The role of microRNAs in intrahepatic cholangiocarcinoma.
Publication in refereed journal


香港中文大学研究人员 ( 现职)

胡嘉麒教授 (麻醉及深切治疗学系)

陈德威教授 (麻醉及深切治疗学系)

全文

典藏于此文库的全文 42746321.pdf 数位物件识别号 (DOI) http://dx.doi.org/10.1111/jcmm.12951

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/0Scopus source URL

其它资讯

摘要Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy with poor prognosis. Despite improvements in its diagnosis and therapy, the prognosis for ICC patients remains poor. An improved understanding of ICC pathogenesis and consequential identification of novel therapeutic targets would improve the prognosis of ICC patients. MicroRNAs (miRNAs) are a class of highly conserved, endogenous, small non-coding RNA molecules of 18-23 nucleotides in length, which regulate gene expression through complementary base-pairing with target messenger RNAs and subsequent gene silencing. Several studies have shown deregulated expression of miRNAs in ICC cell lines and tissues, in which these miRNAs play important roles in ICC apoptosis, cell proliferation, invasion, migration and metastasis. In this review, we illustrate the potential role of miRNA in the pathogenesis of ICC and explore the possibilities of using miRNAs as prognostic and diagnostic markers, as well as therapeutic targets in ICC.

着者Zheng Li, Jianxiong Shen, Matthew T.V. Chan, William Ka Kei Wu
期刊名称JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/017
月份1
卷号21
期次1
出版社WILEY-BLACKWELL
页次177 - 184
国际标準期刊号1582-4934
语言英式英语