Current State of PCR-Based Epstein-Barr Virus DNA Testing for Nasopharyngeal Cancer
Publication in refereed journal


香港中文大学研究人员 ( 现职)

陈君赐教授 (化学病理学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1093/jnci/djx007

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/1Scopus source URL

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摘要Clinical studies have shown plasma Epstein-Barr virus (EBV) DNA level to be an independent prognostic biomarker for nasopharyngeal carcinoma (NPC). However, the proportion of NPC patients whose tumors are associated with EBV vary with geographic location, and there are a variety of assays for plasma EBV. To develop the level of evidence needed to demonstrate the clinical utility of plasma EBV DNA detection for NPC patients and encourage widespread adoption of this biomarker test in clinical laboratories, validated harmonized assays are needed. In 2http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/15, the National Cancer Institute (NCI) convened a Workshop on Harmonization of EBV Testing for Nasopharyngeal Cancer, where experts in head and neck oncology and laboratory medicine addressed the limitations of currently available polymerase chain reaction-based EBV DNA quantitation assays and discussed strategies for advancing the development of harmonized EBV DNA assays and their appropriate clinical use. This article presents the key recommendations to direct future efforts in assay harmonization and validation.

着者Kim KY, Le QT, Yom SS, Pinsky BA, Bratman SV, Ng RHW, El Mubarak HS, Chan KCA, Sander M, Conley BA
期刊名称JNCI: Journal of the National Cancer Institute
详细描述Commentary
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/17
月份3
卷号http://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/09
期次4
出版社Oxford University Press (OUP)
页次http://aims.cuhk.edu.hk/converis/portal/Publication/1 - 7
国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/027-8874
语言英式英语

Web of Science 学科类别Oncology;Oncology