Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 龙浩锋教授 (肿瘤学系) |
| 陈德章教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.oraloncology.2014.01.010 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/7WOS source URL
其它资讯
摘要In conjunction with radiotherapy, the concurrent use of systemic chemotherapy has been proven to improve treatment outcome and thus have been incorporated into the treatment paradigm for patients with loco-regionally advanced Nasopharyngeal carcinoma. The benefits from the use of chemotherapy in stage II disease remain controversial. There is now also increasing evidence for the use of neoadjuvant chemotherapy prior to definitive concurrent chemoirradiation, which is associated with decreased risks of distant metastases, translating to improvement in overall survival. Dose intensity of chemotherapy administered during radiotherapy has been shown to have prognostic significance in NPC treatment. The role of adjuvant chemotherapy after completion of concurrent chemoirradiation is less well defined, with studies indicating an insignificant survival improvement. However, this approach may still be of value in patients with high-risk disease. Data in support of this approach shall become available in the coming years. This article will discuss and highlight these findings and controversies in systemic treatment of NPC. (C) 2014 Elsevier Ltd. All rights reserved.
着者Loong HH, Chan ATC
期刊名称Oral Oncology
出版年份2014
月份9
日期1
卷号50
期次9
出版社Elsevier
页次http://aims.cuhk.edu.hk/converis/portal/Publication/785 - http://aims.cuhk.edu.hk/converis/portal/Publication/790
国际标準期刊号1368-83http://aims.cuhk.edu.hk/converis/portal/Publication/75
电子国际标準期刊号18http://aims.cuhk.edu.hk/converis/portal/Publication/79-0593
语言英式英语
关键词Adjuvant chemotherapy; Concurrent chemoirradiation; Dose intensity; Nasopharyngeal carcinoma; Neoadjuvant chemotherapy
Web of Science 学科类别Dentistry, Oral Surgery & Medicine; DENTISTRY, ORAL SURGERY & MEDICINE; Oncology; ONCOLOGY
