Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 于君教授 (内科及药物治疗学系) |
| 陈德威教授 (麻醉及深切治疗学系) |
| 周泰昌先生 (内科及药物治疗学系) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 黄曦教授 (内科及药物治疗学系) |
| 王显嵩先生 (内科及药物治疗学系) |
| 王华婷教授 (李嘉诚健康科学研究所) |
| 邝毅扬博士 (李嘉诚健康科学研究所) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/molbev/msw295 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
其它资讯
摘要Focal copy number gains or losses are important genomic hallmarks of cancer. The genomic distribution of oncogenes and tumor-suppressor genes (TSG) in relation to focal copy number aberrations is unclear. Our analysis revealed that the mean distance of TSGs from oncogenes was significantly shorter than that of noncancer genes, suggesting that oncogenes and TSGs tend to be in close physical proximity in the human genome. Such relationship was conserved in mouse and drosophila. Pan-cancer analysis using data from The Cancer Genome Atlas indicated that oncogenes without a nearby TSG are more prone to amplification. In conclusion, our study provides evidence for the nonrandom distribution of oncogenes and TSGs across different species. Our data also support that the existence of a neighboring TSG can suppress amplification of an oncogene, shedding new light on a previously unappreciated protective mechanism of TSGs.
着者Wu, Li, Wang, Dai, Cheng, Wang, Kwong, Chow, Yu, Chan, Wong
期刊名称Molecular biology and evolution
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/017
月份1
卷号34
期次4
页次9http://aims.cuhk.edu.hk/converis/portal/Publication/03 - 9http://aims.cuhk.edu.hk/converis/portal/Publication/07
国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/0737-4http://aims.cuhk.edu.hk/converis/portal/Publication/038
语言英式英语
关键词oncogene,tumor-suppressor gene,copy number aberration,amplification
