A generalized drop-the-loser urn for clinical trials with delayed responses
Publication in refereed journal


香港中文大学研究人员 ( 现职)

张绍洪教授 (统计学系)

陈伟森教授 (金融学系)

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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/22WOS source URL

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摘要Urn models are popular and useful for adaptive designs in clinical studies. Among various urn models, the drop-the-loser rule is an efficient adaptive treatment allocation scheme, recently proposed for comparing different treatments in a clinical trial. This rule is superior to other randomization schemes in terms of variability and power. In this paper, the drop-the-loser rule is generalized to cope with more popular and practical circumstances, including (1) delayed responses when test results cannot be obtained immediately, (2) continuous responses, and (3) a prespecified target of allocation proportion. In addition, our proposed procedure has several favorable asymptotic properties such as strong consistency and asymptotic normality of the allocation proportions.

着者Zhang LX, Chan WS, Cheung SH, Hu FF
期刊名称Statistica Sinica
出版年份2007
月份1
日期1
卷号17
期次1
出版社STATISTICA SINICA
页次387 - 409
国际标準期刊号1017-0405
电子国际标準期刊号1996-8507
语言英式英语

关键词asymptotic normality; asymptotic power; clinical trial; delayed response; randomized play-the-winner rule; strong consistency
Web of Science 学科类别Mathematics; Statistics & Probability; STATISTICS & PROBABILITY