Publication in refereed journal
香港中文大学研究人员 ( 现职)
| Professor Warwick Dean NGAN KEE (麻醉及深切治疗学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/3WOS source URL
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摘要We investigated the effect of diluent volume on analgesia and systemic absorption from epidural meperidine after cesarean section in a randomized, double-blind study. At the first request for postoperative analgesia, http://aims.cuhk.edu.hk/converis/portal/Publication/36 parturients were given epidural meperidine 25 mg diluted with saline to either 2 mL (12.5 mg/mL), 5 mL (5 mg/mL), or 10 mL (2.5 mg/mL). Visual analog pain scores measured in the first http://aims.cuhk.edu.hk/converis/portal/Publication/30 min were greater in the 2-mL group compared with both the 5-mL group (P = 0.028) and the 10-mL group (P = 0.0http://aims.cuhk.edu.hk/converis/portal/Publication/31). Onset of analgesia (time for visual analog pain scores to decrease by 50%) was also slower in the 2-mL group (17.5 min) compared with the 5-mL group (9 min; P = 0.015) and the 10-mL group (12 min; P = 0.00http://aims.cuhk.edu.hk/converis/portal/Publication/3); there were no differences between the 5-mL group and the 10-mL group. Duration of analgesia and plasma concentrations of meperidine were similar among groups. No adverse side effects were recorded. Previous work has suggested that injection of epidural opioids in large volumes increases the potential risk of respiratory depression from cephalad spread of the drug. Therefore, we conclude that analgesia is optimum when epidural meperidine is administered diluted to 5 mL.
着者Kee WDN, Lam KK, Chen PP, Gin T
期刊名称Anesthesia and Analgesia
出版年份1997
月份8
日期1
卷号85
期次2
出版社WILLIAMS & WILKINS
页次http://aims.cuhk.edu.hk/converis/portal/Publication/380 - http://aims.cuhk.edu.hk/converis/portal/Publication/384
国际标準期刊号000http://aims.cuhk.edu.hk/converis/portal/Publication/3-2999
电子国际标準期刊号1526-7598
语言英式英语
Web of Science 学科类别Anesthesiology; ANESTHESIOLOGY
