carcinomas. Theranostics 2018; 8(1):61-77.

Li L, Li C, Mao H, Du Z, Chan WY, Murray P, Luo B, Chan AT, Mok TS, Chan FK, Ambinder RF, Tao Q. Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers. Sci Rep 2016 May 26; 6:26591.

Li L, Zhang Y, Fan Y, Sun K, Su X, Du Z, Tsao SW, Loh TK, Sun H, Chan AT, Zeng YX, Chan WY, Chan FK, Tao Q. Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes. Epigenomics 2015; 7(2):155-73.

Li L, Ying J, Tong X, Zhong L, Su X, Xiang T, Shu X, Rong R, Xiong L, Li H, Chan AT, Ambinder RF, Guo Y, Tao Q. Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas. Cell Mol Life Sci 2014; 71(11):2179-92.

Li L, Ying J, Li H, Zhang Y, Shu XS, Fan Y, Tan J, Cao Y, Tsao SW, Srivastava G, Chan AT, Tao Q. The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through WNT/β-catenin signaling and silenced in common carcinomas. Oncogene 2012; 31(34):3901-12.

Li L, Li W, Xiao L, Xu J, Chen X, Tang M, Dong Z, Tao Q, Cao Y. Viral oncoprotein LMP1 disrupts p53-induced cell cycle arrest and apoptosis through modulating K63-linked ubiquitination of p53. Cell Cycle 2012; 11(12):2327-36.

Li L, Tao Q*, Jin H, van Hasselt A, Poon FF, Wang X, Zeng MS, Jia WH, Zeng YX, Chan AT*, Cao Y* (*corresp authors). The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma. Clin Cancer Res 2010; 16(11):2949-58.

Li L, Guo L, Tao Y, Zhou S, Wang Z, Luo W, Hu D, Li Z, Xiao L, Tang M, Yi W, Tsao SW, Cao Y. Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases. Cancer Lett 2007; 255 (2):219-231.

Li L, Li Z, Zhou S, Xiao L, Guo L, Tao Y, Tang M, Shi Y, Li W, Yi W, Cao Y. Ubiquitination of MDM2 modulated by Epstein-Barr virus encoded latent membrane protein 1. Virus Res 2007; 130(1-2):275-80.

Ai MD, Li L, Zhao XR, Wu Y, Gong JP, Cao Y. Regulation of survivin and CDK4 by Epstein-Barr virus encoded latent membrane protein 1 in nasopharyngeal carcinoma cell lines. Cell Res 2005, 15 (10):777-84.


Google Scholar


https://scholar.google.com.hk/citations?user=6lZzARsAAAAJ&hl=zh-TW&oi=ao