Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陈彦博士 (肿瘤学系) |
| 李力力教授 (肿瘤学系) |
| 陶谦教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.5732/cjc.011.10344 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/12WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/15Scopus source URL
其它资讯
摘要Breast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations. Recent studies revealed that abnormal gene expression induced by epigenetic changes, including aberrant promoter methylation and histone modification, plays a critical role in human breast carcinogenesis. Silencing of tumor suppressor genes (TSGs) by promoter CpG methylation facilitates cells growth and survival advantages and further results in tumor initiation and progression, thus directly contributing to breast tumorigenesis. Usually, aberrant promoter methylation of TSGs, which can be reversed by pharmacological reagents, occurs at the early stage of tumorigenesis and therefore may serve as a potential tumor marker for early diagnosis and therapeutic targeting of breast cancer. In this review, we summarize the epigenetic changes of multiple TSGs involved in breast pathogenesis and their potential clinical applications as tumor markers for early detection and treatment of breast cancer.
着者Xiang T.X., Yuan Y., Li L.L., Wang Z.H., Dan L.Y., Chen Y., Ren G.S., Tao Q.
期刊名称Chinese Journal of Cancer
详细描述In press.
出版年份2013
月份1
日期17
卷号32
期次1
出版社BioMed Central
出版地United States
页次http://aims.cuhk.edu.hk/converis/portal/Publication/12 - 20
国际标準期刊号1000-467X
电子国际标準期刊号1944-446X
语言英式英语
关键词Breast cancer, CpG, Methylation, Tumor marker, Tumor suppressor gene
