Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 阮文宾教授 (儿科学系) |
| 戚其威教授 (儿科学系) |
| 梁廷勋教授 (儿科学系) |
| 宋银子教授 (医学院) |
| 李志光教授 (儿科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1080/088800100276686 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/11WOS source URL
其它资讯
摘要A previous study demonstrated impaired systolic function in 29% of patients treated with anthracycline as part of their therapy for malignant disease. A follow-up echocardiographic study was performed to determine whether there had been further deterioration of cardiac function. At least 40 months after the first study, those patients In whom abnormal systolic function had been detected and who had not received further anthracycline were studied by echocardiography using the same protocol as the initial study (group A). A second group of pediatric oncology patients who had not been given anthracycline but who had previously had cardiac assessment was selected as a control group (group N). The age and sex distributions of the two groups were comparable. Group A comprised 29 patients assessed on 2 occasions at mean times of 46 months and 89 months from the last dose of anthracycline. The mean dose of anthracycline received was 233 mg/m(2) (range 20-400). Nine of 16 patients and 4 of 5 patients who had abnormal ejection fraction (EF) and fractional shortening (FS) at first assessment had normal EF and FS at the second assessment. There were no significant changes in EF, FS, and left ventricular wall stress (LVWS) between the two examinations. In group N, 20 patients were assessed after a mean interval of 43 months. There were no significant changes in EF FS, or LVWS between the two examinations. At the first but not the second examination there were significant differences in the left ventricular internal diameters, EF, FS, and LVWS between group A and group N. Mildly abnormal cardiac indices detected in child? en after cessation of treatment with anthracycline did riot deteriorate in 3 to 4 years follow-up. ii longer cardiac follow-up study is indicated to assess the late outcome.
着者Li CK, Sung RYT, Kwok KL, Leung TF, Shing MMK, Chik KW, Yu CW, Yam MC, Yuen PMP
期刊名称PEDIATRIC HEMATOLOGY AND ONCOLOGY
出版年份2000
月份1
日期1
卷号17
期次1
出版社HEMISPHERE PUBL CORP
页次77 - 83
国际标準期刊号0888-0018
语言英式英语
关键词anthracycline; cardiac function; children
Web of Science 学科类别Hematology; HEMATOLOGY; Oncology; ONCOLOGY; Pediatrics; PEDIATRICS
