Publication in refereed journal
香港中文大学研究人员 ( 现职)
| Professor Gavin Matthew JOYNT (麻醉及深切治疗学系) |
| Professor Charles David GOMERSALL (麻醉及深切治疗学系) |
| Professor Tony GIN (麻醉及深切治疗学系) |
| Professor Jeffrey LIPMAN (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/jac/40.2.269 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/65WOS source URL
其它资讯
摘要Ceftazidime is frequently used in critically ill patients, particularly for the treatment of Pseudomonas aeruginosa infections. The recommended dosing regimen is based on pharmacokinetic data obtained in healthy volunteers and may not be appropriate in the critically iii. We administered ceftazidime in the maximum recommended dose (2 g iv every 8 h) to ten critically ill patients with normal plasma creatinine. Eighteen arterial blood samples were taken from each patient over the first 8 h for measurement of ceftazidime concentrations and subsequent compartmental pharmacokinetic analysis. An additional trough sample was taken from each patient on day 3. Although mean pharmacokinetic variables did not differ from previously reported data in normal volunteers there was wide variability in plasma drug concentrations. Three of our patients had plasma ceftazidime concentrations less than the MIC for P. aeruginosa (8 mg/L) and nine had concentrations less than 5 x MIG, which has been recommended to ensure efficacy. On day 3 trough ceftazidime concentrations were less than the MIC in four out of the seven patients in whom measurements were made and less than 5 x MIC in the remaining three. There was no clinical predictor of which patients would have low plasma concentrations. Our results show that plasma concentrations of ceftazidime are very variable when the recommended intermittent bolus dosing regimen is used and may result in inadequate plasma concentrations of drug in critical infections. This may result in treatment failure and the emergence of antibiotic resistance. A loading dose followed by continuous infusion should overcome these problems but this awaits in-vivo evaluation.
着者Young RJ, Lipman J, Gin T, Gomersall CD, Joynt GM, Oh TE
期刊名称Journal of Antimicrobial Chemotherapy
出版年份1997
月份8
日期1
卷号40
期次2
出版社OXFORD UNIV PRESS
页次269 - 273
国际标準期刊号0305-7453
电子国际标準期刊号1460-2091
语言英式英语
Web of Science 学科类别Infectious Diseases; INFECTIOUS DISEASES; Microbiology; MICROBIOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
