Clinical Signs, Staphylococcus and Atopic Eczema-Related Seromarkers
Publication in refereed journal


香港中文大学研究人员 ( 现职)

曾燕静小姐 (妇产科学系)

黄振国教授 (化学病理学系)

韩锦伦教授 (儿科学系)

梁廷勋教授 (儿科学系)

林伟棋医生 (化学病理学系)

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典藏于此文库的全文 molecules-22-http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0291.pdf 数位物件识别号 (DOI) http://dx.doi.org/10.3390/molecules22020291 出版商提供的全文 ○○@1http://aims.cuhk.edu.hk/converis/portal/Publication/0$@○○

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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/0Scopus source URL

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摘要Childhood eczema or atopic dermatitis (AD) is a distressing disease associated with pruritus, sleep disturbance, impaired quality of life and Staphylococcus aureus isolation. The pathophysiology of AD is complex and various seromarkers of immunity are involved. We investigated if anti-staphylococcal enterotoxin IgE (anti-SE), selected seromarkers of T regulatory (Treg), T helper (Th) and antigen-presenting cells (APC) are associated with clinical signs of disease severity and quality of life. Disease severity was assessed with the Scoring Atopic Dermatitis (SCORAD) index, and quality of life with the Children’s Dermatology Life Quality Index (CDLQI) in AD patients ≤18 years old. Concentrations of anti-staphylococcus enterotoxin A and B immunoglobulin E (anti-SEA and anti-SEB), selected Treg/Th/APC chemokines, skin hydration and transepidermal water loss (TEWL) were measured in these patients. Forty patients with AD [median (interquartile range) age of 13.1 (7.9) years) were recruited. Backward stepwise linear regression (controlling for age, personal allergic rhinitis and asthma, and other blood markers) showed the serum anti-SEB level was positively associated with S. aureus and S. epidermidis isolations, objective SCORAD, clinical signs and CDLQI. TNF-α (a Th1 cytokine) was positively associated with objective SCORAD (B = 4.935, p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0), TGF-β (a Treg cytokine) negatively with disease extent (B = ?http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/015, p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01), IL-18 (an APC cytokine) positively with disease extent (B = http://aims.cuhk.edu.hk/converis/portal/Publication/0.438, p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/01) and with TEWL (B = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/04http://aims.cuhk.edu.hk/converis/portal/Publication/0, p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0), and IL-23 (an APC cytokine) negatively with disease extent (B = ?2.812, p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/06) and positively with pruritus (B = http://aims.cuhk.edu.hk/converis/portal/Publication/0.387, p = http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/07). Conclusions: Blood levels of anti-SEB, Th1, Treg and APC cytokines are correlated with various clinical signs of AD. AD is a systemic immunologic disease involving Staphylococcus aureus, cellular, humoral, cytokine and chemokine pathophysiology.

出版社接受日期15.http://aims.cuhk.edu.hk/converis/portal/Publication/02.2http://aims.cuhk.edu.hk/converis/portal/Publication/017
着者Kam Lun Hon, Kathy Yin Ching Tsang, Jeng Sum C. Kung, Ting Fan Leung, Christopher W. K. Lam and Chun Kwok Wong
期刊名称MOLECULES
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/017
月份2
日期15
卷号22
期次2
出版社MDPI
国际标準期刊号142http://aims.cuhk.edu.hk/converis/portal/Publication/0-3http://aims.cuhk.edu.hk/converis/portal/Publication/049
语言美式英语

关键词atopic dermatitis, anti-staphylococcal enterotoxin IgE, eosinophil, IgE, antigen presenting cell, CDLQI, SCORAD, T helper and Treg lymphocytes