Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 黄曦教授 (内科及药物治疗学系) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
| 于君教授 (内科及药物治疗学系) |
| 吴兆文教授 (外科学系) |
| 杜家辉教授 (病理解剖及细胞学系) |
| 陈家亮教授 (内科及药物治疗学系) |
| 沈祖尧教授 (内科及药物治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.semcancer.2013.09.005 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/9WOS source URL
其它资讯
摘要Colorectal cancer is a leading cause of morbidity and mortality worldwide. Understanding its genetic mechanisms is key to improving risk prediction, prognostication and treatment. Results from genome-wide association studies have engendered a growing list of colorectal cancer susceptibility genes whereas the application of genome-wide mutational analysis has enabled the depiction of mutational landscape of colorectal cancer at high resolution. The development of novel technologies, such as metagenomic and single-cell sequencing, is expected to have positive impact on future genetic studies. However, challenges remain to address the changing epidemiology of colorectal cancer, issues on genetic testing, and clinical utilization of genomic data. (C) 2013 Elsevier Ltd. All rights reserved.
着者Wong SH, Sung JJY, Chan FKL, To KF, Ng SSM, Wang XJ, Yu J, Wu WKK
期刊名称SEMINARS IN CANCER BIOLOGY
出版年份2013
月份12
日期1
卷号23
期次6
出版社ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
页次502 - 511
国际标準期刊号1044-57http://aims.cuhk.edu.hk/converis/portal/Publication/9X
语言英式英语
关键词Colorectal cancer; GWAS; Mutation; Next-generation sequencing
Web of Science 学科类别Oncology; ONCOLOGY
