Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 黄振国教授 (化学病理学系) |
| 陈瑞燕教授 (心理学系) |
| 施黎敏博士 (心理学系) |
| 张嘉珆小姐 (心理学系) |
| 郑伟成先生 (化学病理学系) |
全文
典藏于此文库的全文
数位物件识别号 (DOI) http://dx.doi.org/doi: 10.3389/fimmu.2017.00011 出版商提供的全文 http://journal.frontiersin.org/journal/immunology |
其它资讯
摘要Previous studies have shown that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASDs). However, this research has been conducted almost exclusively in Western contexts, and only a handful of studies on immune measures have been conducted in Asian populations, such as Chinese populations. The present study examined whether immunological abnormalities are associated with cognitive deficits and problem behaviors in Chinese children with ASD and whether these children show different immunological profiles. Thirteen typically developing (TD) children and 22 children with ASD, aged 6-17?years, participated voluntarily in the study. Executive functions and short-term memory were measured using neuropsychological tests, and behavioral measures were assessed using parent ratings. The children were also assessed on immunological measures, specifically, the levels of cytokines and chemokines in the blood serum. Children with ASD showed greater deficits in cognitive functions, as well as altered levels of immunological measures, including CCL2, CCL5, and CXCL9 levels, compared to TD children, and the cognitive functions and associated behavioral deficits of children with ASD were significantly associated with different immunological measures. The children were further sub-classified into ASD with only autistic features (ASD-only) or ASD comorbid with attention deficit hyperactivity disorder (ASD?+?ADHD). The comorbidity results showed that there were no differences between the two groups of ASD children in any of the cognitive or behavioral measures. However, the results pertaining to immunological measures showed that the children with ASD-only and ASD?+?ADHD exhibited distinct cytokine and chemokine profiles and that abnormal immunologic function was associated with cognitive functions and inattention/hyperactivity symptoms. These results support the notion that altered immune functions may play a role in the selective cognitive and behavioral symptoms of ASD.
出版社接受日期04.01.2017
着者Yvonne M.Y. Han, Winnie K.Y. Cheung, Chun Kwok Wong, Sophia L. Sze, Timmy W. S. Cheng, Michael K. Yeung, Agnes S. Chan
期刊名称Frontiers in Immunology
详细描述Article 11
This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
出版年份2017
月份1
日期23
卷号8
出版社Frontiers Media
页次1 - 12
国际标準期刊号1664-3224
语言英式英语
关键词immunologic function, autism, cognitive function, hyperactivity, comorbidity
