Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 于君教授 (内科及药物治疗学系) |
| 沈祖尧教授 (内科及药物治疗学系) |
| 曹之宪教授 (生物医学学院) |
| 杜家辉教授 (病理解剖及细胞学系) |
| 陈家亮教授 (内科及药物治疗学系) |
| 吴兆文教授 (外科学系) |
| 罗晓敏先生 (生物医学学院) |
| 郑诗乐教授 (生物医学学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.critrevonc.2012.11.009 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/26WOS source URL
其它资讯
摘要Multiple intracellular signaling pathways, such as Wnt/beta-catenin signaling, epidermal growth factor receptor/Ras signaling, and p53 signaling are frequently dysregulated in colorectal cancer. Recent evidence also points to the involvement of signaling pathways in the developmental process, including Notch signaling, Hedgehog signaling, and Hippo signaling. Dysregulation of these signaling pathways contribute to the acquisition of malignant phenotypes, including unchecked cell cycle progression, evasion of apoptosis, induction of genetic instability, and enhanced invasiveness and metastasis. Understanding their relative importance and crosstalk will provide a rational basis for anticancer drug development. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
着者Wu WKK, Wang XJ, Cheng ASL, Luo MXM, Ng SSM, To KF, Chan FKL, Cho CH, Sung JJY, Yu J
期刊名称Critical Reviews in Oncology/Hematology
详细描述To ORKTS: Duplicate records P131114 & P1http://aims.cuhk.edu.hk/converis/portal/Publication/26447 deleted.
出版年份2013
月份6
日期1
卷号86
期次3
出版社Elsevier
页次251 - 277
国际标準期刊号1040-8428
电子国际标準期刊号1879-0461
语言英式英语
关键词Cell signaling; Colorectal cancer; p53; Ras; Wnt
Web of Science 学科类别Hematology; HEMATOLOGY; Oncology; ONCOLOGY
