Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 罗德贤博士 (微生物学系) |
| 沈祖尧教授 (内科及药物治疗学系) |
| 于君教授 (内科及药物治疗学系) |
| 曹之宪教授 (生物医学学院) |
| 李中华先生 (内科及药物治疗学系) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/carcin/bgq243 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/84WOS source URL
其它资讯
摘要Colon carcinogenesis represents a stepwise progression from benign polyps to invasive adenocarcinomas and distant metastasis. It is believed that these pathologic changes are contributed by aberrant activation or inactivation of protein-coding proto-oncogenes and tumor suppressor genes. However, recent discoveries in microRNA (miRNA) research have reshaped our understanding of the role of non-protein-coding genes in carcinogenesis. In this regard, a remarkable number of miRNAs exhibit differential expression in colon cancer tissues. These miRNAs alter cell proliferation, apoptosis and metastasis through their interactions with intracellular signaling networks. From a clinical perspective, polymorphisms within miRNA-binding sites are associated with the risk for colon cancer, whereas miRNAs isolated from feces or blood may serve as biomarkers for early diagnosis. Altered expression of miRNA or polymorphisms in miRNA-related genes have also been shown to correlate with patient survival or treatment outcome. With further insights into miRNA dysregulation in colon cancer and the advancement of RNA delivery technology, it is anticipated that novel miRNA-based therapeutics will emerge.
着者Wu WKK, Law PTY, Lee CW, Cho CH, Fan DM, Wu KC, Yu J, Sung JJY
期刊名称Carcinogenesis
出版年份2011
月份3
日期1
卷号32
期次3
出版社Oxford University Press (OUP): Policy B - Oxford Open Option B
页次247 - 253
国际标準期刊号0143-3334
电子国际标準期刊号1460-2180
语言英式英语
Web of Science 学科类别Oncology; ONCOLOGY
