Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 孙德生教授 (医学院) |
| 陈恩强教授 (内科及药物治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/qjmed/90.8.535 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/9WOS source URL
其它资讯
摘要Warfarin requirements are lower in the Chinese, but it is not known if this applies to heparin. We investigated the optimal dose for heparin therapy in Chinese patients, and to assess relationship between i.v. heparin dosage and anticoagulation efficacy. One hundred Chinese patients requiring intravenous heparin therapy were given an initial bolus followed by continuous intravenous infusion. The main outcome measures were: (i) Efficacy of anticoagulation assessed by blood coagulation studies (APTT) compared to heparin dosage, (ii) Determinants of dosage variation-age, gender, body weight, height, indication for heparin therapy and number of medications, other disease, and serum albumin level. it was found that the mean therapeutic infusion dose requirement of heparin was 848.7 +/- 274.7 units/h, 7http://aims.cuhk.edu.hk/converis/portal/Publication/9% required a dose of 1000 units/h or less. Heparin dose correlated negatively with age (r = -0.40; p < 0.001) and positively with weight (r=0.44 p<0.001) and height (r = 0.4http://aims.cuhk.edu.hk/converis/portal/Publication/9; p < 0.001). Chinese subjects require lower heparin doses (about 800 units/h) than usually recommended for Caucasians (usual dose 1000-1500 units/h). This can be partly explained by the lower body weight in Chinese patients.
着者Yu CM, Chan TYK, Tsoi WC, Sanderson JE
期刊名称QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
出版年份1http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/97
月份8
日期1
卷号http://aims.cuhk.edu.hk/converis/portal/Publication/90
期次8
出版社OXFORD UNIV PRESS
页次535 - 543
国际标準期刊号0033-5622
语言英式英语
Web of Science 学科类别General & Internal Medicine; Medicine, General & Internal; MEDICINE, GENERAL & INTERNAL
