Postpartum patients have slightly prolonged neuromuscular block after mivacurium
Publication in refereed journal


香港中文大学研究人员 ( 现职)

陈德威教授 (麻醉及深切治疗学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1097/00000539-199801000-00016

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/1WOS source URL

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摘要Postpartum patients have decreased plasma cholinesterase activity, which may slow the metabolism of mivacurium. We compared the duration of a mivacurium neuromuscular block in http://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/1 women undergoing postpartum tubal ligation 36-99 h after delivery with that in http://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/1 control women undergoing gynecological surgery. Anesthesia was induced with propofol and fentanyl and maintained with propofol and nitrous oxide. Neuromuscular block was monitored by electromyography, and the ulnar nerve was stimulated transcutaneously using a train-of-four pattern. Patients received a bolus dose of mivacurium 0.http://aims.cuhk.edu.hk/converis/portal/Publication/15 mg/kg. The median (range) duration of neuromuscular block until 25% recovery of the first twitch response was longer in the postpartum group, http://aims.cuhk.edu.hk/converis/portal/Publication/19.4 (http://aims.cuhk.edu.hk/converis/portal/Publication/15.6-25.2) min, compared with the control group, http://aims.cuhk.edu.hk/converis/portal/Publication/16.3 (http://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/1.0-23.4) min (P = 0.04). The median (range) plasma cholinesterase activity was decreased in the postpartum group, 4.0 (0.http://aims.cuhk.edu.hk/converis/portal/Publication/1-5.5) kU/L, compared with the control group, 7.http://aims.cuhk.edu.hk/converis/portal/Publication/1 (6.2-http://aims.cuhk.edu.hk/converis/portal/Publication/10.0) kU/L (P < 0.00http://aims.cuhk.edu.hk/converis/portal/Publication/1). The duration of neuromuscular block was inversely correlated with cholinesterase activity (Kendall rank correlation tau = -0.43, P = 0.005). The slight prolongation of neuromuscular block should not be significant clinically. Implications: Postpartum patients have decreased amounts of the plasma cholinesterase enzyme. This would slow the metabolism of the muscle relaxant mivacurium. However, the duration of muscle paralysis is only prolonged by approximately 3 min, which would not normally cause any significant problems.

着者Gin T, Derrick JL, Chan MTV, Chui PT, Mak TWL
期刊名称Anesthesia and Analgesia
出版年份http://aims.cuhk.edu.hk/converis/portal/Publication/1998
月份http://aims.cuhk.edu.hk/converis/portal/Publication/1
日期http://aims.cuhk.edu.hk/converis/portal/Publication/1
卷号86
期次http://aims.cuhk.edu.hk/converis/portal/Publication/1
出版社LIPPINCOTT WILLIAMS & WILKINS
页次82 - 85
国际标準期刊号0003-2999
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1526-7598
语言英式英语

Web of Science 学科类别Anesthesiology; ANESTHESIOLOGY