Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 于君教授 (内科及药物治疗学系) |
| 陈家亮教授 (内科及药物治疗学系) |
| 李中华先生 (内科及药物治疗学系) |
| 曹之宪教授 (生物医学学院) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.yexcr.2011.03.005 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/5WOS source URL
其它资讯
摘要Mammalian target of rapamycin complex 1 (mTORC1) is dysregulated in gastric cancer. The biologic function of mTORC1 in gastric carcinogenesis is unclear. Here, we demonstrate that disruption of mTORC1 function by RNA interference-mediated downregulation of raptor substantially inhibited gastric cancer cell proliferation through induction of G(0)/G(1)-phase cell cycle arrest. The anti-proliferative effect was accompanied by concomitant downregulation of activator protein-1 and upregulation of Smad2/3 transcriptional activities. In addition, the expression of cyclin D(3) and p21(Waf1), which stabilizes cyclin D/cdk4 complex for G(1)-S transition, was reduced by raptor knockdown. In conclusion, disruption of mTORC1 inhibits gastric cancer cell proliferation through multiple pathways. This discovery may have an implication in the application of mTORC1-directed therapy for the treatment of gastric cancer. (C) 2011 Elsevier Inc. All rights reserved.
着者Wu WKK, Lee CW, Cho CH, Chan FKL, Yu J, Sung JJY
期刊名称Experimental Cell Research
出版年份2011
月份6
日期10
卷号317
期次10
出版社Elsevier
页次13http://aims.cuhk.edu.hk/converis/portal/Publication/53 - 13http://aims.cuhk.edu.hk/converis/portal/Publication/58
国际标準期刊号0014-4827
电子国际标準期刊号1090-2422
语言英式英语
关键词AP-1; Cell cycle; Gastric cancer; mTOR; Proliferation; Smad
Web of Science 学科类别Cell Biology; CELL BIOLOGY; Oncology; ONCOLOGY
