Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 包立怡教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/hmg/ddq474 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/37WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/41Scopus source URL
其它资讯
摘要Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic involvement. The susceptibility genes identified so far can only explain a small proportion of disease heritability. Through a genome-wide association in a Hong Kong Chinese cohort and subsequent replication in two other Asian populations, with a total of 3164 patients and 4482 matched controls, we identified association of ELF1 (E74-like factor 1) with SLE (rs7329174, OR = 1.26, joint P = 1.47 × 10-8). ELF1 belongs to the ETS family of transcription factors and is known to be involved in T cell development and function. Database analysis revealed transcripts making use of three alternative exon1s for this gene. Near equivalent expression levels of distinct transcripts initiated from alternative exon1s were detected in peripheral blood mononuclear cells from both SLE patients and healthy controls. Although a direct association of rs7329174 with the three forms of transcripts for this gene was not detected, these findings support an important role of ELF1 in SLE susceptibility and suggest a potentially tight regulation for the expression of this gene. ? The Author 2010. Published by Oxford University Press. All rights reserved.
着者Yang J., Yang W., Hirankarn N., Ye D.Q., Zhang Y., Pan H.-F., Mok C.C., Chan T.M., Sing Wong R.W., Mok M.Y., Lee K.W., Wong S.N., Ho Leung A.M., Li X.-P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Baum L., Kwan P., Lee T.L., Kung Ho M.H., Wah Lee P.P., Sang Wong W.H., Zeng S., Zhang J., Wong C.-M., Lin Ng I.O., Garcia-Barcelo M.-M., Cherny S.S., Tam P.K.-H., Sham P.C., Lau C.S., Lau Y.L.
期刊名称Human Molecular Genetics
出版年份2011
月份2
日期1
卷号20
期次3
出版社Oxford University Press
出版地United Kingdom
页次601 - 607
国际标準期刊号0964-6906
电子国际标準期刊号1460-2083
语言英式英语
