Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陈明乐博士 (肿瘤学系) |
| 马碧如教授 (肿瘤学系) |
| 吴兆文教授 (外科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.3748/wjg.v20.i14.3847 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/6WOS source URL
其它资讯
摘要Colorectal cancer (CRC) is one of the most prevalent cancers in developed countries. On the other hand, CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or sigmoidoscopy. Since CRC develops slowly from precancerous lesions, early detection can reduce both the incidence and mortality of the disease. Fecal occult blood test is a widely used non-invasive screening tool for CRC. Although fecal occult blood test is simple and cost-effective in screening CRC, there is room for improvement in terms of the accuracy of the test. Genetic dysregulations have been found to play an important role in CRC development. With better understanding of the molecular basis of CRC, there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for CRC. In this review, the molecular basis of CRC development, the characteristics and applications of different non-invasive molecular biomarkers, as well as the technologies available for the detection were discussed. This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state, colorectal adenoma. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
着者Tsang AHF, Cheng KH, Wong ASP, Ng SSM, Ma BBY, Chan CML, Tsui NBY, Chan LWC, Yung BYM, Wong SCC
期刊名称World Journal of Gastroenterology
出版年份2014
月份4
日期14
卷号20
期次14
出版社W J G PRESS
页次3847 - 3857
国际标準期刊号1007-9327
电子国际标準期刊号2219-2840
语言英式英语
关键词Colorectal adenoma; Colorectal cancer; Fecal occult blood test; Molecular diagnostics; Non-invasive
Web of Science 学科类别Gastroenterology & Hepatology; GASTROENTEROLOGY & HEPATOLOGY
