Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡锦生教授 |
| 祁理治教授 (内科及药物治疗学系) |
| 汤宁信教授 |
| 孙德生教授 (医学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1042/CS19980149 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/19WOS source URL
其它资讯
摘要Although beta-adrenoreceptor antagonists appear to be beneficial in chronic heart failure there is little information on their effects on autonomic and baroreceptor function which may have important prognostic implications. We sought to determine first whether beta-adrenoreceptor blockade will improve baroreceptor function and vagal tone in chronic heart failure, and second whether there were any differences between standard therapy with metoprolol and the second-generation vasodilating beta-blocker celiprolol. in this double-blind randomized placebo-controlled study 50 patients with stable chronic heart failure received either celiprolol 200 mg daily, metoprolol 50 mg twice daily or placebo for 12 weeks after a 4-week dose titration period. Thirty-five healthy normal subjects were also studied. Baroreceptor gain was assessed noninvasively by cross-spectral analysis of R-R and systolic blood pressure low- and high-frequency components (the alpha angle) during controlled respiration. High-frequency power was used as a measure of vagal modulation. Satisfactory recordings for analysis were obtained in 31 patients with heart failure. The results showed that at baseline baroreceptor gain (alpha(HF)) was significantly depressed in patients with heart failure compared with the normal control group (4.95 +/- 0.55 versus [ 1.73 +/- 1.32 ms/mmHg, P < 0.0001). After 12 weeks of treatment with metoprolol baroreceptor gain improved significantly whether measured while supine (P = 0.03) or standing (P = 0.009), and this was associated with a significant increase in R-R HF power (P = 0.008). There were no significant changes after treatment with celiprolol or placebo. We conclude that metoprolol but not celiprolol therapy restores baroreceptor gain towards normal and increases vagal tone in chronic heart failure. The ancillary properties of celiprolol do not appear to provide any advantages over metoprolol for the restoration of autonomic and baroreceptor function in heart failure.
着者Sanderson JE, Yeung LY, Chan S, Tomlinson B, Kay R, Woo KS, Bernardi L
期刊名称CLINICAL SCIENCE
出版年份http://aims.cuhk.edu.hk/converis/portal/Publication/1999
月份2
日期1
卷号96
期次2
出版社PORTLAND PRESS
页次137 - 146
国际标準期刊号0143-5221
电子国际标準期刊号1470-8736
语言英式英语
关键词autonomic nervous system; baroreceptors; beta-blockers; heart failure
Web of Science 学科类别Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine
