Human metapneumovirus detection in patients with severe acute respiratory syndrome
Publication in refereed journal


香港中文大学研究人员 ( 现职)

沈祖尧教授 (内科及药物治疗学系)

朱妙婷女士 (微生物学系)

沈祖尧教授 (内科及药物治疗学系)

锺尚志教授 (外科学系)

朱妙婷女士 (微生物学系)

张丽群博士 (那打素护理学院)

许树昌教授 (内科及药物治疗学系)

李礼舜教授 (内科及药物治疗学系)

杜家辉教授 (病理解剖及细胞学系)

Professor Gavin Matthew JOYNT (麻醉及深切治疗学系)

吴景祥医生 (微生物学系)

李志光教授 (儿科学系)

陈维智博士 (药剂学院)

陈基湘教授 (微生物学系)

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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/84WOS source URL

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摘要We used a combination approach of conventional virus isolation and molecular techniques to detect human metapneumovirus (HMPV) in patients with severe acute respiratory syndrome (SARS). Of the 48 study patients, 25 (52.1%) were infected with HMPV; 6 of these 25 patients were also infected with coronavirus, and another 5 patients (10.4%) were infected with coronavirus alone. Using this combination approach, we found that human laryngeal carcinoma (HEp-2) cells were superior to rhesus monkey kidney (LLC-MK2) cells commonly used in previous studies for isolation of HMPV. These widely available HEp-2 cells should be included in conjunction with a molecular method for cell culture followup to detect HMPV, particularly in patients with SARS.

着者Chan PKS, Tam JS, Lam CW, Chan E, Wu A, Li CK, Buckley TA, Ng KC, Joynt GM, Cheng FWT, To KF, Lee N, Hui DSC, Cheung JLK, Chu I, Liu E, Chung SCA, Sung JJY
期刊名称Emerging Infectious Diseases
出版年份2003
月份9
日期1
卷号9
期次9
出版社CENTER DISEASE CONTROL
页次1058 - 1063
国际标準期刊号1080-6040
电子国际标準期刊号1080-6059
语言英式英语

Web of Science 学科类别Immunology; IMMUNOLOGY; Infectious Diseases; INFECTIOUS DISEASES