Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 梁廷勋教授 (儿科学系) |
| 李?前教授 (药剂学院) |
| 韩锦伦教授 (儿科学系) |
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Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/19Scopus source URL
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摘要Objectives Atopic eczema is a chronic relapsing skin disease associated with atopy, and characterised by reduced skin hydration, impaired skin integrity (transepidermal water loss), and poor quality of life. Proper emollient usage is an important facet of its management. This study aimed to establish an approach to evaluate the efficacy of using an emollient over a 4-week period. Design Prospective observational study. Setting A paediatric dermatology out-patient clinic of a university teaching hospital in Hong Kong. Patients Consecutive new patients aged 5 to 18 years with atopic eczema diagnosed according to Hanifin and Rajka's criteria were recruited from March to August 2009. They or their parents were instructed to liberally apply the test emollient to the flexures and areas affected with eczema, twice daily. Outcome assessments were repeated 2 and 4 weeks later. Main outcome measures Skin hydration and transepidermal water loss in the right forearm (2 cm below antecubital flexure), and disease severity (SCORing Atopic Dermatitis index) and Children's Dermatology Life Quality Index. At the end of the study period, a global assessment of treatment was recorded. Results Thirty-three patients with atopic eczema were recruited and treated with applications of a pseudoceramide-containing cream (Curel, Kao, Japan). The mean age of the patients (16 males and 17 females) was 12 (standard deviation, 4) years. Four weeks following the use of the cream, skin hydration improved significantly and fewer patients were using topical corticosteroids. In these patients, there was no deterioration in transepidermal water loss, eczema severity, or quality of life. Conclusion The pseudoceramide cream improved skin hydration but not severity or quality of life over a 4-week usage. ? http://aims.cuhk.edu.hk/converis/portal/Publication/1995-2011 HKAM.
着者Hon K.L., Wang S.S., Lau Z., Lee H.C., Lee K.K.C., Leung T.F., Luk N.M.
期刊名称Hong Kong Medical Journal
出版年份2011
月份4
日期1
卷号17
期次2
出版社Hong Kong Academy of Medicine Press
出版地Hong Kong
页次132 - 136
国际标準期刊号1024-2708
语言英式英语
关键词Atopic, Child, Dermatitis, Eczema, Emollients, Insensible, Water loss
