Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
| 陈锦荣先生 (化学病理学系) |
| 潘力行教授 (化学病理学系) |
| 赵慧君教授 (化学病理学系) |
| 梁子昂教授 (妇产科学系) |
| 刘子建教授 (妇产科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1073/pnas.0637450100 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/230WOS source URL
其它资讯
摘要The discovery of circulating fetal nucleic acid in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. Thus far, a gender- and polymorphism-independent fetal-specific target that can be used for prenatal screening and monitoring in all pregnant women has not been reported. In addition, the origin of such circulating nucleic acid has remained unclear. Here we provide direct evidence that the placenta is an important source of fetal nucleic acid release into maternal plasma by demonstrating that mRNA transcripts from placenta-expressed genes are readily detectable in maternal plasma. The surprising stability of such placental mRNA species in maternal plasma and their rapid clearance after delivery demonstrate that such circulating mRNA molecules are practical markers for clinical use. The measurement of such plasma mRNA markers has provided a gender-independent approach for noninvasive prenatal gene expression profiling and has opened up numerous research and diagnostic possibilities.
着者Ng EKO, Tsui NBY, Lau TK, Leung TN, Chiu RWK, Panesar NS, Lit LCW, Chan KW, Lo YMD
期刊名称PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
出版年份2003
月份4
日期15
卷号100
期次8
出版社NATL ACAD SCIENCES
页次4748 - 4753
国际标準期刊号0027-8424
语言英式英语
Web of Science 学科类别Multidisciplinary Sciences; MULTIDISCIPLINARY SCIENCES; Science & Technology - Other Topics
